Review
Biochemistry & Molecular Biology
Innokenty A. Savin, Marina A. Zenkova, Aleksandra V. Sen'kova
Summary: Bronchial asthma is a diverse disease characterized by persistent inflammation, airway hyperreactivity, and airflow obstruction. Airway remodeling and lung fibrosis are key features of asthma, and are also associated with the severity and treatment resistance of the disease. Distinguishing between asthma and other lung disorders with similar structural characteristics is a diagnostic challenge, requiring the identification of specific molecular characteristics and biomarkers. This review discusses the etiology, pathogenesis, morphological characteristics, as well as the continuous progression of airway remodeling and lung fibrosis in bronchial asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Katarzyna Kaczynska, Monika Jampolska, Piotr Wojciechowski, Dorota Sulejczak, Kryspin Andrzejewski, Dominika Zajac
Summary: Lactoferrin (LF) is a versatile glycoprotein with various properties that can be used to treat lung diseases. Although in vitro and in vivo studies show significant potency of LF in treating lung diseases, its effectiveness in human studies is only confirmed for respiratory tract infections. For other diseases such as lung cancer, COVID-19, and sepsis, the reports are conflicting, and there is a lack of conclusive human studies on the beneficial effects of LF.
Review
Biochemistry & Molecular Biology
Yuko Abe, Yasuhiko Suga, Kiyoharu Fukushima, Hayase Ohata, Takayuki Niitsu, Hiroshi Nabeshima, Yasuharu Nagahama, Hiroshi Kida, Atsushi Kumanogoh
Summary: Asthma is a disease characterized by airway inflammation, airway hyperresponsiveness, and airway remodeling. Current antibody therapeutics and biomarkers for asthma treatment are not satisfactory, and an ideal phenotype classification is needed to predict the response to antibody treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Nirmin F. Juber, Chien-Chang Lee, Wen-Chi Pan, Jason J. Liu
Summary: This study found that having pediatric asthma is associated with increased risks of hypertension, diabetes, and stomach diseases diagnosed in adulthood. The associations may vary by sex and age of asthma and other NCD diagnoses.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Suyu Guo, Dongmei Chen, Jiawei Chen, Canhong Zhu, Li Huang, Zhengrong Chen
Summary: This study investigated the relationship between climate changes and hospitalizations for pediatric bronchial asthma in Suzhou before and after the COVID-19 pandemic. The results showed that after the outbreak, the rate of asthma exacerbation and the infection rate of respiratory syncytial virus decreased, while the proportion of school-aged children and the infection rate of rhinovirus increased. Temperature and PM2.5 were found to be related to the incidence of acute asthma attacks. These findings suggest that meteorological and environmental factors play a role in the development of bronchial asthma and may aid in predicting incidence and attack rates.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Manish Purohit, Gaurav Gupta, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sami I. Alzarea, Imran Kazmi, Waleed Hassan Almalki, Monica Gulati, Indu Pal Kaur, Sachin Kumar Singh, Kamal Dua
Summary: The JAK/STAT system is a crucial signaling pathway for the signal transduction of several key cytokines in sepsis. Activation of JAK kinases by cytokine-receptor binding leads to selective phosphorylation of STATs, which play a key role in gene transcription in the nucleus. The JAK/STAT pathway is involved in various biological activities, including hematopoiesis, immunological modulation, cell differentiation, and apoptosis. This review discusses the importance of the JAK/STAT signaling pathway in severe lung inflammation, which is a major public health concern worldwide.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Allergy
Alexis Celle, Pauline Esteves, Guillaume Cardouat, Fabien Beaufils, Edmee Eyraud, Isabelle Dupin, Elise Maurat, Sabrina Lacomme, Olga Ousova, Hugues Begueret, Matthieu Thumerel, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger, Thomas Trian
Summary: This study demonstrates a novel mechanism of bronchial smooth muscle (BSM) remodeling in patients with severe asthma following rhinovirus (RV) exacerbation. The specific migration of BSM cells towards RV-infected bronchial epithelium (BE) is driven by the chemokine ligand C-X-C motif chemokine ligand 10. Decreased expression and activation of the CXCR3-B-specific isoform in BSM cells from patients with severe asthma contribute to this mechanism. These findings highlight the potential therapeutic target of the C-X-C motif chemokine ligand 10/CXCR3-A axis in severe asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Cyndi Henry, Sabrina Biardel, Magali Boucher, Krystelle Godbout, Jamila Chakir, Andreanne Cote, Michel Laviolette, Ynuk Bosse
Summary: Bronchial thermoplasty is effective in improving respiratory symptoms and reducing exacerbations in severe asthma, but it impairs the response to bronchodilator drugs. This study provides physiological evidence of therapeutic efficacy.
RESPIRATORY MEDICINE
(2023)
Article
Allergy
Scott P. Ginebaugh, Matthias Hagner, Anuradha Ray, Serpil C. Erzurum, Suzy A. A. Comhair, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Prescott G. Woodruff, Stephanie A. Christenson, Eugene R. Bleecker, Deborah A. Meyers, Annette T. Hastie, Wendy C. Moore, David T. Mauger, Elliot Israel, Bruce D. Levy, Sally E. Wenzel, Matthew J. Camiolo
Summary: This study investigated the transcriptional response of bronchial epithelial cells to inhaled corticosteroids. It was found that a subset of asthma patients with poor hormone treatment response had worse lung function and quality of life. Furthermore, the response to hormone treatment could be predicted using blood samples.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Respiratory System
Adam Peel, Ran Wang, Waqar Ahmed, Iain White, Maxim Wilkinson, Yoon K. Loke, Andrew M. Wilson, Stephen J. Fowler
Summary: Inhalation of mannitol can cause changes in exhaled volatile organic compounds (VOCs), which could be used as a diagnostic test and model for acute asthma attacks. These changes in VOCs may be associated with acute airway inflammation and bronchoconstriction, and could be potential biomarkers for asthma.
Article
Medicine, General & Internal
Ewelina Wawryk-Gawda, Monika Zybowska, Klaudia Ostrowicz
Summary: The determination of NLR can be used to diagnose specific types of asthma. Analysis of laboratory test results of 482 patients showed that the NLR value in asthma patients was significantly higher compared to the control group. Additionally, patients with allergic asthma had the highest NLR value. This blood test can assist in the diagnosis and differentiation of asthma types when other test results are inconclusive.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Geoffrey Chupp, Joel N. Kline, Sumita B. Khatri, Charlene McEvoy, Gerard A. Silvestri, Adrian Shifren, Mario Castro, Sundeep Bansal, Marc McClelland, Mark Drans Field, Jennifer Trevor, Nick Kahlstrom, Michael Simoff, Momen M. Wahidi, Carla R. Lamb, J. Scott Ferguson, Andrew Haas, D. Kyle Hogarth, Richard Tejedor, Jennifer Toth, Jamie Hey, Adnan Majid, Peter LaCamera, Mark Fitzgerald, Kyle Enfield, Mark Grubb, Edmund A. McMullen, Jennifer L. Olson, Michel Laviolette
Summary: Bronchial thermoplasty can significantly reduce severe exacerbations, hospitalizations, emergency department visits, and corticosteroid usage in patients with severe asthma even after a 5-year follow-up. Clinical improvement was observed in all subgroups regardless of baseline clinical and biomarker characteristics.
Article
Medicine, General & Internal
Yuji Fujita, Kenji Miyamoto, George Imataka, Shigemi Yoshihara
Summary: Bronchiolitis obliterans is a chronic obstructive respiratory disease with poor prognosis, potentially requiring oxygen therapy or lung transplantation. In children, infections by respiratory pathogens such as adenoviruses can lead to postinfectious bronchiolitis obliterans. Early appropriate treatment is crucial for improving prognosis, and it is important to differentiate it from bronchial asthma.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yosri Akl, Eman Kamal Ibrahim, Tareq Muhammad Algarf, Rasha R. Mostafa, Hoda M. Abdel-Hamid, Asmaa Ibrahim Muhammed
Summary: The purpose of this study was to investigate nasal histopathological changes in HP patients and identify any shared pathological features between the upper airways and HP. The study included 40 HP patients who underwent thorough evaluations and nasal mucosal biopsy. The results showed that 87.5% of HP patients had chronic inflammation of the nasal mucosa, with predominant lymphocytic infiltration in 72.5% of patients. Additionally, 77.5% of patients had a high burden of sinonasal symptoms, which was positively associated with cough severity.
SCIENTIFIC REPORTS
(2023)
Review
Allergy
Hans Jacob L. Koefoed, Annelies M. Zwitserloot, Judith M. Vonk, Gerard H. Koppelman
Summary: This systematic review found that factors such as asthma, wheezing, bronchial hyper-responsiveness, and early-life allergic sensitization can impact the development of large and small airway lung function in early childhood, potentially leading to lower levels of lung function growth. However, in later childhood, even with the presence of asthma or wheezing, lung function development continues at a lower level but largely tracks parallel to individuals without these conditions.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Correction
Nursing
Russel J. Roberts, Abdullah M. Alhammad, Lindsay Crossley, Eric Anketell, LeeAnn Wood, Greg Schumaker, Erik Garpestad, John W. Devlin
INTENSIVE AND CRITICAL CARE NURSING
(2021)
Article
Oncology
Abdullah M. Alhammad, Nora Alkhudair, Rawan Alzaidi, Latifa S. Almosabhi, Mohammad H. Aljawadi
Summary: This study translated and validated the Arabic version of the FLIE tool for assessing the impact of chemotherapy-induced nausea and vomiting on quality of life among Arabic-speaking cancer patients. The FLIE showed excellent reliability in a sample of cancer patients in Saudi Arabia, with minimal impact on daily life.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2022)
Article
Infectious Diseases
Thamer A. Almangour, Alya Alruwaili, Rehab Almutairi, Aljwhara Alrasheed, Abdullah A. Alhifany, Khalid Eljaaly, Hadeel Alkofide, Abdullah M. Alhammad, Leen Ghonem, Aynaa Alsharidi
Summary: This study compared the effectiveness and safety of aerosolized plus intravenous colistin with intravenous colistin alone in treating nosocomial pneumonia caused by multidrug-resistant Gram-negative bacteria. The results showed that the combination of aerosolized and intravenous colistin achieved higher rates of clinical cure and microbiological eradication compared to intravenous colistin alone.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Mansour Almuqbil, Lamees Alrojaie, Haya Alturki, Abdullah Alhammad, Yasmin Alsharawy, Aljawharah Alkoraishi, Abdulaziz Almuqbil, Sara Alrouwaijeh, Syed Wajid, Mohamed N. Al-Arifi
Summary: This study assessed the use of drug information centers by healthcare professionals in Saudi Arabia to improve medication safety. The findings highlight the role of drug information specialists in providing evidence-based information and preventing medication errors.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Education & Educational Research
Ghada Bawazeer, Ibrahim Sales, Huda Albogami, Ahmed Aldemerdash, Mansour Mahmoud, Majidah A. Aljohani, Abdullah Alhammad
Summary: The study evaluated pharmacy students' perceptions of crossword puzzles as a learning tool in the pharmacotherapy cardiovascular module, finding that most students had favorable views, especially female and undergraduate pharmacy students. There was no significant association found between preferred learning styles and students' perceptions of the game. The crossword puzzle game was seen as an innovative and creative active learning tool that accommodated all learning style preferences.
BMC MEDICAL EDUCATION
(2022)
Article
Pharmacology & Pharmacy
Khalid Al Sulaiman, Ohoud Aljuhani, Abdullah M. Alhammad, Kholoud Al Aamer, Sara Alshehri, Abdulmohsen Alhuwahmel, Abdullah Kharbosh, Areej Alshehri, Hanan Alshareef, Ibrahim Al Sulaihim, Albandari Alghamdi, Shmeylan Al Harbi, Ramesh Vishwakarma, Numan Alabdan, Yousef Alrajhi, Abdulmalik Al Katheri, Abeer A. Alenazi, Mai Alalawi, Ghassan Al Ghamdi
Summary: This study aimed to evaluate whether adjunctive ascorbic acid therapy helps prevent colistin-induced nephrotoxicity in critically ill patients. The results show that adjunctive use of ascorbic acid during colistin therapy was not associated with lower odds of CIN.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Hematology
Khalid Al Sulaiman, Ohoud Aljuhani, Ghazwa B. Korayem, Awatif Hafiz, Mai Alalawi, Hisham A. Badreldin, Ali F. Altebainawi, Ramesh Vishwakarma, Abdulrahman Alissa, Albandari Alghamdi, Abeer A. Alenazi, Huda Al Enazi, Shahad Alanazi, Abdullah Alhammad, Jahad Alghamdi, Mashael AlFaifi, Faisal A. Al Sehli, Maram A. Aldossari, Alaa A. Alhubaishi, Anfal Y. Al-Ali, Hasan M. Al-Dorzi
Summary: Prophylactic use of enoxaparin in critically ill patients with COVID-19 may significantly reduce the occurrence of thrombotic events with similar bleeding risk compared to unfractionated heparin (UFH).
THROMBOSIS JOURNAL
(2022)
Article
Critical Care Medicine
Scott Bolesta, Lisa Burry, Marc M. Perreault, Celine Gelinas, Kathryn E. Smith, Rebekah Eadie, Federico C. Carini, Katrianna Saltarelli, Jennifer Mitchell, Jamie Harpel, Ryan Stewart, Richard R. Riker, Gilles L. Fraser, Brian L. Erstad
Summary: This international observational study found that a small proportion of ICUs use policies/protocols for opioid and sedative weaning or IWS, and even when these policies/protocols are in place, they are implemented in a small percentage of patients.
CRITICAL CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Ghazwa B. Korayem, Lama Ali Alqahtani, Sultanah Hisham Alsulaiman, Abdullah M. Alhammad, Hisham A. Badreldin, Nora Alkhudair, Khalid Al Sulaiman, Ohoud Aljuhani
Summary: This study evaluated the effort spent on direct patient care by clinical faculty members of pharmacy schools in Saudi Arabia and identified factors that hinder or facilitate providing direct patient care services. The survey results showed that although most clinical pharmacy faculty members were involved in direct patient care, half of them devoted only 20% or less of their time to it. Thus, a clinical faculty workload model is needed to allocate effort effectively and set realistic expectations about time spent on clinical and non-clinical duties.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Abdullah M. Alhammad, Thamer A. Almangour, Imtinan Almasoudi, Wesal Alalayet, Mansour Almuqbil, Yazed S. Alsowaida, Naif H. Alotaibi
Summary: This retrospective cohort study evaluated the effectiveness of antibiotic-loaded bone cement (ALBC) in preventing prosthetic joint infections (PJI) after total joint arthroplasty (TJA). The study found that ALBC was not associated with a reduction in PJI rates after primary TJA. More research is needed to further evaluate the effectiveness of ALBC in preventing PJI.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Health Care Sciences & Services
Nadia H. Ismail, Abdullah M. Alhammad, Abdulrahman Alshaya, Nada Alkhani, Ahmed O. Alenazi, Ohoud Aljuhani
Summary: This study reveals that critical care pharmacists (CCPs) in Saudi Arabia play integral roles in ICU patient care and make significant contributions to clinical, educational, and administrative activities. The study emphasizes the need for standardized CCP-to-patient ratios and calls for further support for CCPs to expand their services, thus enhancing healthcare quality.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2023)
Article
Education & Educational Research
Abdullah M. Alhammad, Rana Almohaimeed, Ghada Alajmi, Sultan Alghadeer, Yasser Alaska
Summary: This study evaluated the impact of high-fidelity patient simulation (HFPS) on pharmacy residents' confidence in managing acute medical scenarios. The results showed that HFPS significantly improved residents' confidence in making decisions, providing recommendations, and delivering optimal patient care during emergency situations.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Medicine, Research & Experimental
Amy J. Montgomery, John Litell, Johnny Dang, Laure Flurin, Ognjen Gajic, Amos Lal
Summary: Digital twin technology creates a virtual patient model for testing interventions in healthcare without harming actual patients. This study achieved consensus among a panel of experts on respiratory pathophysiology in the intensive care unit. The expert rule statements produced align with expert knowledge and can be used for developing a digital twin-patient model for acute respiratory failure.
BIOMOLECULES AND BIOMEDICINE
(2023)
Review
Pharmacology & Pharmacy
Abdulrahman I. Alshaya, Abdullah M. Alhammad, Nadia Ismail, Nada Alkhani, Shmeylan Alharbi, Ahmed O. Alenazi, Ohoud Aljuhani
Summary: Clinical pharmacy services in Saudi Arabia have been steadily incorporating critical care services, leading to improved patient outcomes and opportunities for professional advancement in the field.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2021)
Meeting Abstract
Critical Care Medicine
Namareq Aldardeer, Maram Alghalbi, Emad Alharbi, Ghada Alajmi, Ahmad Aljabri, Mohammad Aljawadi, Thamer Almangour, Abdullah Alhammad
CRITICAL CARE MEDICINE
(2021)