Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

Gemcitabine and Taxane Adjuvant Therapy with Chemoradiation in Resected Pancreatic Cancer: A Novel Strategy for Improved Survival?

(2018) Zaheer S. Kanji et al.   ANNALS OF SURGICAL ONCOLOGY

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

(2017) Dimakatso Alice Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells

(2017) Yu-Hsien Lee et al.   Oncology Letters

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation

(2016) Suho Seo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

(2016) Angelika Riedl et al.   JOURNAL OF CELL SCIENCE

Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability

(2016) Ji-Ye Kee et al.   PHYTOMEDICINE

The relevance of using 3D cell cultures, in addition to 2D monolayer cultures, when evaluating breast cancer drug sensitivity and resistance

(2016) Susan Breslin et al.   Oncotarget

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Quercetin in Cancer Treatment, Alone or in Combination with Conventional Therapeutics?

(2015) Ana Brito et al.   CURRENT MEDICINAL CHEMISTRY

Three-Dimensional Cell Culture: A Breakthrough in Vivo

(2015) Delphine Antoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HIF-1α Induces Multidrug Resistance in Gastric Cancer Cells by Inducing MiR-27a

(2015) Qun Zhao et al.   PLoS One

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Molecular Targeted Intervention for Pancreatic Cancer

(2015) Altaf Mohammed et al.   Cancers

P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

(2015) Hossam M. Abdallah et al.   Journal of Advanced Research

Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment

(2014) D. Herrmann et al.   CARCINOGENESIS

Cytotoxicity of gemcitabine enhanced by polyphenolics fromAronia melanocarpain pancreatic cancer cell line AsPC-1

(2014) Noor Azela Abdullah Thani et al.   JOURNAL OF CLINICAL PATHOLOGY

Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways

(2014) Poyil Pratheeshkumar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

(2013) Paola Longati et al.   BMC CANCER

The Antioxidant Effects of Isorhamnetin Contribute to Inhibit COX-2 Expression in Response to Inflammation: A Potential Role of HO-1

(2013) Kyuhwa Seo et al.   INFLAMMATION

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Liver Cancer Targeting of Doxorubicin with Reduced Distribution to the Heart Using Hematoporphyrin-Modified Albumin Nanoparticles in Rats

(2011) Ji-Eun Chang et al.   PHARMACEUTICAL RESEARCH

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Synergistic effects of acyclic retinoid and gemcitabine on growth inhibition in pancreatic cancer cells

(2008) Takayuki Nakagawa et al.   CANCER LETTERS