Article
Cell Biology
Hyuk-Joon Jeon, Minsung Kang, Jae-Sung Kim, Jeong Su Oh
Summary: The study found that telomeres in oocytes experience shortening during postovulatory aging, but overexpression of Translationally Controlled Tumor Protein (TCTP) can reverse this shortening by upregulating telomerase activity. TCTP prevents telomere attrition during postovulatory aging in mouse oocytes by increasing telomerase activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Ryan L. Brown, Elissa E. Epel, Jue Lin, Dena B. Dubal, Aric A. Prather
Summary: Aging biomarkers may be interconnected through direct co-regulation or common processes associated with aging or stress. Klotho, an aging regulator, is involved in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammation. This study investigated the association between klotho levels and telomere length in immune cells among mothers caregiving for children with or without autism spectrum disorder (ASD), to understand the potential impact of high caregiving stress on these aging biomarkers. Our results showed a positive association between klotho levels and telomere length in certain immune cells among high-stress mothers of children with ASD, but not among low-stress mothers of neurotypical children. There were no significant associations between klotho and telomerase activity in either group.
Article
Plant Sciences
Katherine M. D'Amico-Willman, Elizabeth S. Anderson, Thomas M. Gradziel, Jonathan Fresnedo-Ramirez
Summary: This study found a significant association between almond age, relative telomere length, and TERT expression, indicating that telomeres shorten and TERT expression decreases as almonds age. These findings contribute to understanding perennial plant aging and provide opportunities for addressing age-related disorders in almond breeding and nursery propagation.
Article
Cell Biology
Alba M. Polonio, Marta Medrano, Lucia Chico-Sordo, Isabel Cordova-Oriz, Mauro Cozzolino, Jose Montans, Sonia Herraiz, Emre Seli, Antonio Pellicer, Juan A. Garcia-Velasco, Elisa Varela
Summary: The SAMP8 model exhibits signs of ovarian aging and reduced fertility, similar to middle-aged women. Female SAMP8 mice have a shorter lifespan and reduced telomere length and telomerase activity in their ovaries at 7 months old. These mice also produce more morphologically abnormal embryos compared to controls.
Article
Cell Biology
M. Donatella Semeraro, Gunter Almer, Wilfried Renner, Hans-Juergen Gruber, Markus Herrmann
Summary: This study questions the utility of RTL in PBMCs as a biomarker for individual aging assessment.
Review
Oncology
Gustavo Borges, Melanie Criqui, Lea Harrington
Summary: Telomere maintenance is crucial for the integrity of both normal and cancer cells. The instability of telomeres can lead to genome instability in cancer and aging, but cancer cells can partially overcome this instability by increasing telomerase expression.
MOLECULAR ONCOLOGY
(2022)
Review
Pediatrics
Bo Zheng, Jianhua Fu
Summary: This review examined the relationship between telomere biology and pediatric congenital and growth-related diseases, highlighting the potential for telomere dysfunction to contribute to the occurrence, development, and prognosis of these diseases. The findings provide new theoretical frameworks and potential therapeutic targets for treating these conditions.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Barbara Jacczak, Blazej Rubis, Ewa Toton
Summary: The stability of telomeres is crucial for cell function, and research on telomere biology and telomerase activity has been of great interest in various medical and scientific fields. Maintaining optimal telomere length and telomerase activity is an important step in anti-aging strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Mohamed A. O. Abdelfattah, Malak Dmirieh, Widad Ben Bakrim, Omar Mouhtady, Mosad A. Ghareeb, Michael Wink, Mansour Sobeh
Summary: Warburgia is a widely distributed genus that possesses anti-inflammatory and antioxidant properties. This study found that an extract from Warburgia bark has significant antioxidant and anti-aging effects, making it a valuable source of bioactive compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Mohamed S. Mady, Heba E. Elsayed, Elsayed K. El-Sayed, Ahmed A. Hussein, Hassan Y. Ebrahim, Fatma A. Moharram
Summary: This study validates the strong antioxidant, analgesic, anti-skin aging, and antidiarrheal activities of C. sabulatus leaves for the first time, with a wide array of bioactive polyphenolic metabolites identified. Ethnopharmacological resources like C. sabulatus with high levels of polyphenols hold potential for managing various human ailments.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
A. Yun, Shangli Shi, Shoujiang Sun, Yuanyuan Jing, Zili Li, Xiaoyan Zhang, Xiaolong Li, Fang Wu
Summary: In this study, we conducted a longitudinal analysis of telomerase activity and relative telomere length in different varieties of alfalfa. We found significant differences in telomerase activity and relative telomere length between plants of different ages and varieties. The relative telomere length is influenced by genetic variation and age, with age exerting a greater effect.
Article
Biochemistry & Molecular Biology
Xuesheng Han, Alice Hirschel, Menelaos Tsapekos, Diego Perez, David Vollmer
Summary: This study provides preliminary evidence that gold nanoparticles may increase telomerase activity and slow down telomere shortening in human fibroblasts, suggesting potential anti-aging effects. However, the effects may vary in different types of fibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Sport Sciences
Marlies Schellnegger, Alvin C. Lin, Niels Hammer, Lars-Peter Kamolz
Summary: Healthy life expectancy lags behind overall life expectancy, and increasing overall fitness through physical activity can attenuate the impact of aging. Telomere biology is a key factor in understanding the relationship between exercise and aging, but there is still uncertainty regarding the optimal intensity, duration, and type of physical activity.
SPORTS MEDICINE-OPEN
(2022)
Review
Cell Biology
Sarah W. Cai, Titia de Lange
Summary: In this review, the authors discuss the role of the CST-Polα/Primase complex in telomere length regulation. They highlight that this complex not only functions in strand synthesis but also controls telomerase to maintain telomere length. Additionally, they emphasize the importance of this complex in preventing telomeric disorders by replenishing lost sequences and determining telomere length.
GENES & DEVELOPMENT
(2023)
Review
Biology
Graciela Gavia-Garcia, Juana Rosado-Perez, Taide Laurita Arista-Ugalde, Itzen Aguiniga-Sanchez, Edelmiro Santiago-Osorio, Victor Manuel Mendoza-Nunez
Summary: Research has shown a strong relationship between oxidative stress, telomere length dynamics, and metabolic syndrome, particularly during aging. The multifactorial nature of metabolic syndrome makes treatment challenging, but evidence supports that healthy lifestyles can prevent oxidative damage, telomere attrition, and the progression of chronic degenerative diseases, improving older adults' living conditions.
Review
Biochemistry & Molecular Biology
Masomeh Maleki, Asal Golchin, Samira Javadi, Nafiseh Khelghati, Pejman Morovat, Zatollah Asemi, Forough Alemi, Mostafa Vaghari-Tabari, Bahman Yousefi, Maryam Majidinia
Summary: Exosomal miRNA plays an important role in the chemo-resistance, diagnosis, and prognosis of colorectal cancer (CRC). Engineered exosomes can deliver functional miRNAs to reverse chemoresistance and serve as promising biomarkers for CRC.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Faezeh Malakoti, Niloufar Targhazeh, Haniye Karimzadeh, Erfan Mohammadi, Milad Asadi, Zatollah Asemi, Forough Alemi
Summary: This article reviews the effects of lncRNA MALAT1 on the progression of six prevalent human cancers, focusing on its ability to regulate post-transcriptional modification and signaling pathways.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Food Science & Technology
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Summary: Various studies have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. It also has positive effects in preventing and ameliorating diabetic complications, possibly due to its anti-inflammatory and anti-oxidant properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Medicinal
Marziyeh Salami, Raziyeh Salami, Mohammad-Hossein Aarabi, Alireza Mafi, Seyedeh Sara Ghorbanhosseini, Rana Shafabakhsh, Zatollah Asemi
Summary: Gliomas, especially glioblastoma, are highly resistant to existing treatments and have a low prognosis, necessitating the search for new treatment options. Nutraceuticals have shown promise in inhibiting tumor growth, angiogenesis, and inducing apoptosis in cancer cells, including glioma. These compounds can target cellular signaling pathways and other mechanisms to disrupt cancer cells. Recent studies have identified potential target molecules and signaling pathways affected by nutraceuticals in glioma cells, suggesting that clinical trials and new approaches are imminent.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Zatollah Asemi, Bahman Yousefi
Summary: Osteosarcoma is the most common primary bone malignancy among children and adolescents, and its high mortality rate is mainly due to lung metastasis. Traditional chemotherapy and surgical treatment have limited efficacy in reducing metastasis rate and improving prognosis. Therefore, it is necessary to explore new therapeutic strategies to enhance the survival rate of osteosarcoma patients. Curcumin, a compound derived from Curcuma longa, has been shown to have multiple anti-cancer effects. Studies have demonstrated that curcumin can inhibit cell proliferation and induce apoptosis in osteosarcoma cells. Additionally, research has identified several signaling pathways involved in the pathogenesis of osteosarcoma, and curcumin has been evaluated for its potential to regulate these pathways and improve treatment outcomes.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Amirhossein Davoodvandi, Pouya Mahdavi Sharif, Parisa Maleki Dana, Zatollah Asemi
Summary: Gastrointestinal (GI) cancers are prevalent worldwide with increasing incidence. Treatment options for these cancers are limited and new strategies are needed. Resveratrol, a natural product found in fruits and plants, has been studied for its effects on microRNAs in neoplastic disorders. This review aims to illustrate the molecular pathways related to resveratrol and evaluate its impacts on microRNAs in the prevention and treatment of GI cancers.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Parisa Maleki Dana, Fatemeh Sadoughi, Russel J. Reiter, Bahman Yousefi, Zatollah Asemi
Summary: Melatonin, a secretion of the pineal gland, has been found to have significant effects on tumor tissues, including inhibiting tumor growth, promoting apoptosis, and suppressing angiogenesis. Current therapeutic strategies for bone cancer are limited, and there is a need to better understand the molecular pathways and cellular functions associated with this disease in order to develop new treatments. This review summarizes the functions of melatonin in osteosarcoma and Ewing's sarcoma, as well as its mechanisms of action as an antitumor agent and its synergistic effects with other chemotherapy drugs.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Omid Vakili, Pooria Asili, Zeinab Babaei, Maryam Mirahmad, Atoosa Keshavarzmotamed, Zatollah Asemi, Alireza Mafi
Summary: Circular RNAs (circRNAs) play important roles in the pathogenesis of Alzheimer's disease (AD) by acting as miRNA sponges or gene transcription modulators, involved in the accumulation of Aβ peptides and tau protein, and have been reported as potential diagnostic and therapeutic biomarkers in AD.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Behnaz Mokhtari, Masoud Hamidi, Reza Badalzadeh, Ata Mahmoodpoor
Summary: This study assessed the effect of mitochondrial transplantation on sepsis-induced myocardial dysfunction in a rat model. Mitotherapy significantly improved 72-hours survival, decreased LDH and cTn-I levels, restored mitochondrial function and gene expression, and suppressed inflammatory response. Mitotherapy offers a promising strategy to overcome life-threatening sepsis challenge.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Oncology
Amirhossein Davoodvandi, Sahand Sadeghi, Seyed Mohammad Amin Alavi, Seyedeh Shaghayegh Alavi, Ameneh Jafari, Haroon Khan, Michael Aschner, Hamed Mirzaei, Mehran Sharifi, Zatollah Asemi
Summary: Cancer is a serious health issue and drug therapy is commonly used for treatment. There is increasing interest in using natural compounds to overcome drug resistance and adverse reactions in cancer treatment. One such compound is berberine, which has a wide range of pharmacological activities and has shown anticancer effects on various gastrointestinal cancers. In this article, the therapeutic effects of berberine and its mechanisms on esophageal, gastric, colorectal, hepatocarcinoma, and pancreatic cancers are summarized.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Malihe Rezaee, Fatemeh Mohammadi, Atoosa Keshavarzmotamed, Sheida Yahyazadeh, Omid Vakili, Yaser Eshaghi Milasi, Vida Veisi, Rohollah Mousavi Dehmordi, Sepideh Asadi, Seyedeh Sara Ghorbanhosseini, Mehdi Rostami, Mina Alimohammadi, Abbas Azadi, Nushin Moussavi, Zatollah Asemi, Azadeh Aminianfar, Hamed Mirzaei, Alireza Mafi
Summary: Breast cancer is the most common cancer among women worldwide, and drug resistance is a major challenge in its treatment. Exosomal non-coding RNAs have the potential to regulate the molecular mechanisms and pathways related to breast cancer progression and drug resistance, and also serve as biomarkers for diagnosis and prognosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Atefe Rahmati, Alireza Mafi, Firooze Soleymani, Zahra Babaei Aghdam, Niloufar Masihipour, Behrooz Ghezelbash, Reza Asemi, Michael Aschner, Omid Vakili, Mina Homayoonfal, Zatollah Asemi, Mehran Sharifi, Abbas Azadi, Hamed Mirzaei, Esmat Aghadavod
Summary: Acute myeloid leukemia (AML) is a aggressive hematological malignancy with poor overall survival rates. Circular RNAs (circRNAs), a class of non-coding RNAs with a unique loop structure, have been found to be dysregulated in AML patients. These dysregulated circRNAs have been shown to regulate leukemia cell proliferation, stemness, and apoptosis in both positive and negative ways. Furthermore, circRNAs show potential as biomarkers and therapeutic targets in AML.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Neda Hedayati, Alireza Yaghoobi, Marziyeh Salami, Yasaman Gholinezhad, Farnaz Aghadavood, Reza Eshraghi, Mohammad-Hossein Aarabi, Mina Homayoonfal, Zatollah Asemi, Hamed Mirzaei, Mohammad Hajijafari, Alireza Mafi, Malihe Rezaee
Summary: Polyphenols, which are abundant in regular diets, have various beneficial effects such as antioxidative, anti-inflammatory, anticancer, neuroprotective, and cardioprotective effects. Recent research has focused on the potential of polyphenols as alternative treatments for cardiac remodeling following cardiovascular diseases. Through a systematic search of online databases, it was found that polyphenols regulate vital molecules and signaling pathways associated with heart failure, such as fibrotic and hypertrophic factors, mitochondrial dysfunction, free radical production, apoptosis, and lipid profile and cellular metabolism. This study aims to provide a comprehensive review of the underlying mechanisms of different polyphenol subclasses in cardiac hypertrophy and heart failure, as well as investigate nano-drug delivery methods to optimize treatment outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Mina Homayoonfal, Hamidreza Gilasi, Zatollah Asemi, Mahmood Khaksary Mahabady, Reza Asemi, Bahman Yousefi
Summary: In recent decades, natural compounds have shown great potential in preventing and treating chronic diseases such as cancer. Quercetin, a bioactive flavonoid, has high pharmacological value and health-promoting effects due to its antioxidant and anti-inflammatory properties. Both in vitro and in vivo studies have confirmed that Quercetin has significant potential in cancer prevention and development. It exerts its anticancer effects by influencing various cellular processes and regulating signaling pathways and non-coding RNAs. This review aims to summarize the impact of Quercetin on molecular pathways and non-coding RNAs in modulating cancer-associated cellular mechanisms.
CELLULAR SIGNALLING
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
