期刊
ORGANIC LETTERS
卷 22, 期 21, 页码 8566-8571出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03171
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资金
- Recruitment Program of Global Experts
- Shanghai Jiao Tong University
A Ni-catalyzed asymmetric hydrocyanation that enables the formation of 4-cyanotetrahydroquinolines in good yields with excellent enantioselectivities is presented herein. A variety of functional groups are well-tolerated, and a gram-scale reaction supports the synthetic potential of the transformation. Additionally, several crucial intermediates for pharmaceutically active agents, including a PGD2 receptor antagonist, are now accessible through asymmetric synthesis using this new protocol.
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