Article
Infectious Diseases
Michael W. Traeger, Rebecca Guy, Jason Asselin, Prital Patel, Allison Carter, Edwina J. Wright, Andrew Grulich, Hamish McManus, Christopher K. Fairley, Eric P. F. Chow, Anna McNulty, Robert Finlayson, Charlotte Bell, Louise Owen, Lewis Marshall, Darren Russell, Darryl O'Donnell, Basil Donovan, Margaret E. Hellard, Mark A. Stoove
Summary: The incidence of bacterial STIs among gay and bisexual men using PrEP in Australia was highest in the early stages of PrEP implementation and declined slightly after wider PrEP uptake. Widespread PrEP implementation can contribute to increased screening and detection of STIs.
LANCET INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Daniel Schmidt, Christian Kollan, Barbara Bartmeyer, Viviane Bremer, Tim Schikowski, Martin Friebe, Sven Schellberg, Stefan Scholten, Markus Bickel, Nikola Hanhoff, Robin Rusenberg, Knud Schewe
Summary: The objective of this study was to evaluate the incidence of HIV and other sexually transmitted infections (STIs) among PrEP users in Germany. The results showed that PrEP is predominantly used by MSM and has a very low HIV infection rate. The incidence rates of STIs also decreased during the observation period. Continued implementation of PrEP coverage through health insurance is crucial in preventing HIV infections.
Letter
Medicine, General & Internal
Kimberly M. Nelson, Alexandra Skinner, Kristen Underhill
Summary: This study examines the current laws regarding minor consent for sexually transmitted infection/HIV services and the level of confidentiality protection in all 50 states and the District of Columbia.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Psychology, Clinical
Ana Karina Pinto Barbosa, Polyana Monteiro, Demetrius Montenegro, Joanna D'Arc Lyra Batista, Ulisses Ramos Montarroyos
Summary: This study followed a cohort of 219 PrEP users in a Brazilian capital city for 10 months and found that PrEP is an effective tool in HIV prevention with minimal complications of adverse events.
ARCHIVES OF SEXUAL BEHAVIOR
(2022)
Article
Immunology
Elisa de Lazzari, Alejandra Martinez-Mimbrero, Ivan Chivite, Ana Gonzalez-Cordon, Maria M. Mosquera, Montserrat Laguno, Josep Costa, Jordi Bosch, Jose L. Blanco, Miriam Alvarez-Martinez, Ainoa Ugarte, Alexy Inciarte, Lorena de la Mora, Berta Torres, Maria Martinez-Rebollar, Juan Ambrosioni, Emma Fernaandez, Juan Carlos Hurtado, Josep Mallolas, Jose M. Miro, Maria A. Marcos, Esteban Martinez
Summary: COVID-19 epidemics in Catalonia, Spain were associated with an increase in some prevalent sexually transmitted infections, a decrease but more advanced HIV infections, and worse nonvirologic healthcare outcomes and higher mortality in people living with HIV.
Article
Immunology
Jane S. Chen, Mitch Matoga, Brian W. Pence, Kimberly A. Powers, Courtney N. Maierhofer, Edward Jere, Cecilia Massa, Shiraz Khan, Sarah E. Rutstein, Sam Phiri, Mina C. Hosseinipour, Myron S. Cohen, Irving F. Hoffman, William C. Miller, Kathryn E. Lancaster
Summary: Combining multiple HIV testing strategies, including acute HIV infection screening, partner notification, and social contact referral, increased the detection of undiagnosed HIV infections within the socio-sexual networks of PLWH in Malawi. This approach proved to be effective in increasing HIV status awareness and promoting linkage to care.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2021)
Article
Public, Environmental & Occupational Health
Patrick Ahaus, Axel J. Schmidt, Adriane Skaletz-Rorowski, Mona Uhrmacher, Katja Serova, Arne Kayser, Janet Wach, Sandeep Nambiar, Norbert H. Brockmeyer, Anja Potthoff
Summary: This study compares the sociodemographic profiles of PrEP users in Germany before and after the reimbursement of costs. The findings show that there were no significant differences in the sociodemographic characteristics between the two cohorts. Almost all PrEP users were men who have sex with men (MSM). Before reimbursement, fewer individuals used PrEP on a daily basis, and more had used PrEP prior to enrolment. During follow-up, there was an increase in the number of sexual and condomless intercourse partners, as well as the proportion of individuals engaging in Chemsex.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Immunology
Holly D. Mitchell, Tatiana Garcia Vilaplana, Sema Mandal, Natasha Ratna, Megan Glancy, Ammi Shah, Ruth Simmons, Celia Penman, Freja Kirsebom, Annastella Costella, Alison E. Brown, Hamish Mohammed, Valerie Delpech, Katy Sinka, Gwenda Hughes
Summary: Since the start of the coronavirus pandemic response in March 2020, there has been a decline in tests, vaccinations, diagnoses, and treatment initiations for sexual health, HIV, and viral hepatitis in England. The rapid shift towards online and outreach services during 2020 highlights the importance of evaluating the impact of these strategies on health inequalities.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Kristina Wihlfahrt, Veronika Guenther, Werner Mendling, Anna Westermann, Damaris Willer, Georgios Gitas, Zino Ruchay, Nicolai Maass, Leila Allahqoli, Ibrahim Alkatout
Summary: An increase in sexually transmitted diseases has been observed among individuals aged 15 to 24, both globally and in Germany. Many infections are asymptomatic or have mild symptoms, resulting in late detection and unintentional transmission. The effects of persistent infection depend on the specific pathogen, with manifestations ranging from pelvic inflammatory disease to genital warts or cervical dysplasia. Most cases can be treated, and treatment should be given to sexual partners as well. Individualized treatment approaches are required for pregnant individuals based on the pathogen and stage of pregnancy.
Editorial Material
Infectious Diseases
Antonio Barrientos-Duran, Adolfo de Salazar, Ana Fuentes-Lopez, Esther Serrano-Conde, Beatriz Espadafor, Natalia Chueca, Marta alvarez-Estevez, Federico Garcia
Summary: It is crucial to use fully validated assays in molecular-based diagnosis, especially in the field of STD. Roche and Hologic provide effective assays for diagnosing CT, NG, MG, and TV, with different sensitivity and specificity parameters on their respective platforms. All assays demonstrated optimal diagnostic capacity to meet IVD DNA-based assay requirements.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Mathematics, Applied
Kai Zhang, Ling Xue, Xuezhi Li, Daihai He
Summary: We propose a mathematical model to examine the causes of sexually transmitted diseases (STDs) epidemics and potential mitigation strategies. By categorizing the susceptible population based on prevention awareness, we analyze how their behavior, population size, and recruitment rate are affected by interventions. Our findings suggest that interventions targeting high-risk susceptible individuals can eliminate STDs, and sex education can effectively reduce the overall infection size. Furthermore, extending the survival time of infected individuals may delay the control of STDs unless high-risk sexual behavior is rejected. We also explore the presence, stability, and direction of Hopf bifurcation, which may explain the periodic oscillations in the infected population size.
ZEITSCHRIFT FUR ANGEWANDTE MATHEMATIK UND PHYSIK
(2023)
Article
Public, Environmental & Occupational Health
Jhosuny Perez-Fernandez, Diego O. Arroyo-Velasco, Mariella R. Huaman, Sarai G. Chavez-Bustamante, Anita P. Llamo-Vilcherrez, Carolina J. Delgado-Flores, Carlos J. Toro-Huamanchumo
Summary: This study found an association between early sexual onset of intercourse and sexually transmitted infections (STIs) in reproductive-age women from Peru, especially in women living in urban areas, with no history of multiple sexual partners, and belonging to the middle to higher wealth index.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Infectious Diseases
Hasnain Javed, Abida Bano, Warda Fatima, Rimsha Khan, Asma Akhtar
Summary: Transgender individuals in Pakistan, particularly sex workers and those residing in urban areas, have a high prevalence of STIs including HIV, HBV, HCV, and Syphilis. This study highlights the need for increased awareness and prevention strategies targeting this neglected population group.
BMC INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Mariana Martel, Eduardo Gotuzzo
Summary: HTLV-1 is a retrovirus that causes various diseases, significantly impacting the quality of life and mortality rate of its infected population. It is neglected despite its global distribution and endemicity in many countries. The virus spreads through vertical, sexual, and parenteral transmission, and prevention measures are crucial due to the lack of effective treatments. This article presents evidence on the magnitude, risk factors, and prevention of sexual transmission, aiming to raise awareness among healthcare workers for eradicating the infection.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Immunology
Kanwal Saleem, Ee Lynn Ting, Andre J. W. Loh, Rachel Baggaley, Maeve B. Mello, Muhammad S. Jamil, Magdalena Barr-Dichiara, Cheryl Johnson, Sami L. Gottlieb, Christopher K. Fairley, Eric P. F. Chow, Jason J. Ong
Summary: Among the 37.7 million people living with HIV in 2020, 6.1 million were unaware of their HIV status. The study highlights the low rate of concurrent HIV testing among individuals tested for other sexually transmitted infections. Integration of HIV and STI services is necessary to improve prevention efforts, early diagnosis, and access to care.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)
Letter
Immunology
Benoit Bailly, Helene Pere, David Veyer, Ana Berceanu, Etienne Daguindau, Pauline Roux, Olivier Hermine, Xavier de Lamballerie, Paul Bastard, Karine Lacombe, Brigitte Autran, Fanny Angelot Delettre, Jean Laurent Casanova, Sandrine Imbeaud, Anne Laure Clairet, Marie Kroemer, Laurie Spehner, Nicolas Robillard, Julien Puech, Solene Marty-Quinternet, Quentin Lepiller, Catherine Chirouze, Kevin Bouiller
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Rebecca Lajaunie, Lise Cuzin, Romain Palich, Alain Makinson, Firouze Bani-Sadr, Claudine Duvivier, Cedric Arvieux, David Rey, Isabelle Poizot-Martin, Cyril Delpierre, Pierre Delobel, Guillaume Martin-Blondel
Summary: A retrospective analysis of PLHIV with a history of KS and controlled HIV replication found that switching from a PI-based regimen to a PI-free one did not increase the risk of KS relapse.
Article
Geriatrics & Gerontology
Coralie Sullerot, Kevin Bouiller, Caroline Laborde, Marine Gilis, Amelie Fevre, Arthur Hacquin, Patrick Manckoundia, Florence Hoefler, Messaline Bermejo, Aline Mendes, Christine Serratrice, Virginie Prendki, Stephane Sanchez, Alain Putot
Summary: This study investigated the association between aspirin use before admission and in-hospital all-cause mortality in older patients hospitalized for COVID-19. The findings suggest that aspirin use before admission did not appear to be associated with improved prognosis and may be related to longer hospital stays and more frequent transfers to the intensive care unit.
Article
Infectious Diseases
Kevin Bouiller, Souheil Zayet, Paul-Emile Lalloz, Anais Potron, Vincent Gendrin, Catherine Chirouze, Timothee Klopfenstein
Summary: This study evaluated the efficacy of oral fosfomycin-trometamol (FT) for the treatment of male urinary tract infections (UTIs) caused by multidrug-resistant Enterobacterales. The results indicate that FT could be a potential alternative option for the treatment of multidrug-resistant Enterobacterales infections in male UTIs.
Article
Cardiac & Cardiovascular Systems
Yohann Bohbot, Gilbert Habib, Cecile Laroche, Elisabeth Stohr, Catherine Chirouze, Marta Hernandez-Meneses, Maria Melissopoulou, Bulent Mutlu, Valentina Scheggi, Luisa Branco, Carmen Olmos, Graciela Reyes, Michal Pazdernik, Bernard Iung, Rouguiatou Sow, Maja Mirocevic, Patrizio Lancellotti, Christophe Tribouilloy
Summary: The study found that patients with left-sided infective endocarditis complicated by congestive heart failure tend to be older, have more comorbidities, and more severe valve damage, leading to significantly higher 30-day and 1-year mortality rates. Early surgery is strongly associated with lower mortality but is only performed on approximately half of these patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Microbiology
Kevin Bouiller, Nathan Peiffer-Smadja, Muge Cevik, Katharina Last, Ivana A. Antunovic, Anja Sterbenc, Maria J. Lopes, Aleksandra Barac, Valentijn Schweitzer, Sarah Delliere
Summary: This study aimed to evaluate the role and perceptions of trainees during the COVID-19 pandemic and found that the majority of trainees played significant roles in patient management, research, and diagnostic procedures. However, most trainees felt more stressed and tired compared to other rotations, and only a minority had access to psychological support.
FUTURE MICROBIOLOGY
(2022)
Article
Infectious Diseases
Michal Pazdernik, Bernard Iung, Bulent Mutlu, Francois Alla, Robert Riezebos, William Kong, Maria Carmo Pereira Nunes, Luc Pierard, Ilija Srdanovic, Hirotsugu Yamada, Andrea De Martino, Marcelo Haertel Miglioranza, Julien Magne, Cornelia Piper, Cecile Laroche, Aldo P. Maggioni, Patrizio Lancellotti, Gilbert Habib, Christine Selton-Suty
Summary: In octogenarians with infective endocarditis, valvular surgery is less frequently indicated and performed, resulting in higher in-hospital and 1-year mortality rates. Age itself is not a predictor of mortality, but lack of surgical intervention when indicated strongly predicts poorer outcomes.
Article
Infectious Diseases
Timothee Klopfenstein, Can Tipirdamaz, Vincent Gendrin, Molka Osman, Julien Mercier, Elodie Bouvier, Kevin Bouiller, Quentin Lepiller, Lynda Toko, Alix Pierron, Pierre-Yves Royer, Pauline Garnier, N'dri-Juliette Kadiane-Oussou, Catherine Chirouze, Souheil Zayet
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Sarah Soueges, Kevin Bouiller, Elisabeth Botelho-Nevers, Amandine Gagneux-Brunon, Catherine Chirouze, Veronica Rodriguez-Nava, Oana Dumitrescu, Claire Triffault-Fillit, Anne Conrad, David Lebeaux, Elisabeth Hodille, Florent Valour, Florence Ader
Summary: This retrospective multicenter cohort study aimed to identify the factors associated with dissemination of Nocardia spp. in patients with Nocardia-confirmed infections. The results showed that autoimmune diseases, lymphopenia, and N. farcinica infection were associated with a higher rate of dissemination. Although patients with disseminated nocardiosis received longer and more intensive treatment, their 12-month overall mortality was significantly higher than that of patients with localized nocardiosis.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Esteban Garcia-Gallo, Laura Merson, Kalynn Kennon, Sadie Kelly, Barbara Wanjiru Citarella, Daniel Vidali Fryer, Sally Shrapnel, James Lee, Sara Duque, Yuli V. Fuentes, Valeria Balan, Sue Smith, Jia Wei, Bronner P. Goncalves, Clark D. Russell, Louise Sigfrid, Andrew Dagens, Piero L. Olliaro, Joaquin Baruch, Christiana Kartsonaki, Jake Dunning, Amanda Rojek, Aasiyah Rashan, Abi Beane, Srinivas Murthy, Luis Felipe Reyes
Summary: The ISARIC COVID-19 dataset is one of the largest international databases of clinical data on hospitalized COVID-19 patients. It includes data from hospitals worldwide and provides comprehensive information on patient characteristics and treatments.
Article
Biology
Can Tipirdamaz, Souheil Zayet, Molka Osman, Julien Mercier, Elodie Bouvier, Vincent Gendrin, Kevin Bouiller, Quentin Lepiller, Lynda Toko, Alix Pierron, Pierre-Yves Royer, Pauline Garnier, N'dri-Juliette Kadiane-Oussou, Catherine Chirouze, Timothee Klopfenstein
Summary: This study investigated the long-term evolution of olfactory disorders in COVID-19 patients. The results showed that 41% of patients experienced persistent olfactory disorders even after recovery. Asthma and cacosmia were identified as potential predictors of persistent olfactory disorders.
Article
Infectious Diseases
Pauline Naudion, Alice Raffetin, Souheil Zayet, Timothee Klopfenstein, Elisabeth Baux, Martin Martinot, Lionel Piroth, Eric Caumes, Catherine Chirouze, Kevin Bouiller
Summary: This study aimed to describe the clinical characteristics, management, and residual symptoms (RS) in patients with definite and possible Lyme neuroborreliosis (LNB). A retrospective French multicenter cohort study was conducted, and 138 adult patients with positive intrathecal antibody index (AI) were included. The study found that definite LNB and duration of symptoms less than 3 months were protective factors against RS at last follow-up. Early diagnosis and treatment are important to improve outcomes and lower potential residual symptoms.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Kevin Bouiller, Michael Z. Z. David
Summary: A systematic literature review was conducted to assess the association between S. aureus genes and outcomes in patients with bone and joint infections. The results showed that PVL genes were associated with poor outcomes in children, while no specific genes were found to have similar associations in adults. Further studies with larger sample sizes and homogeneous patient populations are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Abdeljallil Zeggay, Alban Atchon, Benoit Valot, Didier Hocquet, Xavier Bertrand, Kevin Bouiller
Summary: Using genomic data, the study determined the origin of MRSA ST398 isolates causing invasive infections in patients with no livestock contact. The isolates were sequenced and analyzed for the presence of virulence and resistance genes. Phylogenetic analysis revealed that MSSA isolates were human-associated, while MRSA isolates were livestock-associated. The results suggest that livestock-associated MRSA acquired virulence genes, enabling them to cause invasive infections in humans.
Article
Infectious Diseases
Kevin Bouiller, Houssein Gbaguidi-Haore, Didier Hocquet, Thomas Crepin, Daniel Wendling, Sophie Borot, Catherine Chirouze, Xavier Bertrand
Summary: This study aimed to evaluate the effects of replacing ceftriaxone with cefotaxime on the incidence of third generation cephalosporin-resistant Enterobacterales (3GC-RE). The results showed that replacing ceftriaxone with cefotaxime reduced the occurrence of 3GC-RE isolates.
INFECTIOUS DISEASES NOW
(2024)
