Article
Immunology
Wen-Lin Su, Chih-Pei Lin, Hui-Ching Hang, Ping-Sheng Wu, Ching-Feng Cheng, You-Chen Chao
Summary: Increased heme levels, anemia, and desaturation occur during infection. Heme and HO-1 enzyme levels significantly increased in the low SpO(2) group, but further studies are required.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Biochemistry & Molecular Biology
Tamas Gall, David Petho, Annamaria Nagy, Gyorgy Balla, Jozsef Balla
Summary: The study shows that oxidized hemoglobins, globin-derived peptides, and heme trigger diverse biological responses, including toll-like receptor 4 activation with inflammatory response, reprogramming of cellular metabolism, differentiation, stress, and even death. The damage caused by oxidized hemoglobin and heme to cells and tissues is related to the pathological consequences of hemorrhage and hemolysis in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Conor McCafferty, Tengyi Cai, Delphine Borgel, Dominique Lasne, Sylvain Renolleau, Meryl Vedrenne-Cloquet, Damien Bonnet, Jemma Wu, Thiri Zaw, Atul Bhatnagar, Xiaomin Song, Suelyn van den Helm, Natasha Letunica, Chantal Attard, Vasiliki Karlaftis, Slavica Praporski, Vera Ignjatovic, Paul Monagle
Summary: This study utilized proteomics to analyze plasma proteins in healthy children, children with MIS-C, and children with COVID-19 ARDS, and identified the affected pathways. The results revealed differentially expressed proteins among these groups and identified key pathways associated with MIS-C and COVID-19 ARDS.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Gufran Beig, Nikhil Korhale, Aditi Rathod, Sujit Maji, Saroj K. Sahu, Shruti Dole, R. Latha, B. S. Murthy
Summary: During a two-month nationwide lockdown in India amid COVID-19, there was a significant decline in carbon monoxide emissions, leading to decreased levels of CO in major cities like Delhi and Mumbai. However, local emissions and long-range transport still played a big role in influencing air quality fluctuations in these urban areas.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Paari Dominic, Javaria Ahmad, Ruchi Bhandari, Sibile Pardue, Juan Solorzano, Keerthish Jaisingh, Megan Watts, Steven R. Bailey, A. Wayne Orr, Christopher G. Kevil, Gopi K. Kolluru
Summary: The study observed significantly reduced levels of NO and H2S in COVID-19 patients, with higher levels in deceased patients. Free sulfide levels were found to be highly predictive of COVID-19 infection.
Review
Biochemistry & Molecular Biology
Malgorzata Iciek, Anna Bilska-Wilkosz, Michal Kozdrowicki, Magdalena Gorny
Summary: This article reviews the potential use of reactive sulfur compounds in the treatment or prevention of adverse effects of COVID-19. Due to their anti-inflammatory, antioxidant, and antiviral effects, certain sulfur compounds may be helpful in treating and preventing diseases caused by SARS-CoV-2.
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Review
Pharmacology & Pharmacy
Khosrow Kashfi, Kush K. Patel
Summary: This article reviews the history of carbon monoxide, highlighting its toxic effects as well as its roles as an endogenously produced molecule and therapeutic agent. The research into its physiological functions and therapeutic applications are often overshadowed by its reputation as a lethal substance.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Zeli Zhang, Jose Mateus, Camila H. Coelho, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Rosa Isela Galvez, Fernanda H. Cortes, Alba Grifoni, Alison Tarke, James Chang, E. Alexandar Escarrega, Christina Kim, Benjamin Goodwin, Nathaniel Bloom, April Frazier, Daniela Weiskopf, Alessandro Sette, Shane Crotty
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Review
Genetics & Heredity
Maurizio Dattilo, D'Amato Giuseppe, Caroppo Ettore, Yves Menezo
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2016)
Article
Urology & Nephrology
Parisa Mohammadi, Hassan Hassani-Bafrani, Marziyeh Tavalaee, Maurizio Dattilo, Mohammad H. Nasr-Esfahani
Review
Genetics & Heredity
Romualdo Sciorio, Maurizio Dattilo
Article
Endocrinology & Metabolism
N. Schiuma, A. Costantino, T. Bartolotti, M. Dattilo, V Bini, M. C. Aglietti, M. Renga, A. Favilli, A. Falorni, S. Gerli
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Article
Nutrition & Dietetics
Maurizio Dattilo, Carolina Fontanarosa, Michele Spine, Vittorio Bini, Angela Amoresano
Summary: By supplementing with micronutrients, the endogenous release and signaling of hydrogen sulfide (H2S) can be modulated in humans, affecting homeostatic functions and disease development.
NUTRITION AND METABOLIC INSIGHTS
(2022)
Article
Multidisciplinary Sciences
Arefeh Golestanfar, Amir Niasari-Naslaji, Farnoosh Jafarpour, Shiva Rouhollahi, Naeimeh Rezaei, Yves Menezo, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani
Summary: Supplementation of oocytes with metabolic enhancers of the one carbon metabolism (OCM) increases blastocyst rate in in vitro fertilization, possibly due to improved DNA methylation and epigenetic programming. The OCM supplementation enhances mitochondrial mass and DNMT3a protein expression, while reducing DNA fragmentation in matured oocytes. However, it does not directly affect the redox balance in matured oocytes. The results suggest the existence of an OCM metabolic checkpoint that hampers oocyte progression to blastocyst stage post-fertilization if not properly primed at the time of maturation.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Tansu Kucuk, Pinar Erol Horozal, Asena Karakulak, Emel Timucin, Maurizio Dattilo
Summary: This study found that follicular homocysteine is associated with the reproductive potential of oocytes in PCOS women after FSH stimulation, and it can be modulated by dietary interventions. These findings may have implications for both PCOS and non-PCOS women.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)