Review
Pharmacology & Pharmacy
Rachel Yoon Kyung Chang, Michael Y. T. Chow, Dipesh Khanal, Donghao Chen, Hak-Kim Chan
Summary: Therapeutic biologics delivered through pulmonary route offer safe and effective treatment options for respiratory diseases, but require careful formulation strategies, manufacturing processes, and stability considerations.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Multidisciplinary Sciences
Y. A. de Reus, P. Hagedoorn, M. G. G. Sturkenboom, F. Grasmeijer, M. S. Bolhuis, I Sibum, H. A. M. Kerstjens, H. W. Frijlink, O. W. Akkerman
Summary: This study assessed the local tolerability, safety, and pharmacokinetic parameters of inhaled HCQ using a dry powder inhaler. The results showed that single doses of inhaled dry powder HCQ up to 20 mg are safe and well tolerated, without significant adverse effects.
Article
Pharmacology & Pharmacy
Kahori Miyamoto, Tomomi Akita, Chikamasa Yamashita
Summary: This study reported the development of a radiolabeling method for lyophilizate for dry powder inhalation (LDPI) formulations, which may be useful for the quantification of drug deposition in human lungs.
Review
Pharmacology & Pharmacy
Francesca Buttini, Eride Quarta, Chiara Allegrini, Federico Lavorini
Summary: Pulmonary drug delivery is focused on directing drugs to lung disease sites for maximum therapeutic benefit, with capsule-based dry powder inhalers (cDPIs) being a popular and convenient option for treating a variety of diseases. cDPI technology is relatively simple, cost-effective, and has a lower carbon footprint compared to other inhaler devices.
Article
Pharmacology & Pharmacy
Wing-Hin Lee, Ching-Yee Loo, Daniela Traini, Paul M. Young
Summary: This study aimed to develop a simple dry powder inhalation (DPI) formulation containing paclitaxel (PTX) and curcumin (CUR) to achieve preferential cytotoxicity towards lung cancer cells.
Review
Medicine, Research & Experimental
Hao Lou, Li Ding, Tian Wu, Weikun Li, Ryan Khalaf, Hugh D. C. Smyth, Darren L. Reid
Summary: This review provides an overview of the critical process parameters in the manufacturing of dry powder inhaler (DPI) products and discusses the application of models and simulations in DPI process development. The authors emphasize the increasing importance of models and simulations in evaluating the impact of material attributes and process parameters on process performance, and expect that advancements in computational power will enable more accurate modeling and simulation of real-world DPI process operations.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Jong-Ju Lee, Linh Dinh, Juhyun Park, Rama Khraisat, Jun Woo Park, Jae Kwan Jeong, Juseung Lee, Hyun Sil Kim, Moo Suk Park, Jun-Hyun Ahn, Sung-Joo Hwang
Summary: This study prepared lysozyme-loaded liposomal dry powder inhalers using various non-ionic surfactants and characterized their properties. The results showed that the formulation with a drug to PS 80 ratio of 1:0.5 w/w maintained protein activity while demonstrating good aerosol performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Benedict Benque, Johannes G. Khinast
Summary: Drug delivery from a capsule-based dry powder inhaler is influenced by the inhaler's design, the drug's formulation, and the inhalation maneuver. Patient variability poses a challenge in designing new inhaler types. Simulation studies show that different inhalation profiles can affect carrier powder motion and acceleration events.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tuangrat Praphawatvet, Zhengrong Cui, Robert O. Williams III
Summary: This paper provides a comprehensive review of the pharmaceutical applications of thin-film freeze-drying (TFF) powders of small molecule drugs. The unique physical properties of TFF powders facilitate efficient pulmonary delivery and improve dissolution and bioavailability after oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Chemical
Shadi Yaqoubi, Mohaddese Sokuti, Sahand Mazloum-Ravasan, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: In this study, a modified version of ultrasonic spray pyrolysis was used to prepare salbutamol sulfate dry powder. The engineered particles showed suitable characteristics for effective drug delivery to the lungs and demonstrated acceptable aerosolization performance. This newly introduced method appears to be capable of producing dry powder formulations of different drugs without the need for surfactants or stabilizers.
JOURNAL OF AEROSOL SCIENCE
(2024)
Article
Pharmacology & Pharmacy
Hana Douafer, Veronique Andrieu, Emmanuel Wafo, Michelle Sergent, Jean Michel Brunel
Summary: The global increase of multidrug resistant bacteria and the lack of new classes of antibiotics are challenging clinicians in treating bacterial infections. A new adjuvant has been identified to enhance antibiotic activity against resistant P. aeruginosa strains. An experimental protocol was developed to optimize a dry powder for inhalation delivering antibiotic and adjuvant simultaneously.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Kahori Miyamoto, Yuko Ishibashi, Tomomi Akita, Chikamasa Yamashita
Summary: The study aimed to develop a formulation of hGhrelin derivative that can eliminate the need for injections and be clinically applied, utilizing a LDPI system. The optimized formulation showed good pharmacokinetic properties in monkeys and is expected to serve as a substitute for injections in clinical settings.
Review
Pharmacology & Pharmacy
Anne Haaije de Boer, Paul Hagedoorn, Floris Grasmeijer
Summary: In this article, examples of ancient inhalation therapy and the development of early dry powder inhalers are discussed. The use of databases and personal communication with historians and custodians of historic manuscripts and artifacts were used to verify information. The article suggests that inhalation therapy may have a longer and more widespread history than currently known.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Khaled Almansour, Iman M. Alfagih, Ahmed O. Shalash, Katrina Brockbank, Raisuddin Ali, Tim Freeman, Mustafa M. A. Elsayed
Summary: The study of flow is crucial for the development of dry powder inhalation formulations. Various static and dynamic rheological measurements were used to investigate different aspects of powder flow and packing. Bulk rheological measurements showed promise as critical material attributes for monitoring and optimizing carrier-based dry powder inhalation formulations. However, dynamic rheological measurements exhibited high variability and implied heterogeneous powder structures.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Joana T. Pinto, Ines Cachola, Joao F. Pinto, Amrit Paudel
Summary: The use of PBPK models in combination with in vitro characterization provided insights into the impact of carrier particles and powder bulk properties on the in vivo performance of a lactose-based DPI. Smaller carrier particles with fines resulted in better performance for capsule-based DPI, while mean particle size was critical for reservoir type DPI. Various parameters like shear cell and air permeability measurements were found to be useful in predicting the in vivo performance of DPI blends.
Article
Nutrition & Dietetics
Edith Visser, Kim de Jong, Janneke J. S. Pepels, Huib A. M. Kerstjens, Anneke ten Brinke, Tim van Zutphen
Summary: This study aimed to explore the relation between diet quality and food intake with incident adult-onset asthma in normal weight and overweight adults. The results showed that diet quality was not associated with incident adult-onset asthma. Although the intake of several food groups differed between cases and controls, only a few remained associated with adult-onset asthma after adjusting for confounders.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Respiratory System
Domenique Zomer, Jakko van Ingen, Regina Hofland, Dutch C. F. Registry Steering group Dutch CF Registry Steering Grp
Summary: A survey and retrospective data analysis from the Dutch CF Registry were conducted to assess the epidemiology and management of NTM isolation and disease in pwCF in the Netherlands. The study revealed an increasing prevalence of NTM isolation, poor treatment outcomes, and an association with declining lung function. The prevention and treatment of NTM pulmonary disease among pwCF in the Netherlands require increased attention.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Respiratory System
Susan Muiser, Kai Imkamp, Dianne Seigers, Nynke J. Halbersma, Judith M. Vonk, Bart H. D. Luijk, Gert-Jan Braunstahl, Jan-Willem van den Berg, Bart-Jan Kroesen, Janwillem W. H. Kocks, Irene H. Heijink, Helen K. Reddel, Huib A. M. Kerstjens, Maarten van den Berge
Summary: Maintenance and reliever therapy (MART) with inhaled corticosteroid (ICS)/formoterol is as effective as fixed-dose fluticasone/salmeterol therapy in reducing exacerbations in moderate to severe patients with chronic obstructive pulmonary disease (COPD). Furthermore, MART requires a lower daily ICS dosage.
Review
Respiratory System
Ekaterina Khaleva, Anna Rattu, Chris Brightling, Andrew Bush, Arnaud Bourdin, Apostolos Bossios, Kian Fan Chung, Rekha Chaudhuri, Courtney Coleman, Ratko Djukanovic, Sven-Erik Dahlen, Andrew Exley, Louise Fleming, Stephen J. Fowler, Atul Gupta, Eckard Hamelmann, Gerard H. Koppelman, Erik Melen, Vera Mahler, Paul Seddon, Florian Singer, Celeste Porsbjerg, Valeria Ramiconi, Franca Rusconi, Valentyna Yasinska, Graham Roberts
Summary: This study systematically reviewed the definitions of response to biologics for severe asthma and found that although high-quality definitions are available, most are based on minimal clinically important difference (MCID) or minimal important difference (MID), which may not be sufficient to justify the cost-effectiveness of continuing biologics.
Review
Allergy
J. Bousquet, E. Melen, T. Haahtela, G. H. Koppelman, A. Togias, R. Valenta, C. A. Akdis, W. Czarlewski, M. Rothenberg, A. Valiulis, M. Wickman, M. Akdis, D. Aguilar, A. Bedbrook, C. Bindslev-Jensen, S. Bosnic-Anticevich, L. P. Boulet, C. E. Brightling, L. Brussino, E. Burte, M. Bustamante, G. W. Canonica, L. Cecchi, J. C. Celedon, C. Chaves Loureiro, E. Costa, A. A. Cruz, M. Erhola, B. Gemicioglu, W. J. Fokkens, J. Garcia-Aymerich, S. Guerra, J. Heinrich, J. C. Ivancevich, T. Keil, L. Klimek, P. Kuna, M. Kupczyk, V. Kvedariene, D. E. Larenas-Linnemann, N. Lemonnier, K. C. Lodrup Carlsen, R. Louis, M. Makela, M. Makris, M. Maurer, I. Momas, M. Morais-Almeida, J. Mullol, R. N. Naclerio, K. Nadeau, R. Nadif, M. Niedoszytko, Y. Okamoto, M. Ollert, N. G. Papadopoulos, G. Passalacqua, V. Patella, R. Pawankar, N. Pham-Thi, O. Pfaar, F. S. Regateiro, J. Ring, P. W. Rouadi, B. Samolinski, J. Sastre, M. Savoure, N. Scichilone, M. H. Shamji, A. Sheikh, V. Siroux, B. Sousa-Pinto, M. Standl, J. Sunyer, L. Taborda-Barata, S. Toppila-Salmi, M. J. Torres, I. Tsiligianni, E. Valovirta, O. Vandenplas, M. T. Ventura, S. Weiss, A. Yorgancioglu, L. Zhang, A. H. Abdul Latiff, W. Aberer, I. Agache, M. Al-Ahmad, I. Alobid, I. J. Ansotegui, S. H. Arshad, E. Asayag, C. Barbara, A. Baharudin, L. Battur, K. S. Bennoor, E. C. Berghea, K. C. Bergmann, D. Bernstein, M. Bewick, H. Blain, M. Bonini, F. Braido, R. Buhl, R. S. Bumbacea, A. Bush, M. Calderon, M. Calvo-Gil, P. Camargos, L. Caraballo, V. Cardona, W. Carr, P. Carreiro-Martins, T. Casale, A. M. Cepeda Sarabia, R. Chandrasekharan, D. Charpin, Y. Z. Chen, I. Cherrez-Ojeda, T. Chivato, E. Chkhartishvili, G. Christoff, D. K. Chu, C. Cingi, J. Correia de Sousa, C. Corrigan, A. Custovic, G. D'Amato, S. Del Giacco, F. De Blay, P. Devillier, A. Didier, M. do Ceu Teixeira, D. Dokic, H. Douagui, M. Doulaptsi, S. Durham, M. Dykewicz, T. Eiwegger, Z. A. El-Sayed, R. Emuzyte, A. Fiocchi, N. Fyhrquist, R. M. Gomez, M. Gotua, M. A. Guzman, J. Hagemann, S. Hamamah, S. Halken, D. M. G. Halpin, M. Hofmann, E. Hossny, M. Hrubisko, C. Irani, Z. Ispayeva, E. Jares, T. Jartti, E. Jassem, K. Julge, J. Just, M. Jutel, I. Kaidashev, O. Kalayci, A. F. Kalyoncu, P. Kardas, B. Kirenga, H. Kraxner, I. Kull, M. Kulus, S. La Grutta, S. Lau, L. Le Tuyet Thi, M. Levin, B. Lipworth, O. Lourenco, B. Mahboub, E. Martinez-Infante, P. Matricardi, N. Miculinic, N. Migueres, F. Mihaltan, Y. Mohammad, M. Moniuszko, S. Montefort, H. Neffen, K. Nekam, E. Nunes, D. Nyembue Tshipukane, R. O'Hehir, I. Ogulur, K. Ohta, K. Okubo, S. Ouedraogo, H. Olze, I. Pali-Schoell, O. Palomares, K. Palosuo, C. Panaitescu, P. Panzner, H. S. Park, C. Pitsios, D. Plavec, T. A. Popov, F. Puggioni, S. Quirce, M. Recto, M. S. Repka-Ramirez, C. Robalo Cordeiro, N. Roche, M. Rodriguez-Gonzalez, J. Romantowski, N. Rosario Filho, M. Rottem, H. Sagara, F. S. Serpa, Z. Sayah, S. Scheire, P. Schmid-Grendelmeier, J. C. Sisul, D. Sole, M. Soto-Martinez, M. Sova, A. Sperl, O. Spranger, R. Stelmach, C. Suppli Ulrik, M. Thomas, T. To, A. Todo-Bom, P. V. Tomazic, M. Urrutia-Pereira, M. Valentin-Rostan, E. Van Ganse, M. van Hage, T. Vasankari, P. Vichyanond, G. Viegi, D. Wallace, D. Y. Wang, S. Williams, M. Worm, P. Yiallouros, O. Yusuf, F. Zaitoun, M. Zernotti, M. Zidarn, J. Zuberbier, J. A. Fonseca, T. Zuberbier, J. M. Anto
Summary: Asthma, rhinitis, and atopic dermatitis are interrelated clinical phenotypes. The concept of one-airway-one-disease, which simplifies the links between upper and lower airway allergic diseases, needs to be reassessed based on new data.
Article
Public, Environmental & Occupational Health
Sophie Kienhorst, Moniek H. D. van Aarle, Quirijn Jobsis, Michiel A. G. E. Bannier, Elin T. G. H. Kersten, Jan Damoiseaux, Onno C. P. van Schayck, Peter J. F. M. Merkus, Gerard Koppelman, Frederik-Jan van Schooten, Agnieszka Smolinska, Edward Dompeling
Summary: This study evaluates the application of a breath test in preschool children with asthma-like symptoms. The test predicts a diagnosis of asthma by analyzing the exhaled breath. The study also explores the relationship between other biological parameters and the odors in the breath.
Article
Health Care Sciences & Services
Johanna Broese, Rianne M. J. J. van der Kleij, Els M. L. Verschuur, Huib A. M. Kerstjens, Ewald M. Bronkhorst, Yvonne Engels, Niels H. Chavannes
Summary: This study aimed to assess the effectiveness of palliative care in patients with COPD. The results showed no improvement in patients' quality of life with palliative care, but it did reduce acute healthcare use. The findings may have been affected by the consequences of the COVID-19 pandemic.
PALLIATIVE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Richard N. Van Zyl-Smit, Huib AM. Kerstjens, Jorge F. Maspero, Konstantinos Kostikas, Motoi Hosoe, Ana-Maria Tanase, Peter Andrea, Karen Mezzi, Dominic Brittain, David Lawrence, Kenneth R. Chapman
Summary: This study evaluated the efficacy of a fixed-dose combination therapy of mometasone furoate/indacaterol acetate/glycopyrronium bromide in asthma patients with and without persistent airflow limitation. The results showed that this therapy improved lung function and reduced asthma exacerbations in patients with airflow limitation.
RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Antonius Timotheus Otten, V Peters, I Barth, C. L. Stevens, A. R. Bourgonje, H. W. Frijlink, H. J. M. Harmsen, A. Rehman, M. J. E. Campmans-Kuijpers, G. Dijkstra
Summary: This article describes a nutritional intervention trial on patients with Crohn's disease (CD) and their healthy household members, investigating the effects of an evidence-based anti-inflammatory diet and an ileocolonic-targeted capsule containing vitamin B2, B3, and C. The results of the study will provide valuable evidence for dietary recommendations for CD patients and physicians.
Article
Medicine, General & Internal
Johanna van Gemert, Fleur Steenberg, Coretta van Leer-Buter, Huib Kerstjens, Willie Steenhuis, Onno Akkerman, Erik Verschuuren, Tji Gan
Summary: COVID-19 causes high mortality in LTx patients, so vaccination in this population is crucial. However, the antibody response is impaired after multiple vaccinations. This study aims to investigate the possibility of increasing this response and identify risk factors for non-response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Primawan Putra Nugrahadi, Wouter L. J. Hinrichs, Henderik W. Frijlink, Christian Schoneich, Christina Avanti
Summary: In recent decades, there has been a significant increase in the use of therapeutic peptides. However, peptides are often unstable in aqueous solutions, which affects their stability and bioactivity. This literature review provides an overview of the degradation pathways and formulation strategies to stabilize therapeutic peptides in aqueous solutions. The most practical approaches to peptide stabilization are pH optimization and selecting the appropriate type of buffer, along with other strategies such as co-solvency, air exclusion, viscosity enhancement, PEGylation, and the use of polyol excipients.
Article
Pharmacology & Pharmacy
Renee S. van der Kooij, Martin Beukema, Anke L. W. Huckriede, Johan Zuidema, Rob Steendam, Henderik W. Frijlink, Wouter L. J. Hinrichs
Summary: Although vaccination is important for public health, the increase in vaccination coverage has slowed down. Single-injection vaccines could solve the problem of multiple injections. Researchers developed injectable microspheres that released bovine serum albumin (BSA) over several weeks. In vitro and in vivo studies showed successful sustained release and immunization.
Letter
Respiratory System
Anne M. Akkerman-Nijland, Bart L. Rottier, Joanne Holstein, Rik L. J. Winter, Daniel J. Touw, Onno W. Akkerman, Gerard H. Koppelman
Article
Multidisciplinary Sciences
Jacobien Niebuur, Judith M. Vonk, Yihui Du, Geertruida H. de Bock, Gerton Lunter, Paul F. M. Krabbe, Behrooz Z. Alizadeh, Harold Snieder, Nynke Smidt, Marike Boezen, Eva Corpeleijn
Summary: This study conducted in the northern Netherlands found that patients with multimorbidity are more likely to have unhealthy lifestyle factors such as physical inactivity, chronic stress, and inadequate sleep. These findings are of great importance for improving the lifestyle of patients with multiple chronic diseases.
Article
Multidisciplinary Sciences
Paula Niewold, Douwe J. Dijkstra, Yi Cai, Delia Goletti, Fabrizio Palmieri, Krista E. van Meijgaarden, Frank A. W. Verreck, Onno W. Akkerman, Regina W. Hofland, Eveline M. Delemarre, Stefan Nierkens, Marije K. Verheul, Andrew J. Pollard, Jaap T. van Dissel, Tom H. M. Ottenhoff, Leendert A. Trouw, Simone A. Joosten
Summary: Tuberculosis (TB) is a common disease with high mortality and morbidity rates. Differentiating TB from other diseases is challenging, especially in clinical settings. The study identified circulating monocytes as the source of complement component C1q, which is a specific biomarker for TB. The expression of C1q was pronounced in classical and intermediate monocytes and varied in non-classical monocytes.
SCIENTIFIC REPORTS
(2023)