期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 375, 期 1809, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2019.0564
关键词
folding; morphogenesis; mechanics; mathematical models
类别
资金
- Sir HenryWellcome Fellowship [103095]
- MRC Fellowship [MR/L009056/1]
- Lister Institute Research Prize Fellowship
- EMBO Young Investigator Programme
- MRC [MC_U12266B]
- MRC [MR/L009056/1] Funding Source: UKRI
Tissue folding is a fundamental process that sculpts a simple flat epithelium into a complex three-dimensional organ structure. Whether it is the folding of the brain, or the looping of the gut, it has become clear that to generate an invagination or a fold of any form, mechanical asymmetries must exist in the epithelium. These mechanical asymmetries can be generated locally, involving just the invaginating cells and their immediate neighbours, or on a more global tissue-wide scale. Here, we review the different mechanical mechanisms that epithelia have adopted to generate folds, and how the use of precisely defined mathematical models has helped decipher which mechanisms are the key driving forces in different epithelia. This article is part of a discussion meeting issue 'Contemporary morphogenesis'.
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