Article
Neurosciences
Shile Qi, Rogers F. Silva, Daoqiang Zhang, Sergey M. Plis, Robyn Miller, Victor M. Vergara, Rongtao Jiang, Dongmei Zhi, Jing Sui, Vince D. Calhoun
Summary: This study introduces a novel three-way parallel group independent component analysis (pGICA) fusion method that effectively incorporates temporal information in multimodal data fusion, demonstrating high accuracy and comparability in estimating cross-modality links. Experimental results suggest the potential of this method in investigating brain disorders.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Helena Hartmann, Markus Ruetgen, Federica Riva, Claus Lamm
Summary: The study found that while there was a significant localized placebo analgesia effect for self-experienced pain, there were no differences between the two hands in empathy conditions, both in terms of behavioral and neural responses. This suggests that there is no evidence of somatosensory sharing in empathy, but it does confirm overlapping brain activity in the affective-motivational component for first-hand and empathy for pain.
Article
Neurosciences
Ali M. Golestani, J. Jean Chen
Summary: Effective separation of signal from noise is a challenge in improving the sensitivity and specificity of resting-state fMRI measurements. Independent component analysis (ICA) is a useful approach for addressing this challenge. Our study found that spatial ICA (sICA) can identify more noise-related signal components, while temporal ICA (tICA) performs better in dealing with physiological effects.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Willem B. Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L. Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A. J. P. Denys, Marco A. N. Echevarria, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Rachael G. Grazioplene, Patricia Gruner, Joyce Y. Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, Jose M. Menchon, Pedro S. Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Jose C. Pariente Zorrilla, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y. C. Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H. Simpson, Carles Soriano-Mas, Nuno M. Sousa, Gianfranco Spalletta, Emily R. Stern, S. Evelyn Stewart, Philip Szeszko, Jinsong Tang, Sophia Thomopoulos, Anders L. Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M. Veer, Ganesan Venkatasubramanian, Nora C. Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A. van Leeuwen, Hein J. F. van Marle, Laurens A. van de Mortel, Anouk van der Straten, Ysbrand D. van der Werf, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Guido A. van Wingen
Summary: Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. A mega-analysis of data from 1024 OCD patients and 1028 healthy controls revealed widespread abnormalities in functional connectivity in OCD, including global hypo-connectivity and few hyper-connections mainly with the thalamus. Classification performances based on resting-state connectivity were poor, indicating that it is not an accurate biomarker for identifying individual patients.
MOLECULAR PSYCHIATRY
(2023)
Article
Biology
Lewis S. Crawford, Noemi Meylakh, Paul M. Macey, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson
Summary: An fMRI study with 47 participants has discovered that stimulus-independent and stimulus-dependent neural networks centered around the midbrain periaqueductal gray region are responsible for an individual's ability to experience placebo analgesia. The specific neural circuits that regulate placebo analgesic responsiveness are still unknown, but involvement of brainstem pain modulatory regions is considered crucial. This study demonstrates differences in neural circuit connectivity between placebo responders and non-responders, highlighting the importance of altered connections involving the hypothalamus, anterior cingulate cortex, and midbrain periaqueductal gray matter in the placebo analgesic response.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Filip Sobczak, Patricia Pais-Roldan, Kengo Takahashi, Xin Yu
Summary: Pupil dynamics serve as a physiological indicator of cognitive processes and arousal states of the brain in diverse behavioral experiments. By decomposing spatiotemporal patterns of resting-state fMRI using PCA and optimizing the PCA component weighting via decoding methods, unique activity patterns related to pupil diameter changes in different trials can be studied in relation to neuromodulatory centers. This novel PCA-based decoding method demonstrates the tight coupling between pupil dynamics and different neuromodulatory centers across trials.
Article
Anatomy & Morphology
Zikuan Chen, Ebenezer Daniel, Bihong T. Chen
Summary: Constructing the FC matrix from phase fMRI data and identifying hub nodes through eigencentrality mapping revealed that the central and posterior regions are the primary functional hubs of the brain.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Marlena Duda, Danai Koutra, Chandra Sripada
Summary: This study investigates the presence of dynamic functional connectivity during rest and proposes a data-driven framework for studying cognitive neuroscience questions using connectivity changes. The framework outperforms the traditional sliding window approach in accuracy and computational efficiency when applied to working memory task data. Additionally, when applied to resting state fMRI data, the method consistently identifies five reliable FC states which show significant correlation with behavioral phenotypes.
HUMAN BRAIN MAPPING
(2021)
Article
Chemistry, Analytical
Hanlu Yang, Trung Vu, Qunfang Long, Vince Calhoun, Tuelay Adali
Summary: This study proposes a framework for subgroup identification of psychiatric patients using functional connectivity profiles obtained from fMRI data. The pipeline incorporates a data-driven method and constraint-based independent component analysis to identify meaningful subgroups with similar activation patterns in certain brain areas. The identified subgroups show significant group differences in multiple meaningful brain areas.
Article
Endocrinology & Metabolism
Yanfang Li, Min Ling, Song Huang, Xinghuan Liang, Yingfen Qin, Zuojie Luo, Jia Zhou
Summary: The study applied independent component analysis to investigate the correlation between clinical manifestation and functional connectivity changes of the sensorimotor network (SMN) and left frontoparietal network (LFPN) in patients with acute thyrotoxic myopathy (ATM). The results indicated that the functional connectivity changes in certain brain regions may be related to the clinical symptoms of ATM patients, providing a potential objective imaging indicator for early clinical intervention.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Xue Jiao, Ming Yuan, Qiuju Li, Yufei Huang, Miaomiao Ji, Jing Li, Shumin Yan, Hao Sun, Xinyu Wang, Zangyu Pan, Qianhui Ren, Dawei Wang, Guoyun Wang
Summary: This study used resting-state functional magnetic resonance imaging to investigate brain morphological alterations and regional dysfunctions in patients with adenomyosis-related pain. The results showed changes in multiple brain regions associated with pain as well as anxiety and depression symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Atsushi Fujimoto, Catherine Elorette, J. Megan Fredericks, Satoka H. Fujimoto, Lazar Fleysher, Peter H. Rudebeck, Brian E. Russ
Summary: This study used noninvasive neuroimaging techniques to assess the impact of a drug on brain functional connectivity. The results showed that an appropriate dose of the drug did not alter brain connectivity, while an excess dose of the drug increased functional connectivity in the frontal regions and may cause deficits related to attention or motivation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
A. Iraji, Z. Fu, A. Faghiri, M. Duda, J. Chen, S. Rachakonda, T. DeRamus, P. Kochunov, B. M. Adhikari, A. Belger, J. M. Ford, D. H. Mathalon, G. D. Pearlson, S. G. Potkin, A. Preda, J. A. Turner, T. G. M. van Erp, J. R. Bustillo, K. Yang, K. Ishizuka, A. Faria, A. Sawa, K. Hutchison, E. A. Osuch, J. Theberge, C. Abbott, B. A. Mueller, D. Zhi, C. Zhuo, S. Liu, Y. Xu, M. Salman, J. Liu, Y. Du, J. Sui, T. Adali, V. D. Calhoun
Summary: This study identifies replicable multi-spatial-scale canonical intrinsic connectivity network (ICN) templates using rsfMRI data from over 100k individuals through multi-model-order independent component analysis (ICA). The feasibility of estimating subject-specific ICNs via spatially constrained ICA is also studied. The results show that subject-level ICN estimations vary as a function of the ICN itself, the data length, and the spatial resolution. Longer scans may not always be desirable and spatial smoothness should be considered in optimizing data length.
HUMAN BRAIN MAPPING
(2023)
Article
Gastroenterology & Hepatology
N. Kohn, J. Szopinska-Tokov, A. Llera Arenas, C. F. Beckmann, A. Arias-Vasquez, E. Aarts
Summary: Research on the gut-brain axis has seen rapid progress in recent years, with a study demonstrating associations between the abundance of specific gut bacteria genera like Prevotella and Bifidobacterium with different brain networks in healthy individuals.
Article
Neurosciences
Michael Schaefer, Anja Kuehnel, Felix Schweitzer, Soeren Enge, Matti Gaertner
Summary: Research has shown that placebos can have beneficial effects even without deception. Several studies have reported improvements in pain, depression, or anxiety. However, it remains unclear whether these effects are biologically objective or simply a bias in response, and the neural mechanisms associated with open-label placebos are still not well-understood.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Markus Rutgen, Eva-Maria Wirth, Igor Riecansky, Allan Hummer, Christian Windischberger, Predrag Petrovic, Giorgia Silani, Claus Lamm
Summary: The study suggests that shared neural representations play a role in empathy across different domains; placebo analgesia can reduce both first-hand and empathic experiences of unpleasant touch, while an opioid antagonist cannot block these effects; there are differences in neural mechanisms between pain empathy and pain.
Article
Neurosciences
Magdalena Boch, Sabrina Karl, Ronald Sladky, Ludwig Huber, Claus Lamm, Isabella C. Wagner
Summary: Using a tailored dog hemodynamic response function significantly improves model fitting in fMRI studies with dogs, showing earlier onset of the response in the visual cortex compared to humans. This suggests the importance of utilizing species-specific HRFs for enhancing detection power in canine neuroimaging.
Article
Multidisciplinary Sciences
I. C. Wagner, B. N. Konrad, P. Schuster, S. Weisig, D. Repantis, K. Ohla, S. Kuehn, G. Fernandez, A. Steiger, C. Lamm, M. Czisch, M. Dresler
Summary: Mnemonic techniques and memory training can enhance memory formation by decreasing task-based activation and increasing memory consolidation, leading to more durable memories.
Article
Neurosciences
Ronald Sladky, Andreas Hahn, Inga-Lisa Karl, Nicole Geissberger, Georg S. Kranz, Martin Tik, Christoph Kraus, Daniela M. Pfabigan, Andreas Gartus, Rupert Lanzenberger, Claus Lamm, Christian Windischberger
Summary: Using dynamic causal modeling, this study investigated the central role of the OFC in regulating amygdala activation during emotional face processing, demonstrating that the OFC downregulates amygdala activation, rather than the DLPFC or VLPFC.
BRAIN CONNECTIVITY
(2022)
Review
Psychiatry
Yuki Mizutani-Tiebel, Martin Tik, Kai-Yen Chang, Frank Padberg, Aldo Soldini, Zane Wilkinson, Cui Ci Voon, Lucia Bulubas, Christian Windischberger, Daniel Keeser
Summary: Transcranial magnetic stimulation (TMS) combined with functional magnetic resonance imaging (fMRI) shows promise as a treatment modality for psychiatric and neurological disorders. The concurrent application of TMS during fMRI requires careful sequencing to avoid image distortions caused by magnetic field inhomogeneities induced by TMS. Recent developments in coil hardware and acquisition techniques have increased the number of TMS-fMRI applications.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
David Linhardt, Maximilian Pawloff, Michael Woletz, Allan Hummer, Martin Tik, Maria Vasileiadi, Markus Ritter, Garikoitz Lerma-Usabiaga, Ursula Schmidt-Erfurth, Christian Windischberger
Summary: This study investigates the reproducibility of pRF mapping in central visual field loss. The results show excellent reproducibility for the pRF center position, but only modest reproducibility for pRF size. The study suggests that pRF mapping can provide robust and reproducible measures of retinal function for monitoring visual deficits.
Article
Multidisciplinary Sciences
Isabella C. Wagner, Luise P. Graichen, Boryana Todorova, Andre Luettig, David B. Omer, Matthias Stangl, Claus Lamm
Summary: Grid cells in the human entorhinal cortex can track the movement of others, contributing to social-spatial navigation.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Zoe Buerger, Veronika I. Mueller, Felix Hoffstaedter, Ute Habel, Ruben C. Gur, Christian Windischberger, Ewald Moser, Birgit Derntl, Lydia Kogler
Summary: Females and males differ in stress reactions and coping strategies. The connectivity between the amygdala and frontal regions plays a key role in stress coping. In this study, the effects of sex and stressor type on the connectivity of the amygdala and frontal regions were examined. Females showed stronger connectivity between the amygdala and certain frontal regions during social exclusion stress compared to achievement stress, indicating the importance of social affiliation for females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Maximilian Pawloff, David Linhardt, Michael Woletz, Allan Hummer, Stefan Sacu, Maria Vasileiadi, Lerma Usabiaga Garikoitz, Graham Holder, Ursula M. Schmidt-Erfurth, Christian Windischberger, Markus Ritter
Summary: This study quantitatively assessed the performance of different visual stimulation approaches for mapping visual field coverage using high-resolution ultra-high field fMRI. The results showed systematic differences in the distribution of pRF center locations between different stimulus techniques, but this had minimal impact on the correspondence with microperimetry (MP) outcomes.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Neurosciences
Catherine-Noemie Alexandrina Guran, Ronald Sladky, Sabrina Karl, Magdalena Boch, Elmar Laistler, Christian Windischberger, Ludwig Huber, Claus Lamm
Summary: Comparative neuroimaging is valuable for studying the evolutionary origins of brain organization. We developed a specialized coil for high-resolution imaging in dogs, which outperforms the human coil in signal-to-noise ratio and improves imaging quality. Our findings demonstrate the importance of hardware improvements for dog-human comparative neuroimaging.
Article
Clinical Neurology
Maria Vasileiadi, Anna-Lisa Schuler, Michael Woletz, David Linhardt, Christian Windischberger, Martin Tik
Summary: This study investigated the functional neuroanatomy of language production by using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS). The results showed a dissociation of language functions within the posterior temporal gyrus, with phonological and semantic errors located in the superior temporal gyrus (STG) and anomia and speech arrest errors located in the middle temporal gyrus (MTG). These findings provide important insights into specific language production difficulties and contribute to the understanding of the neural basis of language production.
Article
Psychiatry
Marianna Ruiz, Alexander Groessing, Alexandrina Guran, Asena U. Kocan, Nace Mikus, Urs M. Nater, Karlijn Kouwer, Maj-Britt Posserud, Maayan Salomon-Gimmon, Boryana Todorova, Isabella C. Wagner, Christian Gold, Giorgia Silani, Karsten Specht
Summary: This paper introduces a protocol for the Music for Autism study, which aims to investigate the effects of music therapy on various outcomes in children with autism. The study aims to improve social communication and functional brain connectivity, and explore comprehensive psychometric, neuroimaging, and biological outcomes.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Lydia Kogler, Veronika I. Mueller, Ewald Moser, Christian Windischberger, Ruben C. Gur, Ute Habel, Simon B. Eickhoff, Birgit Derntl
Summary: Testosterone levels modulate resting-state functional connectivity between brain regions involved in affective processing and executive functions. Significant sex differences were found, with higher testosterone levels associated with lower connectivity between the amygdala and the superior frontal gyrus in women. Testosterone may have sex-specific patterns in affect and cognition networks, as well as in the frontal down-regulation of the amygdala.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Magdalena Boch, Isabella C. Wagner, Sabrina Karl, Ludwig Huber, Claus Lamm
Summary: Comparative fMRI in dogs and humans reveals functionally analogous body- and animacy responsive areas in the occipito-temporal lobe of both species and divergent neural representations of faces and conspecific bodies in dog olfactory regions.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Psychiatry
Maria Vasileiadi, Martin Tik, G. Kranz, M. Ruetgen, M. Princic, T. Vanicek, D. M. Pfabigan, A. Hahn, R. Sladky, R. Lanzenberger, C. Lamm, C. Windischberger
PSYCHIATRIA DANUBINA
(2022)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.