期刊
ORGANIC LETTERS
卷 22, 期 19, 页码 7433-7438出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02418
关键词
-
资金
- European Union
- WEFO
- Cardiff University
- Cardiff University Research Opportunities Program (CUROP)
An operationally simple mechanochemical C-S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.
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