期刊
PHARMACOLOGICAL RESEARCH
卷 163, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2020.105240
关键词
Mitophagy; Alzheimer's disease (AD); Parkinson's disease (PD); Huntington's disease (HD); Amyotrophic lateral sclerosis (ALS)
资金
- National Natural Sciences Foundation of China [81872855, 81673420]
- CAMS Innovation Fund for Medical Sciences [2017-12M-2-004]
- National Science and Technology Major Special Project on Major New Drug Innovation of China [2018ZX09711001-003-005, 2018ZX09711001-003-009]
- National Key RAMP
- D Program of China [2019YFC1708901]
Neurodegenerative diseases are common and incurable disorders in the elderly, with impaired mitophagy playing a significant role in their progression. Therapeutic strategies targeting mitophagy show promise in recent studies.
Neurodegenerative diseases are the most common diseases of the nervous system in elderly people, which are currently incurable and cause great burden to families and societies. Mitochondria are the energy factory of the cell and have extremely important effects on neuronal function. The elimination of dysfunctional mitochondria is essential for the mitochondrial metabolic homeostasis, energy supply, and neuronal survival. Recent studies suggest that the impaired mitophagy may lead to the accumulation of damaged mitochondria and therefore contribute to the progression of neurodegenerative diseases. This review mainly focuses on mitophagy, mitochondrial dynamics, and their abnormal changes in neurodegenerative diseases, as well as the therapeutic strategies targeting mitophagy that have shown promise in recent preclinical and clinical studies.
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