Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

(2019) Li-Ming Gan et al.   Nature Communications

Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model

(2019) Alicia J. Angelbello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development

(2018) Ziming Mao et al.   CANCER LETTERS

Using Genome Sequence to Enable the Design of Medicines and Chemical Probes

(2018) Alicia J. Angelbello et al.   CHEMICAL REVIEWS

Small Molecule Targeted Recruitment of a Nuclease to RNA

(2018) Matthew G. Costales et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis

(2018) Lovorka Stojic et al.   NUCLEIC ACIDS RESEARCH

Selective Small Molecule Recognition of RNA Base Pairs

(2018) Hafeez S. Haniff et al.   ACS Combinatorial Science

High-throughput determination of RNA structures

(2018) Eric J. Strobel et al.   NATURE REVIEWS GENETICS

C9orf72-mediated ALS and FTD: multiple pathways to disease

(2018) Rubika Balendra et al.   Nature Reviews Neurology

A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence

(2018) Jessica L. Childs-Disney et al.   Chem

Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing

(2018) Naidi Sun et al.   Scientific Reports

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit

(2017) Matthew G. Costales et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

(2017) Sai Pradeep Velagapudi et al.   ACS Central Science

Rational Design of Small Molecules Targeting Oncogenic Noncoding RNAs from Sequence

(2016) Matthew D. Disney et al.   ACCOUNTS OF CHEMICAL RESEARCH

Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs

(2016) Matthew D. Disney et al.   ACS Chemical Biology

Analysis of secondary structural elements in human microRNA hairpin precursors

(2016) Biao Liu et al.   BMC BIOINFORMATICS

Design of a small molecule against an oncogenic noncoding RNA

(2016) Sai Pradeep Velagapudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique MicroRNA signatures associated with early coronary atherosclerotic plaques

(2015) Rong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis

(2015) Quanlu Duan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Simultaneous characterization of cellular RNA structure and function with in-cell SHAPE-Seq

(2015) Kyle E. Watters et al.   NUCLEIC ACIDS RESEARCH

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Sequence-based design of bioactive small molecules that target precursor microRNAs

(2014) Sai Pradeep Velagapudi et al.   Nature Chemical Biology

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

(2014) Zhaoming Su et al.   NEURON

MicroRNA-377 Regulates Mesenchymal Stem Cell-Induced Angiogenesis in Ischemic Hearts by Targeting VEGF

(2014) Zhili Wen et al.   PLoS One

The Hypoxia-Inducible MicroRNA Cluster miR-199a∼214 Targets Myocardial PPARδ and Impairs Mitochondrial Fatty Acid Oxidation

(2013) Hamid el Azzouzi et al.   Cell Metabolism

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Vascular endothelial growth factor in heart failure

(2013) Ziad Taimeh et al.   Nature Reviews Cardiology

VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level

(2013) T. Arcondeguy et al.   NUCLEIC ACIDS RESEARCH

SMMRNA: a database of small molecule modulators of RNA

(2013) Ankita Mehta et al.   NUCLEIC ACIDS RESEARCH

Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations

(2012) Tuan Tran et al.   Nature Communications

Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble

(2011) Andrew C Stelzer et al.   Nature Chemical Biology

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

RNA Dynamics by Design: Biasing Ensembles Towards the Ligand-Bound State

(2010) Andrew C. Stelzer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology