Article
Critical Care Medicine
Laura C. Amado-Rodriguez, Raquel Rodriguez-Garcia, Giacomo Bellani, Tai Pham, Eddy Fan, Fabiana Madotto, John Laffey, Guillermo Albaiceta
Summary: The study suggests that higher airway pressures in patients with cardiogenic pulmonary edema are associated with increased mortality. These patients may be at a higher risk of ventilator-induced lung injury.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Critical Care Medicine
Yukie Ito, Matias G. Herrera, Justin C. Hotz, Miyako Kyogoku, Christopher J. L. Newth, Anoopindar K. Bhalla, Muneyuki Takeuchi, Robinder G. Khemani
Summary: The study found that airway pressure measured during occlusion maneuvers can be used to estimate respiratory effort in children, and expiratory occlusion pressure has the strongest correlation with esophageal pressure change.
Article
Respiratory System
Masako Kawai, Erquan Zhang, Jane Chanda Kabwe, Amphone Okada, Junko Maruyama, Hirofumi Sawada, Kazuo Maruyama
Summary: In this study, rats with monocrotaline-induced pulmonary hypertension were found to have reduced damage from high tidal volume ventilation compared to normal rats. The findings suggest that structural changes in hypertensive pulmonary vasculature may protect against ventilator-induced lung injury, regardless of the type of pulmonary hypertension.
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ning Ding, Hui Xiao, Lixiao Zhen, Huiqing Li, Zengzhen Zhang, Junke Ge, Haiyan Jia
Summary: Mechanical ventilation (MV) can lead to lung injury, inflammation, and dysfunction of other organs. This study investigates the effects of MV on gut injury and the involvement of cytokines. High tidal volume MV in mice results in elevated levels of proinflammatory cytokines TNF-α, IL-13, and IL-6 in serum and gut, which are correlated with gut injury and PANoptosis. The study also demonstrates that inhibiting cytokine production with Imp7 siRNA nanoparticle can protect against MV-induced gut injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Physiology
Nada Ismaiel, Sara Whynot, Laurette Geldenhuys, Zhaolin Xu, Arthur S. Slutsky, Valerie Chappe, Dietrich Henzler
Summary: The study found that low tidal volume ventilation reduces mechanical damage to the lung and attenuates ventilator-associated lung injury (VALI), while hypercapnia reduces inflammation and biochemical mechanisms of injury to attenuate VALI. Both lung-protective ventilation and hypercapnia may have a synergistic effect in preventing VALI.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Elena Spinelli, Antonio Pesenti, Gianluca Lopez, Anna Damia, Francesco Damarco, Erica Garbelli, Gaia Dal Santo, Alessio Caccioppola, Giorgio Giudici, Virginia Figgiaconi, Osvaldo Biancolilli, Michele Battistin, Caterina Lonati, Valentina Vaira, Lorenzo Rosso, Stefano Ferrero, Stefano Gatti, Tommaso Mauri
Summary: In a model of unilateral ligation of the pulmonary artery, inhaled CO2 but not hypercapnia grants bilateral lung protection by reducing overdistension of the non-ligated lung and increasing perfusion of the ligated lung.
FRONTIERS IN MEDICINE
(2022)
Article
Physiology
Gabriel C. Motta-Ribeiro, Tilo Winkler, Eduardo L. V. Costa, Nicolas de Prost, Mauro R. Tucci, Marcos F. Vidal Melo
Summary: Lung perfusion redistribution is associated with increased inflammation, nondependent capillary obliteration, and lung derecruitment susceptibility depending on endotoxemia level and ventilation strategy during pre-ARDS protective ventilation in animals.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Brian M. Fuller, Nicholas M. Mohr, Enyo Ablordeppey, Olivia Roman, Dylan Mittauer, Yan Yan, Marin H. Kollef, Christopher R. Carpenter, Brian W. Roberts
Summary: Mechanically ventilated emergency department (ED) patients experience high morbidity and mortality. In a prior trial, ED-based lung-protective ventilation was associated with improved care delivery and outcomes. This study aims to assess the practice change and clinical outcomes associated with ED lung-protective ventilation.
CRITICAL CARE MEDICINE
(2023)
Article
Veterinary Sciences
Joaquin Araos, Pablo Cruces, Manuel Martin-Flores, Pablo Donati, Robin D. Gleed, Tomas Boullhesen-Williams, Agustin Perez, Francesco Staffieri, Jaime Retamal, Marcos Vidal F. Melo, Daniel E. Hurtado
Summary: This study describes the magnitude and spatial distribution of lung strain in healthy anesthetized, mechanically ventilated dogs with and without positive end-expiratory pressure (PEEP). It found that lung heterogeneity affects the accuracy of global lung strain in representing regional total tissue lung strain. PEEP reduced dynamic strain but induced a large static strain. Limiting dynamic strain may be an important clinical target in healthy and diseased lungs, but further research is needed.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Critical Care Medicine
Gary Nieman, Michaela Kollisch-Singule, Harry Ramcharran, Joshua Satalin, Sarah Blair, Louis A. Gatto, Penny Andrews, Auyon Ghosh, David W. Kaczka, Donald Gaver, Jason Bates, Nader M. Habashi
Summary: Time-controlled adaptive ventilation (TCAV) is a novel ventilator approach that considers the temporal aspects of dynamic lung mechanics. It aims to reduce the risk of ventilator-induced lung injury (VILI) by adjusting the duration of expiration and inspiration, leading to improved survival rate of patients.
Article
Physiology
Courtney L. Mattson, Kayo Okamura, Patrick S. Hume, Bradford J. Smith
Summary: This study aims to understand the spatial and temporal changes in ventilator-induced lung injury (VILI) and validate protective ventilation strategies. The results show that cellular injury exhibits a diffuse, quasi-random distribution and further develops through the expansion of high-density regions. Interestingly, the spatial distribution of leukocytes is not correlated with cellular injury or changes in lung function. These findings suggest that protective ventilation should focus on protecting the interface between healthy and injured regions to prevent injury propagation.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Respiratory System
Yong Song, Seiha Yen, Melissa Preissner, Ellen Bennett, Stephen Dubsky, Andreas Fouras, Peter A. Dargaville, Graeme R. Zosky
Summary: The regional transcriptomic response to mechanical ventilation differs depending on the presence or absence of pre-existing lung injury. Mechanical ventilation induces up-regulation of immune response genes, while the combination of lipopolysaccharide (LPS) and mechanical ventilation disrupts PI3K/Akt and MEK/ERK signaling. This study provides insights into the mechanisms underlying lung inhomogeneity in ventilator-induced lung injury.
RESPIRATORY RESEARCH
(2022)
Article
Physiology
Mattia Busana, Carmelo Zinnato, Federica Romitti, Michela Palumbo, Simone Gattarello, Aurelio Sonzogni, Ann-Kathrin Gersmann, Annika Richter, Peter Herrmann, Guenter Hahn, Serena Brusatori, Roberta Maj, Mara Velati, Onnen Moerer, Konrad Meissner, Tom Barnes, Michael Quintel, John J. Marini, Luciano Gattinoni
Summary: Energy dissipation within the respiratory system is recognized as a factor promoting ventilator-induced lung injury (VILI). In this study, we reduced energy dissipation by modulating expiratory flow, but most of the reduction occurred across the endotracheal tube rather than in the respiratory system. Therefore, in healthy lungs, the advantages of reducing energy dissipation do not decrease the risk of VILI, but these advantages may be more significant in diseased lungs under injurious ventilation.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Enric Barbeta, Marta Arrieta, Ana Motos, Joaquim Bobi, Hua Yang, Minlan Yang, Giacomo Tanzella, Pierluigi Di Ginnatale, Stefano Nogas, Carmen Rosa Vargas, Roberto Cabrera, Denise Battaglini, Andrea Meli, Kasra Kiarostami, Nil Vazquez, Laia Fernandez-Barat, Montserrat Rigol, Ricard Mellado-Artigas, Gerard Frigola, Marta Camprubi-Rimblas, Pau Ferrer, Daniel Martinez, Antonio Artigas, Carlos Ferrando, Miquel Ferrer, Antoni Torres
Summary: This study successfully established an accurate animal model of ARDS induced by pulmonary sepsis. The model was created in pigs by inducing ARDS through pneumonia, the most common risk factor in humans, and analyzed the additional effect of ventilator-induced lung injury.
Article
Respiratory System
Alessandro Ghiani, Joanna Paderewska, Swenja Walcher, Claus Neurohr
Summary: The study demonstrates that dynamic lung-thorax compliance normalized MP accurately differentiates between low and high-risk patients for weaning failure following prolonged mechanical ventilation. The discriminatory performance of MP indices increases over the course of weaning, reaching maximum accuracy immediately before completion.
BMC PULMONARY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Serenella Castelvecchio, Matteo Frigelli, Francesco Sturla, Valentina Milani, Omar A. Pappalardo, Michele Citarella, Lorenzo Menicanti, Emiliano Votta
Summary: The study aimed to elucidate the mechanisms of left ventricle functional recovery after surgical ventricular reconstruction. Real-time 3-dimensional transthoracic echocardiography was performed on patients with anterior left ventricle remodeling and ischemic heart failure. The results showed that surgical ventricular reconstruction led to significant improvement in left ventricle function, indicating the important role of remote myocardium in enhancing recovery.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Francesco Sturla, Alessandro Caimi, Rodrigo M. Romarowski, Giovanni Nano, Mattia Glauber, Alberto Redaelli, Emiliano Votta, Massimiliano M. Marrocco-Trischitta
Summary: A novel method for fast-approximate computation of displacement forces (DFs) in thoracic endovascular aortic repair (TEVAR) is proposed, utilizing computed tomography (CT) and a measure of central aortic pressure. The method was tested and showed high consistency with computational fluid dynamics (CFD) results in 34 subjects.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Physiology
David C. Berger, Lena Zwicker, Kay Nettelbeck, Daniela Casoni, Paul Phillipp Heinisch, Hansjorg Jenni, Matthias Haenggi, Luciano Gattinoni, Kaspar F. Bachmann
Summary: Assessment of native cardiac output during extracorporeal circulation is challenging. This study evaluated a modified Fick principle for accurately measuring cardiac output under different conditions. The findings provide important insights for understanding veno-arterial extracorporeal membrane oxygenation (V-A ECMO).
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Immunology
Ilaria Righi, Valentina Vaira, Letizia Corinna Morlacchi, Giorgio Alberto Croci, Valeria Rossetti, Francesco Blasi, Stefano Ferrero, Mario Nosotti, Lorenzo Rosso, Mario Clerici
Summary: This pilot study found that PD-1-expressing T lymphocytes were associated with acute rejection and the development of chronic lung allograft dysfunction (CLAD) in lung transplant patients, indicating a central role of PD-1 in the pathogenesis of rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Giugno, Giovanni Maria Formato, Massimo Chessa, Emiliano Votta, Mario Carminati, Francesco Sturla
Summary: This article describes a case of successful percutaneous intervention in a complex pediatric mid-aortic syndrome (MAS) using a patient-specific 3D-printed model and a dedicated in vitro platform for pre-procedural planning. The feasibility of stenting procedure was successfully tested on the 3D-printed model and applied in pre-procedural assessment. Therefore, the use of patient-specific 3D-printed models and in vitro dedicated platforms is encouraged to enhance intervention success.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Critical Care Medicine
Tommaso Pozzi, Francesca Collino, Serena Brusatori, Federica Romitti, Mattia Busana, Onnen Moerer, Luigi Camporota, Davide Chiumello, Silvia Coppola, Luciano Gattinoni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Serena Brusatori, Carmelo Zinnato, Tommaso Pozzi, Luigi Camporota, John J. Marini, Luciano Gattinoni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Simone Saitta, Ludovica Maga, Chloe Armour, Emiliano Votta, Declan P. O'Regan, M. Yousuf Salmasi, Thanos Athanasiou, Jonathan W. Weinsaft, Xiao Yun Xu, Selene Pirola, Alberto Redaelli
Summary: This study aims to generate and thoroughly characterize a large dataset of synthetic 4D aortic velocity profiles that have features similar to clinical cohorts of patients with ATAA. By utilizing PCA and statistical shape model, a dataset of 437 synthetic cases with realistic properties was generated. Results showed that the synthetic data presented similar characteristics as the clinical population in terms of key morphological parameters. This study provides a data-driven generative model for computational studies of blood flow.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Francesca Collino, Luigi Camporota
INTENSIVE CARE MEDICINE
(2023)
Article
Physiology
Rosanna D'Albo, Federica Romitti, Luigi Camporota, Onnen Moerer, Mattia Busana, Luciano Gattinoni
Summary: The conditions of temperature, pressure, and saturation in which respiratory gas volumes are expressed are often ignored in clinical practice. This study investigates the effects of gas volume corrections on key respiratory and metabolic variables, and the possible clinical consequences. The findings suggest that gas volume corrections are mostly relevant when assessing CO2 clearance, and knowing when the appropriate corrections are needed allows for a better understanding of patients' clinical conditions and tailored treatment.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Chiara Verdelli, Giulia Stefania Tavanti, Irene Forno, Valentina Vaira, Riccardo Maggiore, Leonardo Vicentini, Paolo Dalino Ciaramella, Francesca Perticone, Giovanni Lombardi, Sabrina Corbetta
Summary: This study found that osteocalcin (OC), a bone matrix protein, can modulate the function of parathyroid tumor cells by activating the calcium sensing receptor (CASR). OC reduces the activity of pERK/ERK and increases the levels of active beta-catenin through CASR activation. It also affects the expression of related genes to influence the physiological functions of parathyroid tumor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Annamaria Morotti, Francesco Gentile, Gianluca Lopez, Giulia Passignani, Luca Valenti, Marco Locatelli, Manuela Caroli, Claudia Fanizzi, Stefano Ferrero, Valentina Vaira
Summary: In this study, the differences in the epigenome of brain metastasis from colon cancer and lung cancer were analyzed and compared with primary tumors. The results show that colon tumors have a higher degree of genome-wide methylation compared to lung cancers. Brain metastasis from lung cancer deeply activates neural signatures, while colon brain metastases show activation of metabolic signaling. These signatures are specific for metastatic tumors and shed light on the epi/molecular mechanisms that colon and lung cancers adopt to thrive in the brain environment.
Article
Biology
Simone Saitta, Francesco Sturla, Riccardo Gorla, Omar A. Oliva, Emiliano Votta, Francesco Bedogni, Alberto Redaelli
Summary: Accurate planning of transcatheter aortic valve implantation (TAVI) is important and currently lacks a standard automated solution. This study trained two convolutional neural networks for anatomical evaluation of the aortic root (AR) using 3D CT scans. The networks effectively segmented the AR, annulus, and sinotubular junction (STJ), providing automated measurements in good agreement with manual annotations. The proposed tool is a fully automatic solution for pre-TAVI planning, offering potential time and cost savings.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Giuseppe Citerio, Arthur S. Slutsky
INTENSIVE CARE MEDICINE
(2023)
Article
Physiology
Alessandro Santini, Alessandro Protti, Michele Ferrari, Francesca Pennati, Luca Pugliese, Cesare Mercalli, Andrea Aliverti, Maurizio Cecconi
Summary: The pathogenesis of hypoxemia in acute respiratory distress syndrome caused by SARS-CoV-2 infection is still debated. This observational study found that in a subset of patients, hypoxemia might be explained by an abnormally high perfusion of a relatively low anatomical shunt.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)