Article
Cell Biology
Oscar A. Pena, Alexandra Lubin, Jasmine Rowell, Yvette Hoade, Noreen Khokhar, Hanna Lemmik, Christopher Mahony, Phoebe Dace, Chianna Umamahesan, Elspeth M. Payne
Summary: Germline loss or mutation of one copy of the transcription factor GATA2 in humans results in clinical phenotypes affecting hematopoietic, lymphatic, and vascular systems. In this research, zebrafish with two copies of the Gata2 gene were used to investigate the effects of these genes on hematopoiesis during development, revealing unique roles at different stages and a potential redundancy between the two genes. The study also showed defects in the myeloid compartment in adult zebrafish with combined heterozygosity loss, similar to GATA2 loss in humans, adding to our understanding of GATA2 deficiency and its developmental effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Samuel B. Shin, Kelly M. McNagny
Summary: The discovery of innate lymphoid cells (ILCs) has expanded our understanding of innate immunity and immune cell interactions at epithelial barrier sites. ILCs, resembling helper T cell subsets in function, differ from T cells in terms of surface receptors and development pathways, potentially originating from T cell progenitors during neonatal development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jing Wu, Hang Cheng, Helei Wang, Guoxia Zang, Lingli Qi, Xinping Lv, Chunyan Liu, Shan Zhu, Mingyou Zhang, Jiuwei Cui, Hideki Ueno, Yong-Jun Liu, Jian Suo, Jingtao Chen
Summary: ILC3 and pDCs show correlations with cancer pathological stage in colorectal cancer patients. There is a negative correlation between the numbers of ILC3s and pDCs in tumor tissues. pDCs can induce apoptosis of ILC3s through the CD95 pathway.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alhomidi Almotiri, Ashleigh S. Boyd, Neil P. Rodrigues
Summary: Zeb1 plays a critical role in regulating the absolute cell number and function of lympho-myeloid primed progenitors (LMPPs), influencing the differentiation potential of HSCs and selection of hematopoietic lineages. Competitive transplantation analysis reveals a reduction in engraftment to hematopoietic organs from Zeb1-deficient mice, indicating the important role of Zeb1 in regulating LMPP differentiation potential in the context of transplantation.
Article
Biochemistry & Molecular Biology
Abhishek Niroula, Aswin Sekar, Mark A. Murakami, Mark Trinder, Mridul Agrawal, Waihay J. Wong, Alexander G. Bick, Md Mesbah Uddin, Christopher J. Gibson, Gabriel K. Griffin, Michael C. Honigberg, Seyedeh M. Zekavat, Kaavya Paruchuri, Pradeep Natarajan, Benjamin L. Ebert
Summary: Studies have shown that clonal hematopoiesis and mosaic chromosomal alterations are associated with lineage-specific hematologic malignancies, and these genetic alterations can be used in combination with blood count parameters to identify individuals at high risk.
Article
Immunology
Lucia Pena-Perez, Shabnam Kharazi, Nicolai Frengen, Aleksandra Krstic, Thibault Bouderlique, Julia Hauenstein, Minghui He, Ece Somuncular, Xiaoze Li Wang, Carin Dahlberg, Charlotte Gustafsson, Ann-Sofie Johansson, Julian Walfridsson, Nadir Kadri, Petter Woll, Marcin Kierczak, Hong Qian, Lisa Westerberg, Sidinh Luc, Robert Mansson
Summary: The study reveals the crucial roles of FOXO3 and FOXO1 in B cell development. Loss of FOXO3 impairs B cell development, while loss of FOXO1 hinders B cell commitment. Simultaneous loss of FOXO1 and FOXO3 results in the complete loss of the B cell lineage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Muxin Gu, Sruthi Cheloor Kovilakam, William G. Dunn, Ludovica Marando, Clea Barcena, Irina Mohorianu, Alexandra Smith, Siddhartha P. Kar, Margarete A. Fabre, Moritz Gerstung, Catherine A. Cargo, Luca Malcovati, Pedro M. Quiros, George S. Vassiliou
Summary: This study analyzes data from UK Biobank participants and finds that the risk of developing different types of myeloid neoplasms can be detected years before diagnosis. The authors develop a predictive model that integrates somatic gene mutations with blood test parameters, which could guide future strategies for early detection and prevention of these diseases.
Article
Hematology
Adam S. Sperling, Veronica A. Guerra, James A. Kennedy, Yuanqing Yan, Joanne Hsu, Feng Wang, Andrew T. Nguyen, Peter G. Miller, Marie E. McConkey, Vanessa A. Quevedo Barrios, Ken Furudate, Linda Zhang, Rashmi Kanagal-Shamanna, Jianhua Zhang, Latasha Little, Curtis Gumbs, Naval Daver, Courtney D. DiNardo, Tapan Kadia, Farhad Ravandi, Hagop Kantarjian, Guillermo Garcia-Manero, P. Andrew Futreal, Benjamin L. Ebert, Koichi Takahashi
Summary: There is increasing evidence that therapy-related myeloid neoplasms (t-MNs) with driver gene mutations arise in the background of clonal hematopoiesis (CH) under the positive selective pressure of chemo- and radiation therapies. This study found that lenalidomide treatment provides a selective advantage to TP53-mutant hematopoietic stem and progenitor cells (HSPCs), promoting the development of TP53-mutated t-MNs. These findings offer a potential alternative strategy to reduce the risk of t-MN development.
Review
Immunology
Tijana Martinov, Kelly M. McKenna, Wei Hong Tan, Emily J. Collins, Allie R. Kehret, Jonathan D. Linton, Tayla M. Olsen, Nour Shobaki, Anthony Rongvaux
Summary: This passage discusses the development principles and challenges of humanized mouse models, focusing on increasing mouse tolerance to human grafts and addressing functional interactions between human immunity and mouse hosts.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pamela Stanley, Ankit Tanwar
Summary: The Notch signaling pathway plays a crucial role in the development of T cells in the thymus and marginal zone B cells in the spleen, as well as in the regulation of myeloid cell production in the bone marrow. The strength of Notch signaling in different cellular contexts is optimized by the regulation of O-glycans attached to Notch receptors, which are crucial for activating Notch signaling and differentially regulated by ligand-receptor binding.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Fei Fei, Michaela Liedtke, Oscar Silva
Summary: This study reports the first case of a MPDCP associated with a lymphoid neoplasm, providing further evidence that MPDCP can arise from a multipotent hematopoietic progenitor with lymphoid and dendritic cell potential.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Ajay Abraham, William Matsui
Summary: Myeloid malignancies arise from normal hematopoiesis and the Hedgehog (HH) signaling pathway plays an important role in these diseases, with SMO inhibitors approved for the treatment of acute myeloid leukemia (AML). Despite the broad activity of SMO inhibitors in AML, clinical studies in other myeloid malignancies remain inconclusive and further research is needed to explore their efficacy.
Article
Pathology
Guilin Tang, Wayne Tam, Nicholas J. Short, Prithviraj Bose, David Wu, Stephanie N. Hurwitz, Adam Bagg, Heesun J. Rogers, Eric D. Hsi, Andres E. Quesada, Wei Wang, Roberto N. Miranda, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Valentina Nardi, Robert P. Hasserjian, Daniel A. Arber, Attilio Orazi, Kathryn Foucar, Sa A. Wang
Summary: Myeloid/lymphoid neoplasms with FLT3 rearrangement exhibit diverse disease presentations but share common features, including extramedullary involvement, associated eosinophilia, and multilineage involvement. Treatment options such as chemotherapy, FLT3 inhibitors, and hematopoietic stem cell transplant have shown therapeutic benefits for these patients.
Article
Immunology
Alessandro Marins-Dos-Santos, Jackline de Paula Ayres-Silva, Dina Antunes, Carlos Jose de Carvalho Moreira, Marcelo Pelajo-Machado, David Alfaro, Agustin G. Zapata, Adriana Cesar Bonomo, Wilson Savino, Juliana de Meis, Desio Aurelio Farias-de-Oliveira
Summary: This study demonstrates that Trypanosoma cruzi causes high tissue parasitism during the acute phase of Chagas disease. In mice with acute oral infection, the bone marrow cells are highly parasitized, particularly in the perivascular, intravascular, and near bone regions. The infection leads to a decrease in hematopoietic cells in the bone marrow, except for an increase in hematopoietic stem and progenitor cells. The study also suggests that the spleen may play a role in emergency hematopoiesis during acute T. cruzi infection. Overall, this research provides important insights into the impact of T. cruzi infection on the hematopoietic system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Binoy Yohannan, Binsah George
Summary: This article provides a comprehensive summary of the current management of Lymphoid Blast Crisis (BC), which is one of the most feared complications of chronic myeloid leukemia (CML). The incidence of BC has significantly decreased in the BCR-ABL tyrosine kinase inhibitor era, but there is still a need for novel therapies to improve the clinical outcomes of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Patrick Fernandes Rodrigues, Llucia Alberti-Servera, Anna Eremin, Gary E. Grajales-Reyes, Robert Ivanek, Roxane Tussiwand
Editorial Material
Immunology
Roxane Tussiwand, Patrick F. Rodrigues
Article
Immunology
Fabian Klein, Julien Roux, Grozdan Cvijetic, Patrick Fernandes Rodrigues, Lilly von Muenchow, Ruth Lubin, Pawel Pelczar, Simon Yona, Panagiotis Tsapogas, Roxane Tussiwand
Summary: The study shows that an uncommitted precursor expressing TdT can generate a large fraction of myeloid and erythro-megakaryocyte cells. Developmental trajectories of hematopoietic stem cells towards different lineages are determined by intrinsic and extrinsic cues. The transient induction of TdT on MPPs reflects a transcriptionally dynamic but uncommitted stage, associated with multilineage differentiation potential.
Article
Immunology
Patrick Fernandes Rodrigues, Athanasios Kouklas, Grozdan Cvijetic, Nicolas Bouladoux, Mladen Mitrovic, Jigar V. Desai, Djalma S. Lima-Junior, Michail S. Lionakis, Yasmine Belkaid, Robert Ivanek, Roxane Tussiwand
Summary: Plasmacytoid dendritic cells (pDCs) play a critical role in immune responses, but recent studies have discovered a previously unknown immune subset called pDC-like cells. These cells not only resemble pDCs but also have features of conventional DCs (cDCs). It has been found that a significant proportion of cDC2s originate from these pDC-like cells, which can be referred to as pre-DC2. This precursor subset responds to homeostatic cytokines and differentiates into cDC2, which prime T helper 17 (TH17) cells. The development of pre-DC2 into specific cDC2 subsets requires the transcription factor KLF4 and plays a role in regulating immune responses at barrier sites.
SCIENCE IMMUNOLOGY
(2023)
