Article
Engineering, Mechanical
Sen Wang, Yinghao Gao, Hailin Huang, Bing Li, Hongwei Guo, Rongqiang Liu
Summary: This paper introduces a method for designing rigid origami flashers for deployment on curved surfaces, utilizing parallel projection principles and numerical methods to obtain vertices, then transforming them into rigid panels using flexible and elastic hinges. The feasibility of the approach is verified through numerical simulations and physical prototypes, providing convenience for its application in space engineering.
MECHANISM AND MACHINE THEORY
(2022)
Article
Chemistry, Multidisciplinary
Shuangshuang Zeng, Mauro Chinappi, Fabio Cecconi, Theo Odijk, Zhen Zhang
Summary: In this study, we propose a nanopore gated sub-attoliter silicon nanocavity device to investigate the behavior and properties of biopolymers in a confined environment. Single DNA molecules are electrically driven and compacted inside the nanocavity, and their dynamic fluctuations are monitored through ionic current measurements. The mechanism for DNA compaction is elucidated by varying different parameters.
Article
Chemistry, Multidisciplinary
Chaolumen Wu, Qingsong Fan, Zhiwei Li, Zuyang Ye, Yadong Yin
Summary: This study demonstrates reversible assembly and active tuning of plasmonic chiral superstructures by introducing a chiral magnetic field. Manipulating the magnetic field controls both the chiral arrangement and spectral properties of the superstructures, enabling fast and reversible tunability.
MATERIALS HORIZONS
(2023)
Review
Chemistry, Multidisciplinary
Jianbang Wang, Zhenzhen Li, Itamar Willner
Summary: DNA nanotechnology utilizes the information stored in nucleic acids to create dynamic reconfigurable structures, networks, and materials. This review highlights recent advancements in the construction and applications of such DNA nanostructures. Topics covered include the reconfiguration of DNA through engineered origami frames, the use of origami frameworks to assemble optical devices and operate chemical processes, and the design of stimuli-responsive all-DNA materials. The review also presents future perspectives and potential applications of dynamic reconfigurable DNA nanostructures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Peng Lin, Huyen Dinh, Eiji Nakata, Takashi Morii
Summary: A three-dimensional DNA scaffold was designed with the ability to undergo shape transition, allowing enzymes to be assembled in an open state and subsequently transformed and enclosed using short DNA closing keys while maintaining their catalytic activity. The nanocarrier with efficient encapsulation ability is potentially applicable for drug delivery, biosensing, biocatalytic, and diagnostic tools.
FRONTIERS IN CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Mostafa A. Elbahnasawy, Mahmoud L. Nasr
Summary: Lipid-bilayer nanodiscs and liposomes are used to stabilize membrane proteins and study their structures and functions. DNA-origami nanostructures can be used as templates to control the shapes and arrangements of lipid bilayers, which is crucial for the study of large membrane proteins.
FRONTIERS IN CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Yang Deng, Weixuan Liu, Yik Kin Cheung, Yongkai Li, Wei Hong, Hongyu Yu
Summary: This paper presents a method for designing curved displays of nondevelopable shapes using a structure-mechanics-inspired functional optimization method. The technology involves microfabrication for manufacturing 2D flexible foldable circuit boards and mold guidance for folding 2D sheets into curved 3D display prototypes. It is suitable for mass production and advances the application of next-generation curved displays.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Dongfang Wang, Lei Yu, Chao-Min Huang, Gaurav Arya, Shuai Chang, Yonggang Ke
Summary: This article introduces a modular design method to programmatically adjust the shapes of DNA origami nanomachines. By changing the length of DNA units and using different combinations of trigger DNA strands, controlled transformations of the overall dimensions and curvatures of DNA origami can be achieved. This modular design has potential applications in more sophisticated molecular nanorobots and smart drug delivery nanocarriers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Yan Liu, Huan Ge, Yuqi Wang, Linlin Tang, Yufeng Pei, Sisi Fan, Yongxiu Song, Chuan Zhang, Jie Song
Summary: The multistep transformation strategy of DNA origami triggered by mechanical forces allows programmable transformations of molecular nanomachines, and can potentially be used to build various DNA-based nanodevices.
Article
Multidisciplinary Sciences
Muren Hu, Chang Feng, Qianqin Yuan, Chenbin Liu, Bujun Ge, Fenyong Sun, Xiaoli Zhu
Summary: mRNA delivery has shown great potential in the treatment of various diseases. Here, the authors develop a lantern-shaped flexible origami for the nanolization of single mRNA molecules and demonstrate efficient delivery of Smad4 mRNA, achieving the suppression of colorectal cancer tumor growth.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Xinpei Dai, Xiaoliang Chen, Xinxin Jing, Yinan Zhang, Muchen Pan, Mingqiang Li, Qian Li, Pi Liu, Chunhai Fan, Xiaoguo Liu
Summary: Integrating dissimilar materials at the nanoscale is crucial for modern electronics and optoelectronics. Researchers have developed a DNA origami-encoded strategy for integrating silica-metal heterostructures and revealed the underlying mechanisms. By programming the densities and lengths of protruding dsDNA strands on DNA origami, high site-addressability of material deposition was achieved.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Xiaotong Shen, Qingwen Ouyang, Hongwei Tan, Jin Ouyang, Na Na
Summary: Researchers designed stable single-stranded DNA (ssDNA) nanorobots by examining the dynamic folding of ssDNA in self-assemblies via molecular dynamics simulations. Two ssDNA strands were successfully assembled into nanorobots using two functional siRNAs, enabling multiple applications. The nanorobots were demonstrated to be stable, flexible, highly utilized, and low in folding errors. This study provides a computational pathway for constructing flexible and multifunctional ssDNA frameworks, expanding the biological application of nucleic acid nanostructures.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Joonas Ryssy, Ashwin K. Natarajan, Jinhua Wang, Arttu J. Lehtonen, Minh-Kha Nguyen, Rafal Klajn, Anton Kuzyk
Summary: The article describes a method for remotely manipulating non-photoresponsive chiral plasmonic molecules (CPMs) using light, inducing DNA triplex link formation through a photoacid medium, resulting in spatial reconfiguration of CPMs. The overall chirality change depends on the fraction of CPMs undergoing reconfiguration, which is related to the intensity of incident light.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Yuchen Wang, Xin Jin, Carlos Castro
Summary: In this study, a data processing pipeline based on Deep Neural Networks (DNNs) was developed to rapidly characterize the mechanical properties of dynamic DNA nanodevices. By quantifying conformational distributions and utilizing limited user input and small training sets, this pipeline enables effective evaluation of the mechanical properties of nanodevices.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Juanjuan Yang, Kevin Jahnke, Ling Xin, Xinxin Jing, Pengfei Zhan, Andreas Peil, Alessandra Griffo, Marko Skugor, Donglei Yang, Sisi Fan, Kerstin Goepfrich, Hao Yan, Pengfei Wang, Na Liu
Summary: In this study, a DNA origami cross (DOC) structure was developed and used to anchor onto giant unilamellar vesicles (GUVs) and polymerize into reconfigurable 1D chains or 2D lattices. These DNA origami-based networks can switch between left-handed (LH) and right-handed (RH) conformations using DNA fuels and effectively remodel the membrane curvatures of GUVs. This work provides insights into designing hierarchically assembled dynamic DNA systems for programmable modulation of synthetic cells for various applications.
Article
Chemistry, Multidisciplinary
Sisi Fan, Jin Cheng, Yan Liu, Dongfang Wang, Tao Luo, Bin Dai, Chuan Zhang, Daxiang Cui, Yonggang Ke, Jie Song
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Dongfang Wang, Lei Yu, Chao-Min Huang, Gaurav Arya, Shuai Chang, Yonggang Ke
Summary: This article introduces a modular design method to programmatically adjust the shapes of DNA origami nanomachines. By changing the length of DNA units and using different combinations of trigger DNA strands, controlled transformations of the overall dimensions and curvatures of DNA origami can be achieved. This modular design has potential applications in more sophisticated molecular nanorobots and smart drug delivery nanocarriers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Mingzhu Huang, Lei Yu, Mingyang Zhang, Zhe Wang, Bohuai Xiao, Yichong Liu, Jin He, Shuai Chang
Summary: This study demonstrates that using a flexible gold-coated nanopipette electrode can enhance the stability of single-molecule junctions and proposes an empirical model for extending the junction lifetime with the flexible electrode. Additionally, it is shown for the first time that the internal conduit of the flexible STM tip can be utilized for controlled molecule delivery and molecular junction formation.
Article
Chemistry, Multidisciplinary
Lei Yu, Jin Cheng, Dongfang Wang, Victor Pan, Shuai Chang, Jie Song, Yonggang Ke
Summary: Programmable DNA nanotechnology has been widely used in various applications, and minimizing mechanical stress is an important design rule for DNA nanostructures. This study compares the self-assembly of a canonical DNA gridiron with a new design that has a higher degree of mechanical stress. The interweaving DNA gridiron exhibits lower yield but promotes the formation of a two-dimensional crystalline lattice. Tuning the design of interweaving gridiron leads to changes in crystal size and regularity. The discovery of the new role of mechanical stress provides useful knowledge for future DNA nanostructure design.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Lei Yu, Mingyang Zhang, Haijian Chen, Bohuai Xiao, Shuai Chang
Summary: A hybrid technique has been developed to investigate the electrical and mechanical properties of a single-molecule junction using atomic force microscopy and the fixed-junction technique simultaneously.
Article
Multidisciplinary Sciences
Chunyang Zhou, Donglei Yang, Sebastian Sensale, Pranav Sharma, Dongfang Wang, Lei Yu, Gaurav Arya, Yonggang Ke, Pengfei Wang
Summary: This study reports a design method for controllable DNA molecular structures through controlled base stacking. Precise control over molecular conformation and transformation is achieved by programming stacking bonds within the junction. Dynamic transformations between different conformations are achieved through specific environmental and molecular stimulations.
Review
Chemistry, Multidisciplinary
Pengfei Zhan, Andreas Peil, Qiao Jiang, Dongfang Wang, Shikufa Mousavi, Qiancheng Xiong, Qi Shen, Yingxu Shang, Baoquan Ding, Chenxiang Lin, Yonggang Ke, Na Liu
Summary: DNA nanotechnology is an interdisciplinary field that combines physics, chemistry, biology, mathematics, engineering, and materials science. The development of DNA origami technique by Paul Rothemund has greatly advanced the field and led to numerous innovative concepts, models, methodologies, and applications. This review highlights the recent progress in DNA origami-engineered nanomaterials over the past five years and explores the potential research directions. It is believed that the legacy of Nadrian Seeman will continue to inspire interdisciplinary innovations and practical applications in the next decade.
Article
Chemistry, Multidisciplinary
Mingzhu Huang, Jianqiao Dong, Zhiye Wang, Yunchuan Li, Lei Yu, Yichong Liu, Gongming Qian, Shuai Chang
CHEMICAL COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Lei Yu, Zhe Wang, Haijian Chen, Jing Guo, Mingyang Zhang, Yichong Liu, Jin He, Shuai Chang
ACS APPLIED NANO MATERIALS
(2020)
Review
Chemistry, Analytical
Zhe Wang, Yichong Liu, Lei Yu, Yunchuan Li, Gongming Qian, Shuai Chang
Article
Chemistry, Analytical
Jing Su, Dongfang Wang, Lena Noerbel, Jianlei Shen, Zhihan Zhao, Yanzhi Dou, Tianhuan Peng, Jiye Shi, Sanjay Mathur, Chunhai Fan, Shiping Song
ANALYTICAL CHEMISTRY
(2017)
