Review
Medicine, Research & Experimental
Xuanyu Zhang, Chao Shang, Xue Qiao, Yan Guo
Summary: This review summarizes the role of immunogenic cell death (ICD) and its biomarkers in the chemoresistance of head and neck squamous cell carcinoma (HNSCC). ICD can improve patient survival and prognosis, and can be used as molecular markers for tumor diagnosis and prognosis. Additionally, the key biomarkers of ICD can be developed into new targets for regulating HNSCC chemoresistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Xinwen Wang, Shouwu Wu, Feng Liu, Dianshan Ke, Xinwu Wang, Dinglong Pan, Weifeng Xu, Ling Zhou, Weidong He
Summary: By identifying ICD-associated subtypes, a new classification system based on ICD signatures can be established in HNSCC patients, which helps in assessing prognosis and effectiveness of immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Susannah von Hofsten, Manuel K. Langer, Katja Korelin, Synnove Magnussen, Dominik Ausbacher, Trude Anderssen, Tuula Salo, Morten B. Strom, Annette Bayer, Ahmed Al-Samadi, Gerd Berge
Summary: This study explores the anticancer activity of a panel of novel compounds (marine product mimics, MPMs) against head and neck squamous cell carcinoma (HNSCC) cell lines. The results indicate that these novel MPMs are more potent than the previously reported MPM-1 and can activate the integrated stress response associated with immunogenic cell death. Cell surface expression of calreticulin and release of HMGB1 and ATP, hallmarks of immunogenic cell death, were also demonstrated. The MPMs show potential as interesting candidates for future HNSCC cancer therapies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Haibin Wang, Lian Zheng
Summary: In this study, the researchers identified two molecular subtypes and three hypoxia-immune subgroups in head and neck squamous cell carcinoma (HNSCC) patients using mRNA expression profiles. They then constructed a prognostic risk model based on these subtypes and subgroups, which showed promising potential in diagnosing and predicting prognosis in HNSCC, as well as predicting the efficacy of immunotherapy and chemotherapy.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Environmental
Guangfei Qu, Junhong Zhou, Wei Ji, Huimin Tang, Kunling Wei, Yun Zhang, Keheng Pan, Ping Ning
Summary: A versatile electrode modification material [PtCl6]2--GO colloid was prepared by adsorption of [PtCl6]2- onto protonated GO. The Pt-rGO obtained featured small Pt particle sizes (1.4 nm). The benefits of the prepared modification material and electrode modification strategies were confirmed through various electrochemical experiments.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Immunology
Zemin Tian, Xinyang Li, Delong Jiang
Summary: This study investigates the role of immunogenic cell death (ICD) in atherosclerosis (AS) using single-cell RNA sequencing data. The results indicate that mDCs and CTLs are strongly associated with the occurrence and development of AS. Furthermore, eight differentially expressed genes related to ICD were identified, which may serve as potential drug targets for AS treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yong Teng, Lixia Gao, Antti A. Makitie, Ewa Florek, Agata Czarnywojtek, Nabil F. Saba, Alfio Ferlito
Summary: This review discusses the relationship between ferroptosis and head and neck cancer treatment, including its conceptual framework, mechanism, functional aspects, and implications for tumor therapy. In addition, strategies for improving the efficacy of head and neck cancer treatment through modulation of ferroptosis are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yun Kyeong Kim, Eun Jung Kwon, Yeuni Yu, Jayoung Kim, Soo-Yeon Woo, Hee-Sun Choi, Munju Kwon, Keehoon Jung, Hyung-Sik Kim, Hae Ryoun Park, Dongjun Lee, Yun Hak Kim
Summary: This study identified the molecular differences in the microbiome of oral and non-oral head and neck squamous cell carcinoma (HNSCC) and found microbial signatures and gene pathways associated with these cancers. These results contribute to understanding the underlying biological mechanisms of these cancers.
CANCER CELL INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Jiulong Zhang, Xiaoyan Sun, Lin Liu, Xiufeng Zhao, Chunrong Yang, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: Increasing extracellular ATP can amplify immunogenic cell death cascade for cancer immunotherapy, but its intra-tumoral delivery is challenging due to the enzyme environment and tumor immunosuppressive microenvironment. To overcome these limitations, researchers have developed a tumor-permeated ATP-based immunogenic cell death amplifier.
APPLIED MATERIALS TODAY
(2022)
Article
Medicine, Research & Experimental
Zhengrui Li, Rao Fu, Xufeng Huang, Xutao Wen, Ling Zhang
Summary: This study aimed to assess the correlation between oral microbiota and the extent of bone resorption in ORN patients. The results showed that the ORN group had higher microbial abundance and species diversity, and specific microbial communities were potentially associated with ORN. In addition, an imbalance in the oral microbiota may disrupt bone regeneration by regulating specific metabolic pathways that increase osteoclastic activity. Therefore, radiation-induced ORN is associated with significant changes in the oral microbiota.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Maria Savvateeva, Anna Kudryavtseva, Elena Lukyanova, Anastasiya Kobelyatskaya, Vladislav Pavlov, Maria Fedorova, Elena Pudova, Zulfiya Guvatova, Dmitry Kalinin, Alexander Golovyuk, Elizaveta Bulavkina, Irina Katunina, George Krasnov, Anastasiya Snezhkina
Summary: This study analyzed somatic mutation profiles in HNPGLs and found that most patients had germline and somatic variants in paraganglioma susceptibility genes or related genes. The study also identified six significantly mutated genes and four mutational signatures associated with HNPGLs. These findings provide important insights into the molecular mechanisms involved in the development of HNPGLs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Michaela Plath, Johanna Gass, Mario Hlevnjak, Qiaoli Li, Bohai Feng, Xavier Pastor Hostench, Matthias Bieg, Lea Schroeder, Dana Holzinger, Marc Zapatka, Kolja Freier, Wilko Weichert, Jochen Hess, Karim Zaoui
Summary: Genomic alterations play a crucial role in the development of head and neck cancer, with computational analysis identifying common mutational signatures associated with etiological risk factors and poor prognosis. This study highlights the potential of somatic mutational signatures as a powerful tool to decipher the pathogenesis of HNC and establish reliable prognostic patterns.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Guangqi Li, Yuanjun Jiang, Guang Li, Qiao Qiao
Summary: This study comprehensively discussed the radioresistance of HNSCC, identified a group of HNSCCs that were likely to benefit from combined radiotherapy and immune checkpoint blockade, and proposed new targets for the treatment of radioresistant HNSCC.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Timothy J. Eviston, Elahe Minaei, Simon A. Mueller, Navid Ahmadi, Bruce Ashford, Jonathan R. Clark, Nicholas West, Ping Zhang, Ruta Gupta, Marie Ranson
Summary: Perineural invasion in head and neck cutaneous squamous cell carcinoma is associated with aggressive clinical behaviors leading to local recurrence and treatment failure. Gene expression analysis found significant up- and down-regulation of 144 genes in HNcSCC with extensive PNI, while focal and non PNI cohorts showed indistinguishable gene expression. A tailored panel of 10 genes was able to identify extensive PNI with high sensitivity and specificity.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ying Zhang, Ying-Kit Cheung, Dennis K. P. Ng, Wing-Ping Fong
Summary: Photodynamic therapy (PDT) utilizes photosensitizer, light, and oxygen to induce immunogenic necroptosis in tumor cells, triggering an anti-tumor immune response. This therapy directly kills tumor cells, exposes damage-associated molecular patterns on the cell surface, and increases the expression of chemokines.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Chenguang Wang, Sathyanarayana Reddy Perumalla, Ruolin Lu, Jianguo Fang, Changquan Calvin Sun
CRYSTAL GROWTH & DESIGN
(2016)
Article
Chemistry, Medicinal
Sanjeewa N. Senadheera, Ti Zhang, Chad E. Groer, M. Laird Forrest
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Oncology
Pingping Fang, Jill A. Madden, Lisa Neums, Ryan K. Moulder, M. Laird Forrest, Jeremy Chien
MOLECULAR CANCER RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Christopher Louizos, Jaime A. Yanez, M. Laird Forrest, Neal M. Davies
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2014)
Article
Chemistry, Multidisciplinary
Ruolin Lu, Chad Groer, Peter A. Kleindl, K. Ryan Moulder, Aric Huang, Jordan R. Hunt, Shuang Cai, Daniel J. Aires, Cory Berkland, M. Laird Forrest
JOURNAL OF CONTROLLED RELEASE
(2019)
Review
Chemistry, Multidisciplinary
Aric Huang, Melissa M. Pressnall, Ruolin Lu, Sebastian G. Huayamares, J. Daniel Griffin, Chad Groer, Brandon J. DeKosky, M. Laird Forrest, Cory J. Berkland
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Biochemical Research Methods
Ninad Varkhede, Peters Bjorn-Hendrik, K. Ryan Moulder, Philip Gao, Christian Schoneich, M. Laird Forrest
Summary: This study used ultra-pressure chromatography-mass spectrometry to investigate the oxidation of TPs in biological matrices. The researchers did not observe oxidation of rGH in ex-vivo and in vitro biological matrices, possibly due to factors such as minor yields of oxidation products or lack of sensitivity of the mass spectrometry method.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Aric Huang, Chad Groer, Ruolin Lu, M. Laird Forrest, J. Daniel Griffin, Cory J. Berkland
Summary: CpG or GA-CpG treatment can suppress tumor growth, but no significant enhancement was observed when combined with anti-PD-1 therapy. However, combination treatment increased immune cell infiltration. Combining GA with anti-PD-1 treatment demonstrated synergistic antitumor effects in the colon cancer model.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Raghu S. Pandurangi, Orsolya Cseh, Hema Artee Luchman, Cynthia Xiuguang Ma, Sanjeewa N. Senadheera, Marcus Laird Forrest
Summary: Traditional drug design focuses on specific targets in cancer cells, but these cells can evade interventions by activating survival pathways. A novel tumor-sensitizing technology called A priori activation of apoptosis pathways of tumor (AAAPT) aims to selectively revive tumor cells that are not responding well to current treatments. Vitamin E derivatives have been synthesized and studied for their anti-tumorigenic properties and synergistic potential with doxorubicin in vitro. Preliminary studies show that AAAPT drugs reduce invasive potential of brain tumor stem cells, synergize with doxorubicin, and enhance its therapeutic index in a breast cancer tumor rat model.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Aparna Raghavachar Chakravarti, Chad E. Groer, Huan Gong, Vivian Yudistyra, Marcus Laird Forrest, Cory J. Berkland
Summary: Next-generation cancer immunotherapies may utilize immunostimulants, such as granulocyte macrophage-colony-stimulating factor (GMCSF), to selectively activate the host immune system against tumor cells. However, the key problem with GMCSF is lack of efficacy and risk of systemic toxicity. Tumor-retentive versions of GMCSF have been designed to overcome these limitations and exhibit enhanced tumor binding and potent immunological activity for the local treatment of solid tumors.
MOLECULAR PHARMACEUTICS
(2023)
Article
Dermatology
Qiuhong Yang, Daniel J. Aires, Shuang Cai, Garth R. Fraga, Da Zhang, Cicy Z. Li, Laird Forrest
JOURNAL OF DRUGS IN DERMATOLOGY
(2014)