期刊
MEDICINAL RESEARCH REVIEWS
卷 41, 期 1, 页码 314-341出版社
WILEY
DOI: 10.1002/med.21733
关键词
autophagy; autophagy flux; cardiac diseases; natural products; therapeutics
资金
- Natural Science Foundation of Guangdong Province [2015A030313476]
- National Natural Science Foundation of China [81573429, U1601227, 81573433]
Autophagy plays a crucial role in cardiac diseases, and various natural products/phytochemicals have been shown to regulate autophagy in cardiomyocytes. These compounds are essential for designing novel therapeutic agents for cardiac diseases.
The global incidence of cardiac diseases is expected to increase in the coming years, imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly regulated lysosomal degradation mechanism important for cell survival, homeostasis, and function. Accumulating pieces of evidence have indicated a major role of autophagy in the regulation of cardiac homeostasis and function. It is well established that dysregulation of autophagy in cardiomyocytes is involved in cardiac hypertrophy, myocardial infarction, diabetic cardiomyopathy, and heart failure. In this sense, autophagy seems to be an attractive therapeutic target for cardiac diseases. Recently, multiple natural products/phytochemicals, such as resveratrol, berberine, and curcumin have been shown to regulate cardiomyocyte autophagy via different pathways. The autophagy-modifying capacity of these compounds should be taken into consideration for designing novel therapeutic agents. This review focuses on the role of autophagy in various cardiac diseases and the pharmacological basis and therapeutic potential of reported natural products in cardiac diseases by modifying autophagic processes.
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