Article
Endocrinology & Metabolism
Marco Stazi, Samuele Negro, Aram Megighian, Giorgia D'Este, Michele Solimena, Ralf Jockers, Florigio Lista, Cesare Montecucco, Michela Rigoni
Summary: Melatonin, a hormone produced by various tissues, has been found to accelerate nerve repair by activating the MT1 receptor and sustaining the ERK1/2 pathway. This receptor-mediated, pro-regenerative action of melatonin suggests its potential as a safe candidate for treating peripheral neurodegenerative conditions.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Marie Deck, Gerben Van Hameren, Graham Campbell, Nathalie Bernard-Marissal, Jerome Devaux, Jade Berthelot, Alise Lattard, Jean-Jacques Medard, Benoit Gautier, Sophie Guelfi, Scarlette Abbou, Patrice Quintana, Juan Manuel Chao de la Barca, Pascal Reynier, Guy Lenaers, Roman Chrast, Nicolas Tricaud
Summary: Lactate production through PKM2 enzyme and aerobic glycolysis is essential for the long-term maintenance of peripheral nerve axon physiology and function.
Article
Neurosciences
Tawaun A. Lucas, Li Zhu, Marion S. Buckwalter
Summary: This study focuses on non-myelinating Schwann cells in the spleen, known as spleen glia, which play a role in neuroimmune communication in the spleen. These glial cells express receptors for neurotransmitters and cytokines, potentially participating in communication between nerves and immune cells. Spleen glia are transcriptionally unique compared to other glial types, with genes related to immune responses being differentially expressed.
Article
Neurosciences
Kathleen K. Catignas, Luciana R. Frick, Marta Pellegatta, Edward Hurley, Zachary Kolb, Kathryn Addabbo, Joseph H. McCarty, Richard O. Hynes, Arjan van der Flier, Yannick Poitelon, Lawrence Wrabetz, Maria Laura Feltri
Summary: The study indicates that alpha(V)-containing integrins play a role in the interaction between Schwann cells and axons in the developing peripheral nervous system. However, animal experiments suggest that overlapping or compensatory mechanisms may mask the function of RGD-binding integrins in vivo in the absence of the alpha(V) subunit.
Article
Immunology
Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang
Summary: The study found that purinergic receptor P2RX1 is highly expressed in acute pancreatitis and plays a role in promoting neutrophil activation to contribute to the inflammatory response, making it a potential therapeutic target for treating the disorder inflammation in acute pancreatitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
P. Komirishetty, K. Zubkow, A. Areti, H. Ong, D. W. Zochodne
Summary: The study found that local delivery of Rb1 siRNA can promote nerve regeneration at the outset, enhancing reinnervation of epidermal axons. Combining intrinsic Rb1 knockdown with exogenous insulin can significantly improve growth patterns of adult sensory neurons in vitro and enhance regeneration outcomes in vivo. Overall, the findings highlight the responsiveness of regrowing peripheral neurons to both intrinsic and exogenous approaches that improve their recovery, as well as a novel local approach to manipulate gene expression and outcome in regrowing axons.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yewon Jeon, Yoon Kyung Shin, Hwigyeong Kim, Yun Young Choi, Minjae Kang, Younghee Kwon, Yongcheol Cho, Sung Wook Chi, Jung Eun Shin
Summary: Beta Pix is identified as a regulator of axonal regeneration, promoting neurite outgrowth and playing an important role in peripheral nerve regeneration. It is localized in regrowing axons and its inhibition causes axon outgrowth defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Daria Skwarzynska, Huayu Sun, Izabela Kasprzak, Supriya Sharma, John Williamson, Jaideep Kapur
Summary: This study demonstrates the role of glycolytic lactate production in sustaining status epilepticus (SE). Inhibition of lactate production can terminate SE and reduce neuronal death, making it a potential therapeutic target.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Developmental Biology
Megan M. Corty, Alexandria L. Hulegaard, Jo Q. Hill, Amy E. Sheehan, Sue A. Aicher, Marc R. Freeman
Summary: This study uses Drosophila wrapping glia to investigate the development and function of non-myelinating axon ensheathment. The selective ablation of these glia severely impairs larval locomotor behavior. Through an RNA interference screen, the conserved receptor tyrosine kinase Discoidin domain receptor (Ddr) is identified as a key regulator in axon ensheathment. Loss of Ddr results in reduced ensheathment of axons and decreased axon caliber, suggesting that Ddr functions as a collagen receptor to drive axon wrapping. In adult nerves, loss of Ddr decreases long-term survival of sensory neurons and significantly reduces axon caliber without overtly affecting ensheathment.
Article
Cell & Tissue Engineering
Qunzhou Zhang, Justin C. Burrell, Jincheng Zeng, Faizan Motiwala, Shihong Shi, D. Kacy Cullen, Anh D. Le
Summary: This study generated gingiva-derived mesenchymal stem cell (GMSC)-repopulated nerve protectors and evaluated their therapeutic effects in a crush injury model. The results showed that the Schwann-like cells converted from GMSCs were able to promote functional recovery and axonal regeneration of injured sciatic nerves.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Neurosciences
Natasha Sukhanov, Anya Vainshtein, Yael Eshed-Eisenbach, Elior Peles
Summary: Cell adhesion proteins of the Cadm family play a crucial role in myelination and axonal organization. The study reveals that Cadm3 is the main axonal ligand for glial Cadm4, and the combined action of Cadm2 and Cadm1 can compensate for its absence. Genetic ablation of all three Cadm genes phenocopies the abnormalities detected in the absence of Cadm4, indicating their interplay in regulating myelination and axonal organization.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sailing Chen, Qianqian Chen, Xiaojiao Zhang, Yinying Shen, Xinyu Shi, Xiu Dai, Sheng Yi
Summary: Peripheral nerves have limited ability to regenerate after injury. The growth factor amphiregulin (AREG) is upregulated in Schwann cells of injured sciatic nerves and stimulates their proliferation and migration. Schwann cell-secreted AREG promotes neurite outgrowth and axon elongation. Administering AREG to injured nerves facilitates Schwann cell proliferation, cord formation, and axon regrowth. Overall, our study identifies AREG as an important neurotrophic factor and offers a promising therapeutic approach for peripheral nerve injuries.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
JoAnn Buchanan, Leila Elabbady, Forrest Collman, Nikolas L. Jorstad, Trygve E. Bakken, Carolyn Ott, Jenna Glatzer, Adam A. Bleckert, Agnes L. Bodor, Derrick Brittain, Daniel J. Bumbarger, Gayathri Mahalingam, Sharmishtaa Seshamani, Casey Schneider-Mizell, Marc M. Takeno, Russel Torres, Wenjing Yin, Rebecca D. Hodge, Manuel Castro, Sven Dorkenwald, Dodam Ih, Chris S. Jordan, Nico Kemnitz, Kisuk Lee, Ran Lu, Thomas Macrina, Shang Mu, Sergiy Popovych, William M. Silversmith, Ignacio Tartavull, Nicholas L. Turner, Alyssa M. Wilson, William Wong, Jingpeng Wu, Aleksandar Zlateski, Jonathan Zung, Jennifer Lippincott-Schwartz, Ed S. Lein, H. Sebastian Seung, Dwight E. Bergles, R. Clay Reid, Nuno Macarico da Costa
Summary: Neurons in the developing brain undergo structural refinement through the engulfment and degradation of axonal branches and synapses by glial cells. In the mouse visual cortex, oligodendrocyte precursor cells (OPCs) were found to surround small branches of axons and engage in axon pruning. Compared to microglia, OPCs were more abundant in phagosomes and phagolysosomes, suggesting their substantial contribution to neuronal circuit refinement during cortical development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yang Tian, Ning Wan, Hanqing Zhang, Chang Shao, Ming Ding, Qiuyu Bao, Haiyang Hu, Huiyong Sun, Chenguang Liu, Kun Zhou, Shuai Chen, Guangji Wang, Hui Ye, Haiping Hao
Summary: Hyperactivated glycolysis is a metabolic characteristic of cancer cells, and glycolytic metabolites have nonmetabolic functions as signaling molecules. However, how these metabolites interact with their targets remains unclear. This study introduces a new approach called TRAP to identify target candidates and interactions of glycolytic metabolites in cancer cells, revealing diverse regulatory modalities and potential for cancer therapy.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
John N. Koberstein, Melissa L. Stewart, Chadwick B. Smith, Andrei Tarasov, Frances M. Ashcroft, Philip J. S. Stork, Richard H. Goodman
Summary: Cellular metabolism is regulated to ensure efficient energy production and consumption. Fluorescent biosensors enable real-time detection of metabolite abundance with single-cell resolution. Researchers have developed a new biosensor called HYlight, which can reliably report the dynamics of glycolysis in living cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Vera Valakh, Erin Frey, Elisabetta Babetto, Lauren J. Walker, Aaron DiAntonio
NEUROBIOLOGY OF DISEASE
(2015)
Article
Neurosciences
J. S. Baizer, K. M. Wong, S. Manohar, S. H. Hayes, D. Ding, R. Dingman, R. J. Salvi
Editorial Material
Cell Biology
Bogdan Beirowski, Elisabetta Babetto, Lawrence Wrabetz
JOURNAL OF CELL BIOLOGY
(2016)
Review
Cell Biology
Keit Men Wong, Elisabetta Babetto, Bogdan Beirowski
NEURAL REGENERATION RESEARCH
(2017)
Article
Multidisciplinary Sciences
Bogdan Beirowski, Keit Men Wong, Elisabetta Babetto, Jeffrey Milbrandt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Anatomy & Morphology
Joan S. Baizer, Keit Men Wong, Richard J. Salvi, Senthilvelan Manohar, Chet C. Sherwood, Patrick R. Hof, James F. Baker, Sandra F. Witelson
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2018)
Article
Anatomy & Morphology
Joan S. Baizer, Keit Men Wong, Nicholas A. Paolone, Nadav Weinstock, Richard J. Salvi, Senthilvelan Manohar, Sandra F. Witelson, James F. Baker, Chet C. Sherwood, Patrick R. Hof
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2014)
Article
Neurosciences
N. Paolone, S. Manohar, S. H. Hayes, K. M. Wong, R. J. Salvi, J. S. Baizer
Correction
Neurosciences
Elisabetta Babetto, Keit Men Wong, Bogdan Beirowski
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Keit Men Wong, Wayne M. Jepsen, Stephanie Efthymiou, Vincenzo Salpietro, Meredith Sanchez-Castillo, Janice Yip, Yamna Kriouile, Susann Diegmann, Steffi Dreha-Kulaczewski, Janine Altmuller, Holger Thiele, Peter Nurnberg, Mehran Beiraghi Toosi, Javad Akhondian, Ehsan Ghayoor Karimiani, Hannah Hummel-Abmeier, Brenda Huppke, Henry Houlden, Jutta Gartner, Reza Maroofian, Peter Huppke
Summary: Mutations in the TAF8 gene cause a severe neurodevelopmental disorder characterized by progressive brain atrophy. Similar phenotypes have been associated with mutations in other subunits of the TFIID complex. These disorders may be related to the specific vulnerability of neuronal tissue to deregulation of gene expression.
Article
Anatomy & Morphology
Joan S. Baizer, Keit Men Wong, Chet C. Sherwood, Patrick R. Hof, Sandra F. Witelson
BRAIN STRUCTURE & FUNCTION
(2018)