Article
Virology
Kimberly J. Paiva, Ricky D. Grisson, Philip A. Chan, Richard C. Huard, Angela M. Caliendo, John R. Lonks, Ewa King, Eric W. Tang, Diane L. Pytel-Parenteau, Ga H. Nam, Evgeny Yakirevich, Shaolei Lu
Summary: This study assessed the sensitivity and specificity of different serology testing methods in COVID-19 patient samples, demonstrating that SQ IgG, Abbott IgG, and Wondfo Total could detect antibodies from 100% of the PCR-confirmed patients after 14 days post-symptom onset with high concordance.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Microbiology
Wayne Dimech, Shannon Curley, Lorenzo Subissi, Ute Stroher, Mark D. D. Perkins, Jane Cunningham
Summary: The markets are flooded with various SARS-CoV-2 serology tests, but there are limited comparative reports on their performance. This study compared 35 rapid diagnostic tests and enzyme immunoassays using samples from individuals with mild to moderate COVID-19 and other coronavirus infections. The results show that independent comparative assessments are important for selecting appropriate test kits, especially during a pandemic.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Sarah E. Turbett, Melis Anahtar, Anand S. Dighe, Wilfredo Garcia Beltran, Tyler Miller, Hannah Scott, Sienna Marie Durbin, Maheetha Bharadwaj, Jason Thomas, Tasos S. Gogakos, Michael Astudillo, Jochen Lennerz, Eric S. Rosenberg, John A. Branda
Summary: Sensitive and specific serologic assays for SARS-CoV-2 are crucial for diagnostic and public health decision-making. Two nucleocapsid antibody tests demonstrated higher sensitivity and specificity compared to a spike protein antibody test. Pairing two different serologic tests in a two-test algorithm improves positive predictive value with minimal impact on negative predictive value.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Microbiology
Steven E. Conklin, Kathryn Martin, Yukari C. Manabe, Haley A. Schmidt, Jernelle Miller, Morgan Keruly, Ethan Klock, Charles S. Kirby, Owen R. Baker, Reinaldo E. Fernandez, Yolanda J. Eby, Justin Hardick, Kathryn Shaw-Saliba, Richard E. Rothman, Patrizio P. Caturegli, Andrew D. Redd, Aaron A. R. Tobian, Evan M. Bloch, H. Benjamin Larman, Thomas C. Quinn, William Clarke, Oliver Laeyendecker
Summary: This study compared the performance of 15 different lateral flow POCTs for detecting SARS-CoV-2-specific antibodies and found variations in sensitivity and specificity. Additionally, the study observed differences in the timing of appearance of IgM and IgG bands.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Medical Laboratory Technology
Evelyne Huyghe, Hilde Jansens, Veerle Matheeussen, Ilse Hoffbauer, Herman Goossens, Bart Peeters
Summary: The development and implementation of SARS-CoV-2 serologic assays are progressing rapidly. Three fully automated SARS-CoV-2 antibody assays were compared in this study, showing acceptable performance. An orthogonal testing algorithm using Siemens and Roche assays achieved the highest positive predictive values for antibody detection in low seroprevalence settings.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Anja Doerschug, Julian Schwanbeck, Andreas Hahn, Anke Hillebrecht, Sabine Blaschke, Kemal Mese, Uwe Gross, Sascha Dierks, Hagen Frickmann, Andreas E. Zautner
Summary: Serological assays can be used to estimate the population's exposure to the SARS-CoV-2 virus, with varying sensitivity and specificity observed in different diagnostic assays for SARS-CoV-2-specific antibodies. Immunoglobulin G showed the best results in terms of sensitivity and agreement between different assays.
Article
Infectious Diseases
Christelle Vauloup-Fellous, Sarah Maylin, Claire Perillaud-Dubois, Segolene Brichler, Chakib Alloui, Emmanuel Gordien, Marie-Anne Rameix-Welti, Elyanne Gault, Frederique Moreau, Slim Fourati, Dominique Challine, Jean-Michel Pawlotsky, Nadhira Houhou-Fidouh, Florence Damond, Vincent Mackiewicz, Charlotte Charpentier, Jean-Francois Meritet, Flore Rozenberg, Isabelle Podglajen, Stephane Marot, Heloise Petit, Sonia Burrel, Sepideh Akhavan, Marianne Leruez-Ville, Veronique Avettand-Fenoel, Jacques Fourgeaud, Tiffany Guilleminot, Elise Gardiennet, Stephane Bonacorsi, Agnes Carol, Guislaine Carcelain, Juliette Villemonteix, Narjis Boukli, Joel Gozlan, Laurence Morand-Joubert, Jerome Legoff, Constance Delaugerre, Marie-Laure Chaix, Ana-Maria Roque-Afonso, Laurent Dortet, Thierry Naas, Jean-Baptiste Ronat, Samuel Lepape, Anne-Genevieve Marcelin, Diane Descamps
Summary: This study evaluated the clinical performances of 30 COVID-19 assays, with only 4 rapid tests and 3 automated/manual tests meeting specified criteria. Serology provides valuable information during the COVID-19 pandemic, but inconsistent performances were observed among the evaluated commercial assays.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Virology
Thomas Perkmann, Patrick Mucher, Darlene Oesze, Antonia Mueller, Nicole Perkmann-Nagele, Thomas Koller, Astrid Radakovics, Ines Flieder, Manuela Repl, Rodrig Marculescu, Michael Wolzt, Oswald F. Wagner, Christoph J. Binder, Helmuth Haslacher
Summary: This study investigated the comparability of WHO standard referenced commercial SARS-CoV-2 antibody tests after three doses of BNT162b2 vaccine for up to 14 months. The results showed systematic differences between the results of the three antibody binding assays, but the differences decreased over time. IgG-based assays had better agreement with each other but were not interchangeable with the Roche assay. In conclusion, standardization of SARS-CoV-2 antibody binding assays needs improvement for reliable longitudinal analysis.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Adnan Alatoom, Shereen Atef, Laila AbdelWareth, Jay Murthy, Matthew Jones, Gerald Cox, Jonathan Harris, Basel Altrabulsi
Summary: The study shows different immunoassays have varying sensitivities in detecting antibodies for SARS-CoV-2 infection, with high specificity. The time of seroconversion varies and is assay-dependent.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Tiffany R. Butterfield, Alrica Bruce-Mowatt, Yakima Z. R. Phillips, Nicole Brown, Keisha Francis, Jabari Brown, Jerome P. Walker, Niel A. L. McKnight, Kelvin Ehikhametalor, Devon K. Taylor, Carl A. Bruce, Donovan McGrowder, Gilian Wharfe, Simone L. Sandiford, Tamara K. Thompson, Joshua J. Anzinger
Summary: The performance of various SARS-CoV-2 tests in Jamaica showed comparable diagnostic sensitivities and specificities, with better results for moderate to critical cases. However, these tests have limited utility for asymptomatic and mild infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medical Laboratory Technology
Marcela Pena-Rodrigez, Oliver Viera-Segura, Mariel Garcia-Chagollan, Jose Sergio Zepeda-Nuno, Jose Francisco Munoz-Valle, Jesus Mora-Mora, Gabriela Espinoza-De Leon, Gustavo Bustillo-Armendariz, Fernanda Garcia-Cedillo, Natali Vega-Magana
Summary: This study evaluated the performance of a chromatographic immunoassay for the rapid diagnosis of SARS-CoV-2 antigen in Western Mexico through a cross-sectional study. It found that the rapid antigen test showed high sensitivity and specificity for SARS-CoV-2 antigen, with symptoms like anosmia being significant factors for positive diagnosis in both tests.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Microbiology
Laura C. Steinhardt, Fehintola Ige, Nnaemeka C. Iriemenam, Stacie M. Greby, Yohhei Hamada, Mabel Uwandu, Maureen Aniedobe, Kristen A. Stafford, Alash'le Abimiku, Nwando Mba, Ndidi Agala, Olumide Okunoye, Augustine Mpamugo, Mahesh Swaminathan, Edewede Onokevbagbe, Temitope Olaleye, Ifeanyichukwu Odoh, Barbara J. Marston, McPaul Okoye, Ibrahim Abubakar, Molebogeng X. Rangaka, Eric Rogier, Rosemary Audu
Summary: Accurate SARS-CoV-2 serological assays are crucial for COVID-19 surveillance, but cross-reactivity issues were found in areas with malaria endemicity. A simple urea wash can help alleviate this cross-reactivity problem.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yong Kwan Lim, Oh Joo Kweon, Hye Ryoun Kim, Tae-Hyoung Kim, Mi-Kyung Lee
Summary: This study evaluated the clinical compliance of seven different SARS-CoV-2 antigen RDTs for COVID-19. The results showed that most RDTs had acceptable compliance for specimens with high viral burdens, but had high false-negative rates for specimens with low viral burdens. Therefore, RDTs should not be used alone for diagnosing asymptomatic patients and molecular assays should be combined.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Microbiology
Kellisha Harley, Ian L. Gunsolus
Summary: Critical evaluation of three commercially available SARS-CoV-2 serologic assays demonstrated high qualitative agreement, specificity, and increased diagnostic sensitivity with symptom onset time. Combining IgG and IgM screening identified additional samples with detectable antibodies, while one immunocompromised patient showed no detectable antibodies using any of the three assays 43 days after symptom onset.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Virology
Helene Haguet, Jonathan Douxfils, Christine Eucher, Marc Elsen, Julie Cadrobbi, Marie Tre-Hardy, Jean-Michel Dogne, Julien Favresse
Summary: The study evaluated the clinical performance of the Panbio COVID-19 IgG/IgM rapid test, showing high sensitivity for IgG, particularly suitable for testing more than 14 days after symptom onset. However, the sensitivity for IgM was lower, while both IgG and IgM exhibited excellent specificity in the assay.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Brian R. Shy, Vivasvan S. Vykunta, Alvin Ha, Alexis Talbot, Theodore L. Roth, David N. Nguyen, Wolfgang G. Pfeifer, Yan Yi Chen, Franziska Blaeschke, Eric Shifrut, Shane Vedova, Murad R. Mamedov, Jing-Yi Jing Chung, Hong Li, Ruby Yu, David Wu, Jeffrey Wolf, Thomas G. Martin, Carlos E. Castro, Lumeng Ye, Jonathan H. Esensten, Justin Eyquem, Alexander Marson
Summary: By using single-stranded DNA HDR templates with reduced toxicity and small-molecule combinations, the efficiency of CRISPR-mediated site-specific transgene insertion can be greatly enhanced. This method is applicable to various target loci, knock-in constructs, and primary human cell types, with high HDR efficiencies. Furthermore, it can be applied in pathogenic gene variant modeling, gene-replacement strategies, and nonviral chimeric antigen receptor-T cell manufacturing with improved knock-in efficiencies and yields.
NATURE BIOTECHNOLOGY
(2023)
Review
Clinical Neurology
Kelli M. Money, T. Allen Barnett, Samuel Rapaka, Rebecca Osborn, Takashi Kitani, Daniel Fuguet, Faria Amjad, Jeffrey R. Clark, Debanjana Chakravarty, Matthew J. Copeland, Justin M. Honce, Princy N. Kumar, Rebecca N. Kumar, Fady Mousa-Ibrahim, Bilaal Sirdar, Rafal Sobota, Mengxuan Tang, Maureen K. Bolon, Eric J. Russell, Michael Wilson, Carlo Tornatore, Ayush Batra, Kenneth L. Tyler, Daniel M. Pastula
Summary: This study presents three cases of Monkeypox virus (MPXV)-associated central nervous system (CNS) disease during the 2022 outbreak, with imaging findings and treatment outcomes. The patients, previously healthy immunocompetent gay men in their 30s, developed a febrile illness followed by progressive neurologic symptoms and vesiculopustular rash. MPXV nucleic acid was detected in skin lesions of two patients, with the third patient having an epidemiological link to a confirmed case. Magnetic resonance imaging showed central spinal cord lesions and other brain abnormalities. All patients received tecovirimat treatment, and two also received immunotherapy. Good neurological recovery was observed in all cases.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Maria M. Galardi, Gavin M. Sowa, Cameron D. Crockett, Robert Rudock, Alyssa E. Smith, Ei E. Shwe, Thidar San, Kyaw Linn, Aye Mya M. Aye, Prashanth S. Ramachandran, Maham Zia, Anne E. Wapniarski, Isobel A. Hawes, Chaw S. Hlaing, Ei H. Kyu, Cho Thair, Yi Y. Mar, Nway Nway, Gregory A. Storch, Kristine M. Wylie, Todd N. Wylie, Josep Dalmau, Michael R. Wilson, Soe S. Mar
Summary: Pediatric encephalitis is prevalent in Myanmar, and the study found that advanced technologies can increase the identification of treatable infectious and autoimmune causes. Developing affordable advanced tests globally is crucial for improving the diagnosis and prognosis of encephalitis.
ANNALS OF NEUROLOGY
(2023)
Letter
Neurosciences
Lindsay S. McAlpine, Brooke Lifland, Joseph R. Check, Gustavo A. Angarita, Thomas T. Ngo, Peixi Chen, Ravi Dandekar, Bonny D. Alvarenga, Weston D. Browne, Samuel J. Pleasure, Michael R. Wilson, Serena S. Spudich, Shelli F. Farhadian, Christopher M. Bartley
BIOLOGICAL PSYCHIATRY
(2023)
Article
Cell Biology
Maureen Ty, Shenghuan Sun, Perri C. Callaway, John Rek, Kathleen D. Press, Kattria van der Ploeg, Jason Nideffer, Zicheng Hu, Sandy Klemm, William Greenleaf, Michele Donato, Stephen Tukwasibwe, Emmanuel Arinaitwe, Felistas Nankya, Kenneth Musinguzi, Dean Andrew, Lauren de la Parte, Diego Martinez Mori, Savannah N. Lewis, Saki Takahashi, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Catherine Blish, P. J. Utz, Purvesh Khatri, Grant Dorsey, Moses Kamya, Michelle Boyle, Margaret Feeney, Isaac Ssewanyana, Prasanna Jagannathan
Summary: Repeated malaria exposure leads to expansion of atypical CD56neg NK cells in Ugandan children, characterized by transcriptional, epigenetic, and phenotypic differences from CD56dim NK cells. CD56neg NK cells display enhanced functionality and greater antibody-dependent cellular cytotoxicity. Higher frequencies of CD56neg NK cells are associated with protection against symptomatic malaria. Continuous exposure to Plasmodium falciparum is necessary to maintain this modified, adaptive-like NK cell subset, as frequencies rapidly decline after reductions in malaria transmission.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Joseph J. Sabatino Jr, Kristen Mittl, William Rowles, Colin R. Zamecnik, Rita P. Loudermilk, Chloe Gerungan, Collin M. Spencer, Sharon A. Sagan, Jessa Alexander, Kira Mcpolin, PeiXi Chen, Chinmay Deshpande, Kerri Wyse, Eric M. Maiese, Michael R. Wilson, Scott S. Zamvil, Riley Bove
Summary: This study evaluates the effects of a third SARS-CoV-2 vaccination on antibody and T cell responses in MS patients treated with anti-CD20 mAb or S1P receptor modulators. The results show lower antibody responses in patients treated with anti-CD20 mAb and S1P receptor modulators compared to healthy controls, while T cell responses are maintained across all groups.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Christopher M. M. Bartley, Thomas T. T. Ngo, Cathryn R. R. Cadwell, Adil Harroud, Ryan D. D. Schubert, Bonny D. D. Alvarenga, Isobel A. A. Hawes, Kelsey C. C. Zorn, Trung Hunyh, Lindsay H. H. Teliska, Andrew F. F. Kung, Shailee Shah, Jeffrey M. M. Gelfand, Felicia C. C. Chow, Matthew N. N. Rasband, Divyanshu Dubey, Sean J. J. Pittock, Joseph L. L. DeRisi, Michael R. R. Wilson, Samuel J. J. Pleasure
Summary: Neuroinvasive infection is a common cause of meningoencephalitis in people with HIV, but autoimmune causes are also possible. In this study, a man with HIV infection and steroid-responsive meningoencephalitis was found to have anti-neural antibodies in his cerebrospinal fluid, specifically targeting the axon initial segment, node of Ranvier, and subpial space. The leading candidate autoantigen identified was ankyrinG. Further analysis revealed the presence of additional autoantibodies. These findings highlight the rare presence of AnkG autoantibodies in cerebrospinal fluid, expanding our understanding of neurological autoimmunity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Sasha Gupta, Milos Simic, Sharon A. Sagan, Chanelle Shepherd, Jason Duecker, Raymond A. Sobel, Ravi Dandekar, Gregory F. Wu, Wesley Wu, John E. Pak, Stephen L. Hauser, Wendell Lim, Michael R. Wilson, Scott S. Zamvil
Summary: This study tested the effect of anti-CD19 CAR-T cells in a B-cell-dependent EAE model and found that it can improve the condition of EAE and effectively eliminate B cells in both peripheral tissues and the central nervous system.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Aurelie Hanin, Jorge Cespedes, Yashwanth Pulluru, Margaret Gopaul, Eleonora Aronica, Danielle Decampo, Ingo Helbig, Charles L. Howe, Anita Huttner, Sookyong Koh, Vincent Navarro, Olga Taraschenko, Annamaria Vezzani, Michael R. Wilson, Julie Xian, Nicolas Gaspard, Lawrence J. Hirsch
Summary: New onset refractory status epilepticus (NORSE), including its subtype with a preceding febrile illness known as febrile infection-related epilepsy syndrome (FIRES), is a severe form of status epilepticus with unknown causes and no disease-specific therapy. Identifying the underlying pathophysiology and discovering specific biomarkers may aid in the management of NORSE patients. However, there is a lack of validated biomarkers due to various factors, such as study variabilities and small sample sizes. The establishment of a biorepository for NORSE/FIRES aims to promote standardized procedures and facilitate the identification of validated biomarkers, providing better clinical management for these patients.
Article
Dermatology
Romy A. Neuner, Jinwoo Lee, Kerri E. Rieger, Caroline Park, Alexander D. Colevas, Anne Lynn S. Chang
Summary: The immune system plays a crucial role in the surveillance and control of keratinocyte cancers. This review provides an overview of key concepts in immunotherapy and highlights important cellular components involved in attacking these cancers. Collaboration across medical disciplines is necessary to evaluate the response to immunotherapy and recognize immune-related adverse events for optimized patient outcomes.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Oncology
Katherine Van Loon, Elia J. Mmbaga, Beatrice P. Mushi, Msiba Selekwa, Ally Mwanga, Larry O. Akoko, Julius Mwaiselage, Innocent Mosha, Dianna L. Ng, Wei Wu, Jordyn Silverstein, Gift Mulima, Bongani Kaimila, Satish Gopal, Jeff M. Snell, Stephen Charles Benz, Charles Vaske, Zack Sanborn, Andrew J. Sedgewick, Amie Radenbaugh, Yulia Newton, Eric A. Collisson
Summary: This study describes the genomic profiles of Esophageal Squamous Cell Carcinoma (ESCC) in Tanzania and compares it to ESCC cases from Malawi. The study found common TP53 mutations in both Tanzania and Malawi, but at lower frequencies than previously reported. The study also identified two unique transcriptional clusters in the Tanzanian cohort.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Immunology
I. A. Hawes, B. D. Alvarenga, W. Browne, A. Wapniarski, R. Dandekar, C. M. Bartley, G. M. Sowa, J. L. DeRisi, P. Cinque, A. N. Dravid, S. J. Pleasure, M. Gisslen, R. W. Price, M. R. Wilson
Summary: Antiretroviral therapy (ART) inhibits HIV replication in plasma and cerebrospinal fluid (CSF). Neurosymptomatic (NS) CSF escape is a rare condition where CNS HIV replication occurs despite therapy. A case-control study was conducted to investigate the immunoreactivity and viral markers in the CSF of NS escape subjects. Epstein-Barr virus (EBV) DNA was more frequently detected in NS escape CSF, and there was evidence of increased immunoreactivity against self-antigens. Further analysis revealed immunodominant epitopes in the CSF of NS escape subjects. The significance of these markers in the pathogenesis of NS escape requires further investigation.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Infectious Diseases
Carolyn Gould, Rebecca J. Free, Julu Bhatnagar, Raymond A. Soto, Tricia L. Royer, Warren R. Maley, Sean Moss, Matthew A. Berk, Rebecca Craig-Schapiro, Rosy Priya L. Kodiyanplakkal, Lars F. Westblade, Thangamani Muthukumar, Yoram A. Puius, Amresh Raina, Azam Hadi, Kymberly A. Gyure, Danielle Trief, Marcus Pereira, Matthew J. Kuehnert, Vennus Ballen, Debra A. Kessler, Kimberly Dailey, Charles Omura, Thuy Doan, Steve Miller, Michael R. Wilson, Jennifer A. Lehman, Jana M. Ritter, Elizabeth Lee, Luciana Silva-Flannery, Sarah Reagan-Steiner, Jason Velez, Janeen J. Laven, Kelly A. Fitzpatrick, Amanda Panella, Emily H. Davis, Holly R. Hughes, Aaron C. Brault, Kirsten St George, Amy B. Dean, Joel Ackelsberg, Sridhar Basavaraju, Charles Y. Chiu, J. Erin Staples
Summary: In 2021, four patients who received solid organ transplants in the USA developed encephalitis 2-6 weeks after transplantation. An investigation found that the encephalitis in these patients was associated with yellow fever virus infection. Two patients recovered, while two patients did not have neurological recovery and died. The investigation also recommended deferring blood donation for at least 2 weeks after receiving a yellow fever vaccine to reduce the risk of transfusion-transmitted infections.
Article
Immunology
Natasha Spottiswoode, Douglas Pet, Annie Kim, Katherine Gruenberg, Maulik Shah, Amrutha Ramachandran, Matthew T. Laurie, Maham Zia, Camille Fouassier, Christine L. Boutros, Rufei Lu, Yueyuan Zhang, Venice Servellita, Andrew Bollen, Charles Y. Chiu, Michael R. Wilson, Liza Valdivia, Joseph L. DeRisi
Summary: A rare and usually fatal case of Balamuthia mandrillaris granulomatous amebic encephalitis in a patient in California, USA, was successfully treated with the repurposed drug nitroxoline, which is typically used for urinary tract infections and was found to have amebicidal activity against Balamuthia in a drug screening.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Caleigh Mandel-Brehm, Sara E. Vazquez, Christopher Liverman, Mickie Cheng, Zoe Quandt, Andrew F. Kung, Audrey Parent, Brenda Miao, Emmanuel Disse, Christine Cugnet-Anceau, Stephane Dalle, Elizaveta Orlova, Elena Frolova, Diana Alba, Aaron Michels, Bergithe E. Oftedal, Michail S. Lionakis, Eystein S. Husebye, Anil K. Agarwal, Xilong Li, Chengsong Zhu, Quan Li, Elif Oral, Rebecca Brown, Mark S. Anderson, Abhinmanyu Garg, Joseph L. DeRisi
Summary: This study identified autoantibodies to PLIN1 in a murine model of APS1 and in patients with acquired lipodystrophy, indicating that PLIN1 autoantibodies may be markers of acquired autoimmune lipodystrophies.