Review
Cell Biology
Zhixiang Wang
Summary: The cell cycle is a series of events driving cell division and production of two new daughter cells, involving phases G1, S, G2, and M. Progression is mediated by Cdks and their cyclin subunits, but growth factor signaling pathways are the driving force. Role of growth factor signaling in phases other than G1 is still poorly understood, with research focusing on regulation of cell cycle progression through different phases.
Review
Endocrinology & Metabolism
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
Summary: The androgen receptor signaling pathway is crucial for spermatogenesis in the testes. Sertoli cells, the only somatic cell type in seminiferous tubules, are regulated by this pathway, which affects both Sertoli and germ cells. The pathway plays roles in Sertoli cell proliferation and maturation, as well as the integrity of the blood-testis barrier. Meiotic and post-meiotic processes are also regulated by this pathway, ensuring the development and release of mature sperm.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Katharina Wissmiller, Sara Bilekova, Andras Franko, Stefan Z. Lutz, Miriam Katsburg, Sebastian Gulde, Natalia S. Pellegata, Arnulf Stenzl, Martin Heni, Lucia Berti, Hans-Ulrich Haering, Heiko Lickert
Summary: The novel insulin/IGF1 signaling modulator inceptor has been found to play a crucial role in prostate cancer progression, with its expression positively correlated with certain genes involved in androgen signaling. In vitro experiments showed that inceptor expression was associated with androgen status, increased cell migration, and IGF1R signaling. These findings provide a basis for further investigation of inceptor in the context of prostate cancer.
MOLECULAR METABOLISM
(2023)
Review
Endocrinology & Metabolism
Rodolfo A. Rey
Summary: Puberty is characterized by major changes in the anatomy and function of reproductive organs, with androgen playing a crucial role in this process.
Review
Endocrinology & Metabolism
Victor A. Ruthig, Dolores J. Lamb
Summary: Since their discovery, Sertoli cells have fascinated researchers in the field of testis biology. They play a crucial role in regulating germ cell state through endocrine and paracrine signals. Recent advances in understanding these signals have potential implications for treating male infertility, while Sertoli cell transplantation has emerged as a promising breakthrough.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Byeong Seong Ki, Sung Han Shim, Chanhyeok Park, Hyunjin Yoo, Hyeonwoo La, Ok-Hee Lee, Youngjoo Kwon, David G. Skalnik, Yuki Okada, Ho-Geun Yoon, Jin-Hoi Kim, Kwonho Hong, Youngsok Choi
Summary: A protein called Cfp1 has been found to play an important role in the development of sperm cells in mice. Its absence interferes with the process of meiosis, which leads to abnormal sperm formation. Cfp1 controls gene expression, including genes related to meiosis and homologous recombination.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Immunology
Rachel L. Washburn, Taylor Hibler, Gurvinder Kaur, Jannette M. Dufour
Summary: Sertoli cells serve a dual role in protecting germ cells from autoimmune destruction and activating immune responses against infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyo-Jung Kim, Bo-Ram Jin, Hyo-Jin An
Summary: Umbelliferone, derived from coumarin, has been found to exert anti-proliferative effects in BPH-1 cells by modulating the STAT3/E2F1 axis and demonstrating an anti-BPH effect in TP-induced rats by reducing prostate size and inhibiting cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hong-Yong Zhang, Ying-Chun Ouyang, Jian Li, Chun-Hui Zhang, Wei Yue, Tie-Gang Meng, Heide Schatten, Qing-Yuan Sun, Wei-Ping Qian
Summary: Gefitinib at a certain concentration does not affect oocyte maturation, but at another concentration severely blocks meiotic progression of oocytes. Treatment with gefitinib increases phosphorylation of CDK1 at the Try15 site, inhibits cyclin B1 entry into the nucleus, and disrupts normal spindle assembly, chromosome alignment, and mitochondria dynamics, ultimately leading to aneuploidy and early apoptosis of oocytes.
Article
Biochemistry & Molecular Biology
Sylwia Lustofin, Alicja Kaminska, Malgorzata Brzoskwinia, Joanna Cyran, Malgorzata Kotula-Balak, Barbara Bilinska, Anna Hejmej
Summary: This study investigates the role of androgens and estrogens, and their receptors, in regulating DSL proteins in Sertoli cells. The results show that testosterone downregulates JAG1 and DLL1 expression via membrane androgen receptor ZIP9 or nuclear androgen receptor AR, respectively. DLL4 expression is stimulated by testosterone independent of AR and ZIP9. On the other hand, 17β-estradiol upregulates the expression of all studied DSL proteins. Estrogen action on JAG1 and DLL1 is mediated chiefly via estrogen receptor alpha (ERα), while DLL4 is controlled via estrogen receptor beta (ERβ) and G-protein-coupled estrogen receptor (GPER).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Yuefeng Gao, Wei Lu, Luyang Jian, Zoltan Machaty, Hailing Luo
Summary: The effect of Vitamin E on the proliferation of ovine Sertoli cells was investigated. Vitamin E was found to effectively promote cell proliferation by enhancing progression through the cell cycle and affecting the expression of genes that regulate cell division. This indicates a positive effect of Vitamin E on sheep reproductive performance.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Plant Sciences
Han-Tsang Wu, Joseph Lin, Yi-En Liu, Hsiao-Fan Chen, Kai-Wen Hsu, Shu-Hsuan Lin, Kai-Yen Peng, Kuo-Juei Lin, Chang-Chi Hsieh, Dar-Ren Chen
Summary: The study showed that luteolin effectively inhibited the proliferation and metastasis of androgen receptor-positive TNBC, reversing the epithelial-mesenchymal transition and downregulating MMP9 expression. The combination of luteolin and AKT/mTOR inhibitors synergistically suppressed the proliferation and metastasis of androgen receptor-positive TNBC cells.
Review
Endocrinology & Metabolism
William W. Wright
Summary: This review focuses on the in vivo regulation of spermatogonial stem cells (SSCs) in adult testes by glial cell line-derived neurotrophic factor (GDNF). Through chemical-genetic approach, the inhibition of GDNF stimulation of SSCs was found to decrease replication and increase differentiation of SSCs, ultimately leading to the loss of all SSCs and resembling the condition of Sertoli cell-only (SCO) syndrome. Abnormally low expression of GDNF, FGF2, and FGF8 was observed in infertile human testes, although some SCO testes still contain SSCs. Restoration of GDNF signaling showed partial rebuilding of depleted SSC pool, suggesting GDNF as a potential therapy for men with SCO syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Xue Jiang, Yu Cheng, Yuzhang Zhu, Caoling Xu, Qiaodan Li, Xuemei Xing, Wenqing Li, Jiaqi Zou, Lan Meng, Muhammad Azhar, Yuzhu Cao, Xianhong Tong, Weibing Qin, Xiaoli Zhu, Jianqiang Bao
Summary: In this study, the researchers uncover the crucial role of N-acetyltransferase 10 (Nat10) in mouse oocyte development. Nat10 is shown to sculpt the maternal transcriptome by degrading poly(A) tail mRNAs, thereby facilitating oocyte meiotic prophase I progression, oocyte growth, and maturation.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Kehan Wang, Feifei Kong, Yuexin Qiu, Tao Chen, Jiayi Fu, Xin Jin, Youqiang Su, Yayun Gu, Zhibin Hu, Jing Li
Summary: Sertoli cells provide a nurturing environment for germ cell development and maturation, and the role of phosphatidylinositol 3-kinase (PtdIns3K) in Sertoli cells is unclear. Deleting the Pik3c3 gene specifically in Sertoli cells resulted in infertility, disrupted Sertoli cell polarity, and impaired spermiogenesis. Accumulation of SCIN caused the disorganization of the F-actin cytoskeleton, while accumulated HDAC6 deacetylated SCIN, leading to a disorganized F-actin cytoskeleton.
Article
Neurosciences
Aliza P. Wingo, Wen Fan, Duc M. Duong, Ekaterina S. Gerasimov, Eric B. Dammer, Yue Liu, Nadia Harerimana, Bartholomew White, Madhav Thambisetty, Juan C. Troncoso, Namhee Kim, Julie A. Schneider, Ihab M. Hajjar, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan Levey, Thomas S. Wingo
NATURE NEUROSCIENCE
(2020)
Article
Genetics & Heredity
Chloe Robins, Yue Liu, Wen Fan, Duc M. Duong, Jacob Meigs, Nadia Harerimana, Ekaterina S. Gerasimov, Eric B. Dammer, David J. Cutler, Thomas G. Beach, Eric M. Reiman, Philip L. De Jager, David A. Bennett, James J. Lah, Aliza P. Wingo, Allan Levey, Nicholas T. Seyfried, Thomas S. Wingo
Summary: The study generated an online brain pQTL resource for 7,376 proteins by analyzing genetic and proteomic data from the dorsolateral prefrontal cortex of 330 older adults. The identified pQTLs tend to be non-synonymous variations, over-represented among brain disease-associated variants, and show good replication in an independent brain dataset. Comparison with brain eQTLs revealed that most pQTLs are also eQTLs, suggesting lower pQTL mapping power and greater evolutionary constraint on protein abundance.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Selina M. Vattathil, Yue Liu, Nadia Harerimana, Adriana Lori, Ekaterina S. Gerasimov, Thomas G. Beach, Eric M. Reiman, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Nicholas T. Seyfried, Allan Levey, Aliza P. Wingo, Thomas S. Wingo
Summary: This study identified a novel genetic locus NTNG1 associated with cerebral atherosclerosis and confirmed two significant SNPs. The research also revealed that these SNPs may impact cerebral atherosclerosis by regulating brain protein expression of CNOT3.
Article
Neurosciences
Nadia Harerimana, Yue Liu, Ekaterina S. Gerasimov, Duc Duong, Thomas G. Beach, Eric M. Reiman, Julie A. Schneider, Patricia Boyle, Adriana Lori, David A. Bennett, James J. Lah, Allan Levey, Nicholas T. Seyfried, Thomas S. Wingo, Aliza P. Wingo
Summary: This study found a genetic correlation between depression and Alzheimer's disease (AD), suggesting a shared genetic basis. Depression was found to have a causal role in AD, potentially driven by specific brain transcripts and proteins. The findings highlight the importance of understanding the relationship between depression and AD.
BIOLOGICAL PSYCHIATRY
(2022)