Review
Immunology
Han Cheng, Lingling Chen, Minchun Huang, Jin Hou, Zhifeng Chen, Xiaojun Yang
Summary: NLRP3 inflammasome plays a key role in radiation-induced tissue injury, but its potential value is not adequately recognized. Early intervention/prevention strategies targeting NLRP3 inflammasome may help resolve clinical problems caused by radiation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Kemal Ugur Tufekci, Bedir Irem Eltutan, Kamer Burak Isci, Sermin Genc
Summary: Our study demonstrates that resveratrol suppresses NLRP3 inflammasome and miR-155 expression in microglia by modulating AMPK and Sirt1 pathways, revealing its anti-inflammatory properties.
NEUROTOXICITY RESEARCH
(2021)
Article
Immunology
Damien Bierschenk, Nikolina Papac-Milicevic, Ian P. Bresch, Valentina Kovacic, Serena Bettoni, Mateusz Dziedzic, Rick A. Wetsel, Susanne Eschenburg, Christoph J. Binder, Anna M. Blom, Ben C. King
Summary: C4BP purified from human plasma is an inhibitor of crystal-induced and particle-induced NLRP3 inflammasome activation. It binds to specific protein domains on the C4BP alpha-chain and is internalised into human primary macrophages, where it inhibits inflammasome complex assembly and cytokine secretion. In mice, C4BP protects against an enhanced inflammatory state.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Guang-Jie Tai, Qing-Qing Yu, Jia-Peng Li, Wei Wei, Xiao-Man Ji, Rui-Fang Zheng, Xiao-Xue Li, Li Wei, Ming Xu
Summary: The research found abnormal activation of NLRP3 inflammasome in aortas of both T2DM and old mice, and the deletion or inhibition of NLRP3 gene improved vascular aging and dysfunction, partially by regulating the growth and migration of aortic endothelial cells and vascular smooth muscle cells.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Meng Li, Yueyao Wang, Zhongwen Qi, Zhuo Yuan, Shichao Lv, Yawei Zheng, Zhipeng Yan, Mingyang Wang, Huanjie Fu, Xinbiao Fan, Nan Ji, Ming Liu, Zhuyuan Fang
Summary: This study predicted the intervention of QSYQ on myocardial I/R injury using network pharmacology and explored its underlying mechanism through autophagy and NLRP3 inflammasome. The results showed that QSYQ attenuated myocardial infarction, inflammation, and autophagosome injury, leading to improved LV systolic function. QSYQ may exert its cardioprotective effects by regulating autophagy-related proteins and inhibiting NLRP3 inflammasome activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ying Shi, Lili Zhao, Jing Wang, Shan Liu, Yifei Zhang, Qin Qin
Summary: In this study, the researchers found that inhibiting the NLRP3 inflammasome with MCC950 improved cardiac dysfunction induced by ISO, including cardiac fibrosis, hypertrophy, and inflammation. Furthermore, MCC950 also attenuated ISO-induced oxidative stress and cell senescence.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xiao-yan Wu, Jin-yan Lv, Shi-qing Zhang, Xin Yi, Zi-wei Xu, Yuan-xing Zhi, Bo-xin Zhao, Jian-xin Pang, Ken Kin Lam Yung, Shu-wen Liu, Ping-zheng Zhou
Summary: The study identified ML365 as a potent inhibitor targeting the TWIK2 channel, which effectively suppressed ATP-induced NLRP3 inflammasome activation without affecting other inflammasomes. Pharmacokinetic analysis revealed good oral bioavailability of ML365, highlighting its potential application in treating related inflammatory diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Integrative & Complementary Medicine
Haiyan Li, Dong-Hua Yang, Yanmei Zhang, Fuchun Zheng, Fenfei Gao, Jiajia Sun, Ganggang Shi
Summary: This study found that geniposide can significantly inhibit NLRP3 inflammasome activation via the AMPK signaling pathway and inhibit pyroptosis of cardiomyocytes. Geniposide has a cardioprotective effect, reducing myocardial infarction size, improving heart function, and suppressing inflammatory response. Additionally, geniposide promotes cellular energy metabolism and reduces oxidative stress levels.
Article
Multidisciplinary Sciences
Renan V. H. de Carvalho, Djalma S. Lima-Junior, Caroline de Oliveira, Dario S. Zamboni
Summary: The New World species of intracellular protozoan parasites in the Leishmania genus can cause mucocutaneous leishmaniases. The presence of Leishmania RNA virus (LRV) in Leishmania guyanensis (L.g.) exacerbates disease and leads to the development of mucocutaneous disease. Research has shown that LRV inhibits caspase-11 activation by Leishmania, shedding light on the mechanisms through which LRV promotes disease exacerbation.
Article
Microbiology
Tingting Huang, Dan Gu, Yaxin Guo, Ang Li, Xilong Kang, Xinan Jiao, Zhiming Pan
Summary: The GalE gene in Salmonella plays a crucial role in modulating inflammasome activation, affecting multiple signaling pathways. Deletion of the GalE gene leads to increased inflammasome activation during Salmonella infection, and the virulence of the Delta fliC Delta galE strain is significantly decreased.
Article
Ophthalmology
Lili Lian, Zhenmin Le, Zhenzhen Wang, Ying-ao Chen, Xiaodong Jiao, Hang Qi, J. Fielding Hejtmancik, Xiaoyin Ma, Qinxiang Zheng, Yueping Ren
Summary: The study investigates whether SIRT1 regulates high glucose-induced inflammation and cataract formation by modulating TXNIP/NLRP3 inflammasome activation in human lens epithelial cells (HLECs) and rat lenses. HG stress induces a decline in SIRT1 expression and activates the TXNIP/NLRP3 inflammasome in HLECs, leading to lens opacity and cataract formation. Knocking down NLRP3 or TXNIP inhibits NLRP3 inflammasome activation, indicating that SIRT1 acts as an upstream regulator of TXNIP/NLRP3 activity.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Licia Shamoon, Jenaro A. Espitia-Corredor, Pilar Dongil, Marta Menendez-Ribes, Alejandra Romero, Ines Valencia, Guillermo Diaz-Araya, Carlos F. Sanchez-Ferrer, Concepcion Peiro
Summary: Endothelial cell senescence contributes to chronic inflammation and cardiovascular disorders. The drug Doxorubicin induces senescence through the NLRP3 inflammasome, and resolvin E1 can reduce the senescence induced by Doxorubicin and interleukin-1β.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dilpreet Kour, Mehboob Ali, Parul Khajuria, Kuhu Sharma, Palash Ghosh, Sukhleen Kaur, Surbhi Mahajan, P. Ramajayan, Sonali S. Bharate, Subhash Bhardwaj, Sanghapal D. Sawant, D. Srinivasa Reddy, Ajay Kumar
Summary: Sickle cell disease (SCD) is characterized by complications arising from the sickling of erythrocytes due to a point mutation in the beta-globin chain of hemoglobin. Flurbiprofen, a COX-2 inhibitor, was found to be a potent inhibitor of heme-induced NLRP3 inflammasome, providing potential for pain management and disease modification in SCD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
ShiChun Shen, Fei He, Cheng Cheng, BangLong Xu, JianLong Sheng
Summary: This study revealed that uric acid exacerbates MI/R injury by promoting ROS generation, while NLRP3 inflammasome inhibitors and ROS scavengers partially reverse this injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Shanshan Dai, Bozhi Ye, Longwang Chen, Guangliang Hong, Guangju Zhao, Zhongqiu Lu
Summary: The study revealed that emodin has a protective effect on septic myocardial injury by alleviating the inflammatory response and cardiomyocyte pyroptosis.
PHYTOTHERAPY RESEARCH
(2021)
Correction
Cell Biology
Hai-han Liao, Jin-xiu Zhu, Hong Feng, Jian Ni, Nan Zhang, Si Chen, Huang-jun Liu, Zheng Yang, Wei Deng, Qi-Zhu Tang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Cell Biology
Hong Feng, Nian Wang, Nan Zhang, Hai-han Liao
Summary: Autophagy is a crucial mechanism for maintaining cellular homeostasis by degrading misfolded proteins and damaged organelles. Alternative autophagy, a new type of autophagy independent of Atg5/Atg7, has been found to play a pivotal role in various diseases, but its precise mechanisms and roles are still unclear.
CELL COMMUNICATION AND SIGNALING
(2022)