Article
Psychiatry
Sowmya Selvaraj, Harleen Chhabra, Damodharan Dinakaran, Vanteemar S. Sreeraj, Shivakumar Venkataram, Janardhanan C. Narayanaswamy, Muralidharan Kesavan, Shivarama Varambally, Ganesan Venkatasubramanian
Summary: The study findings support the pathogenetic role of ASD in AVH in SZ. Lack of effect on ASD following single-session tDCS suggests the need for multi-session studies in the future.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Johanna C. Badcock, Rachel Brand, Neil Thomas, Mark Hayward, Georgie Paulik
Summary: This study found that 72.1% of clients reported experiencing multimodal hallucinations in the past month. Both multimodal and unimodal hallucination groups showed improvement in distress and frequency of hallucinations post-treatment, with no significant group differences in treatment outcomes. Within the subgroup reporting ongoing effects of traumatic events, clients with multimodal hallucinations had significantly higher posttraumatic stress symptoms.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Branislava Curcic-Blake, Annemarie de Vries, Remco J. Renken, Jan Bernard C. Marsman, Jane Garrison, Kenneth Hugdahl, Andre Aleman
Summary: This study investigated the differences in brain structures between schizophrenia patients with auditory verbal hallucinations (AVH) and healthy controls. The findings revealed that patients with AVH had a longer length of PCS (paracingulate sulcus), while the clinical group fell between the healthy and AVH groups. Additionally, the cortical thickness surrounding the PCS region was significantly diminished in AVH patients compared to the healthy controls. These results contribute to further understanding the underlying mechanisms of hallucinations.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Pablo Lopez-Silva, Alvaro Cavieres, Clara Humpston
Summary: This paper discusses the extensive phenomenological variation of first-personal reports on auditory verbal hallucinations, introduces the concept of pseudohallucination to describe hallucinatory-like phenomena that do not exhibit paradigmatic features of genuine hallucinations, and explores the inner/outer distinction proposed by Karl Jaspers. The concept of pseudohallucination has received criticism but the inner/outer distinction remains a challenge for dominant theories about the neurocognitive origin of auditory verbal hallucinations.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Adrian Andrzej Chrobak, Anna Krupa, Dominika Dudek, Marcin Siwek
Summary: The study revealed a low overlap between different assessment tools for neurological soft signs, which limits reproducibility and hinders the unification of knowledge from existing data. The diversity in NSS assessment tools suggests the need for further research on the non-localizable nature of NSS.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neuroimaging
Paola Fuentes-Claramonte, Joan Soler-Vidal, Pilar Salgado-Pineda, Nuria Ramiro, Maria Angeles Garcia-Leon, Ramon Cano, Antonio Arevalo, Josep Munuera, Francisco Portillo, Francesco Panicali, Salvador Sarro, Edith Pomarol-Clotet, Peter McKenna, Wolfram Hinzen
Summary: Auditory verbal hallucinations (AVH) are a key symptom of schizophrenia. This study investigated the neural correlates of processing language dimensions in patients with AVH and controls. The results showed differences in neural activity between the schizophrenia group and the control group, suggesting anomalies in language processing in schizophrenia patients.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychiatry
Stephanie M. Hare, Bhim M. Adhikari, Xiaoming Du, Laura Garcia, Heather Bruce, Peter Kochunov, Jonathan Z. Simon, L. Elliot Hong
Summary: The study found that auditory perceptual disturbances in schizophrenia are associated with deficits in both local and long-range functional connectivity. Reduced ReHo in the left and right putamen, left temporoparietal junction (TPJ), and right hippocampus-pallidum was significantly linked to the severity of APD. Together, local and long-distance connectivity measures explained 40.3% of the variance in APD, with the left TPJ ReHo being the strongest predictor.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychiatry
Helena Storchak, Justin Hudak, Thomas Dresler, Florian B. Haeussinger, Andreas J. Fallgatter, Ann-Christine Ehlis
Summary: This study validated neural correlates of inner speech and auditory verbal imagery using fNIRS and fMRI, showing congruent activations in key brain areas associated with monitoring processes. Results indicated that activations during inner speech and monitoring processes were dependent on sentence form, with more active brain areas associated with second person sentences.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Elena M. Bonke, Michaela Bonfert, Stefan M. Hillmann, Johanna Seitz-Holland, Malo Gaubert, Tim L. T. Wiegand, Alberto De Luca, Kang Ik K. Cho, Stian B. Sandmo, Eukyung Yhang, Yorghos Tripodis, Caroline Seer, David Kaufmann, Elisabeth Kaufmann, Marc Muehlmann, Jolien Gooijers, Alexander P. Lin, Alexander Leemans, Stephan P. Swinnen, Roald Bahr, Martha E. Shenton, Ofer Pasternak, Uta Tacke, Florian Heinen, Inga K. Koerte
Summary: This study investigates the association between neurological soft signs (NSS) and brain structure alterations in physically trained adolescents. The results show that adolescents with NSS have higher gyrification in specific brain regions and lower fractional anisotropy (FAt) and higher axial and radial diffusivity (ADt, RDt) in widespread areas. This suggests that NSS in adolescents are associated with brain structure alterations.
Article
Psychiatry
Cheng Chen, Huan Huang, Xucong Qin, Liang Zhang, Bei Rong, Gaohua Wang, Huiling Wang
Summary: This study explored inter-hemispheric connectivity in schizophrenia patients with auditory verbal hallucination (AVH), excluding potential confounding factors. Results showed decreased inter-hemispheric connectivity in certain brain regions in AVH patients compared to control groups, and this impairment was negatively correlated with hallucination scores.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Marina P. Valerio, Julieta Lomastro, Ana Igoa, Diego J. Martino
Summary: Recent research examined the relationship between neurological soft signs (NSS) and various variables in bipolar disorder (BD) patients. The study found that NSS were negatively associated with years of education and increased with age. Additionally, BD type I patients had higher NSS scores compared to BD type II patients. NSS were also correlated with lower premorbid IQ and poorer performance in attention, language, and executive functions. However, when included in a multiple regression model, NSS did not significantly contribute to functional outcomes.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Qianjin Wang, Honghong Ren, Zongchang Li, Jinguang Li, Lulin Dai, Min Dong, Jun Zhou, Jingqi He, Xiaogang Chen, Lin Gu, Ying He, Jinsong Tang
Summary: This study aimed to explore the relationship between olfactory identification dysfunction and cognitive function in patients with schizophrenia (SCZ). Compared to healthy controls, SCZ patients showed significant deficits in olfactory identification and cognitive function, with no differences between subgroups. In the subgroup without auditory verbal hallucinations (AVHs), poorer olfactory identification scores were positively correlated with total and delayed recall. Factors affecting olfactory identification impairment differed in the two SCZ patient subgroups. This study highlights the commonality of olfactory identification dysfunction in SCZ patients and the importance of olfactory assessment in different subtypes of SCZ patients.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Thomas Fovet, Pierre Yger, Renaud Lopes, Amicie de Pierrefeu, Edouard Duchesnay, Josselin Houenou, Pierre Thomas, Sebastien Szaffarczyk, Philippe Domenech, Renaud Jardri
Summary: A novel automated fMRI capture method was developed to detect auditory-verbal hallucinations in patients with schizophrenia, achieving high accuracy in detecting AVH and demonstrating potential for generalizability between different patients.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Honghong Ren, Qianjin Wang, Chunwang Li, Zongchang Li, Jinguang Li, Lulin Dai, Min Dong, Jun Zhou, Jingqi He, Yanhui Liao, Ying He, Xiaogang Chen, Jinsong Tang
Summary: This study aimed to investigate the association between persistent auditory verbal hallucinations (pAVHs) and cortical thinning in patients with schizophrenia (SCZ). The results showed that the pAVH group exhibited significantly reduced cortical thickness in the bilateral lateral orbitofrontal region compared to the non-AVH group and the healthy control group. Furthermore, the cortical thickness of the left and right lateral orbitofrontal cortex was negatively correlated with the severity of pAVH.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Benjamin Buck, Jeffrey Munson, Ayesha Chander, Weichen Wang, Carolyn J. Brenner, Andrew T. Campbell, Dror Ben-Zeev
Summary: In addition to schizophrenia-spectrum disorders, auditory verbal hallucinations can also occur in other psychiatric disorders and among healthy individuals. The way voices are appraised determines the level of distress and social dysfunction caused by hallucinations. This study found that appraisals of voices are related to negative affect and social functioning, and are linked to day-to-day changes in behavior and emotions.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Behavioral Sciences
Giorgio Pigato, Stella Rosson, Nicola Bresolin, Tommaso Toffanin, Fabio Sambataro, Daniele Olivo, Giulia Perini, Francesco Causin, Luca Denaro, Andrea Landi, Domenico D'Avella
Summary: This study conducted a long-term follow-up on 5 patients with treatment-resistant depression (TRD) who received vagus nerve stimulation (VNS) implant. The results showed that VNS had long-lasting effectiveness in improving symptoms and functioning in patients with severe and chronic depression. The study supports VNS as a viable treatment option for TRD due to its sustained efficacy and good tolerability.
Article
Biochemistry & Molecular Biology
Nicolo Trevisan, Fabio Di Camillo, Niccolo Ghiotto, Giulia Cattarinussi, Maddalena Sala, Fabio Sambataro
Summary: In this study, the complexity of cortical folding (CCF) was compared between patients with cocaine addiction and controls. Patients with cocaine addiction showed reduced CCF in the left insula, the supramarginal gyrus, and the left medial orbitofrontal cortex. The reduction in cortical folding in the left medial orbitofrontal cortex was associated with the age of onset of cocaine addiction and attentional impulsivity.
Editorial Material
Neurosciences
Malika P. Renz, Francesca Zidda, Jamila Andoh, Marcel Prager, Markus Sack, Robert Becker, Matthias Ruf, Mike M. Schmitgen, Robert C. Wolf, Andreas Meyer-Lindenberg, Heike Tost
Summary: This article reports on the technical challenges encountered when using multiband echoplanar imaging and short repetition times for continuous fMRI neurofeedback. The possible origins of the problem are identified, and an interim solution is described. Workflows and code are provided for researchers who wish to use a similar approach.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Katharina M. Kubera, Mike M. Schmitgen, Viviane Hildebrandt, Corinne Neukel, Marie-Luise Otte, Maurizio Sicorello, Sylvia Steinmann, Sabine C. Herpertz, Robert Christian Wolf
Summary: This study found that individuals with borderline personality disorder who experience auditory verbal hallucinations have abnormal brain morphology, particularly in regions associated with the language network. These abnormalities may be related to speech generation, perception, memory, and executive control.
NEUROPSYCHOBIOLOGY
(2023)
Article
Neurosciences
Mario Luciano, Gaia Sampogna, Bianca Della Rocca, Alessio Simonetti, Pasquale De Fazio, Marco Di Nicola, Giorgio Di Lorenzo, Maria Pepe, Fabio Sambataro, Maria Salvina Signorelli, Alexia Emilia Koukopoulos, Roberto Delle Chiaie, Gabriele Sani, Andrea Fiorillo
Summary: This study investigated the relationship between affective temperaments and suicidality. It found that certain affective dispositions were associated with the onset and intensity of suicidal ideation and behaviors. Therefore, evaluating affective dispositions in clinical settings can help identify individuals at risk of suicide and develop effective preventive interventions.
Article
Clinical Neurology
Jan Kasper, Simon B. Eickhoff, Svenja Caspers, Jessica Peter, Imis Dogan, Robert Christian Wolf, Kathrin Reetz, Juergen Dukart, Michael Orth
Summary: Kasper et al. found that in Huntington's disease, the functional integrity of the dopamine receptor-rich caudate nucleus plays a crucial role in maintaining network function. Loss of caudate functional integrity leads to motor signs independent of atrophy. This finding may have implications for other neurodegenerative diseases.
Article
Clinical Neurology
Marie-Luise Otte, Mike M. Schmitgen, Nadine D. Wolf, Katharina M. Kubera, Vince D. Calhoun, Stefan Fritze, Lena S. Geiger, Heike Tost, Ulrich W. Seidl, Andreas Meyer-Lindenberg, Dusan Hirjak, Robert Christian Wolf
Summary: Insight into illness plays a crucial role in the treatment and social integration of patients with schizophrenia. This study aimed to examine the structural and functional differences between patients with schizophrenia and healthy controls, and to investigate the associations between illness insight and these neuroimaging measures. The findings suggest that aberrant structural and functional integrity in neural systems related to cognitive control, memory, and self-reference are closely related to illness insight in schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Review
Clinical Neurology
M. S. Depping, L. Koehler-Ipek, P. Ullrich, K. Hauer, R. C. Wolf
Summary: This narrative review examines the comorbidity of late-life depression and frailty, with a focus on neuroscientific findings. Frailty leads to more chronic depression and poorer efficacy and tolerability of antidepressant medication. Depression and frailty share motivational and psychomotor characteristics, particularly apathy, decreased physical activity, and fatigue.
Article
Clinical Neurology
Gudrun M. Henemann, Mike M. Schmitgen, Nadine D. Wolf, Dusan Hirjak, Katharina M. Kubera, Fabio Sambataro, Patrick Bach, Julian Koenig, Robert Christian Wolf
Summary: This study used functional magnetic resonance imaging (fMRI) to compare the brain activity of excessive smartphone users and non-excessive users, and found that excessive smartphone users had lower connectivity strength in the frontoparietal system. This suggests that excessive smartphone use may be associated with the cognitive control network of the frontoparietal cortex.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Neurosciences
Nicolo Trevisan, Giulia Cattarinussi, Daniele Olivo, Andrea Di Ciano, Lucia Giudetti, Alan Pampallona, Katharina M. M. Kubera, Dusan Hirjak, Robert Christian Wolf, Fabio Sambataro
Summary: This study investigated the neural bases of social victimization using functional magnetic resonance imaging. The results showed increased activation in certain brain areas during social victimization, as well as correlations with personality traits such as neuroticism and irritability.
Article
Clinical Neurology
Alessandro Miola, Nicolo Trevisan, Margherita Salvucci, Matteo Minerva, Silvia Valeggia, Renzo Manara, Fabio Sambataro
Summary: Facial emotion recognition, especially for sadness, is impaired in bipolar disorder. The association between this impairment and brain structure, clinical variables, and subtypes of bipolar disorder remains unclear.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Review
Clinical Neurology
Mahan Shafie, Elnaz Shahmohamadi, Giulia Cattarinussi, Hossein Sanjari Moghaddam, Shahin Akhondzadeh, Fabio Sambataro, Chiara Moltrasio, Giuseppe Delvecchio
Summary: This review summarizes the findings of resting-state functional magnetic resonance imaging (rsfMRI) studies in individuals with borderline personality disorder (BPD). The results indicate aberrant functional connectivity within and between several brain networks, including the default mode network (DMN), salience network (SN), and central executive network (CEN), as well as selective functional impairments in specific brain regions. However, the generalizability of these results is limited by the observational design, small sample size, and heterogeneity across imaging methodologies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Alessio Simonetti, Mario Luciano, Gaia Sampogna, Bianca Della Rocca, Emiliana Mancuso, Pasquale De Fazio, Marco Di Nicola, Giorgio Di Lorenzo, Maria Pepe, Fabio Sambataro, Maria Salvina Signorelli, Alexia Emilia Koukopoulos, Roberto Delle Chiaie, Andrea Fiorillo, Gabriele Sani
Summary: This multicentric observational study aimed to investigate the relationship between affective temperaments and bipolar disorder (BD) or major depressive disorder (MDD), as well as their influence on the severity and course of the diseases. The results revealed that specific affective temperaments were associated with certain disease characteristics. Evaluating affective temperaments may contribute to a better understanding of mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Meeting Abstract
Psychiatry
N. Trevisan, F. Di Camillo, G. Cattarinussi, N. Ghiotto, M. Sala, F. Sambataro
EUROPEAN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Michele Fornaro, Claudio Caiazza, Niccolo Solini, Michele De Prisco, Martina Billeci, Martina Vannini, Risa Shorr, Stefano Caiolo, Marialaura Lussignoli, Dan Siskind, Giorgio Pigato, Annarita Barone, Fabio Sambataro, Andrea de Bartolomeis, Christoph U. Correll, Marco Solmi
Summary: This study conducted a network meta-analysis on antipsychotic-induced sialorrhea. The results showed that dopamine receptor antagonists, metoclopramide, and sulpiride were effective in treating sialorrhea, while antihistamines and atropine showed no significant effect on nocturnal sialorrhea. This study provides some guidance for the treatment of antipsychotic-related sialorrhea.
MOLECULAR PSYCHIATRY
(2023)
