Association of Killer Cell Immunoglobulin-like Receptor and Human Leukocyte antigen-C Genotype with HLA-B27 Associated Acute Anterior Uveitis and Idiopathic Acute Anterior Uveitis in a Chinese Han Population

Purpose whether killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens C(HLA-C) are associated withHLA-B27associated acute anterior uveitis (B27AAU) and idiopathic AAU (IAAU) remains unclear. Methods PCR with sequence-specific primers was used to analyzeKIRgenes andHLA-Calleles in a Chinese Han population of 196AAU patients and 210 control subjects. Results The higher frequencies ofHLA-C2andKIR2DL1/HLA-C2(p = .009 andp = .044, respectively) and the lower frequencies ofHLA-C1C1andHLA-C1(p = .034 andp = .009, respectively) were observed in B27AAU than control group. The higher frequencies ofKIR2DL2andKIR2DL2/HLA-C1(p = .009 andp = .044, respectively) and the lower frequencies ofKIR2DL3andKIR2DL3/HLA-C1(p = .000 andp = .001, respectively) were observed in IAAU than control group. ConclusionsHLA-C2 andKIR2DL1/HLA-C2, KIR2DL2, andKIR2DL2/HLA-C1might be susceptible for B27AAU and IAAU, respectively.HLA-C1C1andHLA-C1, KIR2DL3andKIR2DL3/HLA-C1might protect from B27AAU and IAAU, respectively.

Automated summary

This study suggests that KIR genes and HLA-C alleles may be associated with HLA-B27-associated acute anterior uveitis (B27AAU) and idiopathic AAU (IAAU).