期刊
MOLECULES
卷 25, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/molecules25173948
关键词
pyrazolo[4; 3-e][1; 2; 4]triazines; anticancer activity; sulfonamides; 1; 2; 4-triazine; fused tetrazole derivatives; fluviols
资金
- Siedlce University of Natural Sciences and Humanities
This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.
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