Article
Pharmacology & Pharmacy
Tianyuan Fan, Rolf Daniels
Summary: Polylactic acid (PLA) was chosen as the electrospinnable polymer for producing triterpene extract (TE)-loaded electrospun fibers. A binary solvent system of dichloromethane (DCM) and dimethyl sulfoxide (DMSO) was optimized for preparing smooth and uniform fibers. The results revealed that TE-loaded electrospun PLA microfibers have promising future prospects in wound therapy.
Article
Multidisciplinary Sciences
Washim Akram, Mohammad Mohsin Ul Hoque, Sumon Miah, Abdus Shahid, Firoz Hossain, Sayed Hasan Mahmud
Summary: This study involves the formation and investigation of a nanofibrous mat made from a PVA-betel leaf mixture. The mat shows antibacterial properties against Staphylococcus aureus and Escherichia coli bacteria, as well as improved moisture and thermal characteristics. It has the potential to be used as a wound dressing material.
Article
Polymer Science
Alitzel Belem Garcia-Hernandez, Eduardo Morales-Sanchez, Blanca M. Berdeja-Martinez, Monserrat Escamilla-Garcia, Ma Paz Salgado-Cruz, Minerva Renteria-Ortega, Reynold R. Farrera-Rebollo, Miguel A. Vega-Cuellar, Georgina Calderon-Dominguez
Summary: This study investigated the biological, physicochemical, structural, and thermal properties of PVA-based electrospun wound dressings with the addition of hydrolyzed collagen and different concentrations of Hypericum perforatum ethanolic extract. The results showed that the materials had suitable fiber diameter, porosity, and pore size, good barrier properties, and demonstrated anti-inflammatory and antimicrobial activity. Moreover, higher crystalline structure was observed with increasing concentration of the ethanolic extract.
Article
Materials Science, Textiles
Pelin Secim Karakaya, Ayberk Oktay, Necdet Seventekin, Ozlem Yesil-Celiktas
Summary: Medical textiles are experiencing rapid growth in the technical textile market, with wound dressings being a significant application. This study focuses on designing a new wound dressing enriched with pine bark extract, which showed superior wound healing effects in in vivo rat studies, compared to traditional dressings.
JOURNAL OF INDUSTRIAL TEXTILES
(2021)
Article
Materials Science, Textiles
Md. Abdus Shahid, Ayub Ali, Md. Nur Uddin, Sumon Miah, Syed Maminul Islam, Md. Mohebbullah, Mohammad Salman Ibna Jamal
Summary: A novel multicomponent nanofibrous mat containing polyvinyl alcohol, honey and Curcumin longa extract was successfully prepared, showing better moisture management properties and antibacterial activity. Characterization by scanning electron microscope, bacterial assay, moisture management tester, and FTIR revealed the presence of desired components and promising properties of the fabricated nanofibrous mats.
JOURNAL OF INDUSTRIAL TEXTILES
(2021)
Article
Chemistry, Applied
Hamidreza Motasadizadeh, Sara Azizi, Alireza Shaabani, Mostafa Ghodrati Sarvestani, Roya Sedghi, Rassoul Dinarvand
Summary: A novel wound healing system with multifunctional properties was prepared in this study, showing excellent mechanical, structural, and biological properties. The CS-g-PNVIM-based nanofibers exhibited promising potential for biocompatible antibacterial wound dressing applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Xingzi Lan, Yurong Liu, Yaqi Wang, Feng Tian, Xiaomin Miao, Han Wang, Yadong Tang
Summary: A series of coaxial nanofiber membranes combining antioxidant tea polyphenols in the core and antibacterial e-poly (L-lysine) in the shell layer were successfully fabricated by coaxial electrospinning. The prepared nanofibers exhibited fast antibacterial release and sustained antioxidant release, showing promise as potential wound dressing materials with good cytocompatibility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Miaomiao Zhang, Shixin Xu, Chen Du, Ruoying Wang, Cuicui Han, Yongan Che, Wei Feng, Chengwei Wang, Shan Gao, Wen Zhao
Summary: In this study, a novel bilayer wound dressing made of poly(L-lactate-caprolactone) copolymer (PLCL) nanofibrous and keratin hydrogel loaded with fibroblast growth factor (FGF-2) was prepared using the low-pressure filtration-assisted method. The bilayer dressing was found to mimic the dermis and epidermis. It exhibited good porosity, maximum water absorption, and tight bond at the interface. In vitro and in vivo studies demonstrated the biocompatibility, biodegradability, and ability to promote skin healing of the bilayer dressing, making it a promising biomedical wound dressing for skin tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Polymer Science
Chang Huang, Xizi Xu, Junhao Fu, Deng-Guang Yu, Yanbo Liu
Summary: Bleeding control is crucial in healthcare, which has led to advancements in wound dressing research and development. Electrospun polyacrylonitrile nanofibers offer excellent properties for wound dressings, showing great potential in manufacturing.
Review
Pharmacology & Pharmacy
Young-A Heo
Summary: A topical gel containing birch bark extract and sunflower oil has been approved in the EU and UK for the treatment of partial thickness wounds. Birch bark extract can accelerate wound healing, improve wound burden and symptoms. Current evidence suggests it is an effective and emerging treatment option.
Review
Pharmacology & Pharmacy
Young-A Heo
Summary: Birch bark extract is an effective treatment option for patients with dystrophic and junctional EB, as it accelerates wound healing and improves wound burden.
Article
Biophysics
Xiaozhou Li, Xuxuan Yang, Zicheng Wang, Yanxiang Liu, Jiaxiang Guo, Yu Zhu, Jiaxing Shao, Jiage Li, Lin Wang, Ke Wang
Summary: The research developed an antibacterial xerogel film using natural antibacterial agent quercetin and poly(vinyl alcohol), which exhibited multiple functions including promoting wound healing, antioxidation, self-healing, and significantly accelerating the healing of skin wounds compared to commercial dressings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Fahimeh Kazeminava, Siamak Javanbakht, Mohammad Nouri, Khosro Adibkia, Khudaverdi Ganbarov, Mehdi Yousefi, Majid Ahmadi, Pourya Gholizadeh, Hossein Samadi Kafil
Summary: In this study, citric acid-based quantum dots were used as a crosslinked agent to synthesize carboxymethyl cellulose/polyvinyl alcohol nanofibers. The resulting nanofibers demonstrated good cytocompatibility and antibacterial efficacy, making them potential wound healing scaffolds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Hursima Izgis, Elif Ilhan, Cevriye Kalkandelen, Emrah Celen, Mehmet Mucahit Guncu, Hilal Turkoglu Sasmazel, Oguzhan Gunduz, Denisa Ficai, Anton Ficai, Gabriel Constantinescu
Summary: In this research, environmentally and cost-effective antimicrobial zinc oxide nanoparticles were produced using a green synthesis method. The nanoparticles were examined for their morphology and chemical properties, and loaded into nanofibers for tissue engineering applications such as wound dressings. The antimicrobial activity of the nanofibers was tested against representative strains of bacteria and fungi. The strength and degradation behavior of the nanofibers were also assessed. The findings suggest that the zinc oxide nanoparticle-loaded nanofibers can be successfully used in tissue engineering applications.
Article
Polymer Science
Claudia Mouro, Ana P. Gomes, Isabel C. Gouveia
Summary: This research focuses on the development of an electrospun wound dressing material made of Poly (L-lactic acid) (PLLA)/Poly (vinyl alcohol) (PVA)/Chitosan (CS). The results showed that the produced electrospun PLLA/PVA/CS fiber mats have properties similar to the extracellular matrix of the skin and can prevent the growth of Staphylococcus aureus without causing harm to normal human dermal fibroblasts. This suggests that these electrospun dressing mats are beneficial in preventing wound infections and facilitating healing.
Article
Pharmacology & Pharmacy
Kashif Ahmad Ghaffar, Rolf Daniels
Editorial Material
Pharmacology & Pharmacy
Dominique Jasmin Lunter, Rolf Daniels
Article
Chemistry, Medicinal
Magda Rhayanny Assuncao Ferreira, Rolf Daniels, Luiz Alberto Lira Soares
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2020)
Article
Pharmacology & Pharmacy
Johannes Schmid, Martin A. Wahl, Rolf Daniels
Summary: The loading of 3D printed drug carriers with APIs using supercritical CO2 shows potential for personalized medicine. By adjusting the pore sizes of the carriers, the drug release rate of the dosage forms can be easily tailored to individual needs.
Article
Pharmacology & Pharmacy
Tianyuan Fan, Rolf Daniels
Summary: Polylactic acid (PLA) was chosen as the electrospinnable polymer for producing triterpene extract (TE)-loaded electrospun fibers. A binary solvent system of dichloromethane (DCM) and dimethyl sulfoxide (DMSO) was optimized for preparing smooth and uniform fibers. The results revealed that TE-loaded electrospun PLA microfibers have promising future prospects in wound therapy.
Article
Pharmacology & Pharmacy
Melanie Sigg, Rolf Daniels
Summary: Alkanediols such as 2-methyl-2,4-pentanediol, 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol can affect the release of triamcinolone acetonide from dermal formulations by influencing solubility and drug suspension. The addition of alkanediols alters the drug release rate, with longer chain lengths increasing solubility and release rate, but also causing drug suspension. The release of triamcinolone acetonide exhibits a Higuchi kinetic pattern in the presence of alkanediols.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Melanie Sigg, Rolf Daniels
Summary: Alkanediols are found to enhance the skin penetration of triamcinolone acetonide, with the extent depending on the formulation used. Longer-chained alkanediols cause the lipids to convert to a more disordered state, favoring drug penetration. Conversely, shorter-chained alkanediols do not exhibit this behavior. Their penetration-enhancing effect is believed to be linked to an interaction with the hydrophilic regions of the stratum corneum.
Article
Radiology, Nuclear Medicine & Medical Imaging
Victor Fritz, Petros Martirosian, Juergen Machann, Rolf Daniels, Fritz Schick
Summary: The study investigated the suitability of different emulsifiers in oil-in-water emulsions used as tissue analogs for MRI experiments. It was found that soy lecithin is the preferred emulsifier due to its high stabilizing ability and invisibility in MRI experiments. Additionally, lecithin can adjust relaxation times and ADC values of water, making it an alternative means for MRI experiments.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Manuel Bunk, Rolf Daniels
Summary: This study focused on the development of foamable emulsions based on aqueous phospholipid blends. The type of cosurfactant and oil phase were found to affect the quality of the resulting foam. Foam formulations are safe and effective therapy options for the treatment of chronic skin conditions.
Article
Pharmacology & Pharmacy
Nuno F. da Costa, Rolf Daniels, Ana I. Fernandes, Joao F. Pinto
Summary: This work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The study found that the flowability of amorphous and co-amorphous OLZ powders decreased compared to crystalline OLZ, but resulted in enhanced water solubility. However, the release rate of the drug decreased in tablets with amorphous OLZ. The research highlights the stability of amorphous and co-amorphous OLZ during tableting and the positive effect of compaction pressure on the formation of co-amorphous OLZ.
Article
Biochemistry & Molecular Biology
Nuno F. da Costa, Rolf Daniels, Ana Fernandes, Joao F. Pinto
Summary: The preparation of amorphous and co-amorphous systems effectively addresses solubility and bioavailability issues. This study evaluated the stability of amorphous olanzapine and olanzapine co-amorphous systems during wet granulation and pelletization. The results showed that the co-amorphous systems were more stable and had higher solubility and dissolution rate, suggesting the potential to reduce production costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Ann-Kathrin Widmann, Martin A. Wahl, Dietmar R. Kammerer, Rolf Daniels
Summary: The study investigated the extraction of Curcuma longa rhizomes using supercritical carbon dioxide at different pressure and temperature conditions, with the optimum yield achieved at 425 bar and 75 degrees C. A comparison was made between supercritical carbon dioxide extraction and solvent extraction using methanol and n-hexane, and the stability of the extracts under different storage conditions was monitored.
Article
Biochemistry & Molecular Biology
Lilo K. Mailaender, Peter Lorenz, Hannes Bitterling, Florian C. Stintzing, Rolf Daniels, Dietmar R. Kammerer
Summary: Matricaria recutita L., or German chamomile, is a widely used medicinal plant with proven efficacy. This study focused on the less explored roots of chamomile and found various active compounds. The root extracts showed antioxidant and antibacterial activities. The results highlight the potential medicinal value of chamomile roots.
Article
Pharmacology & Pharmacy
Ulrike Soepper, Anja Hoffmann, Rolf Daniels
Summary: Transmucosal drug delivery using mucoadhesive carrier systems, including CBD-loaded silica carriers and polymers like HPMC, chitosan, and carbomer, showed promising results in enhancing buccal retention and mucosal penetration. However, while HPMC and carbomer significantly improved mucoadhesion, they hindered CBD penetration, requiring the use of propylene glycol as an enhancer. Chitosan, on the other hand, increased mucoadhesion and enhanced CBD absorption, making it a promising polymer for combined effects in drug delivery.
SCIENTIA PHARMACEUTICA
(2021)
Article
Pharmacology & Pharmacy
Janosch Klinger, Rolf Daniels
Summary: This study tested a mass-based method for the extemporaneous preparation of low-dose pediatric capsules and found that the quality of the capsules depends on the homogeneity of the powder mixture and the use of defined parameters for capsule preparation.