Development of MnO2hollow nanoparticles for potential drug delivery applications

This study reports the development of hollow nanoparticles, formed from manganese dioxide (delta-MnO2) sheets, that are coated with polydopamine for potential immobilization of chemical agents. The biodegradability and colloidal stability of the uncoated hollow MnO(2)nanoparticles were investigated in comparison to commercially synthesized solid MnO(2)nanoparticles and graphene oxide sheets. The MnO(2)hollow nanoparticles degraded at a faster rate and seem to have a higher surface area and better colloidal dispersion than solid MnO(2)nanoparticles. Xanthan gum (as a dispersant) was proven to improve colloidal dispersion of these hollow nanoparticles and were used for further cell studies. In this study, cancer and healthy cells were treated with coated hollow nanoparticles, and the studies indicate that this novel nanoparticle can internalize cells. Particle aggregation has shown to inhibit cell growth. Further studies with this novel hollow nanoparticle may lead to a groundbreaking solution to new drug delivery systems for cancers or other applications.

Automated summary

This study reported the development of novel hollow manganese dioxide nanoparticles coated with polydopamine for potential immobilization of chemical agents. Through comparison with solid manganese dioxide nanoparticles and graphene oxide sheets, the hollow manganese dioxide nanoparticles were found to degrade faster, have a higher surface area, and better colloidal dispersion. The study also showed that the novel nanoparticles can internalize cells and inhibit cell growth through particle aggregation, providing a potential groundbreaking solution for new drug delivery systems in cancer or other applications.