Article
Biochemistry & Molecular Biology
Gopal Venkateshbabu, M. K. Prasannakumar, Subban Kamalraj, Karthik. S. Narayan, Perumal Palani
Summary: This study isolated and identified Curvularia lunata, the pathogen that causes black kernel disease in rice. The experiment showed that the gene expression of Cl3HNR, the trihydroxynaphthalene reductase in C. lunata, was downregulated when treated with the fungicide tricyclazole. Further analysis revealed interaction points within the active site of Cl3HNR. This research highlights the importance of melanin biosynthetic genes in the pathogenesis of C. lunata and provides a basis for developing enzyme inhibitors to control rice diseases.
PROCESS BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Qin, Chengming Tian, Fanli Meng
Summary: This study found that the pressure in the mature appressorium of the anthracnose pathogen is influenced by melanin synthesis-related genes and fatty acid metabolism pathway genes. These observations may highlight the co-evolution between the pathogen and its host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Shaoqing Wang, Zhixiang Lu, Bo Lang, Xinhua Wang, Yaqian Li, Jie Chen
Summary: This review summarizes research on the understanding of Curvularia leaf spot (CLS) in China, including the biological characteristics of the disease, virulence factors of Curvularia lunata, host resistance genetics, and disease management strategies.
Article
Mycology
Xiaolian Wang, Dongxiao Lu, Chengming Tian
Summary: In Colletotrichum gloeosporioides, CgCmr1 and CgPks1 play important roles in DHN melanin biosynthesis, but melanin is not essential for penetration and pathogenicity. Deletion of CgCmr1 and CgPks1 results in hypersensitivity to hydrogen peroxide oxidative stress, but not to other abiotic stresses.
Article
Plant Sciences
Dandan Fu, Jiayang Li, Xue Yang, Wenling Li, Zengran Zhou, Shuqin Xiao, Chunsheng Xue
Summary: Iron is essential for activating maize resistance against Curvularia lunata by recruiting more iron and causing ROS bursts after infection, which highlights the important role of iron in plant-pathogen interactions. The up-regulation of genes related to intracellular iron consumption and ROS production, as well as iron homeostasis, further supported the involvement of iron in maize defense mechanisms.
Review
Biochemistry & Molecular Biology
Anthony L. Sylvester, David X. Zhang, Sophia Ran, Natalya S. Zinkevich
Summary: Reactive oxygen species (ROS) play important roles in health and disease, with both beneficial and harmful effects. Different sources of ROS have different roles in various pathologies. NOX1 is associated with hypertension through ROS production, making it a promising therapeutic target. NOX2 and NOX4 produce hydrogen peroxide, influencing cellular processes. Increased ROS production from NOX5 contributes to atherosclerosis.
Article
Biochemistry & Molecular Biology
Jinxin Gao, Jie Chen
Summary: The study reveals the interactions of the Clt1 protein with xylanase and acetyl xylan esterase, providing important insights into the growth and metabolism of Curvularia. Additionally, the down-regulation of PKS18 and its surrounding genes in the toxin production-deficient mutant T806 possibly indicates their role in toxin biosynthesis in Curvularia.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Microbiology
Fen Wang, Kexin Liu, Jiahui Wang, Yuxin Sun, Shuqin Xiao, Chunsheng Xue
Summary: Research identified the involvement of ROS metabolic genes and key signaling genes of MAPK and cAMP-PKA pathways in cell fate decisions, sexual reproduction, and host infection in Curvularia lunata. H2O2 acts as a signaling molecule regulating these processes.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukas Gola, Laura Bierhansl, Julia Csatari, Christina B. Schroeter, Lisanne Korn, Venu Narayanan, Manuela Cerina, Sara Abdolahi, Anna Speicher, Alexander M. Hermann, Simone Koenig, Albena T. Dinkova-Kostova, Tawfeeq Shekh-Ahmad, Sven G. Meuth, Heinz Wiendl, Ali Gorji, Matthias Pawlowski, Stjepana Kovac
Summary: Hyperexcitability is associated with neuronal dysfunction, cellular death, and neurodegeneration. NOX4, an NADPH oxidase, is found to regulate reactive oxygen species (ROS) levels and calcium homeostasis, thereby preventing hyperexcitability and neuronal death. These findings suggest that NOX4 might have a crucial role in neurodegenerative diseases by acting as a potential redox regulator.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mara Fiorani, Rita De Matteis, Barbara Canonico, Giulia Blandino, Alessandro Mazzoli, Mariele Montanari, Andrea Guidarelli, Orazio Cantoni
Summary: The conversion of human SW872 preadipocytes to mature adipocytes involves time-dependent changes in differentiation markers' expression, morphological changes, and accumulation of lipid droplets. Reactive oxygen species (ROS) formation was significant at specific time points during differentiation, with NADPH oxidase (NOX)-2 playing a role. Mitochondrial ROS (mROS) were only detected in the late phase of differentiation, indicating potential mitochondrial dysfunction. These findings suggest a potential link between ROS, adipogenesis, and adipose tissue dysfunction in SW872 cells.
Article
Biochemistry & Molecular Biology
Stephenson B. Owusu, Elodie Hudik, Celine Ferard, Sophie Dupre-Crochet, Eric C. D. K. Addison, Kwasi Preko, Tania Bizouarn, Chantal Houee-Levin, Laura Baciou
Summary: Simulating oxidative stress with gamma irradiation leads to shortened half-lives of neutrophils but pre-activates surviving cells to produce superoxide anions. Incomplete assembly of the NADPH oxidase complex after irradiation significantly enhances neutrophil reactivity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Man-Hau Ho, Chia-Hung Yen, Tsung-Hsun Hsieh, Tzu-Jen Kao, Jing-Yuan Chiu, Yung-Hsiao Chiang, Barry J. Hoffer, Wen-Chang Chang, Szu-Yi Chou
Summary: This study found that CCL5 plays an important role in activating GPX1 antioxidant activity during days 1-3 post-injury, protecting hippocampal neurons from ROS damage, and improving memory function after trauma.
Article
Biochemistry & Molecular Biology
Rana M. Nassif, Elias Chalhoub, Pia Chedid, Margarita Hurtado-Nedelec, Elia Raya, Pham My-Chan Dang, Jean-Claude Marie, Jamel El-Benna
Summary: Metformin exhibits anti-inflammatory effects by inhibiting the differentiation of human monocytes into proinflammatory macrophages and by limiting ROS production by macrophages via the activation of AMPK.
Article
Microbiology
Hasnaa Maksouri, Dounia Darif, Jerome Estaquier, Myriam Riyad, Christophe Desterke, Meryem Lemrani, Pham My-Chan Dang, Khadija Akarid
Summary: This study evaluated the impact of Moroccan strains of L. major and L. tropica on PMNs. The results showed that L. tropica inhibited O-2(-) production, while L. major did not. Additionally, Leishmania soluble antigens from both species inhibited O-2(-) induction.
Article
Agronomy
Jie Li, Lidan Feng, Dong Li, Xianglin Liu, Yangyang Pan, Jing He, Junxia Zhang
Summary: This study investigates the role of ROS mediated by NADPH oxidase in the growth of F. solani. The results demonstrate that NCF2 gene plays a significant role in regulating the activity of NADPH oxidase and the expression of ROS metabolism enzyme genes, which affects colony growth in F. solani. Furthermore, exogenous H2O2 treatment also influences the growth and ROS metabolism of F. solani.
Article
Engineering, Multidisciplinary
Zexing Yu, Jiaying Sun, Chao Xu, Fei Du
Summary: A novel AE source locating approach is proposed in this study, which can efficiently and accurately locate the damage source in stiffened plates. By combining the concepts of time-reversal guided wave and time-domain spectral finite element method, the focused wavefield can be rapidly obtained without the need for high-cost and large devices. Experimental validation demonstrates the feasibility and accuracy of this method.
STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL
(2023)
Article
Engineering, Civil
Junxian Zhao, Lijian Yan, Chen Wang, Yun Zhou, Ruobing Chen, Tak -Ming Chan
Summary: This paper investigates the damage-control design and seismic behavior of BRB-MFs with sliding gusset connections. The test results show that the sliding gusset connections effectively reduce the frame action at the system level, and the BRB-MF designed with the damage-control design procedure demonstrates excellent seismic performance under multiple earthquake loading levels.
ENGINEERING STRUCTURES
(2023)
Article
Environmental Sciences
Yang Li, Yonghui Wei, Yanping Wang, Yun Lin, Wenjie Shen, Wen Jiang
Summary: Millimeter wave radar SLAM technology is effective for detecting trapped vehicles in tunnel accidents. This paper presents a radar multi-path scattering theory to study the difference between false and true radar detection in closed spaces. Two radar false detection revising methods are proposed and validated through experiments.
Review
Neurosciences
Zheng Wang, Hui Xu, Hang Zhou, Yang Lei, Lulu Yang, Juan Guo, Yuxia Wang, Yunfeng Zhou
Summary: This systematic review found that tuina therapy can significantly improve the clinical efficacy and sleep quality of patients with primary insomnia, providing a theoretical basis and treatment guidance for these patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Psychiatry
Leilei Wang, Wanjun Zeng, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Song Chen, Hongzhen Fan, Xingguang Luo, Shuping Tan, Zhiren Wang, Chiang-Shan R. Li, Baopeng Tian, Li Tian, Chuanlian Ma, Yanli Li, Yunlong Tan
Summary: The study investigates the relationship between sensory gating deficits, childhood trauma, and schizophrenia onset. It is found that patients with first-episode schizophrenia have more severe childhood trauma experiences and sensory gating deficits. Sensory gating deficits might mediate the effects of childhood trauma on the onset of schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Engineering, Civil
Yun Zhou, Hetian Shao, Eric M. Lui, Genquan Zhong, Zhuang Li
Summary: This study presents an experimental and numerical investigation of a novel buckling-restrained brace made from an elliptical steel tube with a dog bone-shaped core plate (CEST-DBRB). Two CEST-DBRB specimens with different major-to-minor axis ratios were subjected to displacement-controlled cyclic loading tests. The results indicate that both specimens exhibit stable hysteretic behavior without overall buckling. However, local bulging of the steel tube was observed under large displacement amplitudes. Finite element models were developed using ABAQUS to analyze these buckling-restrained braces and to investigate stress concentrations contributing to local instability. Compared to circular BRBs, these elliptical BRBs demonstrate comparable hysteretic behavior, while being lighter and smaller in volume by 30%-40%. Additionally, a criterion to prevent steel tube bulging is proposed, along with an equation to calculate the lateral force exerted on the restraining unit by the core plate.
Article
Mechanics
Bo Liu, Yunfei Zhou
Summary: In this paper, the damage failure mechanism of unidirectional SiCf/SiC composites under uniaxial tension was studied. The interfacial shear stress was described using Coulomb's law based on the conventional shear-lag model. The matrix cracking stress and interface debonding length were calculated using energy balance and fracture mechanics debonding criterion. The effects of various factors on the matrix cracking stress and the stress-strain curve of the composites were discussed.
COMPOSITE STRUCTURES
(2023)
Article
Environmental Sciences
Yujie Zhou, Tianyun Shao, Guotao Men, Jiahao Chen, Na Li, Xiumei Gao, Xiaohua Long, Zed Rengel, Ming Zhu
Summary: This study investigated the effects of a conditioning agent and cultivating Jerusalem artichoke on saline soils in Inner Mongolia. The results showed that the application of the conditioning agent and planting Jerusalem artichoke can significantly reduce soil salinity, increase soil organic carbon fractions, and improve soil structure. Furthermore, it also alters the soil microbial community composition.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Materials Science, Multidisciplinary
Mingming Fu, Yifeng Shen, Hao Zhou, Xiaojia Liu, Wenjun Chen, Xing Ma
Summary: Gallium-based liquid metals have unique properties that have attracted significant interest in the biomedical field. Photothermal therapy has shown great development in antitumor treatment and the photothermal capability of gallium-based liquid metals provides unparalleled advantages. This review presents the major preparation methods of liquid metal micro/nanoparticles, the mechanism of liquid metal photothermal conversion, and discusses the factors affecting the photothermal properties of liquid metals. The biological applications, challenges, and opportunities for the clinical translation of liquid metals in biomedical applications are also discussed.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Oncology
Xiaofeng Zhang, Chen Yuan, Xuemin Xiao, Rui Yin, Hongzhao Lei, Yan Li, Shumao Zheng, Sijian Wen, Dongsheng Li, Xuejun Wang, Zhong Lu, Yunfeng Zhang, Weihui Zeng, Sijin He, Yuzhen Li, Dan Jian, Jun Yang, Hua Zhong, Dawei Han, Xiaoying Chen, Junfeng Zhou, Yantao Cai, Xi Peng, Zhiming Li, Xueying Liu, Tong Lin, Ruzhi Zhang, Guang Li, Yin Zhuang, Ling Liu, Yan Yan, Baoxi Wang
Summary: This study evaluated the efficacy and safety of Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) for port-wine stain (PWS) in a real-life setting and investigated factors that influence the efficacy. A total of 1679 patients were included in the study. The response rate of purple-type PWS was significantly lower than that of pink-type PWS, and the response rate was lower in male patients with an age > 3 years or <= 6 years. Hemoporfin-PDT was well tolerated.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Zhimin Yu, Yang Yang, Jiaming Sun
Summary: Y-0.9(GdxBi1-x)(0.1)BO3 phosphors were synthesized at high temperature, and their differentiated phases and micro-morphologies were determined. Strong photon emissions were observed under both ultraviolet and visible radiation, confirming the effectiveness of energy transfer from Bi3+ to Gd3+ ions. The optimal emission was obtained from Y0.9Gd0.08Bi0.02BO3 phosphor annealed at 800 degrees C, with maximum quantum yields (QYs) of 24.75% and 1.33% under 273 nm and 532 nm excitations, respectively. These UVB luminescent phosphors based on co-doped YBO3 orthoborates have potential applications in skin treatment.
Article
Chemistry, Multidisciplinary
Yang Yang, Haiyan Pei, Zejun Ye, Jiaming Sun
Summary: Amorphous Al2O3-Y2O3:Er nanolaminate films are prepared on silicon using atomic layer deposition, and the resulting metal-oxide-semiconductor light-emitting devices exhibit similar electroluminescence (EL) at 1530 nm. The addition of Y2O3 in Al2O3 reduces the electric field for Er excitation and significantly enhances the EL performance without affecting electron injection and radiative recombination of doped Er3+ ions. The 0.2 nm Y2O3 cladding layers for Er3+ ions increase the external quantum efficiency from around 3% to 8.7% and the power efficiency by nearly one order of magnitude to 0.12%. The EL is attributed to impact excitation of Er3+ ions by hot electrons, originated from Poole-Frenkel conduction mechanism within the Al2O3-Y2O3 matrix.
Article
Engineering, Biomedical
Chengnan Li, Yingying Gan, Zongshao Li, Mengjing Fu, Yuzhen Li, Xinran Peng, Yongqiang Yang, Guo-bao Tian, Yi Yan Yang, Peiyan Yuan, Xin Ding
Summary: This study reports a neutrophil-inspired antibacterial delivery system for targeted photothermal treatment, stimuli-responsive antibiotic release, and endotoxin neutralization. The system is composed of poly(lactic-co-glycolic acid) nanoparticles loaded with indocyanine green and rifampicin, coated with neutrophil membrane. The delivery system exhibited specific targeting properties, endotoxin neutralization, and synergistic antibacterial effect.
BIOMATERIALS RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Fang-e Shi, Zhe Yu, Chengyue Sun, Peiliang Gao, Haiyan Zhang, Jihong Zhu
Summary: This study aims to monitor, identify, and compare the adverse events (AEs) related to tenecteplase and alteplase, with the objective of exploring the potential safety of tenecteplase for acute ischemic stroke (AIS) and guiding its use to enhance patient safety.
EXPERT OPINION ON DRUG SAFETY
(2023)
Article
Ecology
Mingyue Yuan, Meng Na, Lettice C. Hicks, Johannes Rousk
Summary: The microbial use of resources such as carbon, nitrogen, and phosphorus plays a crucial role in decomposition and nutrient provisioning to plants. This study investigates the limiting factors for soil microorganisms in a subarctic tundra heath and examines the impact of climate change on resource availability. The results show that carbon and phosphorus are the primary limiting factors for microbial growth, with nitrogen also playing a secondary role. The availability of carbon is alleviated by litter treatment but intensified by nitrogen fertilization. Bacteria are found to be closer to phosphorus limitation compared to fungi. The findings suggest that climate change-induced changes in resource availability will affect microbial resource limitation, potentially leading to competition between plants and microorganisms and altering ecosystem productivity.
