Therapeutic Strategies in the Development of Anti-viral Drugs and Vaccines Against SARS-CoV-2 Infection

Three Emerging Coronaviruses in Two Decades

(2020) Jeannette Guarner   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Chloroquine and hydroxychloroquine as available weapons to fight COVID-19

(2020) Philippe Colson et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Coronavirus infections and immune responses

(2020) Geng Li et al.   JOURNAL OF MEDICAL VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Pathogenicity and transmissibility of 2019-nCoV—A quick overview and comparison with other emerging viruses

(2020) Jieliang Chen   MICROBES AND INFECTION

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

(2020) Emmie de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses

(2020) Ning Wang et al.   Frontiers in Microbiology

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know

(2020) Jinoos Yazdany et al.   ANNALS OF INTERNAL MEDICINE

Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review

(2020) Adrian V. Hernandez et al.   ANNALS OF INTERNAL MEDICINE

Tocilizumab, an anti-IL-6 receptor antibody, to treat COVID-19-related respiratory failure: a case report

(2020) J.-M. Michot et al.   ANNALS OF ONCOLOGY

Why judiciously timed anti-IL 6 therapy may be of benefit in severe COVID-19 infection

(2020) Louise Cunningham et al.   AUTOIMMUNITY REVIEWS

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

Identification of a novel coronavirus causing severe pneumonia in human

(2020) Li-Li Ren et al.   CHINESE MEDICAL JOURNAL

Could Chloroquine /Hydroxychloroquine Be Harmful in Coronavirus Disease 2019 (COVID-19) Treatment?

(2020) Maurizio Guastalegname et al.   CLINICAL INFECTIOUS DISEASES

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis

(2020) Wei-jie Guan et al.   EUROPEAN RESPIRATORY JOURNAL

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

(2020) Christian A. Devaux et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies

(2020) Ming Zhao   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

(2020) Xiaochen Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Symptom of COVID‐19: Loss of Taste and Smell

(2020) Jean‐François Gautier et al.   Obesity

COVID-19 and Cancer: a Comprehensive Review

(2020) Rohit Gosain et al.   Current Oncology Reports

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

Loss of Taste and Smell as Distinguishing Symptoms of Coronavirus Disease 2019

(2020) Patrick Dawson et al.   CLINICAL INFECTIOUS DISEASES

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

(2020) David R. Boulware et al.   NEW ENGLAND JOURNAL OF MEDICINE

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

(2019) Ariane J. Brown et al.   ANTIVIRAL RESEARCH

Mitochondrial MiRNA in Cardiovascular Function and Disease

(2019) Rui Song et al.   Cells

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Origin and evolution of pathogenic coronaviruses

(2018) Jie Cui et al.   NATURE REVIEWS MICROBIOLOGY

Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity

(2018) Anna C.C. Aguiar et al.   International Journal for Parasitology-Drugs and Drug Resistance

Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy

(2017) Yu Zhang et al.   ENDOCRINE REVIEWS

Immunotherapeutic implications of IL-6 blockade for cytokine storm

(2016) Toshio Tanaka et al.   Immunotherapy

MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets

(2015) Mitsuo Kato et al.   Annals of the New York Academy of Sciences

Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors

(2015) Encouse B. Golden et al.   Neurosurgical Focus

Diabetic nephropathy—emerging epigenetic mechanisms

(2014) Mitsuo Kato et al.   Nature Reviews Nephrology

Plasma microRNAs serve as biomarkers of therapeutic efficacy and disease progression in hypertension-induced heart failure

(2013) Brent A. Dickinson et al.   EUROPEAN JOURNAL OF HEART FAILURE

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Inhibition of miR-208a Improves Cardiac Function and Survival During Heart Failure

(2011) Rusty L. Montgomery et al.   CIRCULATION

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

CCR5: From Natural Resistance to a New Anti-HIV Strategy

(2010) Lucia Lopalco   Viruses-Basel

KIR2DL5 alleles mark certain combination of activating KIR genes

(2008) Z Du et al.   GENES AND IMMUNITY