期刊
ORGANIC LETTERS
卷 22, 期 20, 页码 7814-7819出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02679
关键词
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资金
- National Natural Science Foundation of China [21871187, 21572137]
- Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education [LZJ1901]
- Key Program of Sichuan Science and Technology Project [2019YFG0146]
The first Pd/Cu catalyzed selective C2-alkenylation of pyridines with internal alkynes has been developed via the pyridinium salt activation strategy. Importantly, the configuration of the product alkenylpyridines could be tuned by the choice of the proper N-alkyl group of the pyridinium salts, thus allowing for both the Z- and E-alkenylpyridines synthesized with good regio- and stereoselectivity. A plausible mechanism was proposed based on the Hammett study and KIE experiment.
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