Article
Pharmacology & Pharmacy
Yawei Xu, Yalei Ning, Yan Zhao, Yan Peng, Fen Luo, Yuanguo Zhou, Ping Li
Summary: Caffeine as a nonspecific antagonist of the adenosine A(2A) receptor enhances learning and memory function while also correlating with feelings of anxiety. The differential effects of inhibiting A(2A)Rs in the dorsal and ventral hippocampus lead to enhanced memory and increased anxiety, respectively. Optogenetic activation of dorsal or ventral hippocampal A(2A)Rs can reverse these behavioral alterations caused by caffeine intake.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Olamide E. Adebiyi, Margaret S. Bynoe
Summary: This study investigates the role of A(1) and A(2A) adenosine receptors in regulating oligodendrocyte precursor cells and myelinating oligodendrocytes in the demyelinated hippocampus. It found that the absence of A(1) and A(2A) adenosine receptors affects spatial learning and memory, and has an impact on hippocampal demyelination and cell apoptosis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Catia R. Lopes, Francisco Q. Goncalves, Simao Olaio, Angelo R. Tome, Rodrigo A. Cunha, Joao Pedro Lopes
Summary: Adenosine regulates synaptic transmission and plasticity through A(1) and A(2A) receptors. Supramaximal activation of A(1)R blocks hippocampal synaptic transmission, and A(2A)R activation decreases A(1)R-mediated inhibition during high-frequency-induced LTP.
Review
Pharmacology & Pharmacy
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Moderate coffee consumption has beneficial effects on various liver diseases, possibly by inhibiting adenosine binding to its receptors. Caffeine is considered a potential drug for the prevention and treatment of liver diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Mukuo Wang, Shujing Hou, Yu Wei, Dongmei Li, Jianping Lin
Summary: Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system. Dual adenosine A(1)/A(2A) receptor antagonists provide a possible effective therapy that can simultaneously solve motor symptoms and nonmotor symptoms in the medical treatment of PD. In this study, a multistage virtual screening approach involving deep learning, pharmacophore models, and molecular docking methods identified two 1,2,4-triazole derivatives as dual adenosine A(1) and A(2A) receptor antagonists. The results of molecular dynamics (MD) simulations showed strong binding interactions between the adenosine A(1)/A(2A) receptors and the compounds.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Johanna C. Arroyave-Ospina, Manon Buist-Homan, Martina Schmidt, Han Moshage
Summary: This study found that caffeine can protect liver cells from the toxic effects of fatty acids by modulating adenosine receptor signaling. By activating protein kinase A and inhibiting the A1AR receptor, caffeine can reduce lipid accumulation and harmful substances produced by mitochondria, thereby alleviating metabolic dysfunction-associated liver disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Yajia Cheng, Peipei Cao, Chao Geng, Xiaoqi Chu, Yuhao Li, Jianlin Cui
Summary: Photoreceptor degeneration is a critical event in various retinal diseases, but there is currently no curative treatment available. This study showed that the A2AR antagonist SCH58261 protected photoreceptors by inhibiting inflammation, apoptosis, and autophagy at the early stage of degeneration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biology
Sonia Tremblay, Yanqiqi Zeng, Aixin Yue, Kiana Chabot, Abigail Mynahan, Stephanie Desrochers, Sarra Bridges, S. Tariq Ahmad
Summary: This study shows that fruit flies fed a caffeine-supplemented diet or with a mutation in adenosine receptor take longer to become sedated when exposed to ethanol vapors. The resistance to sedation is reversed upon caffeine withdrawal and heterozygous adenosine receptor mutant flies are resistant to sedation. These findings suggest that caffeine and adenosine receptors modulate the sedative effects of ethanol in fruit flies.
Article
Biochemistry & Molecular Biology
Erine Craey, Fabian Hulpia, Jeroen Spanoghe, Simona Manzella, Lars E. Larsen, Mathieu Sprengers, Dimitri De Bundel, Ilse Smolders, Evelien Carrette, Jean Delbeke, Kristl Vonck, Paul Boon, Serge Van Calenbergh, Wytse J. Wadman, Robrecht Raedt
Summary: This study reports the design, synthesis, and validation of a novel compound that can precisely release adenosine A1 receptor agonist using light. By monitoring the strength of neurotransmission and controlling the release of light, the study achieved regulation of neurotransmission. This research method is of great significance for the treatment of diseases associated with neuronal hyperexcitability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Adam Gorlewicz, Barbara Pijet, Kristina Orlova, Leszek Kaczmarek, Ewelina Knapska
Summary: This study investigates the role of GluN2B in the pathophysiology of temporal lobe epilepsy and suggests the potential therapeutic use of ifenprodil, a GluN2B selective NMDAR antagonist. The findings provide insights into the factors contributing to recurrent seizures and propose a new candidate treatment for temporal lobe epilepsy.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Neurosciences
Ana Moreira-de-Sa, Vanessa S. Lourenco, Paula M. Canas, Rodrigo A. Cunha
Summary: Extracellular adenosine serves as a paracrine signal of cellular effort produced during increased metabolic activity or stress. Adenosine receptors, particularly A(2A) receptors, play a significant role in promoting physiological changes in brain function. Overactivation of A(2A) receptors may contribute to synaptic and neuronal damage, and could be an early indicator of brain disease progression.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Takao Kamai, Toshiki Kijima, Toyonori Tsuzuki, Akinori Nukui, Hideyuki Abe, Kyoko Arai, Ken-Ichiro Yoshida
Summary: In patients with metastatic RCC, high expression of A2AR in primary tumors was associated with metastatic profiles. Patients treated with anti-PD-1 antibody or a combination of anti-PD-1 and anti-CTLA4 antibodies, or anti-VEGF agents showed better response and longer overall survival if the primary tumor had higher PD-L1 expression and lower A2AR expression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Canyong Guo, Lingyun Yang, Zhijun Liu, Dongsheng Liu, Kurt Wuthrich
Summary: Eight hundred and twenty-six human G protein-coupled receptors (GPCRs) play a significant role in mediating the actions of hormones, neurotransmitters, and drugs. Studying the structure and dynamics of GPCRs in lipid bilayer environments is crucial for understanding their functionality and developing new drugs. This study incorporates the A(2A) adenosine receptor into lipid nanodiscs, providing a detergent-free environment for structural studies using NMR. The findings demonstrate the stability and mimicry of the lipid nanodisc and LMNG/CHS micelles in preserving the overall fold and local structure of the receptor.
Article
Biochemistry & Molecular Biology
Thu Hang Lai, Magali Toussaint, Rodrigo Teodoro, Sladjana Dukic-Stefanovic, Mathias Kranz, Winnie Deuther-Conrad, Rares-Petru Moldovan, Peter Brust
Summary: The research focuses on developing a PET radiotracer for monitoring the expression and occupancy of the non-dopaminergic target A(2A) receptor in Parkinson's disease therapy. Novel fluorinated analogs are designed and evaluated in preclinical studies, showing specific in vitro binding to A(2A)R but no specific in vivo binding in dynamic PET/MRI studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Meimei Guo, Jie Wang, Yikang Yuan, Lei Chen, Jingang He, Wei Wei, Fuqiang Xu, Qing Liu, Mian Peng
Summary: This study reveals the vital role of the adenosine A(2A) receptor (A(2A)R) in propofol-anesthesia-induced loss of consciousness (LOC). The adenosine signals in the nucleus accumbens (NAc) are regulated by A(2A)R and have an impact on the duration and depth of propofol anesthesia.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Catarina B. Ferreira, Mikael Marttinen, Joana E. Coelho, Kaisa M. A. Paldanius, Mari Takalo, Petra Makinen, Luukas Leppanen, Catarina Miranda-Lourenco, Joao Fonseca-Gomes, Sara R. Tanqueiro, Sandra H. Vaz, Rita F. Belo, Ana Maria Sebastiao, Ville Leinonen, Hilkka Soininen, Ian Pike, Annakaisa Haapasalo, Luisa V. Lopes, Alexandre de Mendonca, Maria Jose Diogenes, Mikko Hiltunen
Summary: SEPTIN5 and its S327 phosphorylation status play a pivotal role in the molecular pathogenesis of Alzheimer's disease. The expression of SEPTIN5 is decreased in the brain tissue of AD patients, while the increased phosphorylation status of S327 is associated with the early development of AD pathology. Further experiments reveal a link between SEPTIN5 S327 phosphorylation status and cellular processes relevant for AD, including amyloid precursor protein processing and autophagy.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ana M. Sebastiao
PURINERGIC SIGNALLING
(2022)
Article
Cell Biology
Sonia Sa Santos, Joao B. Moreira, Marcia Costa, Rui S. Rodrigues, Ana M. Sebastiao, Sara Xapelli, Susana Sola
Summary: Neural stem cells (NSCs) play a crucial role in memory and buffering depressive behavior in the adult brain. This study shows that the deacetylase Sirtuin 3 (SIRT3) plays a role in regulating the fate of NSCs under aging and depression-like contexts. Increasing the expression of SIRT3 can restore the function of aged NSCs.
Article
Neurosciences
Miguel Farinha-Ferreira, Nadia Rei, Joao Fonseca-Gomes, Catarina Miranda-Lourenco, Paula Serrao, Sandra H. Vaz, Joana I. Gomes, Valeria Martins, Beatriz de Alves Pereira, Ana M. Sebastiao
Summary: Chronic exposure to adolescent cannabinoid receptor agonists can lead to persistent increases in depressive-like behaviors. However, different compounds may have different effects. In this study, the highly potent CB1R/CB2R agonist HU-210 did not significantly affect adult anxious or depressive behaviors, but induced short-term increases in stress-induced reactivity.
Article
Neurosciences
Rafael Y. S. Hirata, Roberto N. Oliveira, Mariana S. C. F. Silva, Adam Armada-Moreira, Sandra H. Vaz, Filipa F. Ribeiro, Ana Maria Sebastiao, Jessica A. Lemes, Jose S. de Andrade, Barbara A. Rosario, Isabel C. Cespedes, Milena B. Viana
Summary: This study investigates the effects of platinum nanoparticles and glutamate dehydrogenase microreactors on the behavioral and neurobiological effects of chronic stress exposure. The results show that the microreactors can alleviate the negative effects of chronic stress on rat behavior and neurogenesis.
BRAIN RESEARCH BULLETIN
(2022)
Article
Materials Science, Biomaterials
Cathrine Abild Meyer, Paula De Dios Andres, Edit Brodszkij, Isabella N. Westensee, Joseph Lyons, Sandra H. Vaz, Brigitte Stadler
Summary: The role of astrocytes in brain function has been increasingly recognized, and this study investigates the interaction between soft material nanoparticles and astrocytes, including primary astrocytes cultured in 3D paper-based chips.
Article
Multidisciplinary Sciences
Nadia Rei, Claudia A. Valente, Sandra H. Vaz, Miguel Farinha-Ferreira, Joaquim A. Ribeiro, Ana M. Sebastiao
Summary: This study found that there is dysfunction of the adenosinergic system in ALS even before disease onset, and suggests that the negative influence of caffeine on ALS animal models may be related to interference with BDNF.
Review
Neurosciences
Goncalo Costa, Filipa F. F. Ribeiro, Ana M. M. Sebastiao, Elizabeth M. M. Muir, Sandra H. H. Vaz
Summary: This article reviews the importance of neuronal regeneration in the central nervous system (CNS) and the characteristics of the glial scar. It discusses the multifactorial context of CNS regeneration and future therapeutic interventions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Arthur Cardoso Souto, Matheus Heidemann Tempone, Lyslie Azeredo Coutinho Goncalves, Vladimir Pedro Peralva Borges-Martins, Maria Carolina Peixoto-Rodrigues, Ana Clara Oliveira Damascena, Gabriel Ferraz, Alex Christian Manhaes, Newton Goncalves Castro, Ricardo Augusto de Melo Reis, Ana Lucia Marques Ventura, Regina Celia Cussa Kubrusly
Summary: Nicotine influences the development of avian embryo retina by reducing GABA uptake and increasing release through NMDAR and PKC pathways, as well as promoting calcium influx.
NEUROCHEMICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Diogo M. Lourenco, Rita Soares, Sonia Sa-Santos, Joana M. Mateus, Rui S. Rodrigues, Joao B. Moreira, Sandra H. Vaz, Ana M. Sebastia, Susana Sola, Sara Xapelli
Summary: This study reveals the role of non-psychoactive cannabinoid CBDV in postnatal neurogenesis in the subventricular zone (SVZ) through TRPV1 modulation. CBDV promotes cell survival, proliferation, and neuronal differentiation via TRPV1, while inhibiting oligodendrocyte differentiation and maturation. These findings provide a new perspective for future neural stem cell studies and repair strategies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Ana M. Sebastiao, Joaquim Alexandre Ribeiro
Summary: It has been about 50 years since the first full paper on the neuromodulatory action of adenosine was published. Adenosine was initially used to increase cyclic AMP, but surprisingly, it decreased neurotransmitter release. Further studies revealed the relationship between adenosine and adenine nucleotides. Our understanding of adenosine's modulation of synapses, circuits, and brain activity has greatly expanded since then. While most attention has been on excitatory synapses, evidence suggests that adenosine also modulates GABAergic transmission through A1 and A2A receptors, with specific effects on different GABAergic neurons and time windows during brain development. The implications of these actions in neuronal function and dysfunction will be the focus of this review.
Meeting Abstract
Biochemistry & Molecular Biology
Goncalo Costa, Ana Filipa Ribeiro, Sara Pinto, Joana Ribeiro, Mariana Sottomayor, Sandra Vaz
JOURNAL OF NEUROCHEMISTRY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Sara Costa-Pinto, Joana Goncalves-Ribeiro, Ana M. Sebastiao, Sandra H. Vaz
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Oksana K. Savchak, Nanying Wang, Miguel A. Ramos-Docampo, Paula de Dios Andres, Ana M. Sebastiao, Filipa F. Ribeiro, Adam Armada-Moreira, Brigitte Stadler, Sandra H. Vaz
Summary: In this study, manganese dioxide nanosheets were used as catalytically active entities to assist mammalian cells under oxidative stress. Additionally, Janus-shaped reactors coated with manganese dioxide nanosheets showed directed locomotion and were able to remove hydrogen peroxide from the media, providing protection for nearby cultured cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)