Emerging importance of dietary phytochemicals in fight against cancer: Role in targeting cancer stem cells

An Integrated In Silico Approach for the Structural and Functional Exploration of Lipocalin 2 and its Functional Insights with Metalloproteinase 9 and Lipoprotein Receptor-Related Protein 2

(2015) Mrinmoy Ghosh et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Epigenetic induction of epithelial to mesenchymal transition by LCN2 mediates metastasis and tumorigenesis, which is abrogated by NF-κB inhibitor BRM270 in a xenograft model of lung adenocarcinoma

(2015) RAJ KUMAR MONGRE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

(2015) Swapna Upadhyay et al.   Oxidative Medicine and Cellular Longevity

A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms

(2015) Monica Cojoc et al.   SEMINARS IN CANCER BIOLOGY

The beating heart of melanomas: a minor subset of cancer cells sustains tumor growth

(2015) Patrick Schmidt et al.   Oncotarget

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

(2015) Amy Barone et al.   Oncotarget

Safely targeting cancer stem cells via selective catenin coactivator antagonism

(2014) Heinz-Josef Lenz et al.   CANCER SCIENCE

Calotropin: A Cardenolide fromCalotropis giganteathat Inhibits Wnt Signaling by Increasing Casein Kinase 1α in Colon Cancer Cells

(2014) Hyun Young Park et al.   CHEMBIOCHEM

Hedgehog signaling pathway: A novel target for cancer therapy: Vismodegib, a promising therapeutic option in treatment of basal cell carcinomas

(2014) Afroz Abidi   INDIAN JOURNAL OF PHARMACOLOGY

Adherence to Mediterranean diet and risk of cancer: A systematic review and meta-analysis of observational studies

(2014) Lukas Schwingshackl et al.   INTERNATIONAL JOURNAL OF CANCER

miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2

(2014) Emanuel Kronski et al.   Molecular Oncology

Evaluation of the Antioxidant, Anti-Inflammatory, and Anticancer Activities of Euphorbia hirta Ethanolic Extract

(2014) Neelesh Sharma et al.   MOLECULES

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

(2014) Haihui Lu et al.   NATURE CELL BIOLOGY

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

Capsaicin-Induced Activation of p53-SMAR1 Auto-Regulatory Loop Down-Regulates VEGF in Non-Small Cell Lung Cancer to Restrain Angiogenesis

(2014) Samik Chakraborty et al.   PLoS One

Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk

(2014) Giovanni Zito et al.   Nature Communications

Viola tricolorInduces Apoptosis in Cancer Cells and Exhibits Antiangiogenic Activity on Chicken Chorioallantoic Membrane

(2014) Hamid Reza Sadeghnia et al.   Biomed Research International

Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention

(2013) Vijay S. Thakur et al.   AAPS Journal

Mulberry Leaf Extract Inhibits Invasive Potential and Downregulates Hypoxia-Inducible Factor-1α (HIF-1α) in SK-N-BE(2)C Neuroblastoma Cells

(2013) Seolhyun PARK et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma

(2013) Winnie W. Lo et al.   CANCER

EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy

(2013) Motohiko Satoh et al.   Cancer Cell International

New Perspectives of Curcumin in Cancer Prevention

(2013) W. Park et al.   Cancer Prevention Research

Curcumin Targets Breast Cancer Stem-like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment

(2013) M. S. Charpentier et al.   CANCER RESEARCH

NSAIDs Inhibit Tumorigenesis, but How?

(2013) Evrim Gurpinar et al.   CLINICAL CANCER RESEARCH

Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation

(2013) Yao-An Shen et al.   Evidence-based Complementary and Alternative Medicine

Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts

(2013) Yanyan Li et al.   Future Oncology

Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction

(2013) Li Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Bioactivity-Guided Identification and Cell Signaling Technology to Delineate the Lactate Dehydrogenase A Inhibition Effects of Spatholobus suberectus on Breast Cancer

(2013) Zhiyu Wang et al.   PLoS One

Curcumin Enhances the Effect of Chemotherapy against Colorectal Cancer Cells by Inhibition of NF-κB and Src Protein Kinase Signaling Pathways

(2013) Mehdi Shakibaei et al.   PLoS One

Epigallocatechin-3-Gallate Inhibits Stem-Like Inflammatory Breast Cancer Cells

(2013) Nora D. Mineva et al.   PLoS One

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway

(2013) Guangwen Shu et al.   TOXICOLOGY LETTERS

Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women

(2012) Theresa Schwartz et al.   CANCER

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Long-term effects of systemic cancer treatment on DNA oxidative damage: The potential for targeted therapies

(2012) Laura Vera-Ramirez et al.   CANCER LETTERS

Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells

(2012) Trang Thi Mai et al.   CANCER LETTERS

Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research

(2012) S. V. Singh et al.   CARCINOGENESIS

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity

(2012) Appalaraju Jaggupilli et al.   Clinical & Developmental Immunology

Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathway

(2012) Shih-Hui Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin

(2012) Sharmila Shankar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells

(2012) Koramit Suppipat et al.   PLoS One

Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors

(2012) A. Gurney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity

(2012) Keitaro Hagiwara et al.   Scientific Reports

Salinomycin can effectively kill ALDHhigh stem-like cells on gastric cancer

(2011) Qiao Ming Zhi et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer Stem Cell Niche: The Place to Be

(2011) T. Borovski et al.   CANCER RESEARCH

Role of Notch signaling in colon homeostasis and carcinogenesis

(2011) Shingo Miyamoto et al.   CANCER SCIENCE

Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives

(2011) Chia-Jui Weng et al.   CANCER TREATMENT REVIEWS

Using ABCG2-molecule-expressing side population cells to identify cancer stem-like cells in a human ovarian cell line

(2011) Jun Dou et al.   CELL BIOLOGY INTERNATIONAL

Epigenetic changes induced by curcumin and other natural compounds

(2011) Simone Reuter et al.   Genes and Nutrition

Understanding tumor heterogeneity as functional compartments - superorganisms revisited

(2011) Thomas GP Grunewald et al.   Journal of Translational Medicine

Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer

(2011) Nathália G. Amado et al.   LIFE SCIENCES

CD90 is Identified as a Candidate Marker for Cancer Stem Cells in Primary High-Grade Gliomas Using Tissue Microarrays

(2011) Jintang He et al.   MOLECULAR & CELLULAR PROTEOMICS

Notch Signaling Contributes to Lung Cancer Clonogenic Capacity In Vitro but May Be Circumvented in Tumorigenesis In Vivo

(2011) J. Osanyingbemi-Obidi et al.   MOLECULAR CANCER RESEARCH

Targeting the Mitochondria Activates Two Independent Cell Death Pathways in Ovarian Cancer Stem Cells

(2011) A. B. Alvero et al.   MOLECULAR CANCER THERAPEUTICS

Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): From bench to clinic

(2011) Sanjeev Banerjee et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

(2011) Bokyung Sung et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Impact of Curcumin, Raspberry Extract, and Neem Leaf Extract on Rel Protein-Regulated Cell Death/Radiosensitization in Pancreatic Cancer Cells

(2011) Jamunarani Veeraraghavan et al.   PANCREAS

Isolation of biologically active constituents from Moringa peregrina (Forssk.) Fiori. (family: Moringaceae) growing in Egypt

(2011) ShahiraM Ezzat et al.   Pharmacognosy Magazine

Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells

(2011) S. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells

(2011) J. M. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Profiling of Melanoma and the Evolution of Patient-Specific Therapy

(2011) Thomas F. Gajewski   SEMINARS IN ONCOLOGY

Curcumin Decreases Survival of Hep3B Liver and MCF-7 Breast Cancer Cells

(2011) Mareike Ströfer et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Analysis of anticancer drugs: A review

(2011) Susanne Nussbaumer et al.   TALANTA

Reduced cancer risk in vegetarians: an analysis of recent reports

(2011) Amy Joy Lanou   Cancer Management and Research

Tomato Lycopene and Lung Cancer Prevention: From Experimental to Human Studies

(2011) Paola Palozza et al.   Cancers

TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA WITH SINGLE-AGENT ARSENIC TRIOXIDE

(2011) Vikram Mathews et al.   Mediterranean Journal of Hematology and Infectious Diseases

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor

(2010) Roberta Riccioni et al.   BLOOD CELLS MOLECULES AND DISEASES

Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies

(2010) Jenny Epstein et al.   BRITISH JOURNAL OF NUTRITION

Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: Towards targeting of cancer stem cells with phytochemicals

(2010) Dunne Fong et al.   CANCER LETTERS

Endothelial Cell-Initiated Signaling Promotes the Survival and Self-Renewal of Cancer Stem Cells

(2010) S. Krishnamurthy et al.   CANCER RESEARCH

Synergistic Activity of Sorafenib and Sulforaphane Abolishes Pancreatic Cancer Stem Cell Characteristics

(2010) Vanessa Rausch et al.   CANCER RESEARCH

Acidic stress promotes a glioma stem cell phenotype

(2010) A B Hjelmeland et al.   CELL DEATH AND DIFFERENTIATION

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Potential of Plant-Derived Natural Products in the Treatment of Leukemia and Lymphoma

(2010) David M. Lucas et al.   CURRENT DRUG TARGETS

CD133 and ABCB5 as stem cell markers on sentinel lymph node from melanoma patients

(2010) P. Gazzaniga et al.   EJSO

Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells

(2010) Barbara Stefanska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mesenchymal stem cells enhance growth and metastasis of colon cancer

(2010) Kei Shinagawa et al.   INTERNATIONAL JOURNAL OF CANCER

Cardiac side-effects of cancer chemotherapy

(2010) Jean-Jacques Monsuez et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Antibodies targeting cancer stem cells: A new paradigm in immunotherapy?

(2010) Mahendra P. Deonarain et al.   mAbs

Growth inhibitory efficacy of lycopene and β-carotene against androgen-independent prostate tumor cells xenografted in nude mice

(2010) Chih-Min Yang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Tea catechins as inhibitors of receptor tyrosine kinases: Mechanistic insights and human relevance

(2010) Christine A. Larsen et al.   PHARMACOLOGICAL RESEARCH

Cancer stem cells in solid tumors

(2010) Patrick C. Hermann et al.   SEMINARS IN CANCER BIOLOGY

The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

(2010) Irene Ma et al.   Stem Cell Reviews and Reports

Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate

(2010) Francesca Pistollato et al.   STEM CELLS

Apoptosis in cancer: Key molecular signaling pathways and therapy targets

(2009) Claudia Burz et al.   ACTA ONCOLOGICA

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

(2009) Madhuri Kakarala et al.   BREAST CANCER RESEARCH AND TREATMENT

How powerful is CD133 as a cancer stem cell marker in brain tumors?

(2009) Jin-Xiang Cheng et al.   CANCER TREATMENT REVIEWS

3,3′-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice

(2009) Yoon Hee Kim et al.   INFLAMMATORY BOWEL DISEASES

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer

(2009) F. Jiang et al.   MOLECULAR CANCER RESEARCH

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Programmed Cell Death Pathways and Current Antitumor Targets

(2009) Mei Lan Tan et al.   PHARMACEUTICAL RESEARCH

Natural compounds for cancer treatment and prevention

(2009) Stefania Nobili et al.   PHARMACOLOGICAL RESEARCH

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

(2009) G. Bertolini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention

(2009) Vidushi S. Neergheen et al.   TOXICOLOGY

In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway

(2008) Ruifen Zhang et al.   APOPTOSIS

High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells

(2008) Ágota Apáti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas

(2008) Heike Immervoll et al.   BMC CANCER

Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

(2008) Zhen Fan Yang et al.   CANCER CELL

Multitargeted therapy of cancer by green tea polyphenols

(2008) Naghma Khan et al.   CANCER LETTERS

Cell Cycle-Dependent Variation of a CD133 Epitope in Human Embryonic Stem Cell, Colon Cancer, and Melanoma Cell Lines

(2008) M. Jaksch et al.   CANCER RESEARCH

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice

(2008) Yoshiyuki Kimura et al.   CANCER SCIENCE

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

(2008) Yan Shi et al.   Cell Stem Cell

Sulforaphane Enhances the Therapeutic Potential of TRAIL in Prostate Cancer Orthotopic Model through Regulation of Apoptosis, Metastasis, and Angiogenesis

(2008) S. Shankar et al.   CLINICAL CANCER RESEARCH

Modulation of gene methylation by genistein or lycopene in breast cancer cells

(2008) Audrey King-Batoon et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-β-induced apoptosis

(2008) Wei Ding et al.   HEPATOLOGY

Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials

(2008) Guo-Ming Shi et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

(2008) Alysha K. Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Notch1 is an effector of Akt and hypoxia in melanoma development

(2008) Barbara Bedogni et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Stem Cells: A Step Toward the Cure

(2008) Bruce M. Boman et al.   JOURNAL OF CLINICAL ONCOLOGY

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

(2008) J A Burger et al.   LEUKEMIA

Aldehyde Dehydrogenase Discriminates the CD133 Liver Cancer Stem Cell Populations

(2008) S. Ma et al.   MOLECULAR CANCER RESEARCH

Multi-targeted therapy by curcumin: how spicy is it?

(2008) Ajay Goel et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of I B Kinase-Nuclear Factor- B Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin

(2008) A. L. Kasinski et al.   MOLECULAR PHARMACOLOGY

The Chemopreventive Agent Curcumin Is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased Reactive Oxygen Species Production and Overactivation of the Mitogen-Activated Protein Kinase Pathway

(2008) P. Javvadi et al.   MOLECULAR PHARMACOLOGY

Cell cycle control as a basis for cancer chemoprevention through dietary agents

(2007) Syed Musthapa Meeran   Frontiers in Bioscience-Landmark