Article
Public, Environmental & Occupational Health
D. Ramonfaur, J. N. Salto-Quintana, G. M. Aguirre-Garcia, N. M. Hernandez-Mata, H. Villanueva-Lozanoc, G. Torre-Amione, M. F. Martinez-Resendez
Summary: This study evaluated the relationship between cumulative steroid dose and the risk of COVID-19 associated pulmonary aspergillosis (CAPA) in hospitalized patients with COVID-19 pneumonia. The findings showed that patients with higher cumulative steroid doses during hospitalization were more likely to develop CAPA. The risk of CAPA increased with a higher cumulative dose of steroids.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Obstetrics & Gynecology
Ashwini Maudhoo, Asma Khalil
Summary: The COVID-19 pandemic has emphasized the increased risk of adverse outcomes for pregnant women and their unborn babies, highlighting the importance of understanding the presentation and management of viral pulmonary infections.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Medicine, Research & Experimental
Kevin C. Doerschug, Gregory A. Schmidt
Summary: SARS-CoV-2 is a respiratory virus that enters through airway epithelium and is associated with certain patient factors such as obesity, tobacco use, and black race. Consolidation and ground-glass opacities on chest imaging are typical findings of COVID-19. Venous thromboembolism occurs infrequently, but capillary microthrombosis is common and contributes to hypoxemia. Remdesivir and glucocorticoids may be beneficial for hospitalized patients. Many patients continue to have symptoms and require healthcare even after two weeks of diagnosis, and lung function may be reduced in some survivors for months.
ANNUAL REVIEW OF MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Sweety Gupta, Rachit Ahuja, Nidhi Sharma, Pragya Singh, Swati Verma, Manoj Gupta
Summary: The covid-19 pandemic has greatly impacted countries worldwide, with patients often developing respiratory diseases that could progress to SARS-CoV-2 pneumonia. Severe cases of SARS-CoV-2 pneumonia trigger a systemic inflammatory response, but low-dose radiation therapy can help by reducing inflammation and modulating the immune system, thereby easing the burden on healthcare systems.
RESPIRATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Miguel Alejandro Pinzon, Santiago Ortiz, Hector Holguin, Juan Felipe Betancur, Doris Cardona Arango, Henry Laniado, Carolina Arias Arias, Bernardo Munoz, Julian Quiceno, Daniel Jaramillo, Zoraida Ramirez
Summary: The study compared the clinical outcomes and laboratory results of hospitalized patients with severe SARS-CoV2 pneumonia treated with 6 mg dexamethasone versus high-dose methylprednisolone. The high-dose methylprednisolone treatment significantly decreased recovery time, need for ICU transfer, and levels of inflammatory markers CRP, D-dimer, and LDH compared to 6 mg dexamethasone treatment. Randomized controlled trials are needed to further confirm the effectiveness of methylprednisolone in COVID-19 treatment.
Article
Infectious Diseases
Alessia Fumagalli, Clementina Misuraca, Achille Bianchi, Noemi Borsa, Simone Limonta, Sveva Maggiolini, Daniela Rita Bonardi, Andrea Corsonello, Mirko Di Rosa, Luca Soraci, Fabrizia Lattanzio, Daniele Colombo
Summary: This study aimed to assess respiratory function in patients surviving COVID-19 pneumonia. The findings suggest that patients may experience clinically relevant alterations in pulmonary function, characterized by a mainly restrictive pattern, even 6 weeks after discharge.
Article
Oncology
Catherine R. Hanna, Kathryn A. Robb, Kevin G. Blyth, Robert J. Jones, Anthony J. Chalmers
Summary: This study explored clinicians' perspectives on the potential use of low-dose radiation therapy in treating COVID-19 lung disease. Barriers identified included potential harm to patients, feasibility of trialing the treatment in clinical settings, and logistics of delivering the treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Cell Biology
Peter M. George, Anna Reed, Sujal R. Desai, Anand Devaraj, Tasnim Shahridan Faiez, Sarah Laverty, Amama Kanwal, Camille Esneau, Michael K. C. Liu, Faisal Kamal, William D. -C. Man, Sundeep Kaul, Suveer Singh, Georgia Lamb, Fatima K. Faizi, Michael Schuliga, Jane Read, Thomas Burgoyne, Andreia L. Pinto, Jake Micallef, Emilie Bauwens, Julie Candiracci, Mhammed Bougoussa, Marielle Herzog, Lavanya Raman, Blerina Ahmetaj-Shala, Stuart Turville, Anupriya Aggarwal, Hugo A. Farne, Alessia Dalla Pria, Andrew D. Aswani, Francesca Patella, Weronika E. Borek, Jane A. Mitchell, Nathan W. Bartlett, Arran Dokal, Xiao-Ning Xu, Peter Kelleher, Anand Shah, Aran Singanayagam
Summary: Interstitial lung disease and associated fibrosis can occur in COVID-19 patients after recovery, and this study provides insights into the mechanisms behind these pulmonary sequelae. The researchers found an up-regulated neutrophil-associated immune response and antiviral signaling in the blood and upper airway of patients with lung changes. Peripheral phosphoproteome analysis identified critical kinases involved in neutrophil inflammatory pathways. Some patients did not achieve full normalization of radiological and functional changes even after 12 months of recovery.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Letter
Toxicology
Rachna Kapoor, James S. Welsh, Vikas Dhawan, Seyed Alireza Javadinia, Edward J. Calabrese, Gaurav Dhawan
Summary: Coronavirus variants are spreading globally, with the United States experiencing a high death toll despite progress in vaccination. The medical community should further investigate the potential of low-dose radiation therapy for COVID-19.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Oncology
Igor Shuryak, Lisa A. Kachnic, David J. Brenner
Summary: The respiratory disease COVID-19 became a global pandemic in 2020, with excessive inflammation believed to be a key factor in severe symptoms and death. Low-dose whole-lung radiation therapy is being considered as an anti-inflammatory treatment for severe pulmonary symptoms of COVID-19, but concerns about long-term risks remain. Studies found that the radiation-induced risks for lung cancer were generally higher than major coronary events, with the highest risks in female smokers and individuals with high heart disease risk factors treated between ages 50 and 60.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Immunology
Mohadeseh Haji Abdolvahab, Shima Moradi-kalbolandi, Mohammad Zarei, Deepanwita Bose, Keivan Majidzadeh-A, Leila Farahmand
Summary: COVID-19, caused by SARS-CoV-2, is a public health crisis originating from bats and transmitted to humans. The disease is mainly spread through respiratory means with an incubation period of 2-14 days, with symptoms including fever, sore throat, and cough. Treatment focuses on supportive care and interferons, with combination therapy potentially being more effective.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Lukas M. Trunz, Patrick Lee, Steven M. Lange, Corbin L. Pomeranz, Laurence Needleman, Robert W. Ford, Ajit Karambelkar, Baskaran Sundaram
Summary: The number of COVID-19 cases associated with PE is increasing, with imaging playing a crucial role in diagnosis and treatment. Knowledge of COVID-19 related PE is rapidly evolving.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Paola Faverio, Giuseppe Paciocco, Elena Tassistro, Paola Rebora, Emanuela Rossi, Anna Monzani, Marta Tundo, Chiara Milano, Martina Messa, Raffaele Marocchi, Alberto Pesci, Giuseppe Foti, Nicola Squillace, Viola Cogliandro, Maddalena Lettino, Maria Grazia Strepparava, Giuseppe Bellelli, Carlo Ferrarese, Maria Grazia Valsecchi, Paolo Bonfanti, Fabrizio Luppi
Summary: This study aimed to identify and characterize the cardio-pulmonary sequelae in patients hospitalized for SARS-CoV-2 pneumonia at 24 months follow-up. The results showed that DLCO and TTE were the most sensitive tools to detect cardio-pulmonary sequelae after severe COVID-19. Dyspnoea was still present in about one-third of patients and required a multidisciplinary approach.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Medicine, General & Internal
Fabiola Atzeni, Ignazio Francesco Masala, Javier Rodriguez-Carrio, Roberto Rios-Garces, Elisabetta Gerratana, Laura La Corte, Manuela Giallanza, Valeria Nucera, Agostino Riva, Gerard Espinosa, Ricard Cervera
Summary: This article reviews drugs used in the treatment of COVID-19 patients, recommending the consideration of immunomodulatory drugs in severe cases, although clinical outcomes are still suboptimal. Early detection and treatment combined with a multidisciplinary approach may aid in better recovery of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
David Montani, Marie-Caroline Certain, Jason Weatherald, Xavier Jais, Sophie Bulifon, Elise Noel-Savina, Ana Nieves, Sebastien Renard, Julie Traclet, Helene Bouvaist, Marianne Riou, Pascal de Groote, Pamela Moceri, Laurent Bertoletti, Nicolas Favrolt, Anne Guillaumot, Etienne-Marie Jutant, Antoine Beurnier, Athenais Boucly, Nathan Ebstein, Mitja Jevnikar, Jeremie Pichon, Sophia Keddache, Mariana Preda, Anne Roche, Sabina Solinas, Andrei Seferian, Martine Reynaud-Gaubert, Vincent Cottin, Laurent Savale, Marc Humbert, Olivier Sitbon
Summary: COVID-19 in patients with precapillary PH was associated with a high in-hospital mortality. The typical risk factors for severe COVID-19 and severity of PH were associated with mortality in this population.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Naiara G. Bediaga, Alexandra L. Garnham, Gaetano Naselli, Esther Bandala-Sanchez, Natalie L. Stone, Joanna Cobb, Jessica E. Harbison, John M. Wentworth, Annette-G. Ziegler, Jennifer J. Couper, Gordon K. Smyth, Leonard C. Harrison
Summary: This study found that cytotoxic CD4(+) T cells play a role in promoting the progression of type 1 diabetes, based on analysis of gene expression and chromatin accessibility in children with the disease.
Article
Endocrinology & Metabolism
Stephanie R. Johnson, Deborah J. Holmes-Walker, Melissa Chee, Arul Earnest, Timothy W. Jones
Summary: After the national subsidy, the uptake of CGM increased significantly and was associated with sustained improvement in glycemic control.
Article
Endocrinology & Metabolism
Madeleine Hall, Helena Oakey, Megan A. S. Penno, Kelly McGorm, Amanda J. Anderson, Pat Ashwood, Peter G. Colman, Maria E. Craig, Elizabeth A. Davis, Mark Harris, Leonard C. Harrison, Aveni Haynes, Claire Morbey, Richard O. Sinnott, Georgia Soldatos, Peter J. Vuillermin, John M. Wentworth, Rebecca L. Thomson, Jennifer J. Couper
Summary: Overall, there was no significant difference in mental health between women with and without type 1 diabetes during late pregnancy and postpartum, and mental health scores were not correlated with glycemic control.
Article
Endocrinology & Metabolism
Claire A. Robertson, Arul Earnest, Melissa Chee, Maria E. Craig, Peter Colman, Helen L. Barrett, Philip Bergman, Fergus Cameron, Elizabeth A. Davis, Kim C. Donaghue, P. Gerry Fegan, P. Shane Hamblin, D. Jane Holmes-Walker, Craig Jefferies, Stephanie Johnson, Meng T. Mok, Bruce R. King, Richard Sinnott, Glenn Ward, Benjamin J. Wheeler, Anthony Zimmermann, Timothy W. Jones, Jenny J. Couper
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Esther Bandala-Sanchez, Alexandra J. Roth-Schulze, Helena Oakey, Megan A. S. Penno, Naiara G. Bediaga, Gaetano Naselli, Katrina M. Ngui, Alannah D. Smith, Dexing Huang, Enrique Zozaya-Valdes, Rebecca L. Thomson, James D. Brown, Peter J. Vuillermin, Simon C. Barry, Maria E. Craig, William D. Rawlinson, Elizabeth A. Davis, Mark Harris, Georgia Soldatos, Peter G. Colman, John M. Wentworth, Aveni Haynes, Grant Morahan, Richard O. Sinnott, Anthony T. Papenfuss, Jennifer J. Couper, Leonard C. Harrison
Summary: The study reveals that pregnant women with type 1 diabetes experience changes in their gut fungal microbiome during pregnancy, accompanied by intestinal inflammation and impaired intestinal barrier function.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Paul Z. Benitez-Aguirre, M. Loredana Marcovecchio, Scott T. Chiesa, Maria E. Craig, Tien Y. Wong, Elizabeth A. Davis, Andrew Cotterill, Jenny J. Couper, Fergus J. Cameron, Farid H. Mahmud, H. Andrew W. Neil, Timothy W. Jones, Lauren A. B. Hodgson, R. Neil Dalton, Sally M. Marshall, John Deanfield, David B. Dunger, Kim C. Donaghue
Summary: The study suggests that adolescents with type 1 diabetes and a high urinary albumin/creatinine ratio (ACR) are at greater risk of diabetic retinopathy progression (3DR), independent of glycemic control.
Article
Endocrinology & Metabolism
Annabelle Hobbs, Maree Thus, Jennifer Couper, Elaine Tham, Jan Fairchild
Summary: Introducing continuous glucose monitoring (CGM) at the diagnosis of type 1 diabetes (T1D) may lead to greater uptake and continuation, with high acceptance across all ages. Although CGM continuation was slightly higher when started at diagnosis, the difference was not statistically significant.
PEDIATRIC DIABETES
(2022)
Article
Medicine, General & Internal
Jane Tuckerman, Kelly Harper, Thomas R. Sullivan, Jennifer Fereday, Jennifer Couper, Nicholas Smith, Andrew Tai, Andrew Kelly, Richard Couper, Mark Friswell, Louise Flood, Margaret Danchin, Christopher C. Blyth, Helen Marshall
Summary: Influenza immunisation is crucial for public health, but the vaccination rate for children and adolescents with special risk medical conditions is suboptimal. Flutext-4U is an innovative strategy targeting healthcare providers and parents to increase influenza immunisation coverage.
Article
Endocrinology & Metabolism
Steven James, Lin Perry, Julia Lowe, Margaret Harris, Maria E. Craig
Summary: This Australian study demonstrates widespread and persistent sub-optimal glycemic control in young people with T1D, highlighting the urgent need to better understand how healthcare services can support improved glycemic control in this population.
PEDIATRIC DIABETES
(2022)
Article
Medicine, Research & Experimental
M. Waibel, H. E. Thomas, J. M. Wentworth, J. J. Couper, R. J. MacIsaac, F. J. Cameron, M. So, B. Krishnamurthy, M. C. Doyle, T. W. Kay
Summary: The goal of this study is to determine if the JAK1/JAK2 inhibitor baricitinib Impairs type 1 diabetes (T1D) autoimmunity and preserves beta cell function. The study will be a double-blind, placebo-controlled randomized trial involving individuals aged 10-30 years with recent-onset T1D. If the preservation of beta cell function is successful, it could improve glucose control and prevent diabetes complications, which may warrant further trials and use in at-risk populations to prevent T1D.
Article
Endocrinology & Metabolism
Kelly J. McGorm, James D. Brown, Rebecca L. Thomson, Helena Oakey, Belinda Moore, Alexandra Hendry, Peter G. Colman, Maria E. Craig, Elizabeth A. Davis, Mark Harris, Leonard C. Harrison, Aveni Haynes, Georgia Soldatos, Peter Vuillermin, John M. Wentworth, Jennifer J. Couper, Megan A. S. Penno
Summary: This study evaluated the use of the ENDIA Facebook page and found that it was a valuable recruitment tool. Participants recruited through Facebook were less likely to withdraw during long-term follow-up and had different sociodemographic characteristics compared to conventional recruits. Content featuring participants received the highest engagement on Facebook.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
John M. Wentworth, Helena Oakey, Maria E. Craig, Jennifer J. Couper, Fergus J. Cameron, Elizabeth A. Davis, Antony R. Lafferty, Mark Harris, Benjamin J. Wheeler, Craig Jefferies, Peter G. Colman, Leonard C. Harrison
Summary: T1D autoantibody screening and metabolic monitoring of older children and young adults in Australia and New Zealand can reduce the risk of DKA and improve glucose control. These clinical benefits support ongoing efforts to increase screening activity in the region.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Rachel E. J. Besser, Kirstine J. Bell, Jenny J. Couper, Anette-G Ziegler, Diane K. Wherrett, Mikael Knip, Cate Speake, Kristina Casteels, Kimberly A. Driscoll, Laura Jacobsen, Maria E. Craig, Michael J. Haller
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Jenny J. Couper, Timothy W. Jones, Melissa Chee, Helen L. Barrett, Philip Bergman, Fergus Cameron, Maria E. Craig, Peter Colman, Elizabeth E. Davis, Kim C. Donaghue, P. Gerry Fegan, P. Shane Hamblin, D. Jane Holmes-Walker, Craig Jefferies, Stephanie Johnson, Meng Tuck Mok, Bruce R. King, Richard Sinnott, Glenn Ward, Benjamin J. Wheeler, Anthony Zimmermann, Arul Earnest
Summary: The study found that BMI in youth with type 1 diabetes has an independent impact on standardized blood pressure and non-HDL cholesterol, with an increase in BMI z-score related to increases in blood pressure and cholesterol. Females and Indigenous youth have a more adverse cardiovascular risk profile.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Stephanie R. Johnson, Deborah J. Holmes-Walker, Melissa Chee, Arul Earnest, Timothy W. Jones
Summary: Following the national subsidy, there was a significant increase in CGM use, which was associated with sustained improvement in glycemic control. This study provides important information for economic analyses, future policy-making, and evaluation of diabetes technologies.
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)