Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer

A genomic and epigenomic atlas of prostate cancer in Asian populations

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Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones

(2020) Makiko Iwafuchi et al.   NATURE GENETICS

Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer

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ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia

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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

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Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma with SP-2509 engages the endoplasmic reticulum stress response

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LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

(2018) Archana Sehrawat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer

(2018) Adam Sharp et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate

(2017) Jung Wook Park et al.   MODERN PATHOLOGY

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an­­d Serve as Models for Evaluating Cancer Therapeutics

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Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions

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Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering

(2016) Yu Zhang et al.   NATURE GENETICS

Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

(2016) Eric Metzger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

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Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

(2016) Eric Metzger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3

(2016) Kamila M. Jozwik et al.   Cell Reports

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

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Integrative Clinical Genomics of Advanced Prostate Cancer

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The Molecular Taxonomy of Primary Prostate Cancer

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Rapid Induction of Androgen Receptor Splice Variants by Androgen Deprivation in Prostate Cancer

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AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

(2014) Emmanuel S. Antonarakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lysine-Specific Demethylase 1 Has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity

(2014) Changmeng Cai et al.   Cell Reports

Target analysis by integration of transcriptome and ChIP-seq data with BETA

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Exploring single-sample SNP and INDEL calling with whole-genome de novo assembly

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(2012) Catherine S. Grasso et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy

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Intragenic Rearrangement and Altered RNA Splicing of the Androgen Receptor in a Cell-Based Model of Prostate Cancer Progression

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Efficient storage of high throughput DNA sequencing data using reference-based compression

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Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

(2011) Dong Wang et al.   NATURE

Abiraterone and Increased Survival in Metastatic Prostate Cancer

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Structurally Designedtrans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1,,§

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Lysine Methylation Regulates E2F1-Induced Cell Death

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Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4

(2010) Eric Metzger et al.   NATURE

FOXA1 is a key determinant of estrogen receptor function and endocrine response

(2010) Antoni Hurtado et al.   NATURE GENETICS

Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer

(2009) Qianben Wang et al.   CELL

Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer

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FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

(2008) Jing Wang et al.   NATURE GENETICS