Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition

Risk factors for breast cancer brain metastases: a systematic review

(2020) Lola Koniali et al.   Oncotarget

Taurine up-regulated 1 accelerates tumorigenesis of colon cancer by regulating miR-26a-5p/MMP14/p38 MAPK/Hsp27 axis in vitro and in vivo

(2019) Lei Tian et al.   LIFE SCIENCES

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu

(2016) Elizabeth A. Fry et al.   INTERNATIONAL JOURNAL OF CANCER

Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner

(2016) A. Esfandiari et al.   MOLECULAR CANCER THERAPEUTICS

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3

(2016) Sona Pechackova et al.   Oncotarget

Wip1 phosphatase: between p53 and MAPK kinases pathways

(2016) Anastasia R. Goloudina et al.   Oncotarget

Collective cell migration: guidance principles and hierarchies

(2015) Anna Haeger et al.   TRENDS IN CELL BIOLOGY

Hsp27 regulates EGF/β-catenin mediated epithelial to mesenchymal transition in prostate cancer

(2014) Thomas Cordonnier et al.   INTERNATIONAL JOURNAL OF CANCER

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

(2014) Aidan G Gilmartin et al.   Nature Chemical Biology

Heat shock protein 27 phosphorylation state is associated with cancer progression

(2014) Maria Katsogiannou et al.   Frontiers in Genetics

Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer

(2013) M. Shiota et al.   CANCER RESEARCH

Off-target response of a Wip1 chemical inhibitor in skin keratinocytes

(2013) Ji-Seon Lee et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Roles of DMP1 in Human Epidermal Growth Factor Receptor 2/neu-Arf-p53 Signaling and Breast Cancer Development

(2010) P. Taneja et al.   CANCER RESEARCH

Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

(2010) Jo Eyles et al.   JOURNAL OF CLINICAL INVESTIGATION

A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor   Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation

(2010) R. J. Mourey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Introduction: Unknown Primary Cancer

(2009) F. Anthony Greco et al.   SEMINARS IN ONCOLOGY

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

(2008) Xiongbin Lu et al.   CANCER AND METASTASIS REVIEWS

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression

(2008) Joong-Won Lee et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Phosphorylated Heat Shock Protein 27 Represses Growth of Hepatocellular Carcinoma via Inhibition of Extracellular Signal-regulated Kinase

(2008) Rie Matsushima-Nishiwaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY