Article
Oncology
Jin Gu, Erlei Zhang, Binyong Liang, Zunyi Zhang, Xiaoping Chen, Min Xiong, Zhiyong Huang
Summary: In HCC patients with Child-Pugh grade A liver function, cirrhosis staging can be determined by measuring liver collagen contents using Collagen Proportional Area (CPA), which significantly affects the risk of Posthepatectomy Liver Failure (PHLF). The study also found a significant correlation between CPA and a non-invasive method called Cirrhotic Severity Scoring (CSS) proposed by the team, showing that higher CPA values and extent of hepatectomy are independent risk factors for PHLF, and there is a positive correlation between CPA and CSS.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Koya Yasukawa, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Hikaru Hayashi, Yuji Soejima
Summary: This study aimed to investigate the impact of liver fibrosis on the prognosis of patients with hepatocellular carcinoma (HCC). The results showed that patients with more severe liver fibrosis had worse cancer-specific prognosis. Moreover, patients with liver fibrosis had a higher incidence of multiple recurrences.
Article
Oncology
Amy K. Kim, James P. Hamilton, Selena Y. Lin, Ting-Tsung Chang, Hie-Won Hann, Chi-Tan Hu, Yue Lou, Yih-Jyh Lin, Terence P. Gade, Grace Park, Harry Luu, Tai-Jung Lee, Jeremy Wang, Dion Chen, Michael G. Goggins, Surbhi Jain, Wei Song, Ying-Hsiu Su
Summary: The study found that urine circulating tumor DNA can be used as a potential screening test for hepatocellular carcinoma, especially in patients with low serum AFP levels, and it can improve the detection rate of early-stage HCC.
BRITISH JOURNAL OF CANCER
(2022)
Review
Cell Biology
Venkateish Vp, Anbarasu Kannan, Madan Kumar Perumal
Summary: Extracellular vesicles, membrane-bound cargos of varying size, play a vital role in transmitting information between cells and organs. In obesity, dysfunctional adipocytes release extracellular vesicles with altered cargo contents, contributing to the progression of chronic liver diseases. This review extensively discusses the impact of adipocyte-derived extracellular vesicles on liver inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma, highlighting the need for newer approaches to utilize these vesicles as biomarkers for diagnosing initial liver inflammation before it becomes irreversible.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Julien Guillard, Valerie Untereiner, Roselyne Garnotel, Camille Boulagnon-Rombi, Cyril Gobinet, Isabelle Proult, Ganesh Dhruvananda Sockalingum, Gerard Thiefin
Summary: This study analyzed the progressive development of cirrhosis in two mouse models using Fourier transform infrared spectral histology. The results showed that glycogen depletion is an early event in the pathological process of cirrhosis, and there is a progressive increase in nucleic acid content during hepatic lesions. These findings provide insights into the pathogenesis of cirrhosis.
LABORATORY INVESTIGATION
(2023)
Review
Oncology
Anshuli Razdan, Nathan M. Main, Vincent Chiu, Nicholas A. Shackel, Paul de Souza, Katherine Bryant, Kieran F. Scott
Summary: Liver cancer, with variable incidence globally and high mortality, typically presents histologically as hepatocellular carcinoma (HCC). Limited treatment options are available for approximately 30-40% of HCC patients diagnosed at an advanced stage, emphasizing the need for novel therapeutic targets. Chronic liver injury from insults like viral infections, alcohol abuse, and NAFLD can progress to HCC, with the eicosanoid pathway being a key pathway studied for its role in inflammation and carcinogenesis. Identifying components of this pathway may hold promise for potential therapeutic targets in HCC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Manon Falette Puisieux, Anna Pellat, Antoine Assaf, Claire Ginestet, Catherine Brezault, Marion Dhooge, Philippe Soyer, Romain Coriat
Summary: Hepatocellular carcinoma (HCC) is a major health problem and the fourth leading cause of cancer-related mortality worldwide. The prognosis for advanced HCC is poor, and the selection of optimal treatment remains a challenge. However, recent studies have shown that the combination of atezolizumab and bevacizumab can significantly improve survival and is recommended as the first-line treatment for advanced HCC. Other treatments, such as regorafenib and cabozantinib, can be considered for disease progression. Transarterial chemoembolization is also an alternative treatment for patients with intermediate-stage HCC. The accurate estimation of liver function is crucial for therapeutic management.
Article
Multidisciplinary Sciences
Christine E. Orr, Peter L. Wang, Lina Chen, Tao Wang
Summary: Cirrhosis is a major risk factor for developing hepatocellular carcinoma, but many surgically resected HCCs are non-cirrhotic. This study found that most resected HCCs from non-cirrhotic patients exhibited features of fibrosis regression in the background liver, suggesting the presence of previously advanced liver disease.
Article
Gastroenterology & Hepatology
Myung-Ho Kim, Mi-Young Kim, Shadi Salloum, Tongqi Qian, Lai Ping Wong, Min Xu, Yoojin Lee, Stuti G. Shroff, Ruslan Sadreyev, Kathleen E. Corey, Thomas F. Baumert, Yujin Hoshida, Raymond T. Chung
Summary: The study found that lipophilic statins, especially atorvastatin, can more significantly suppress the activation of YAP and AKT pathways, which are associated with liver cancer development. Atorvastatin also attenuates a high-risk clinical prognostic liver signature in models of hepatitis C and nonalcoholic fatty liver disease. These findings suggest that atorvastatin is the most potent statin in reducing the risk of liver cancer in patients with viral and metabolic liver diseases.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Health Care Sciences & Services
Evgenia Kotsifa, Chrysovalantis Vergadis, Michael Vailas, Nikolaos Machairas, Stylianos Kykalos, Christos Damaskos, Nikolaos Garmpis, Georgios D. Lianos, Dimitrios Schizas
Summary: HCC is the most common primary liver malignancy associated with liver cirrhosis and chronic liver disease. Key risk factors for HCC development include viral infections, alcoholic liver disease, and nonalcoholic fatty liver disease. Treatment options for HCC depend on tumor burden, liver function, and patient's health status, with surgical resection, transplantation, ablation, TACE, and systemic therapy being potential strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Yutaka Nakamura, Hisamitsu Miyaaki, Satoshi Miuma, Yuko Akazawa, Masanori Fukusima, Ryu Sasaki, Masafumi Haraguchi, Akihiko Soyama, Masaaki Hidaka, Susumu Eguchi, Kazuhiko Nakao
Summary: This study found that analyzing the fibrotic histological phenotypes in non-tumor lesions can effectively distinguish hepatocellular carcinoma (HCC) from non-HCC.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Tomomi Kogiso, Takaomi Sagawa, Makiko Taniai, Eriko Shimada, Kei Inai, Tokuko Shinohara, Katsutoshi Tokushige
Summary: This study found that the complication of polysplenia and a higher MELD-XI score may be independent risk factors for the development of hepatocellular carcinoma (HCC) in patients with Fontan-associated liver disease (FALD), and patients with these risk factors tend to have a poor prognosis.
Review
Biochemistry & Molecular Biology
Reina Sasaki-Tanaka, Ranjit Ray, Mitsuhiko Moriyama, Ratna B. Ray, Tatsuo Kanda
Summary: Alcohol is a major cause of liver diseases, such as liver cirrhosis and hepatocellular carcinoma. This is due to the conversion of alcohol to acetaldehyde in hepatocytes, leading to various liver damage, as well as the production of toxins from intestinal bacteria aggravating inflammation. Genetic factors also play a role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Daniel Q. Huang, Darren J. H. Tan, Cheng Han Ng, Maral Amangurbanova, Nancy Sutter, Phoebe Wen Lin Tay, Wen Hui Lim, Jie Ning Yong, Ansel Tang, Nicholas Syn, Mark D. Muthiah, Eunice X. X. Tan, Shravan Dave, Benjamin Tay, Abdul M. Majzoub, Danielle Gerberi, Beom Kyung Kim, Rohit Loomba
Summary: A pooled analysis of time-to-event data revealed that the incidence of hepatocellular carcinoma (HCC) in alcohol-associated cirrhosis is significant, with cumulative risks of 3% and 9% at 5 and 10 years, respectively.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Respiratory System
Julien Braux, Marie-Laure Jourdain, Christine Guillaume, Valerie Untereiner, Olivier Piot, Andrea Baehr, Nikolai Klymiuk, Nathalie Winter, Mustapha Berri, Dominique Buzoni-Gatel, Ignaccio Caballero, Antoine Guillon, Mustapha Si-Tahar, Jacky Jacquot, Frederic Velard
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Biochemical Research Methods
Dinesh K. R. Medipally, Daniel Cullen, Valerie Untereiner, Jane Bryant, Ganesh D. Sockalingum, Thi N. Q. Nguyen, Emma Noone, Shirley Bradshaw, Marie Finn, Mary Dunne, Aoife M. Shannon, John Armstrong, Aidan D. Meade, Fiona M. Lyng
JOURNAL OF BIOPHOTONICS
(2020)
Article
Biochemistry & Molecular Biology
Hossam Taha Mohamed, Valerie Untereiner, Gianfelice Cinque, Sherif Abdelaziz Ibrahim, Martin Goette, Nguyet Que Nguyen, Romain Rivet, Ganesh D. Sockalingum, Stephane Brezillon
Article
Biochemistry & Molecular Biology
Charlie Colin-Pierre, Valerie Untereiner, Ganesh D. Sockalingum, Nicolas Berthelemy, Louis Danoux, Vincent Bardey, Solene Mine, Christine Jeanmaire, Laurent Ramont, Stephane Brezillon
Summary: This study utilized infrared spectral imaging (IRSI) to investigate the expression and distribution changes of glypicans in different hair follicle compartments during various phases of the hair growth cycle, providing a new perspective on hair shaft growth. The results demonstrate the capability of IRSI to simultaneously reveal the location of proteins, PGs, GAGs, and sulfated GAGs in hair follicles in a reagent- and label-free manner.
Article
Medicine, Research & Experimental
Pascaline Bouzy, Shane O'Grady, Honey Madupalli, Mary Tecklenburg, Keith Rogers, Francesca Palombo, Maria P. Morgan, Nicholas Stone
Summary: The study investigates the mineralization of MDA-MB-231 breast cancer cells using Raman micro-spectroscopy. Results indicate that the uptake of inorganic phosphate (Pi) accelerates mineralization, while the uptake of beta-Glycerophosphate (beta G) suggests the presence of a precursor phase during hydroxyapatite crystal formation.
LABORATORY INVESTIGATION
(2021)
Article
Genetics & Heredity
Thomas Hunaut, Camille Boulagnon-Rombi, Hugo Thorn, Martine Doco-Fenzy, Gerard Thiefin
Summary: Cockayne syndrome (CS) is a rare autosomal recessive genetic disorder characterized by growth failure and multisystem dysfunction. A case study reported here presents a 21-year-old CS patient who developed jaundice following treatment with metronidazole (MTZ) combined with spiramycin for dental care. Liver biopsy showed portal and lobular inflammation with severe cholestasis, but no bile duct damage. Jaundice regressed over 6 weeks. This case underscores the importance of strictly avoiding the prescription of MTZ in CS patients.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Oncology
Camille Mazza, Vincent Gaydou, Jean-Christophe Eymard, Philippe Birembaut, Valerie Untereiner, Jean-Francois Cote, Isabelle Brocheriou, David Coeffic, Philippe Villena, Stephane Larre, Vincent Vuiblet, Olivier Piot
Summary: Assessing the tumor response to chemotherapy is crucial for improving patient care. In this study, we used infrared spectroscopy to analyze tissue samples from muscle-invasive bladder cancer and developed a classification model to predict the response to chemotherapy. This study highlights the potential of infrared imaging for personalized treatment.
Article
Oncology
Pierre Nizet, Valerie Untereiner, Ganesh D. Sockalingum, Isabelle Proult, Christine Terryn, Albin Jeanne, Lise Nannan, Camille Boulagnon-Rombi, Christele Sellier, Romain Rivet, Laurent Ramont, Stephane Brezillon
Summary: Lumican inhibits the growth of ovarian cancer by altering collagen fibrilogenesis. Immunohistochemical analysis confirmed the impact of lumican on tumor growth through this mechanism.
Article
Medicine, Research & Experimental
Julien Guillard, Valerie Untereiner, Roselyne Garnotel, Camille Boulagnon-Rombi, Cyril Gobinet, Isabelle Proult, Ganesh Dhruvananda Sockalingum, Gerard Thiefin
Summary: This study analyzed the progressive development of cirrhosis in two mouse models using Fourier transform infrared spectral histology. The results showed that glycogen depletion is an early event in the pathological process of cirrhosis, and there is a progressive increase in nucleic acid content during hepatic lesions. These findings provide insights into the pathogenesis of cirrhosis.
LABORATORY INVESTIGATION
(2023)
Article
Parasitology
Bastian Marquis, Florent Demonmerot, Carine Richou, Gerard Thiefin, Laurence Millon, Martine Wallon, Dominique Angele Vuitton, Anne Grall-Jezequel, Frederic Grenouillet, Olivier Epaulard, Philippe Gervais, Oriol Manuel, Solange Bresson-Hadni
Summary: This study aimed to investigate the occurrence of alveolar echinococcosis (AE) in transplant patients. The research found that AE had a higher mortality and faster clinical progression in transplant patients, possibly due to the reactivation of latent liver lesions through immunosuppression, and suggested the use of Western blot serology as the preferred diagnostic method. Surgery had a low success rate and high mortality, while conservative treatment with albendazole was well tolerated.
Article
Chemistry, Analytical
Pascaline Bouzy, Iain D. Lyburn, Sarah E. Pinder, Robert Scott, Jessica Mansfield, Julian Moger, Charlene Greenwood, Ihssane Bouybayoune, Eleanor Cornford, Keith Rogers, Nick Stone
Summary: Microcalcifications play a key role in cancer detection, but linking their morphology, composition, and the nature of a specific breast lesion is challenging. By utilizing vibrational spectroscopy and multiphoton imaging techniques, we explored the composition of microcalcifications in depth. Through O-PTIR and Raman spectroscopy, we confirmed the presence of carbonate ions in microcalcifications for the first time, and multiphoton imaging allowed us to create stimulated Raman histology (SRH) images that provide chemical information similar to histological images. In conclusion, we established an efficient protocol for analyzing microcalcifications through iterative refinement of the area of interest.
ANALYTICAL METHODS
(2023)