Article
Infectious Diseases
Dan Yuan, Yan Zhang, Yiping Li, Ling Li, Hong Yang, Wei Yang, Hang Yu, Liao Feng, Shu Liang
Summary: This study analyzed the CD4(+) T cell count changes of PLWH infected with different HIV-1 subtypes in Sichuan Province after treatment, identifying factors such as virus subtype, gender, age, and education level that influence CD4(+) T cell count growth.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, Research & Experimental
Osaretin E. Asowata, Alveera Singh, Abigail Ngoepe, Nicholas Herbert, Rabiah Fardoos, Kavidha Reddy, Yenzekile Zungu, Faith Nene, Ntombifuthi Mthabela, Dirhona Ramjit, Farina Karim, Katya Govender, Thumbi Ndung'u, J. Zachary Porterfield, John H. Adamson, Fusi G. Madela, Vukani T. Manzini, Frank Anderson, Alasdair Leslie, Henrik N. Kloverpris
Summary: Research conducted on a large cohort recruited from high HIV endemic areas in South Africa revealed that people living with HIV presented at a younger age for GI clinic investigation, with severe CD4(+) T cell depletion in the GI tract, particularly in the colon. Despite full suppression of plasma viremia, HIV-p24 staining showed persistent viral expression, emphasizing the irreversible loss of GI CD4(+) T cells as a key event in HIV pathogenesis in PLWH in South Africa.
Article
Microbiology
Maria Pino, Susan Pereira Ribeiro, Amelie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L. Harper, Colin T. King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A. Delman, Theron Stuart, Michael Lowe, Jason M. Brenchley, Cynthia A. Derdeyn, Kirk Easley, Rafick P. Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C. Marconi
Summary: Clinical outcomes are inferior in individuals with HIV experiencing suboptimal CD4 T-cell recovery during ART. The study found that immunologic suboptimal responders (ISR) had higher HIV-DNA levels in multiple CD4 T-cell subsets and higher expression of PD-1 and TIGIT exclusively on CM and TM CD4 T-cells pre-ART, indicating higher HIV reservoir maintenance. Additionally, ISR showed a lack of response to IL-7 and IL-15, potentially contributing to suboptimal CD4 T-cell recovery during ART.
Review
Pharmacology & Pharmacy
Xiao-Li Zhang, Ming-Hui Chen, Shi-Tao Geng, Juehua Yu, Yi-Qun Kuang, Hua-You Luo, Kun-Hua Wang
Summary: Probiotics can reduce the incidence of AIDS-related diarrhea in HIV/AIDS patients, with long-term use showing more significant effects than short-term use. However, probiotics have no impact on CD4 cell counts in HIV/AIDS patients. Further research is needed to explore the potential of probiotics as a preventive strategy for AIDS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Laura I. Levi, Shweta Sharma, Mark R. Schleiss, Hansjakob Furrer, Daniel E. Nixon, Mark Blackstad, Nelmary Hernandez-Alvarado, Dominic E. Dwyer, Alvaro H. Borges, H. Clifford Lane, Jens Lundgren, James D. Neaton, Jean-Michel Molina
Summary: This study assessed the prevalence of cytomegalovirus (CMV) viremia in HIV-positive patients starting antiretroviral therapy (ART) and found that baseline CMV viremia is associated with advanced infection. The study also found that only persistent CMV viremia after ART initiation is associated with a higher risk of morbidity and mortality.
Article
Multidisciplinary Sciences
Eugene Enah Fang, Raymond Babila Nyasa, Emmanuel Menang Ndi, Denis Zofou, Tebit Emmanuel Kwenti, Edith Pafoule Lepezeu, Vincent P. K. Titanji, Roland N. Ndip
Summary: The study revealed that a considerable percentage of HIV patients in the Bamenda Health District of Cameroon were infected with Toxoplasma gondii, with a majority experiencing chronic infection. There were significant associations between marital status, contact with garden soil, and garden ownership with T. gondii infection. The study also found no significant difference in CD4+ T-cell count among HIV patients with different toxoplasma infection statuses.
Article
Multidisciplinary Sciences
Bertrand Sagnia, Sandra Kiazyk, Adrienne F. A. Meyers, Margot Plews, Tamsir O. Diallo, Samuel Martin Sosso, Georgia Ambada, Rachel Kamgaing, Nadesh Nji, Paul Sandstrom, Blake T. Ball, Godwin Nchinda, Alexis Ndjolo
Summary: Participation in an EQA program for CD4 T-cell enumeration is essential for quality assurance and improved clinical management in HIV patients. Continuous training and corrective actions can help reduce errors and increase laboratory performance. Collaboration with QASI can serve as a model for successful implementation of EQA in resource-limited countries.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Armando B. D. Djiyou, Calixte Ida Penda, Yoann Madec, Grace Dalle Ngondi, Astrid Moukoko, Marie Varloteaux, Laure-Amelie de Monteynard, Cecile Moins, Carole Else Eboumbou Moukoko, Avelin F. Aghokeng
Summary: This study assessed the rate of sustained viral suppression (VS) and factors associated with virological failure (VF) in a cohort of adolescents receiving antiretroviral therapy (ART) in Cameroon. The study found a high rate of VS, indicating that achieving the UNAIDS 95% VS rate is feasible in this population.
Article
Environmental Sciences
Abdulkadir Ademu, Umut Gazi, Ozgur Tosun, I. Helen Inabo, Maryam Aminu, Aysegul Taylan Ozkan
Summary: This study aimed to determine the prevalence and risk factors of intestinal parasitic infections among diarrheic HIV patients in Abuja, Nigeria. The overall prevalence of intestinal parasitic infection was 18%, with the most common parasites being Entamoeba histolytica/dispar and Ascaris lumbricoides. Opportunistic protozoan parasites were only detected in the HIV seropositive group. No demographic characteristics were associated with enteric parasite infections among HIV seropositive volunteers.
FRESENIUS ENVIRONMENTAL BULLETIN
(2022)
Article
Multidisciplinary Sciences
Caroline Dufour, Corentin Richard, Marion Pardons, Marta Massanella, Antoine Ackaoui, Ben Murrell, Bertrand Routy, Rejean Thomas, Jean-Pierre Routy, Remi Fromentin, Nicolas Chomont
Summary: The phenotypic diversity of HIV-infected cells persisting during antiretroviral therapies (ART) was investigated. CD4+ T cells expressing integrin VLA-4 were found to be enriched in replication-competent HIV. Clonally expanded cells with identical proviruses displayed diverse phenotypes, indicating the role of cellular proliferation in the phenotypic diversification of the HIV reservoir. Genetically intact and inducible viral genomes were associated with higher levels of VLA-4 expression in CD4+ T cells. Replication-competent HIV was highly enriched in memory CD4+ T cells expressing high levels of VLA-4.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Yik Lim Kok, Valentina Vongrad, Sandra E. Chaudron, Mohaned Shilaih, Christine Leemann, Kathrin Neumann, Katharina Kusejko, Francesca Di Giallonardo, Herbert Kuster, Dominique L. Braun, Roger D. Kouyos, Huldrych F. Gunthard, Karin J. Metzner
Summary: Characteristics of HIV-1 integration sites are established as early as during primary infection and are found in both resting and activated CD4(+) T cells. HIV-1 integration sites preferentially occur in specific genes and highly expressed genes, regardless of the activation state of CD4(+) T cells. The preference for cancer-related genes is more prominent at later stages of HIV-1 infection.
Article
Pharmacology & Pharmacy
Salvador Resino, Maria Angeles Jimenez-Sousa, Julia Blanco, Yolanda M. Pacheco, Jorge del Romero, Joaquim Peraire, Ana Virseda-Berdices, Maria Jose Munoz-Gomez, Carlos Galera-Penaranda, Lucio Jesus Garcia-Fraile, Jose M. Benito, Norma Rallon
Summary: The study found that DHCR7 rs3829251 and DBP rs7041 gene polymorphisms are associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Abhishek Verma, Ashley M. Hine, Andrew Joelson, Rena Mei, Robert A. Pitts, Benjamin Lebwohl, Jordan E. Axelrad
Summary: The etiology of diarrhea in HIV/AIDS patients is related to CD4 count and hospitalization. Clinicians should consider these factors when interpreting GI panel results.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Aissatou Abba, Joseph Fokam, Rachel Simo Kamgaing, Junie Flore Yimga, Aude Christelle Ka'e, Alex Durand Nka, Michel Carlos Tommo Tchouaket, Collins Ambe Chenwi, Ezechiel Ngoufack Jagni Semengue, Alexis Ndjolo, Samuel Martin Sosso
Summary: Malnutrition in resource-limited settings can lead to disease progression and mortality in HIV patients, highlighting the importance of monitoring the nutritional status of individuals receiving ART.
Article
Immunology
Kazuhiro Ogai, Benderli Christine Nana, Yukie Michelle Lloyd, John Paul Arios, Boonyanudh Jiyarom, Honore Awanakam, Livo Forgu Esemu, Aki Hori, Ayaka Matsuoka, Firzan Nainu, Rosette Megnekou, Rose Gana Fomban Leke, Gabriel Loni Ekali, Shigefumi Okamoto, Takayuki Kuraishi
Summary: The presence of HIV infection can significantly alter the composition and diversity of the skin microbiome, suggesting a potential link between HIV infection and cutaneous diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Applied
Jean Emmanuel Mbosso Teinkela, Xavier Siwe Noundou, Simone Fannang, Achille Mbem Song, Jules Clement Assob Nguedia, Heinrich C. Hoppe, Rui Werner Macedo Krause
Summary: A new ceramide, terminaliamide, was isolated from the roots of Terminalia mantaly along with 4 known compounds. Compound 1 showed moderate antibacterial activity against Staphylococcus aureus, while the crude MeOH extract highly reduced Plasmodium falciparum growth and the hexane fraction highly reduced Trypanosoma brucei brucei growth. All tested samples showed little or no cytotoxicity on HeLa cell line, indicating their potential as antimicrobial, antiplasmodial, and antitrypanosomal agents.
NATURAL PRODUCT RESEARCH
(2021)
Article
Immunology
Achu Che Awah Nforbugwe, Emmanuel Acha Asongalem, Rengerline Bihnwi Nchotu, Elvis Asangbeng Tanue, Frankline Sevidzem Wirsiy, Jules Clement Nguedia Assob
INTERNATIONAL JOURNAL OF STD & AIDS
(2020)
Review
Veterinary Sciences
Faham Khamesipour, Taghi Taktaz-Hafshejani, Kwenti E. Tebit, Seyed Mostafa Razavi, Seyed Reza Hosseini
Summary: The prevalence of parasitic infections in equines in Iran is high, with helminths being the most common parasites. Donkeys are the most affected equine, while ticks and Gasterophilus flies are the frequently reported ectoparasites. Further research is needed to identify the risk factors and effectively control these parasites for the health and well-being of the animals.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Francine D. Kouemo Motse, Dickson Shey Nsagha, Pride M. Teyim, Dieudonne Adiogo, Loick P. Kojom Foko, Danielle C. Kedy Koum, Guy P. Ngaba, Jules C. Assob Nguedia
Summary: This study aimed to determine the prevalence and risk factors associated with RIF-resistant tuberculosis using GeneXpert technology among TB-infected Cameroonian patients in the Littoral Region. The results showed a prevalence of 6.7% for RIF resistance, with significantly higher rates among relapse cases. Further extensive studies are needed to understand the situation in other parts of the country.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2021)
Article
Immunology
Kagoue Simeni Luc-Aime, Yindom Louis-Marie, Loni Ekali Gabriel, Clauvis Kunkeng Yengo, F. Esemu Livo, Nguedia Jules Clement Assob
Summary: This study investigated the role of KIR gene variants in mother-to-child transmission of HIV in a cohort of infants born to HIV-infected mothers in Yaounde, Cameroon. The results showed differential effects of KIR genes on MTCT of HIV-1, with certain genes like KIR2DL1 and KIR2DL5 displaying significant differences in frequencies between exposed and unexposed infants. These findings suggest a potential link between KIR genes and the transmission of HIV from mother to child.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sylvie Georgette Zebaze Temgoua Kemleu, Laure Ngando, Elvige Nguekeng, Balotin Fogang, Marie Mafo Kapen, Styve Iruch Fopa, Marie Florence Biabi, Estelle Essangui, Jules Clement Assob Nguedia, Lawrence Ayong
Summary: The study highlights the utility of whole blood RT-LAMP for rapid screening of blood donors and suspected neonates, showing higher sensitivity compared to light microscopy and RDT.
Article
Multidisciplinary Sciences
Ginette Claude Mireille Kalla, Josette Farida L. Mboumnyemb, Jules Clement Nguedia Assob, Marcelle Nina Ehouzou Mandeng, Nelly Kamgaing Noubi, Marie Claire Okomo Assoumou, Francois-Xavier Mbopi-Keou, Francisca MonebeniMp
Summary: The study aimed to determine the prevalence of cryptococcal antigenemia and its determinants in children infected with HIV. The results showed that severe immunosuppression and contact with pigeons were independent factors significantly associated with carrying the cryptococcal antigen.
Article
Infectious Diseases
Ephesians N. Anutebeh, Lambed Tatah, Vitalis F. Feteh, Desmond Aroke, Jules C. N. Assob, Simeon Pierre Choukem
Summary: This study investigated the immune response to hepatitis B vaccine in infants in Cameroon and assessed factors associated with non-response or poor response. The results showed a high seroprotective rate following vaccination, although a 2.5% non-response rate was observed. Further large-scale studies are needed to explore non-response to the vaccine.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Eugene Enah Fang, Raymond Babila Nyasa, Emmanuel Menang Ndi, Denis Zofou, Tebit Emmanuel Kwenti, Edith Pafoule Lepezeu, Vincent P. K. Titanji, Roland N. Ndip
Summary: The study revealed that a considerable percentage of HIV patients in the Bamenda Health District of Cameroon were infected with Toxoplasma gondii, with a majority experiencing chronic infection. There were significant associations between marital status, contact with garden soil, and garden ownership with T. gondii infection. The study also found no significant difference in CD4+ T-cell count among HIV patients with different toxoplasma infection statuses.
Article
Public, Environmental & Occupational Health
Conrald Ekukole Metuge, Anastase Dzudie, Peter Vanes Ebasone, Jules Clement Nguedia Assob, Marcelin Ngowe Ngowe, Emmanuel Njang, Stephane Mabouna, Christian Eyoum
Summary: Substance use is a major global public health issue, particularly among students in tertiary institutions. In Buea, the prevalence of substance use among tertiary students is significantly high, with tobacco and alcohol being the most commonly used substances. Stress relief is the primary reason for substance use, and it is associated with negative effects such as conflicts and financial loss. Male students are more likely to engage in substance use.
PAN AFRICAN MEDICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Ginette Claude Mireille Kalla, Ursule Larissa Temgoua Dongmo, Jules Clement Nguedia Assob, Nelly Kamgaing Noubi, Francois-Xavier Mbopi-Keou, Francisca Monebenimp
Summary: Children infected with HIV are at increased risk of impaired neurodevelopment, and this study in Cameroon found that about one out of ten HIV-infected children experienced psychomotor delay. Factors such as low birth weight, growth retardation, and elevated viral load were significantly associated with this delay.
PAN AFRICAN MEDICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Bernard Wabo, Dickson Shey Nsagha, Theophile Njamen Nana, Clement Jules Nguedia Assob
Summary: The study aimed to investigate the prevalence and risk factors associated with precancerous cervical lesions among women in Cameroon. The results showed that 12.2% of women had precancerous lesions, and age and parity were significant risk factors.
PAN AFRICAN MEDICAL JOURNAL
(2022)
Meeting Abstract
Infectious Diseases
Merlin Jonas Wandji Takemegni, Clement Jules Nguedia Assob, Jerome Ateudjieu, George Orock Enow, Francois-Xavier Mbopi-Keou, Marcelin Ngowe Ngowe
JAC-ANTIMICROBIAL RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Guy Pascal Ngaba, Ginette Claude Mireille Kalla, Jules Clement Nguedia Assob, Abdel Jelil Njouendou, Christian Nelly Jembe, Emile Telesphore Mboudou, Francois-Xavier Mbopi-Keou
Summary: The study evaluated the diagnostic performance of two rapid diagnostic tests for COVID-19 in Cameroon. The BIOSYNEX (R) COVID-19 Ag + BSS showed higher sensitivity compared to BIOSYNEX (R) COVID-19 Ag BSS, with similar specificity. Both rapid tests had high negative predictive values and agreement rates, suggesting their usefulness in mass screenings and remote area screenings.
PAN AFRICAN MEDICAL JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Guy Pascal Ngaba, Ginette Claude Mireille Kalla, Jules Clement Nguedia Assob, Abdel Jelil Njouendou, Christian Nelly Jembe, Emile Telesphore Mboudou, Francois-Xavier Mbopi-Keou
Summary: The study in Cameroon assessed the diagnostic performance of AmpliQuick (R) SARS-CoV-2 compared to the classic RT-PCR for COVID-19 testing. Results showed that AmpliQuick (R) SARS-CoV-2 had a higher sensitivity (83.5%) compared to the classic RT-PCR (67.8%), with a significant reduction in testing time.
PAN AFRICAN MEDICAL JOURNAL
(2021)