Article
Chemistry, Applied
Jintao Shen, Wencheng Jiao, Ziyuan Chen, Chunqing Wang, Xingshuang Song, Lei Ma, Ziyan Tang, Wenrui Yan, Hua Xie, Bochuan Yuan, Chenyun Wang, Jing Dai, Yunbo Sun, Lina Du, Yiguang Jin
Summary: The modified chitosan/oxidized dextran hydrogels have been designed to accelerate the wound healing of combined radiation and burn injury (CRBI) by eliminating ROS and exhibiting strong antioxidant and antibacterial properties. These hydrogels have shown potential as a clinical treatment for CRBI.
CARBOHYDRATE POLYMERS
(2023)
Article
Food Science & Technology
Farzaneh Tajfiroozeh, Ali Moradi, Fakhri Shahidi, Jebrail Movaffagh, Hossein Kamali, Sahar Roshanak, Azadeh Shahroodi
Summary: This study aimed to develop biodegradable electrospun chitosan/polyethylene oxide membranes loaded with gallic acid and nisin for antioxidant and antibacterial properties. The core-shell chitosan/polyethylene oxide nanofiberous membranes loaded with gallic acid and nisin were successfully fabricated through electrospinning and characterized using various techniques. The loaded membranes exhibited maximum tensile strength, antioxidant, and antimicrobial effects for different durations, suggesting their potential use as food packaging membranes.
Article
Biochemistry & Molecular Biology
Mohamed A. Mohamady Hussein, Jose Manuel Olmos, Michal K. Pieranski, Mariusz Grinholc, Eva Miriam Buhl, Oguzhan Gunduz, Ahmed M. Youssef, Carlos M. Pereira, Ibrahim M. El-Sherbiny, Mosaad Megahed
Summary: The present study proposes two unique systems for combining Ag, chitosan (CS), and gallic acid (GA) into a single particulate nanostructure using free radical-induced grafting reactions. The grafting of GA into CS-AgNPs was confirmed, and the obtained hybrid NPs II showed lower toxicity, higher antioxidant, and antibacterial activity compared to other samples. The results suggest that grafting GA to CS-AgNPs is a unique process with potential future applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wenhao Pan, Xiaoliang Qi, Yajing Xiang, Shengye You, Erya Cai, Teng Gao, Xianqin Tong, Rongdang Hu, Jianliang Shen, Hui Deng
Summary: This study successfully constructed a hydrogel dressing with excellent ROS scavenging and antibacterial properties, which can promote wound healing and improve the therapeutic effects of skin defect models in diabetic rats.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Gyeong Min Lee, Se-jeong Kim, Eun Mi Kim, Eunhyung Kim, Sangmin Lee, Eunjin Lee, Hee Ho Park, Heungsoo Shin
Summary: A composite hydrogel incorporating epigallocatechin-gallate (EGCG)-coated nanofiber particles (EF) was developed. Compared to traditional GelMA hydrogel, this composite hydrogel showed significant improvements in cell viability, intracellular oxidative stress, and cell spreading and migration ability.
ACTA BIOMATERIALIA
(2022)
Article
Biotechnology & Applied Microbiology
Yuxuan Pang, Lin Guan, Yanlin Zhu, Ruijuan Niu, Song Zhu, Quan Lin
Summary: A composite hydrogel, CGH/PDA@HAP, with excellent mechanical properties and enhanced cellular affinity was synthesized. The introduction of PDA@HAP promoted the differentiation of BMSCs into osteoblasts, leading to enhanced bone regeneration. Moreover, the grafting of gallic acid onto chitosan effectively inhibited the growth of bacteria.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Omer Isildak, Ilyas Yildiz, Nusret Genc
Summary: In this study, a new type of solid-state-contact potentiometric PVC membrane sensor was developed for the evaluation of 1,1-diphenyl-1-picrylhydrazil (DPPH) radical scavenging activity. The sensor demonstrated simple, fast, stable, and low-cost characteristics, and could measure at low volumes. The results obtained were in accordance with the spectroscopic method.
Article
Biochemistry & Molecular Biology
Min A. Gwak, Su Jin Lee, Dongjin Lee, Su A. Park, Won Ho Park
Summary: A novel self-crosslinkable bioink derived from chitosan and gallic acid is developed, which possesses excellent printability, gelation, mechanical properties, and cytocompatibility. The CS-GA hydrogel can rapidly form at physiological pH without chemical crosslinking agents. The CS-GA hydrogel exhibits various physical and chemical interactions, fast gelation rates, and excellent mechanical properties (>337 kPa), and significantly improves cell viability and proliferation. This self-crosslinkable bioink has the potential to overcome the limitations of conventional bioinks.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Bozica Kovacevic, Corina Mihaela Ionescu, Melissa Jones, Susbin Raj Wagle, Michael Lewkowicz, Maja Danic, Momir Mikov, Armin Mooranian, Hani Al-Salami
Summary: The pathophysiology of many diseases is influenced by bioenergetic dysfunction. Healthy mitochondria are crucial for the regulation and function of various cell types. Chitosan and deoxycholic acid are commonly used polymers and excipients in the manufacture of nanogels, but deoxycholic acid may be more suitable for drug delivery systems.
Article
Biochemistry & Molecular Biology
Gyu Ri Park, Min A. Gwak, Yun Hyeok Choi, Won Ho Park
Summary: Malignant tumors are a significant health issue, therefore, there is increasing interest in developing pH-sensitive polymers for targeted drug delivery. In this study, gallic acid (GA) was used to enhance the pH-sensitivity of chitosan (CS) hydrogel beads, which showed excellent swelling/deswelling abilities at different pH values. The reversible breakage/recovery of imine crosslinks in the CS-GA hydrogel beads was confirmed, and the beads demonstrated potential as a drug delivery system sensitive to acidic tumor sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chengkun Liu, Chang Liu, Zhiyuan Liu, Zhuang Shi, Shihai Liu, Xiaojuan Wang, Xiaoqiang Wang, Fang Huang
Summary: A thermogelling chitosan/glycerophosphate formulation was developed by incorporating dihydrocaffeic acid (DHCA), which significantly enhanced gel-forming capacity and tissue adherence. The thermosensitive hydrogels showed improved hemostasis and reduced blood loss in both in vitro and in vivo models. The results demonstrated the potential of enhancing thermogelling and bioadhesion of chitosan-based hydrogels through noncovalent supramolecular mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Shuo Wang, Jinhua Chi, Zhiwen Jiang, Huiwen Hu, Chaozhong Yang, Wanshun Liu, Baoqin Han
Summary: The study developed a biocompatible, self-repairing, and in-situ injectable hydrogel using CMCTS and OHA as a vitreous substitute. The hydrogel showed good cytocompatibility on mouse fibroblast L929 and histocompatibility in New Zealand Rabbits, without significant and persistent adverse effects observed.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Biomedical
Lei Lei, Rui Cong, Yifei Ni, Xin Cui, Xulei Wang, Hongmei Ren, Zun Wang, Mengyuan Liu, Jiasheng Tu, Lei Jiang
Summary: This study reports a dual-functional injectable hydrogel for treating osteoarthritis, which can scavenge reactive oxygen species (ROS) to inhibit inflammation and provide lubrication to reduce joint wear and tear. The hydrogel possesses a unique structure that allows it to be injected, self-heal, and provide lubrication, offering a new approach for osteoarthritis treatments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Paper & Wood
Bo-Nan Jiang, Dan Li, Xue-Na Zou, Hui-Ge Wei, Cheng Zhong, Li-Qiang Chu
Summary: Biopolymer-based injectable hydrogels with antibacterial activity have great potential for biomedical applications. In this study, a double network hydrogel was successfully prepared, which exhibited excellent injectability and antibacterial activity.
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Inorganic & Nuclear
Ngoc Thuy Trang Le, Binh T D Trinh, Dai Hai Nguyen, Lam Dai Tran, Cuong Hung Luu, Thai Thanh Hoang Thi
Summary: The green synthesized P.Gua-AgNPs and T.Ind-AgNPs are fabricated through oxidation-reduction reactions, showing different morphology and size. Due to the presence of organic functional groups in the silver nanoparticles, they exhibit high antifungal ability against various fungi.
JOURNAL OF CLUSTER SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Ngoc Thuy Trang Le, Thai Thanh Hoang Thi, Dai Hai Nguyen, Yern Chee Ching, Ngoc Hoi Nguyen, Dong Yen Pham Nguyen, Quynh Mong Truong
Summary: The feasibility of using plant extracts for metallic nanoparticle fabrication has been demonstrated, with Garcinia mangostana shell and Tradescantia spathacea leaf extract used to synthesize two types of silver nanoparticles. Structural characterization and antifungal tests revealed that these nanoparticles have high antifungal efficiency.
CURRENT NANOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Dieu Linh Tran, Phuong Le Thi, Si Min Lee, Thai Thanh Hoang Thi, Ki Dong Park
Summary: By co-immobilizing heparin and copper nanoparticles onto a surface, enhanced hemocompatibility and anti-inflammatory effects were achieved. The material not only promotes endothelialization and inhibits coagulation and inflammation, but also improves the adaptation of implants.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Thai Thanh Hoang Thi, Estelle J. A. Suys, Jung Seok Lee, Dai Hai Nguyen, Ki Dong Park, Nghia P. Truong
Summary: This review highlights the importance of lipid-based nanoparticles in the development of COVID-19 vaccines and other nanomedicines, focusing on innovations that have obtained regulatory approval or are in clinical trials. It also discusses the physicochemical properties required for specific applications, emphasizes the differences in requirements for delivering different cargos, and introduces current challenges that need further development.
Correction
Biochemistry & Molecular Biology
Minh Nhat Ho, Long Giang Bach, Dai Hai Nguyen, Cong Hao Nguyen, Cuu Khoa Nguyen, Ngoc Quyen Tran, Ngoc Vinh Nguyen, Thai Thanh Hoang Thi
Article
Biochemistry & Molecular Biology
Dieu Phuong Nguyen Thi, Dieu Linh Tran, Phuong Le Thi, Ki Dong Park, Thai Thanh Hoang Thi
Summary: The study involved encapsulating bioactive compounds from Cordyline terminalis leaf extract in gelatin-polyethylene glycol-tyramine (GPT) / alpha-cyclodextrin (α-CD) gels to create materials for biomedical applications with antioxidant properties and high biocompatibility. The addition of the extract delayed gelation time, but sustained release of polyphenols was achieved by adjusting the aqCT amount and gel properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ngoc Thuy Trang Le, Ngoc Hoi Nguyen, Minh Chau Hoang, Cuu Khoa Nguyen, Dai Hai Nguyen, Dieu Linh Tran
Summary: A model paclitaxel-encapsulated nanoliposome carrier was synthesized to enhance the solubility and accumulation of paclitaxel at tumor sites, showing therapeutic effects towards breast cancer cells in vitro. The study suggests that extrusion is a simple and convenient method for nano-sizing and homogenising liposome suspension for effective drug delivery.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Thai Thanh Hoang Thi, Binh D. T. Trinh, Phuong Le Thi, Dieu Linh Tran, Ki Dong Park, Dai Hai Nguyen
Summary: In this study, bioactive CS/AV-GDA hydrogels were fabricated with reduced glutaraldehyde concentration using compounds of Aloe barbadensis Miller, showing excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. The hydrogels released natural nitrite and promoted cell activities, demonstrating potential for biomedical applications in medicine regeneration and tissue engineering.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Polymer Science
Ngoc Nhon Hoang, Tri Khoi Nguyen, Tuyet Hoa Vo, Ngoc Hoi Nguyen, Dai Hai Nguyen, Dieu Linh Tran
Summary: This study presented the isolation, purification, characterization, and biological activities of fucoidan from Ceratophyllum submersum for the first time. The FCS exhibited strong antioxidant properties, as well as antibacterial, antifungal, anticoagulant, and anti-inflammatory activities. It also displayed better inhibition on breast cancer cells compared to liver cancer, lung cancer, and cervical cancer cells. This research contributes valuable information and a basic platform for further studies on fucoidan from C. submersum.
MACROMOLECULAR RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Phuong Le Thi, Thi Yen Nhi Tran, Hung Cuong Luu, Dieu Linh Tran, Thai Thanh Hoang Thi, Dai Hai Nguyen
Summary: An injectable gelatin-cyclodextrin click hydrogel with high drug loading capacity and prolonged drug release was designed and prepared. The physico-chemical properties of the hydrogel could be controlled by adjusting the cross-linker feed amount. The hydrogel showed good cell compatibility in vitro.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Polymer Science
Ngoc Hoi Nguyen, Dieu Linh Tran, Ngoc-Hang Truong-Thi, Cuu Khoa Nguyen, Cam Tu Tran, Dai Hai Nguyen
Summary: This study demonstrates the use of polyethylene glycol (PEG) as a capping agent to control the mesoporous shell thickness of hollow mesoporous silica nanoparticles (HMSN). Increasing the molecular weight or concentration of PEG leads to an increase in the mesoporous shell thickness. The samples synthesized with PEG exhibit higher surface area and better sustained release profile for drug delivery applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Materials Science, Biomaterials
Phuong Le Thi, Dieu Linh Tran, Thai Thanh Hoang Thi, Yunki Lee, Ki Dong Park
Summary: The dual role of reactive oxygen and nitrogen species (RONS) in physiological and pathological processes has been widely studied. Injectable hydrogels have emerged as promising biomaterials for controlling RONS levels and have shown potential in regenerative medicine and tissue engineering applications.
REGENERATIVE BIOMATERIALS
(2022)