Article
Chemistry, Multidisciplinary
Lu Liu, Yiming Hu, Shaofeng Huang, Yinghua Jin, Jingnan Cui, Weitao Gong, Wei Zhang
Summary: Integrating macrocyclic hosts into ordered porous polymeric frameworks can transform established supramolecular chemistry principles into the solid state for practical applications such as molecular separation, catalysis, and pollution remediation. A novel pillar[5]arene-derived hetero-porous COF, P5-COF, with selective gas adsorption and enhanced host-guest binding interactions, was successfully designed and synthesized in this study, demonstrating a new strategy for developing COFs with customizable molecular recognition/separation properties.
Article
Chemistry, Multidisciplinary
Huaqiang Ju, Chao Nan Zhu, Hu Wang, Zachariah A. Page, Zi Liang Wu, Jonathan L. Sessler, Feihe Huang
Summary: This study introduces a stimuli-responsive invisible ink for time-dependent encryption of information, which displays time-dependent photochromic behavior with tailorable fading rates by controlling the density of host-guest crosslinks. Encryption security of information is achieved through selectively placing host and guest competitors and UV patterning, providing an initially false image that gradually reveals the encrypted data.
ADVANCED MATERIALS
(2022)
Article
Biophysics
Wenhui Liu, Weiwei Xu, Hang-Hang Luan, Guang Li, Junan Liu, Fan Zhang, Haibing Li, Zhiyan Lu
Summary: In this study, a functional chiral gold surface was constructed to recognize L-ribose based on host-guest interactions, showing good detection effect and recyclability.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Applied
Bingbing Shi, Weichun Li, Peng Qin, Xing-Xing Zhao, Xiao-Ni Qi, Yongping Chai, Hao-Hang Yang, Wen-Juan Qu, Hong Yao, You-Ming Zhang, Tai-Bo Wei, Qi Lin
Summary: This study presented a highly selective and stable vapochromic system constructed by pillar[5]arene-based host-guest interactions, showing specific selective responsiveness to chloroform vapor. The material can maintain its color stably in air for at least two months, and thin film and LED responsive to CHCl3 vapor were successfully prepared as well.
Article
Nanoscience & Nanotechnology
Ming Cheng, Fei Zhu, Weiwei Xu, Siyun Zhang, Manivannan Kalavathi Dhinakaran, Haibing Li
Summary: The creation of chiral OMS nanochannels by introducing L-alanine-pillar[5]arene host in achiral OMS has shown excellent selectivity in separating racemic drugs with high reusability and stability. The enantioselective separation mechanism was identified as molecular-recognition-adsorbed transport. This work demonstrates the significant potential of chiral OMS nanochannels for enantioselective separation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Zhanqi Cao, Fan Yang, Dongpu Wu, Lulu Wu, Lijie Liu, Guoxing Liu, Xiaochuan Li, Xin Zheng, Xianfu Zheng, Dahui Qu
Summary: A novel pillar[5]arene-bridged monomer with TPE and nitrile group was synthesized and it formed supramolecular aggregates based on the host-guest interaction. The supramolecular aggregates exhibited significant aggregation-induced emission due to the restricted intramolecular rotation of the TPE core.
Article
Polymer Science
Chengdi Huang, Hanwei Zhang, Ziqing Hu, Youping Zhang, Xiaofan Ji
Summary: Polymer gels are widely used in tissue engineering, sensing, and drug delivery due to their excellent biocompatibility, hydrophilicity, and degradability. However, their weak mechanical properties limit their application fields. The incorporation of reversible non-covalent bonds can improve the mechanical properties of polymer gels.
Article
Chemistry, Applied
Ming Cheng, Guang Li, Weiwei Xu, Haonan Qu, Xiaowei Mao, Haibing Li
Summary: A novel 8-hydroxyquinoline-pillar[5]arene was synthesized and applied in a fluorometric chemosensor to detect phoxim with great selectivity and sensitivity. The formation of an inclusion complex between the host and guest molecules contributed to the high performance of this chemosensor, which was not affected by the presence of other common pesticides. This work provides a reliable and rapid method for detecting pesticide residue.
Article
Chemistry, Multidisciplinary
Bingbing Shi, Yun-Fei Zhang, Zheng-Hua Zhang, Hong Yao, Wen-Juan Qu, You-Ming Zhang, Tai-Bao Wei, Qi Lin
Summary: A PbS QD-based supramolecular polymer network is formed through host-guest complexation involving pillar[5]arene, allowing for living cell imaging applications.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Multidisciplinary
Tan-Hao Shi, Shunsuke Ohtani, Kenichi Kato, Shixin Fa, Tomoki Ogoshi
Summary: Pillar[n]arenes typically form 1:1 host-guest complexes with guest molecules, but unique properties arise from the formation of new structures and the crystalline state. Cooperative binding of guest molecules to pillar[n]arene assemblies is crucial to achieve unique host-guest behavior. Moreover, planar chirality of pillar[n]arenes allows for chiral inversion, memory, and erasure, which is coupled with their host-guest properties. In this review, the diversity, functionality, and supramolecular chirality of host-guest pillar[n]arene assemblies are discussed.
TRENDS IN CHEMISTRY
(2023)
Review
Polymer Science
Xiao-Ni Qi, Qi Lin, Tai-Bao Wei, Wei Tian, Zhen-Liang Li
Summary: Among advanced materials, supramolecular gel (SG) materials based on pillar[5]arene have attracted significant attention due to their fine processability, recyclability, stimulus-responsiveness, and self-repair capabilities. This review thoroughly discusses the dependency relationship between multiapplication performance and design strategy of SGs based on pillar[5]arene. Various specific application examples are summarized, including fluorescence sensing, pollutant separation, stimulus conversion, self-healing, and dye removal. The opportunities, challenges, and prospects of pillar[5]arene-based SGs in this field are also discussed.
Article
Chemistry, Multidisciplinary
Yunxuan Feng, Shaolong Qi, Xinyang Yu, Xueyan Zhang, Huangtianzhi Zhu, Guocan Yu
Summary: Despite the breakthrough of immunotherapy, immune checkpoint inhibitors often have low response rate and resistance towards solid tumors. A hypoxic tumor microenvironment provides tumor cells with high concentrations of HIF-1 and polyamines to evade immune cell destruction. Reprogramming the immunogenic microenvironment has shown promising results in boosting immunotherapeutic performances.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yuxiao Mei, Qi-Wei Zhang, Qingyi Gu, Zhichao Liu, Xiao He, Yang Tian
Summary: This article describes a new supramolecular fluorescent probe that efficiently identifies largescale neurotransmitters and enables high-throughput analysis using principal component analysis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Huangtianzhi Zhu, Junkai Liu, Yitao Wu, Lei Wang, Haoke Zhang, Qi Li, Hu Wang, Hao Xing, Jonathan L. Sessler, Feihe Huang
Summary: In this study, a room-temperature phosphorescence (RTP) system responsive to alkyl halides was described. The system consisted of a meta-formylphenyl-bearing pillar[5]arene derivative that supported effective through-space charge transfer. Treatment with bromoethane enhanced the emission. An isomeric para-formylphenyl-bearing pillar[5]arene system proved ineffective in producing an RTP effect.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemical Research Methods
Guang Li, Wen Gong, Lei Yang, Ming Cheng, Hewei Yan, Jiaxin Quan, Fan Zhang, Zhiyan Lu, Haibing Li
Summary: The study successfully fabricated a planar-chiral NH2pillar[5]arene modified silicon surface for highly enantioselective adsorption of proteins, providing deeper insights into the chiral influence of protein adsorption on biointerfaces.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jan Alfuth, Beata Zadykowicz, Barbara Wicher, Katarzyna Kazimierczuk, Tadeusz Polonski, Teresa Olszewska
Summary: In this study, a series of new 4-iodoethynyl and 4,7-bis-(iodoethynyl)benzo-2,1,3-chalcogenadiazole derivatives were investigated for their crystal self-assembly behavior using X-ray diffraction and analysis of intermolecular interactions. The results revealed the influence of chalcogen atom nature on the solid-state arrangement and highlighted the importance of chalcogen and halogen bonding interactions in the molecular self-assembly process.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Organic
Anna Janas, Krystian Pyta, Maria Gdaniec, Piotr Przybylski
Summary: A ketolide derivative with atypical structure was synthesized using a novel reaction condition, and its structure was characterized by NMR and X-ray methods. Furthermore, by adjusting the reaction conditions, new macrolide derivatives with different conformations were obtained.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jinhua Wang, Barbara Wicher, Victor Maurizot, Ivan Huc
Summary: Folded molecules with complex interaction interfaces can self-assemble into various structures. Aromatic foldamers, due to their stability, can be used to form self-assembled architectures. In the presence of acridine units, self-assembly occurs via aromatic stacking, which can result in helix-helix association patterns. Metal coordination with acridine units further enhances self-assembly, leading to multihelical structures including macrocycles. These findings demonstrate the ability to access different types of foldamer-containing architectures.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Dominik Langer, Barbara Wicher, Wioletta Bendzinska-Berus, Barbara Bednarczyk-Cwynar, Ewa Tykarska
Summary: This study reports the synthesis and structural characterization of new esters of oleanolic acid and its 11-oxo derivatives. The compounds crystallize in four isostructural groups, with each group containing one to four structures. Single-crystal X-ray analysis reveals that molecules in non-isostructural groups self-assemble according to two schemes, which also describe supramolecular architectures in crystals of glycyrrhetinic acid derivatives. The formation of structural motifs is attributed to van der Waals forces. Parameters introduced for the analysis of one- and two-dimensional assemblies enable the comparison of motifs in isostructural and non-isostructural crystals, including polymorphs, and the qualitative assessment of differences in molecular self-assembly. One-, two- or three-dimensional similarity has been confirmed using XPac calculations.
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Anna Makowska, Franciszek Saczewski, Patrick J. Bednarski, Maria Gdaniec, Lukasz Balewski, Magdalena Warmbier, Anita Kornicka
Summary: A series of copper(II) complexes were synthesized and screened for their activity against human cancer cell lines, showing significant inhibitory properties. The newly prepared Cu(II) complexes often displayed increased activity compared to the free ligands. Among the complexes, certain compounds exhibited higher potency than cisplatin against the tested cell lines.
Article
Chemistry, Physical
Tomasz Koczorowski, Barbara Wicher, Rafal Krakowiak, Kinga Mylkie, Aleksandra Marusiak, Ewa Tykarska, Marta Ziegler-Borowska
Summary: Magnesium(II) sulfanyl porphyrazine with peripheral morpholinethoxy substituents was successfully embedded on the surface of titanium(IV) dioxide nanoparticles, which exhibited excellent photocatalytic properties.
Article
Chemistry, Multidisciplinary
Friedericke S. Menke, Barbara Wicher, Victor Maurizot, Ivan Huc
Summary: Aromatic oligoamide sequences were designed to fold into stable helical conformations with hydrogen-bond donors and acceptors on their surface. Solid-phase synthesis was used to prepare the sequences. NMR studies and crystallographic structures showed that stable hydrogen-bond-mediated dimeric helix bundles could form either heterochiral or homochiral dimers. The formation of these dimers could be controlled by different chlorinated solvents or by imposing absolute handedness to the helices to forbid PM species.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Tomasz Koczorowski, Wojciech Szczolko, Pawel Bakun, Barbara Wicher, Lukasz Sobotta, Maria Gdaniec, Anna Teubert, Jadwiga Mielcarek, Ewa Tykarska, Jozef Korecki, Kvetoslava Burda, Tomasz Goslinski
Summary: Iron(III) porphyrazines with different substituents were synthesized and characterized. X-ray analysis revealed the influence of octahedral geometries of iron cation on the packing mode of molecules in crystals. Mossbauer studies suggested the presence of low-spin reduced iron states at low- or high-symmetry binding sites. Temperature-dependent measurements showed the stabilization of diamagnetic state in Fe2+ ion at a high symmetry binding site due to the increased flexibility of the macrocycle ring.
Article
Chemistry, Organic
Friedericke S. S. Menke, Daniela Mazzier, Barbara Wicher, Lars Allmendinger, Brice Kauffmann, Victor Maurizot, Ivan Huc
Summary: The first abiotic foldamer tertiary structures have been reported, consisting of aromatic helix-turn-helix motifs based on oligo-quinolinecarboxamides held together by intramolecular hydrogen bonds. Computational modelling predicted and X-ray crystallography verified the tertiary folds. Investigation into the conformational preference of each helix revealed that the removal of some hydrogen bonds did not strongly destabilize the tertiary folds.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Dominik Langer, Barbara Wicher, Zbigniew Dutkiewicz, Wioletta Bendzinska-Berus, Barbara Bednarczyk-Cwynar, Ewa Tykarska
Summary: Oleanolic and glycyrrhetinic acids and their derivatives have various pharmacological properties. The crystal structures of these compounds provide valuable information about their assembly modes. In the known crystals of their esters, different types of ribbons and layers are formed through van der Waals forces and weak C-H. . .O interactions. New crystal structures of other esters reveal an alternative mode of aggregation with helical chains stabilized by O-H. . .O hydrogen bonds. The intermolecular interaction energies calculation shows that even in motifs formed by O-H. . .O hydrogen bonds, dispersive forces have a significant impact.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Ewa Wieczorek-Dziurla, Andrzej Lapinski, Adam Mizera, Leonid A. Shemchuk, Dmitry A. Lega, Barbara Wicher, Andrzej K. Gzella
Summary: The investigated symmetrical bis-adducts exist in a double tautomeric enol form in both liquid and solid phases, allowing acid-base interactions and intramolecular O-H···O- hydrogen bond formation. The crystal structures of the investigated compounds containing different anion molecules were analyzed in terms of hydrogen bonding networks, and the interactions were studied using various spectroscopic and theoretical techniques.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Natalia Skrzypczak, Krystian Pyta, Wiktor Bohusz, Aleksandra Lesniewska, Maria Gdaniec, Piotr Ruszkowski, Wojciech Schilf, Franz Bartl, Piotr Przybylski
Summary: A metal-free cascade transformation of geldanamycin benzoquinone core is proposed under mild conditions. This approach leads to new benzoxazole ansamycin antibiotics and allows for their functionalization in an atom-economic manner, regardless of the type of amine used. The analysis of the heterocyclization process reveals that the rate depends on the para-substituent nature within the benzylamine moiety (electron-donating group/electron-withdrawing group) and the strength of the base. The reduction of the ansamycin core enhances anticancer potency and selectivity.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Albano Galan, Kristijan Lulic, Jingqi Wang, Barbara Wicher, Ivan Huc, Jean Duhamel, Victor Maurizot
Summary: Deprotonation of acid-terminated helical aromatic foldamers with a mineral base in chlorinated solvents resulted in their dimerization through the coordination of a metal cation (Li+, Na+, K+, Ag+, or Hg2+) with the terminal carboxylate functions. This novel ligation method was utilized for the oligomerization of diacid-functionalized foldamers.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Friedericke S. Menke, Barbara Wicher, Lars Allmendinger, Victor Maurizot, Ivan Huc
Summary: Through the synthesis of four helically folded aromatic oligoamide sequences, it was found that the 2-(2-aminophenoxy)-propionic acid unit can quantitatively bias helix handedness in chloroform and dichloromethane. Helix handedness control was achieved by introducing an N-terminal (1H)-camphanyl group or a 2-(2-aminophenoxy)-propionic acid unit in specific helical segments. The formation of stable helix-turn-helix tertiary folds was observed in some cases.
Article
Chemistry, Multidisciplinary
Abu Talha Aqueel Ahmed, Sankar Sekar, Shubhangi S. Khadtare, Nurul Taufiqu Rochman, Bathula Chinna, Abu Saad Ansari
Summary: In this study, MnCo2S4 nanosheet catalyst was successfully synthesized and found to exhibit superior performance in hydrogen evolution. Compared to MnCo2S4, MnCo2S4 showed low overpotentials, moderate Tafel slope, and excellent sustainability. The outstanding performance can be attributed to the increased number of electrochemically active sites and enhanced electronic conductivity on the catalyst surface.
Article
Chemistry, Multidisciplinary
Victor V. Maltsev, Elena A. Volkova, Elizaveta V. Koporulina, Diana D. Mitina, Vladimir L. Kosorukov, Anna I. Jiliaeva, Daniil A. Naprasnikov, Konstantin N. Gorbachenya, Viktor E. Kisel
Summary: The phase relationships, crystal properties and luminescence kinetics of two complex systems were studied, including unit cell parameters, segregation coefficients of impurities, and lifetimes of energy levels.
Article
Chemistry, Multidisciplinary
Xiaoman Zhang, Wangwang Xu, W. J. Meng, Andrew C. Meng
Summary: This study successfully grew high-quality single crystal AlScN nanowires through ultra-high vacuum reactive sputtering technique and characterized their structure and properties. The nanowires exhibit significantly reduced mosaic spread and predominantly single ferroelectric domains, as well as a high piezoelectric constant.
Article
Chemistry, Multidisciplinary
Tom E. de Vries, Elias Vlieg, Rene de Gelder
Summary: Networks are important for describing relationships between people, roads between cities, reactions between chemicals, and other interactions. Bipartiteness, dividing the network into two groups, can facilitate the study of the network's structure. We have developed an algorithm that can find a near-optimal bipartisation within a reasonable time frame and used it to uncover the hidden structure of the CSD cocrystal network.
Article
Chemistry, Multidisciplinary
Chuchu Han, Jing Yang, Xin Zhang, Aisen Li, Jiang Peng
Summary: An elastic crystal based on a photo-reactive acylhydrazone derivative is reported, which exhibits reversible bending behavior under UV irradiation and heating. The crystal undergoes reversible E<->Z isomerization under light and heating conditions. The crystal demonstrates excellent elastic properties and the bending can be controlled to control the output direction of red light.
Article
Chemistry, Multidisciplinary
Lingfeng Zhang, Yu Wang, Yefeng Wang, Shuai Liu, Na Zhang, Mingmin Yang, Haixia Ma, Zhaoqi Guo
Summary: This study designs and synthesizes a series of high-energy salts compounds without heavy metal ions and azide groups. The molecular structures and stability of the compounds are confirmed through single-crystal X-ray diffraction and intermolecular interaction analysis. Furthermore, the thermal stability, energetic properties, and electrical initiation properties of the compounds are investigated, suggesting their potential as primary explosives.
