期刊
LABORATORY ANIMALS
卷 55, 期 1, 页码 76-80出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0023677220950782
关键词
Refinement; voluntary oral ingestion; stress; rodents; jam
资金
- Universidade do Porto/FMUP
- European Social Fund [NORTE-08-5369-FSE000011]
- Fundacao Grunenthal [Bolsa para Jovens Investigadores em Dor 2018]
Oral drug delivery through voluntary intake of drugs can minimize stress and pain in experimental rodents, improving their comfort and the accuracy of experimental results.
Drug administration to experimental rodents is often invasive and stressful, thus reducing animal welfare and potentially confounding experimental results. Methods of oral drug delivery in which rodents cooperate voluntarily minimize stress, pain and morbidity. We herein describe a method for oral administration through voluntary intake of strawberry jam, developed for C57BL/6J mice. During a 3-day habituation period, animals were placed in individual cages once daily and presented with a drop of jam. Five days later, the jam was again offered with admixed drug. Mice ingested it in less than 5 min, with latency times below 1 min, confirming the suitability of the administration method.
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