Article
Medicine, General & Internal
Alexander Kovacevic, Stefan Bar, Sebastian Starystach, Michael Elsasser, Thomas van der Locht, Aida Mohammadi Motlagh, Eva Ostermayer, Renate Oberhoffer-Fritz, Peter Ewert, Matthias Gorenflo, Annette Wacker-Gussmann
Summary: This study surveyed parents from four national tertiary medical care centers using a validated questionnaire, and found that parents counseled during the pandemic for fetal congenital heart disease showed significantly increased concern and uncertainty about their child's diagnosis and therapy, as well as a greater need for written and/or online information.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Liping Fu, Huajun Sun, Kaibo Xu
Summary: This study investigates the impact of public participation on the central government's policy response in the context of the COVID-19 pandemic in China. The findings reveal that the Chinese central government adopts both top-down and bottom-up governance strategies, with public participation playing a crucial role in triggering the latter. Additionally, new media acts as a catalyst in shaping public opinion and prompting timely policy responses from the central government.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Laurentina Schaler, Mary Wingfield
Summary: Studies show that COVID-19 vaccines do not affect future fertility, and pregnant women are at higher risk of complications from the virus, emphasizing the importance of vaccination for those planning a pregnancy. It is crucial to control the spread of misinformation regarding vaccine effects on fertility and ensure healthcare providers are well-informed on the topic.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Immunology
Susanna Esposito, Caterina Caminiti, Rosanna Giordano, Alberto Argentiero, Greta Ramundo, Nicola Principi
Summary: Myocarditis is a rare inflammatory disease that can cause severe heart failure and even death. Viruses, including SARS-CoV-2, are common causes of myocarditis. The incidence of myocarditis has increased after the COVID-19 pandemic, and there have been reports of myocarditis following COVID-19 vaccination. However, most cases of myocarditis after vaccination are mild and should not change the recommendations for COVID-19 vaccination.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bissera Pilicheva, Radka Boyuklieva
Summary: Despite progress in fighting against COVID-19, it remains a dramatic challenge for scientists worldwide. Various approaches, including repurposed medications and nasal administration, are being utilized. Several vaccines have been approved, with many more in clinical and preclinical investigation.
Article
Multidisciplinary Sciences
Heike Kluever, Felix Hartmann, Macartan Humphreys, Ferdinand Geissler, Johannes Giesecke
Summary: Recent evidence shows that vaccination hesitancy is too high in many countries to effectively control COVID-19. A study conducted in Germany involving 20,500 online respondents found that providing freedoms, financial remuneration, and local access to vaccination can increase vaccine uptake by 2-3 percentage points overall and up to 13 percentage points among undecided individuals. Different age groups responded differently to the strategies, with older cohorts preferring local access and younger cohorts favoring enhanced freedoms for vaccinated individuals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Psychology, Multidisciplinary
Haywantee Ramkissoon
Summary: The COVID-19 crisis has led to more people struggling to cope with existing medical conditions and issues like domestic violence, drugs, and alcohol abuse. Strategies are needed to provide additional support for individuals facing emotional distress in confined settings. The importance of promoting interventions to help people adapt to the pandemic and post-pandemic world is crucial for global well-being and public health.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Mattia Miotto, Lorenzo Di Rienzo, Giorgio Gosti, Edoardo Milanetti, Giancarlo Ruocco
Summary: In the COVID-19 pandemic, researchers have found it challenging to understand the geographical differences in virus contagiousness and lethality, as well as the potential role of infected individuals' blood types in infectivity and disease progression. A recent hypothesis suggests that SARS-CoV-2 may retain erythrocyte antigens from the source individual during transmission, potentially triggering an immune response in the recipient. This hypothesis implies a blood type-dependent infection rate and could contribute to the observed heterogeneity in epidemic spread.
Article
Green & Sustainable Science & Technology
Yining Chen, Yaqin Dai, Anyu Liu, Wei Liu, Lei Jia
Summary: This study integrates the knowledge-attitude-practice theory and theory of planned behavior to explore the influence of knowledge on responsible tourism behavior intention. It also develops a new scale for assessing responsible tourism behavior in the post COVID-19 era. The study finds that knowledge partially mediates responsible behavioral intention, and the effects of behavioral attitude and subjective norm are causally moderated by tourists' past travel experience.
JOURNAL OF SUSTAINABLE TOURISM
(2023)
Article
Immunology
Xuefeng Gu, Ling Sha, Shaofeng Zhang, Duo Shen, Wei Zhao, Yongxiang Yi
Summary: The study aimed to develop a diagnostic model for asymptomatic and moderate COVID-19 patients based on demographic, clinical, and laboratory variables. Comparing the two groups, it was found that neutrophil count and lymphocyte count were independent predictors for the presence of clinical symptoms after COVID-19 infection, serving as diagnostic predictors of asymptomatic COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Economics
Hung-Hao Chang, Brian Lee, Feng-An Yang, Yu-You Liou
Summary: This paper presents the first evidence of the causal effect of COVID-19 on metro use using real-time data from the Taipei Metro System in Taiwan. Despite not enforcing strict lockdown measures, Taiwan's major prevention strategies against the pandemic include promoting social distancing, mandating face masks, and quarantining international arrivals. The study found that each additional confirmed case of COVID-19 leads to a 1.43% reduction in metro use, primarily due to residents' perception of health risks associated with using public transportation.
JOURNAL OF TRANSPORT GEOGRAPHY
(2021)
Article
Multidisciplinary Sciences
Enrico Baldi, Roberto Primi, Sara Bendotti, Alessia Currao, Sara Compagnoni, Francesca Romana Gentile, Giuseppe Maria Sechi, Claudio Mare, Alessandra Palo, Enrico Contri, Vincenza Ronchi, Giuseppe Bergamini, Francesca Reali, Pierpaolo Parogni, Fabio Facchin, Ugo Rizzi, Daniele Bussi, Simone Ruggeri, Sabina Campi, Paola Centineo, Roberto De Ponti, Luigi Oltrona Visconti, Simone Savastano
Summary: The study found a significant correlation between daily incidence of COVID-19 and out-of-hospital cardiac arrests during both pandemic waves at a provincial level. Monitoring the pandemic trend closely may help predict areas more likely to experience an increase in cardiac arrests, guiding the proper reallocation of health resources in case of future pandemic waves.
Article
Hospitality, Leisure, Sport & Tourism
Seongseop (Sam) Kim, Jungkeun Kim, Youngjoon Choi, Jongwon Shin, Alastair M. Morrison
Summary: The purpose of this research was to investigate the effects of airline companies' communication with potential passengers during the COVID-19 pandemic on their behavioral intentions towards international air travel. The study found that the loss message regarding cash-redeemable coupons was most effective in increasing intentions to take an international flight and obtaining positive evaluations of the message content. Covariates such as income level, travel purpose, premium card ownership, perceived risk, importance of airline brand, and sanitation were significant in determining the intention to take international flights. These findings can inform the development of promotional strategies for international travel in the post-pandemic era.
JOURNAL OF HOSPITALITY AND TOURISM MANAGEMENT
(2022)
Article
Microbiology
Leyla Sahebi, Mohsen Hosseini, Alireza Abdollahi, Nahid Farrokhzad, Samrand Fattah Ghazi, Farzaneh Samaei Noroozi, Fereshteh Ghiasvand
Summary: The aim of this study was to determine the correlation between rubella IGG titers and the severity of COVID-19. The study found a negative correlation between rubella IgG antibody titers and COVID-19 severity, indicating that MR vaccination may have a positive effect in reducing the severity of the disease.
Review
Immunology
Barbora Lampova, Ivo Doskocil, Lenka Kourimska, Aneta Kopec
Summary: COVID-19 is caused by SARS-CoV-2 and serious complications are mainly due to an exaggerated immune response called a cytokine storm. Supplementation of n-3 polyunsaturated fatty acids may improve clinical outcomes in critically ill COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Chris Piech, Ali Malik, Eric J. Topol
Review
Biochemistry & Molecular Biology
Pranav Rajpurkar, Emma Chen, Oishi Banerjee, Eric J. Topol
Summary: This Review discusses the potential of AI to reshape medicine and make healthcare more accurate, efficient, and accessible. It covers recent progress in medical AI, including advances in medical image analysis, non-image data sources, and human-AI collaboration. The article also addresses technical and ethical challenges, such as data scarcity and racial bias.
Article
Multidisciplinary Sciences
Steven R. Steinhubl, Jill Waalen, Anirudh Sanyal, Alison M. Edwards, Lauren M. Ariniello, Gail S. Ebner, Katie Baca-Motes, Robert A. Zambon, Troy Sarich, Eric J. Topol
Summary: In a trial screening for atrial fibrillation (AF), the study found that patients diagnosed through screening had a lower rate of clinical events compared to observational controls, but the impact of early AF diagnosis through screening on this result remains unclear. These observational data support the need for randomized trials to determine whether AF screening can provide meaningful protection from strokes and other clinical events.
Editorial Material
Multidisciplinary Sciences
Eric Topol
Editorial Material
Multidisciplinary Sciences
Ravindra K. Gupta, Eric J. Topol
Article
Health Care Sciences & Services
Matteo Gadaleta, Jennifer M. Radin, Katie Baca-Motes, Edward Ramos, Vik Kheterpal, Eric J. Topol, Steven R. Steinhubl, Giorgio Quer
Summary: Individual smartwatch or fitness band sensor data have shown promise in identifying COVID-19 infection, and a explainable gradient boosting prediction model based on decision trees was proposed for detection. The model demonstrated good performance in symptomatic individuals and also performed well in all individuals, including asymptomatic and pre-symptomatic cases.
NPJ DIGITAL MEDICINE
(2021)
Article
Medicine, General & Internal
Siegfried Karl Wagner, Fintan Hughes, Mario Cortina-Borja, Nikolas Pontikos, Robbert Struyven, Xiaoxuan Liu, Hugh Montgomery, Daniel C. Alexander, Eric Topol, Steffen Erhard Petersen, Konstantinos Balaskas, Jack Hindley, Axel Petzold, Jugnoo S. Rahi, Alastair K. Denniston, Pearse A. Keane
Summary: Retinal signatures of systemic disease are being revealed through high-resolution ophthalmic imaging and advanced modelling. However, progress is limited due to the lack of large labelled datasets. This study aims to link longitudinal multimodal retinal imaging with systemic disease data to identify hidden retinal signatures for earlier detection and risk management of life-threatening conditions.
Article
Health Care Sciences & Services
Giorgio Quer, Matteo Gadaleta, Jennifer M. Radin, Kristian G. Andersen, Katie Baca-Motes, Edward Ramos, Eric J. Topol, Steven R. Steinhubl
Summary: The ability to track physiological changes in individuals after vaccination using wearable devices can provide objective evidence of vaccine-induced immune response. Preliminary findings show that resting heart rate increases after vaccination in most individuals and returns to normal within days. Vaccine dosage, gender, and age may also affect the physiological response.
NPJ DIGITAL MEDICINE
(2022)
Letter
Biotechnology & Applied Microbiology
Giorgio Quer, Eric J. Topol, Steven R. Steinhubl
NATURE BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jay A. Pandit, Jennifer M. Radin, Giorgio Quer, Eric J. Topol
Summary: During the COVID-19 pandemic, smartphone apps played a crucial role in tracking outbreaks, individual screening, and contact tracing. Despite limitations and concerns, there is ample evidence that these apps have been beneficial in understanding and controlling the spread of the virus.
NATURE BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Rayan Krishnan, Pranav Rajpurkar, Eric J. Topol
Summary: This Review examines the advantages and limitations of self-supervised methods and models in medicine and healthcare, as well as the challenges in collecting unbiased data for their training. The utilization of self-supervised learning has the potential to accelerate the development of medical artificial intelligence, particularly in tasks involving multimodal datasets and the analysis of electronic health records, medical images, bioelectrical signals, and genetic and protein sequences and structures.
NATURE BIOMEDICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Julian N. Acosta, Guido J. Falcone, Pranav Rajpurkar, Eric J. Topol
Summary: This Review discusses the potential applications, technical pitfalls, and challenges of multimodal artificial intelligence models in the field of health and medicine. By utilizing data from large biobanks, electronic health records, medical imaging, and genomics, multimodal AI solutions have the ability to capture the complexity of human health and disease. Key areas such as personalized medicine, digital clinical trials, remote monitoring and care, pandemic surveillance, and virtual health assistants offer opportunities, but data, modeling, and privacy challenges need to be addressed for the full potential of multimodal AI in health to be realized.
Review
Microbiology
Hannah E. Davis, Lisa McCorkell, Julia Moore Vogel, Eric J. Topol
Summary: Long COVID is a common and debilitating illness that affects at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, with a wide range of symptoms and impacts on multiple organ systems. There are an estimated 65 million individuals worldwide with long COVID, and the number of cases is increasing daily. Current diagnostic and treatment options are insufficient, and there is a need for clinical trials to address leading hypotheses. Future research should account for biases and testing issues, build on viral-onset research, include marginalized populations, and meaningfully engage patients.
NATURE REVIEWS MICROBIOLOGY
(2023)
Correction
Microbiology
Hannah E. Davis, Lisa McCorkell, Julia Moore Vogel, Eric J. Topol
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Bertalan Mesko, Eric J. J. Topol
Summary: The rapid advancements in AI have led to the development of sophisticated large language models (LLMs) such as GPT-4 and Bard. The potential implementation of LLMs in healthcare settings has gained attention due to their diverse applications, but caution is necessary as these models are trained differently and require regulatory oversight to ensure safety and protect patient privacy. This paper provides practical recommendations for regulators to bring this vision to reality.
NPJ DIGITAL MEDICINE
(2023)
