Review
Chemistry, Analytical
Tais Aparecida Reis Cordeiro, Mayra Asevedo Campos de Resende, Simone Cristina dos Santos Moraes, Diego Leoni Franco, Arnaldo Cesar Pereira, Lucas Franco Ferreira
Summary: Neglected tropical diseases are a group of infectious and parasitic diseases prevalent in tropical and subtropical regions, with limited access to proper healthcare. The development of low-cost biosensors for fast diagnosis in these areas is crucial for better treatment and eradication. While progress has been made in the past decade, challenges remain in early detection of neglected tropical diseases using biosensors.
Review
Infectious Diseases
O. Rey, B. L. Webster, T. Huyse, D. Rollinson, F. Van den Broeck, J. Kincaid-Smith, A. Onyekwere, J. Boissier
Summary: This paper reviews the genetic studies of both animal and human infecting schistosomes, discussing population genetic structures at different spatial scales, genetic diversity within species, and the impact of factors such as mass drug administration. The paper also explores the ability for intra-species hybridisation and its implications for control and elimination measures.
INFECTION GENETICS AND EVOLUTION
(2021)
Review
Rheumatology
Rasmi Ranjan Sahoo, Anupam Wakhlu, Vikas Agarwal
Summary: Dealing with rheumatic diseases in tropical countries is complex due to limited healthcare infrastructure, lack of diagnostic and therapeutic facilities, impact of dominant prevalent diseases, and challenges in differentiating from infectious and non-infectious disease mimics. Several tropical diseases present with musculoskeletal and rheumatic manifestations, leading to delayed diagnosis or misdiagnosis and poor patient outcomes.
CLINICAL RHEUMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rachel H. Clare, Steven R. Hall, Rohit N. Patel, Nicholas R. Casewell
Summary: Snakebite envenoming causes up to 138,000 deaths annually, making it the deadliest neglected tropical disease. Current treatment with biologic antivenoms is outdated and expensive, but there is great potential in developing small molecule drugs to inhibit venom toxins. Strategies successful in treating other NTDs could be utilized to facilitate the development of next-generation snakebite treatments.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Immunology
Martin Walker, Jonathan I. D. Hamley, Philip Milton, Frederic Monnot, Sally Kinrade, Sabine Specht, Belen Pedrique, Maria-Gloria Basanez
Summary: Drug-based interventions are crucial in addressing major diseases, with a growing consensus on the need for new therapeutic options in some cases. In this field, minimizing wastage of money and resources is essential.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Yushi Lin, Kailu Fang, Yang Zheng, Hong-liang Wang, Jie Wu
Summary: This study aimed to assess the global burden and trends of neglected tropical diseases (NTDs) from 1990 to 2019. The results showed that the age-standardized incidence rate (ASIR) and number of incident cases of total NTDs increased globally, while the mortality rate and DALYs decreased. Tropical Latin America was the only region to experience a decreasing trend in ASIR. Children and older adults were vulnerable to certain diseases, and females had a higher incidence rate but lower mortality rate and DALY rate.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Immunology
Hollie-Ann Hatherell, Hope Simpson, Rebecca F. Baggaley, T. Deirdre Hollingsworth, Rachel L. Pullan
Summary: The WHO's 2030 road map for neglected tropical diseases highlights the importance of strengthened, institutionalized post-elimination surveillance, but lacks practical guidance on implementation. Nationally representative survey programs, such as DHS, may provide a platform for integrating disease surveillance within national health systems, with a focus on maximizing utility and addressing priorities for further data collection and characterization.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Wendemagegn Enbiale, Alemayehu Bekele, Nigus Manaye, Fikre Seife, Zeyede Kebede, Filmon Gebremeskel, Johan van Griensven
Summary: Subcutaneous mycoses are endemic in Ethiopia, with cases reported throughout the country, especially in the northern regions. The lack of research and surveillance programs for these diseases highlights the need for routine programs and systems to identify and record cases.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Pharmacology & Pharmacy
Leonardo L. G. Ferreira, Josue de Moraes, Adriano D. Andricopulo
Summary: Neglected tropical diseases, such as leishmaniasis and schistosomiasis, continue to be a public health challenge in developing countries. However, advancements in drug discovery using modern strategies have shown promise in addressing these diseases by combining medicinal chemistry and parasite biology.
DRUG DISCOVERY TODAY
(2022)
Article
Medicine, General & Internal
Tolulope Alade, Thuy-Huong Ta-Tang, Sulaiman Adebayo Nassar, Akeem Abiodun Akindele, Raquel Capote-Morales, Tosin Blessing Omobami, Pedro Berzosa
Summary: This study found that schistosomiasis and soil-transmitted helminthiases are still endemic in Osun State, Nigeria, with a low prevalence and light infection intensity. Urinary infection was the most common, with higher prevalence in children over 10 years old. There were no significant associations between gender and age and urogenital or intestinal parasites.
Article
Immunology
Amanda Minter, Lorenzo Pellis, Graham F. Medley, T. Deirdre Hollingsworth
Summary: As countries strive to meet WHO goals for reducing morbidity and eliminating disease transmission, they will need to plan for the next stages of surveillance and control in low prevalence settings. Going beyond simple predictions of treatment program effectiveness, more nuanced intervention choices informed by quantitative analyses will be necessary for sustainable gains in the long term. Identifying policy goals and finding the right balance between intervention and surveillance constraints will be key challenges in achieving multiple aims such as minimizing morbidity and costs simultaneously.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Theresa W. Gyorkos, Helene Carabin, Maneesh Phillip, Leshawn Benedict, Amy Davis, Janet Hatcher Roberts, Kishor M. Wasan, Momar Ndao, Alison Krentel
Summary: Canadian researchers have published over 160 publications per year on neglected tropical diseases between 2010 and 2019, covering all 20 NTDs. The most commonly studied diseases were leishmaniasis, dengue fever, chikungunya, Chagas disease, soil-transmitted helminthiases, and rabies.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Editorial Material
Biology
Kathryn Forbes, Maria-Gloria Basanez, T. Deirdre Hollingsworth, Roy M. Anderson
Summary: Twenty neglected tropical diseases (NTDs) are prioritized by the World Health Organization for eradication, elimination, or control by 2030. This issue discusses the progress made since the 2012 London Declaration on NTDs and the challenges faced in achieving these goals. It includes contributions on intensified disease management and preventive chemotherapy, as well as the impact of COVID-19 on NTD programs.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Chemistry, Medicinal
Igor Jose dos Santos Nascimento, Misael de Azevedo Teotonio Cavalcanti, Ricardo Olimpio de Moura
Summary: Neglected tropical diseases (NTDs) are a group of infectious diseases that mainly affect impoverished populations in tropical countries. They cause many deaths worldwide and require substantial investments in public health to treat and control them. Protozoan diseases such as Chagas disease, sleeping sickness, and Leishmaniasis, as well as the big three diseases (AIDS, tuberculosis, and malaria), are endemic in tropical countries. However, there is still a gap in treatment, emphasizing the need for new alternatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, General & Internal
Juan Garcia-Bernalt Diego, Pedro Fernandez-Soto, Antonio Muro
Summary: Neglected Tropical Diseases (NTDs), particularly those caused by parasites, continue to be a major public health issue in tropical and subtropical regions, affecting 10% of the global population. Isothermal nucleic acid amplification techniques, especially loop-mediated isothermal amplification (LAMP), have emerged as an affordable alternative to PCR for molecular diagnostics in parasite-caused NTDs.
Article
Parasitology
F. D. Chibwana, G. Nkwengulila
JOURNAL OF HELMINTHOLOGY
(2016)
Article
Parasitology
F. D. Chibwana, G. Nkwengulila, S. A. Locke, J. D. McLaughlin, D. J. Marcogliese
PARASITOLOGY RESEARCH
(2015)
Article
Ecology
Alfred Hugo, Oluwole Daniel Makinde, Santosh Kumar, Fred F. Chibwana
JOURNAL OF BIOLOGICAL DYNAMICS
(2017)
Article
Infectious Diseases
Fred D. Chibwana, Isabel Blasco-Costa, Simona Georgieva, Kenneth M. Hosea, Gamba Nkvvengulila, Tomas Scholz, Aneta Kostadinova
INFECTION GENETICS AND EVOLUTION
(2013)
Article
Parasitology
F. D. Chibwana, G. Nkwengulila
JOURNAL OF HELMINTHOLOGY
(2010)
Article
Parasitology
Anna Mahulu, Catharina Clewing, Bjoern Stelbrink, Fred D. Chibwana, Immaculate Tumwebaze, J. Russell Stothard, Christian Albrecht
PARASITES & VECTORS
(2019)