Review
Immunology
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
Summary: Semaphorins, originally identified as axon-guidance molecules essential for neural development, have critical functions in various pathophysiological processes beyond the neural system, with mTOR signaling being a central regulator of their functions.
INTERNATIONAL IMMUNOLOGY
(2021)
Article
Cell Biology
Alaknanda Emery, Kylie R. Dunning, Doan T. Dinh, Lisa K. Akison, Rebecca L. Robker, Darryl L. Russell
Summary: The ovarian follicle is a complex structure that protects and helps in the maturation and release of the oocyte. The progesterone receptor (PGR) plays a key role in regulating ovulation-related gene expression changes. The study found disrupted expression of the cellular adhesion receptor gene Sema7A in the granulosa cells of PGR-/- mice during ovulation. Furthermore, it was discovered that gonadotropins and hypoxia promote the expression of Sema7A in preovulatory follicles, resulting in an asymmetrical pattern with enriched SEMA7A protein. After an ovulatory stimulus, Sema7A expression is downregulated, the abundance of SEMA7A protein is reduced, and the asymmetrical pattern becomes more homogeneous. The study also found that adhesive receptor Itga5 is significantly increased during ovulation, while repulsive Plxnc1 receptor is inversely regulated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Immunology
Shreya M. Kanth, Salina Gairhe, Parizad Torabi-Parizi
Summary: Semaphorins are a group of proteins that play a critical role in neuronal development and have effects on tumors, autoimmune diseases, and immune responses. Recent literature has highlighted their regulatory role in innate immunity and diseases caused by acute injuries, such as in the kidneys, abdomen, heart, and lungs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Jacqueline L. Steele, Michelle M. Morrow, Harvey B. Sarnat, Ebba Alkhunaizi, Tracy Brandt, David A. Chitayat, Colette P. DeFilippo, Ganka V. Douglas, Holly A. Dubbs, Houda Zghal Elloumi, Megan R. Glassford, Mark C. Hannibal, Benedicte Heron, Linda E. Kim, Elysa J. Marco, Cyril Mignot, Kristin G. Monaghan, Kenneth A. Myers, Sumit Parikh, Shane C. Quinonez, Farrah Rajabi, Suma P. Shankar, Marwan S. Shinawi, Jiddeke J. P. van de Kamp, Aravindhan Veerapandiyan, Amy T. Waldman, William D. Graf
Summary: This study describes the neurological and neurodevelopmental phenotypes of boys with maternally inherited hemizygous PLXNA3 variants, suggesting a novel X-linked intellectual disability syndrome. Greater understanding of PLXNA3 variant pathogenicity in humans will require additional clinical, computational, and experimental validation.
PEDIATRIC NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Manuela Simonetti, Eszter Paldy, Christian Njoo, Kiran Kumar Bali, Thomas Worzfeld, Claudia Pitzer, Thomas Kuner, Stefan Offermanns, Daniela Mauceri, Rohini Kuner
Summary: The study reveals that Sema4C-PlexinB2 signaling plays a crucial role in the recall of fear memory by mediating fear-induced structural plasticity. These findings offer insights into maladaptive plasticity in fear circuits and have implications for novel therapeutic strategies against fear-related disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Cardiac & Cardiovascular Systems
Dianne Vreeken, Caroline Suzanne Bruikman, Wendy Stam, Stefan Martinus Leonardus Cox, Zsofia Nagy, Huayu Zhang, Rudmer Johannes Postma, Anton Jan van Zonneveld, Gerard Kornelis Hovingh, Janine Maria van Gils
Summary: The study demonstrates differential expression of NGCs in endothelial cells and monocytes under pro-inflammatory conditions, with reduced expression of endothelial PLXNA4. PLXNA4 plays a crucial role in maintaining endothelial barrier function, preventing vascular leakage of fluids and cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Oncology
Desislava Germanova, Jiri Keirsse, Arnaud Kohler, Jean-Francois Hastir, Peter Demetter, Sandrine Delbauve, Yvon Elkrim, Laurine Verset, Lionel Larbanoix, Nicolas Preyat, Sophie Laurent, Sergei Nedospasov, Vincent Donckier, Jo A. Van Ginderachter, Veronique Flamand
Summary: Liver ischemia-reperfusion injury following hepatic resection in patients with metastases can lead to tumor relapse, with the death of Kupffer cells and recruitment of monocytes possibly playing key roles.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Neurosciences
Chaojun Hu, Shan Zhang, Qian Chen, Rong Wang
Summary: Ovatodiolide (OVA) can alleviate neurological deficits and brain tissue damage caused by ischemia-reperfusion (I/R) by inhibiting neuronal apoptosis and microglial inflammation.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Thiago Henrique Caldeira Oliveira, Vincent Vanheule, Sofie Vandendriessche, Fariba Poosti, Mauro Martins Teixeira, Paul Proost, Mieke Gouwy, Pedro Elias Marques
Summary: The study suggests that interfering with chemokine function using a peptide called MIG30 can disrupt neutrophil recruitment to the injured liver during ischemia-reperfusion injury (IRI). Mice treated with MIG30 showed significantly lower liver injury and dysfunction, as well as reduced levels of chemokines and proinflammatory cytokines. This indicates that MIG30 holds promise as a potential treatment strategy for liver IRI and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Shen-ping Tang, Xin-li Mao, Ya-hong Chen, Ling-ling Yan, Li-ping Ye, Shao-wei Li
Summary: Liver transplantation is the ultimate method for treating end-stage liver disease. The increasing prevalence of obesity and non-alcoholic fatty liver has led to a rise in the number of patients who may require liver transplantation. Ischemia-reperfusion injury and oxidative stress play key roles in the pathogenesis of non-alcoholic fatty liver and its sensitivity to transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Peripheral Vascular Disease
Li Liu, Youde Jiang, Jena J. Steinle
Summary: Research indicates that inflammation plays a crucial role in damaging the retinal vasculature. This study investigates the regulation of inflammatory pathways and suggests that semaphorin 7a (Sema7a) is involved in the increased inflammatory mediators and permeability changes in retinal endothelial cells (REC) grown in high glucose. The use of Sema7a siRNA shows promise as a potential treatment avenue.
MICROVASCULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Raquel G. Bardallo, Arnau Panisello-Rosello, Sergio Sanchez-Nuno, Norma Alva, Joan Rosello-Catafau, Teresa Carbonell
Summary: In response to stress signal, Nrf2 regulates the expression of genes involved in antioxidant defense and detoxification, maintaining cellular homeostasis. During ischemia-reperfusion injury, Nrf2 activation can enhance cellular defense and promote hepatic recovery by mitigating oxidative stress and inflammation.
Article
Biotechnology & Applied Microbiology
Qi Chen, Yating Song, Ningli Yang, Xiaoming Ai, Liyong Pu, Lianbao Kong
Summary: This study found that aging worsened ischemia/reperfusion injury and suppressed TRIB1 protein expression and anti-inflammatory function in macrophages. Restoring TRIB1 can alleviate liver damage by activating M2 polarization and anti-inflammatory response.
Article
Medicine, Research & Experimental
Zhangliu Jin, Meng Dou, Weihui Peng, Boen Xiao, Jinjin Liu, Wen Meng, Wei Liu
Summary: This study aimed to analyze alterations in gene expression, immune infiltration components, and potential biomarkers in liver ischemia-reperfusion injury (IRI) following liver transplantation (LT). The study identified differentially expressed genes associated with inflammation, apoptosis, cell proliferation, immune disorders, and cellular response, as well as various immune cell types infiltrating the IRI. The study also identified potential biological biomarkers, which may contribute to the diagnosis and prognosis of IRI post-transplant.
Article
Multidisciplinary Sciences
Christopher T. Turner, Megan Pawluk, Juliana Bolsoni, Matthew R. Zeglinski, Yue Shen, Hongyan Zhao, Tatjana Ponomarev, Katlyn C. Richardson, Christopher R. West, Anthony Papp, David J. Granville
Summary: This study investigated the therapeutic effect of sulfaphenazole (SP) in pressure injuries. The results showed that SP could alleviate the severity of pressure injuries, promote wound closure, and improve wound tensile strength. Additionally, SP rapidly restored tissue perfusion, reduced tissue hypoxia, inflammation, and fibrosis. Moreover, SP demonstrated bactericidal activity through enhanced macrophage activity. The effectiveness of SP in reducing thermal injury severity was also demonstrated. Therefore, SP has the potential to be a therapeutic option for pressure injuries and other ischemic skin injuries.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
David Koehler, Tiago Granja, Julia Volz, Michael Koeppen, Harald F. Langer, Georg Hansmann, Ekaterina Legchenko, Tobias Geisler, Tamam Bakchoul, Claudia Eggstein, Helene A. Haeberle, Bernhard Nieswandt, Peter Rosenberger
NATURE COMMUNICATIONS
(2020)
Article
Immunology
Kristian-Christos Ngamsri, Christoph Jans, Rizki A. Putri, Katharina Schindler, Jutta Gamper-Tsigaras, Claudia Eggstein, David Koehler, Franziska M. Konrad
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Annika Nelde, Tatjana Bilich, Jonas S. Heitmann, Yacine Maringer, Helmut R. Salih, Malte Roerden, Maren Luebke, Jens Bauer, Jonas Rieth, Marcel Wacker, Andreas Peter, Sebastian Hoerber, Bjoern Traenkle, Philipp D. Kaiser, Ulrich Rothbauer, Matthias Becker, Daniel Junker, Gerard Krause, Monika Strengert, Nicole Schneiderhan-Marra, Markus F. Templin, Thomas O. Joos, Daniel J. Kowalewski, Vlatka Stos-Zweifel, Michael Fehr, Armin Rabsteyn, Valbona Mirakaj, Julia Karbach, Elke Jaeger, Michael Graf, Lena-Christin Gruber, David Rachfalski, Beate Preuss, Ilona Hagelstein, Melanie Maerklin, Tamam Bakchoul, Cecile Gouttefangeas, Oliver Kohlbacher, Reinhild Klein, Stefan Stevanovic, Hans-Georg Rammensee, Juliane S. Walz
Summary: SARS-CoV-2-specific T cell epitopes were identified in convalescent and unexposed individuals, showing cross-reactivity with common cold coronaviruses. The diversity of SARS-CoV-2 T cell responses may be associated with mild symptoms of COVID-19.
Article
Cell Biology
Tiago Granja, Harry Magunia, Patricia Schuessel, Claudius Fischer, Thomas Pruefer, David Schibilsky, Lina Serna-Higuita, Hans Peter Wendel, Christian Schlensak, Helene Haeberle, Peter Rosenberger, Andreas Straub
Summary: Blood flow through left ventricular assist devices may lead to platelet activation and dysfunction, causing inflammatory tissue damage. This observational study investigated patients undergoing LVAD implantation and control patients undergoing CABG/AVR surgery. The study found that LVAD implantation is associated with platelet dysfunction and proinflammatory platelet-leukocyte binding, with less pronounced changes observed in patients treated with the newer generation LVAD HM3.
Review
Cardiac & Cardiovascular Systems
Marius Keller, Valbona Mirakaj, Michael Koeppen, Peter Rosenberger
Summary: Cardiovascular pathologies are often caused by inflammation, which affects vascular endothelial biology and can complicate ischemia, reperfusion injury, cell migration, and platelet activation. Therapeutic approaches have historically targeted cytokines and chemokines to manage cardiovascular changes, but recent research suggests that neuronal guidance proteins (NGPs) may also play a significant role in controlling inflammation and immune cell activation in the cardiovascular system.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Andreas Koerner, Alice Bernard, Julia C. Fitzgerald, Juan Carlos Alarcon-Barrera, Sarantos Kostidis, Torsten Kaussen, Martin Giera, Valbona Mirakaj
Summary: In summary, this passage discusses the role of the neuroimmune guidance cue Semaphorin 7A in regulating macrophage metabolism and the resolution of inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Hematology
Stefanie Hammer, Helene Haeberle, Christian Schlensak, Michael Bitzer, Nisar P. Malek, Rupert Handgretinger, Peter Lang, Sebastian Hoerber, Andreas Peter, Peter Martus, Valbona Mirakaj, Meinrad Gawaz, Tobias Geisler, Karina Althaus, Peter Rosenberger, Tamam Bakchoul
Summary: This study found that COVID-19 patients have impaired fibrinolytic activity in the blood. Compared with healthy controls, significant abnormalities in clotting and fibrinolysis markers were observed in ICU COVID-19 patients.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Critical Care Medicine
Helene Haeberle, Harry Magunia, Peter Lang, Henning Gloeckner, Andreas Koerner, Michael Koeppen, Tamam Backchoul, Nisar Malek, Rupert Handgretinger, Peter Rosenberger, Valbona Mirakaj
Summary: The study shows that MSC infusion is a safe treatment for severe COVID-19-induced ARDS, improving pulmonary function and overall outcome. Patients receiving MSC treatment had higher survival rates and lower lung injury scores compared to the control group.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Sport Sciences
Florencio Diniz-Sousa, Tiago Granja, Giorjines Boppre, Lucas Veras, Vitor Devezas, Hugo Santos-Sousa, John Preto, Leandro Machado, Joao Paulo Vilas Boas, Jose Oliveira, Helder Fonseca
Summary: Patients who undergo bariatric surgery have an increased risk of falls. A study found that a supervised multicomponent exercise intervention program can improve balance parameters, reducing falls and associated injuries in these patients.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Multidisciplinary Sciences
Luis Monteiro Rodrigues, Sergio Loureiro Nuno, Tiago Granja, Margarida Esteves Florindo, Joao Gregorio, Tiago Atalaia
Summary: This preliminary study aims to explore potential relationships between physiological perfusion and plantar pressure variables in humans. The study found asymmetries in perfusion, plantar pressure, and stance, with the perfusion asymmetries differing between phases. Plantar pressure was mainly concentrated in the hindfoot. Additionally, significant correlations were found between BMI and plantar pressure, as well as a negative correlation between perfusion and plantar pressure.
Article
Multidisciplinary Sciences
Tiago Granja, Sergio Faloni de Andrade, Luis Monteiro Rodrigues
Summary: Microcirculatory impairment is an important theme in vascular research. The development of live imaging systems, including optoacoustic tomography (OT), has provided new opportunities for real-time, quantifiable functional imaging. OT combines optical absorption and spatial resolution capacities with tissue depth, and shows great potential in functional imaging.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Cell Biology
Tiago F. Granja, David Kohler, Veronika Leiss, Claudia Eggstein, Bernd Nurnberg, Peter Rosenberger, Sandra Beer-Hammer
Summary: This study investigated the role of extracellular platelet nucleotide signaling in ischemic inflammatory response (IIR) and identified a cybernetic circle, including feedback loops, in the regulation of platelet function in IIR. The study confirmed the presence of different components and feedback loops in the cybernetic system and demonstrated the impact of platelet-neutrophil complex (PNC) formation on blood and inflamed tissue. The integration of extracellular nucleotide signaling, PNC formation, and tissue damage in IIR was described through this study.
Article
Biology
Luis Monteiro Rodrigues, Tiago F. Granja, Sergio Faloni de Andrade
Summary: Functional imaging with new photoacoustic tomography (PAT) offers improved spatial and temporal resolution quality in in vivo human skin vascular assessments. In this study, the effects of suprasystolic reactive hyperemia (RH) on superficial and deeper vascular structures in the skin were explored. Results showed that RH not only affects superficial vessels but also impacts deeper structures.