Article
Orthopedics
Felix Rohrer, Anita Maurer, Hubert Noetzli, Brigitta Gahl, Andreas Limacher, Tanja Hermann, Jan Bruegger
Summary: The use of prolonged surgical antibiotic prophylaxis (PSAP) in orthopaedic surgery, despite guidelines advising against it, was found to be 12% in this study. Patient-related factors associated with PSAP use included older age, higher BMI, ASA classification >= 3, and lung disease, while surgery-related factors included use of prosthetics, knee surgery, longer surgery duration, and presence of drains. All four surgical site infections (SSI) occurred in the SAP group, indicating a potentially lower SSI risk in the PSAP group. Surgeons varied in their frequencies of administering PSAP, suggesting differing approaches to antibiotic prophylaxis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Infectious Diseases
Maia Simon, Nathalie Thilly, Ouarda Pereira, Celine Pulcini
Summary: This study identified clusters of general practitioners (GPs) and characteristics associated with the appropriateness of antibiotic prescriptions using routinely collected data. This has important implications for guiding antibiotic stewardship interventions.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Xinyu Wu, Mengjie Ye, Jiahui Sun, Qi Yan, Bin Shi, Haibin Xia
Summary: This study evaluated patient-reported outcome measures (PROMs) of dental implant surgeries and analyzed associated indicators. The results showed that alcohol consumption, pain during surgery, and age were associated with discomfort following dental implant surgery.
Article
Veterinary Sciences
Juan Pablo Villanueva-Cabezas, Karma Rinzin, Sithar Dorjee, Pema Tshewang, Ugyen Namgyel, Puspa Maya Sharma, Mark A. Stevenson, Jodie McVernon
Summary: The study investigates veterinary antibiotic prescriptions in Bhutan, showing positive features of antimicrobial stewardship. However, it highlights the need for close monitoring of antibiotic prescriptions for key species and further improvements in antibiotic stewardship practices.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, General & Internal
Anum Kazmi, Zia Abbas, Zohra Saleem, Safdar Haider, Waqas Ahmed Farooqui, Shaheen Ahmed
Summary: The objective of this study was to evaluate the levels of salivary matrix metalloproteinases (MMP-8) in oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) for early stage diagnosis using a non-invasive method. The study found that MMP-8 levels were underexpressed in OSCC and OSF patients compared to controls, indicating an inverse relationship between MMP-8 levels and OSCC and OSF.
Article
Health Care Sciences & Services
Michael E. Otim, Desmond Kabuya Demaya, Amina Al Marzouqi, Jean Mukasa
Summary: Inappropriate use of antibiotics is common at Juba Teaching Hospital in South Sudan, despite the presence of local guidelines. This highlights an increased risk for antibiotic resistance and the need for antibiotic stewardship programs and continuous national surveillance to address the issue.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Article
Obstetrics & Gynecology
Benjamin B. B. Albright, Quetrell D. D. Heyward, Alaattin Erkanli, Andrew P. P. Loehrer, Evan R. R. Myers, Laura J. J. Havrilesky, Haley A. A. Moss
Summary: This study describes the population rate of hysterectomy for benign disease in the USA, and analyzes the geographic variation across states and Hospital Service Areas. The annual population rate of hysterectomy for benign disease is 49 per 10,000 eligible residents, with a slight decline over time, mostly among reproductive-age populations. There are significant differences in rates across states and HSAs, and population characteristics such as government-sponsored insurance and race are associated with lower rates.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Microbiology
Aida Bianco, Francesca Licata, Alessandro Trovato, Francesco Napolitano, Maria Pavia
Summary: The study found that despite 93.7% of Italian community pharmacists knowing that DAwP is illegal, about 37.1% claimed to be involved in this practice. Most pharmacists reported always/often asking clients about drug allergies and medication history, with 66.2% warning clients about potential drug side effects and 55% informing them about the importance of completing the full course of antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Haitao Wang, Haitao Shi, Yan Wang, Na Wang, Youjia Li, Qianting Yang, Ya Li, Chenwei Liu, Ying Zan, Siping Feng, Jiao Xie
Summary: The prevalence of hazardous drug-drug interactions (DDIs) related to oral antineoplastic agents (OAAs) appears to be low in cancer patients. However, physicians and clinical pharmacologists should be aware of the potential hazardous DDIs when prescribing OAAs, especially certain pH-dependent molecular targeted agents and drugs that can prolong QTc interval.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
Cristian Abelairas-Gomez, Daniel C. Schroeder, Aida Carballo-Fazanes, Bernd W. Bottiger, Sergio Lopez-Garcia, Santiago Martinez-Isasi, Antonio Rodriguez-Nunez
Summary: A survey involving 3423 schoolteachers in Spain found that they have some understanding of first aid and BLS, but lack knowledge in identifying cardiac arrest and CPR. While willing to teach basic life support, schoolteachers require more thorough training and support to effectively educate schoolchildren.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Education & Educational Research
Mohammad Kamal, Mohammad Abdulwahab
Summary: The study evaluated the self-confidence of undergraduate dental students at Kuwait University in relation to oral and maxillofacial surgery using a questionnaire developed by the Association of British Academic Oral Maxillofacial Surgeons. The majority of students expressed confidence in their knowledge for independent practice, but reported lower confidence levels in surgical extraction of teeth.
BMC MEDICAL EDUCATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Maria Grazia Cagetti, Fabio Cocco, Ezio Calzavara, Davide Augello, Phunchok Zangpoo, Guglielmo Campus
Summary: The study aimed to evaluate dental caries severity among schoolchildren in Zanskar Valley, Ladakh, India and its association with anthropometric factors and background variables. Significant relationships were found between caries severity and gender, waist circumference, BMI, oral hygiene frequency, and self-reported chewing problems. Low BMI values and reduced waist circumference were identified as main predictors for caries risk.
Review
Dentistry, Oral Surgery & Medicine
Iciar Arteagoitia, Fabio Rodriguez Sanchez, Amaia Figueras, Nagore Arroyo-Lamas
Summary: The effectiveness of oral clindamycin in preventing infection after oral surgery, except for third molar extraction, is limited.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jamie M. Alberga, Arjan Vissink, Anke Korfage, Sebastiaan A. H. J. de Visscher, Max J. H. Witjes, Johannes A. Langendijk, Gerry M. Raghoebar
Summary: By assessing radiation dosages on implant regions, it was found that an implant-specific D-mean higher than 50 Gy is associated with more peri-implant bone loss and eventual implant loss.
Article
Infectious Diseases
Sien De Koster, Moniek Ringenier, Christine Lammens, Arjan Stegeman, Tijs Tobias, Francisca Velkers, Hans Vernooij, Marjolein Kluytmans-van den Bergh, Jan Kluytmans, Jeroen Dewulf, Herman Goossens
Summary: This study found marked differences in antibiotic resistance between countries, farms, and within farms in Belgium and the Netherlands. ESBL-E. coli were more prevalent in Belgian samples, while CiproR-E. coli were highly prevalent in broilers of both countries. Multidrug resistance was frequently observed in samples from both countries, with a higher prevalence of ESBL production in combination with ciprofloxacin resistance in samples from Belgium.
Article
Biotechnology & Applied Microbiology
Wannes Van Holm, Justien Ghesquiere, Nico Boon, Tim Verspecht, Kristel Bernaerts, Naiera Zayed, Ioanna Chatzigiannidou, Wim Teughels
Summary: The use of viability quantitative PCR (v-qPCR) has revolutionized the assessment of microbial viability, but the selection of qPCR amplicon length is crucial for accurate live/dead distinction. Longer amplicon lengths increase the difference in quantification cycle (C-q) between live and dead cells, but decrease qPCR efficiency. The optimal amplicon length for v-qPCR is around 400 bp, balancing efficiency with the ability to distinguish between live and dead bacteria.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pedro Barreiros, Joao Braga, Ricardo Faria-Almeida, Cristina Coelho, Wim Teughels, Julio C. M. Souza
Summary: This study evaluated the sterilization effectiveness against biofilms on healing abutments used in implant dentistry, revealing that some abutments still had remnant biofilm biomass, including pathogenic species. Further research should be conducted on different materials, design, and connections of healing abutments in relation to clinical disinfection procedures.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Review
Biochemical Research Methods
A. Wylleman, F. Vuylsteke, C. Dekeyser, W. Teughels, M. Quirynen, I Laleman
Summary: The study found that the effectiveness of alternative therapies for intra-oral halitosis is uncertain, with significant variations in results, and currently there is insufficient evidence to prove the added value of alternative therapies in the treatment of halitosis.
JOURNAL OF BREATH RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pierre Lahoud, Siebe Diels, Liselot Niclaes, Stijn Van Aelst, Holger Willems, Adriaan Van Gerven, Marc Quirynen, Reinhilde Jacobs
Summary: This study developed and validated a novel AI-driven tool for fast and accurate mandibular canal segmentation on CBCT scans. Using a deep learning algorithm trained on 235 CBCT scans, the automated segmentation demonstrated high precision and speed, providing a potential solution to relieve practitioners from manual segmentation tasks.
JOURNAL OF DENTISTRY
(2022)
Article
Multidisciplinary Sciences
S. A. M. Siawasch, C. Andrade, A. B. Castro, W. Teughels, A. Temmerman, M. Quirynen
Summary: This study evaluated the effect of local and systemic administration of antimicrobials to leukocyte- and platelet-rich fibrin (L-PRF). The results showed that incorporating metronidazole solution can enhance the antibacterial capacity of L-PRF against periodontal pathogens without affecting the release of growth factors.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mihai Tarce, Joe Merheb, Marc Meeus, Karla de Faria Vasconcelos, Marc Quirynen
Summary: This study validates a novel method for bone augmentation of horizontal alveolar bone defects using a surgical guide. The use of the guide resulted in improved accuracy of the resulting graft shape, reduced amount of graft material outside the planned volume, and increased surgical time.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Iciar Arteagoitia, Fabio Rodriguez Sanchez, Amaia Figueras, Nagore Arroyo-Lamas
Summary: The effectiveness of oral clindamycin in preventing infection after oral surgery, except for third molar extraction, is limited.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Anna Ockerman, Amber Hendrickx, Wouter Willekens, Heleen Fehervary, Julie Vastmans, Wim Coucke, Peter Verhamme, Constantinus Politis, Thomas Vanassche, Annabel Braem, Marc Quirynen, Reinhilde Jacobs
Summary: The study found that L-PRF membranes from patients on anticoagulants were weaker, less stretchable, and contained fewer leukocytes compared to those from patients not taking these drugs.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Rutger Dhondt, Marc Quirynen, Mihai Tarce, Wim Teughels, Andy Temmerman, Reinhilde Jacobs
Summary: The objective of this review was to assess the accuracy of available means of determining the buccal bone thickness and/or level. The study included clinical, in vitro, and animal trials examining the buccal bone plate at oral implants. The results indicated a significant underestimation of buccal bone thickness by CBCT in vitro studies.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mihai Tarce, Alexander de Greef, Pierre Lahoud, Karla de Faria Vasconcelos, Reinhilde Jacobs, Marc Quirynen
Summary: This study assessed the factors influencing implant blooming using a human-like imaging phantom and 3D-printed mandibles. The results showed that implant diameter, presence of a cover screw, implant design/material, implant position, and the presence of additional implants all affected the extent of implant blooming. The study also found that the effect of implant diameter was more pronounced for zirconium implants.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Wim Teughels, Lorenz Seyssens, Veronique Christiaens, Andy Temmerman, Ana B. B. Castro, Jan Cosyn
Summary: Based on the analysis of four randomized controlled trials, it is found that the adjunctive use of local or systemic antimicrobials during surgical therapy for peri-implantitis does not improve the clinical efficacy in terms of pocket probing depth reduction. The use of systemic antimicrobials only showed disease resolution in 50% of cases after one year, and the true effect of local antimicrobials remains unclear.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Microbiology
Gerard Alvarez, Alexandre Arredondo, Sergio Isabal, Wim Teughels, Isabelle Laleman, Maria Jose Contreras, Lorena Isbej, Enrique Huapaya, Gerardo Mendoza, Carolina Mor, Jose Nart, Vanessa Blanc, Ruben Leon
Summary: The aim of this study was to compare the prevalence and load of nine pathobionts in subgingival samples of healthy individuals and periodontitis patients from four different countries. The results showed that most species, except T. socranskii, were significantly associated with periodontitis in all countries except Peru. Furthermore, the species exhibited higher loads in sites with greater clinical attachment loss and pocket probing depth, but not in sites with higher bleeding on probing. Relative load was found to be a reliable variable for discriminating the association of the species with periodontitis. Based on this, F. alocis, P. endodontalis, P. gingivalis, T. denticola and T. forsythia may be biomarkers of periodontal disease in Belgium, Chile and Spain.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gorka Santamaria Arrieta, Fabio Rodriguez Sanchez, Carlos Rodriguez-Andres, Luis Barbier, Iciar Arteagoitia
Summary: This study found that preoperative oral clindamycin administration during dental implant surgery in healthy adults may not reduce early implant failure or postoperative complications.
CLINICAL ORAL INVESTIGATIONS
(2023)
