Article
Psychiatry
Ebba Du Rietz, Erik Pettersson, Isabell Brikell, Laura Ghirardi, Qi Chen, Catharina Hartman, Paul Lichtenstein, Henrik Larsson, Ralf Kuja-Halkola
Summary: ADHD shows strong genetic associations with neurodevelopmental disorders, and its comorbidity is largely explained by genetically influenced general psychopathology. The link between ADHD and externalising or internalising disorders is weaker and influenced by non-shared environmental effects.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Chemistry, Medicinal
Daniel Fernandez-Villa, Gerardo Asensio, Manuel Silva, Rosa Ana Ramirez-Jimenez, Laura Saldana, Nuria Vilaboa, Ana Leite-Oliveira, Julio San Roman, Blanca Vazquez-Lasa, Luis Rojo
Summary: The study presented novel vitamin B9 derivatives with divalent cations, which demonstrated bioactivity in modulating osteogenic-like or fibrocartilaginous-like phenotypes. These compounds show potential for further in vivo studies for musculoskeletal regeneration applications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Giulia Crisci, Sara Caviola, Ramona Cardillo, Irene C. Mammarella
Summary: The study found that all children in the clinical samples showed impairments in executive function measures, with a more specific pattern emerging in the updating tasks. Children with SLD had significant impairment in verbal updating, while those with ADHD, and those with SLD in comorbidity with ADHD, performed worst in visuospatial updating.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Pasquale Mastropierro, Alan R. Kennedy, Eva Hevia
Summary: The study presents a new method for rational design of bimetallic complexes combining an alkali-metal with a lower electropositive metal by synthesizing a new family of potassium metal(ates). The reactivity studies reveal the unique chemical profiles of these complexes, showcasing their potential for various applications in chemical cooperativity.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Kuzan, Marta Wujczyk, Rafal J. Wiglusz
Summary: Atherosclerosis is a multifactorial disease with a complex etiology that currently cannot be effectively prevented or reduce mortality from cardiovascular diseases. Analyzing the levels of micro- and macroelements has revealed interrelationships between elements during atherogenesis, providing important insights for further understanding the pathomechanism of atherosclerosis and the impact of dietary supplements on cardiovascular diseases in the future.
Article
Pediatrics
Lorena Frances, Jessica Caules, Antoni Ruiz, Catalina Virginia Soler, Amaia Hervas, Alberto Fernandez, Alberto Rodriguez-Quiroga, Javier Quintero
Summary: This study aimed to estimate the real prevalence of neurodevelopmental disorders in Spain and worldwide, and emphasized the importance of early detection programs and health planning. Assessments were conducted on 291 6-year-old children, revealing an overall risk of neurodevelopmental disorders of 55.4%. This included a 23.4% risk of ADHD, 2.8% risk of ASD, 30.6% risk of learning disorder with reading difficulties, 5.5% risk of tics, and 22.5% risk of language problems.
Article
Psychiatry
Johan Nyrenius, Jonas Eberhard, Mohammad Ghaziuddin, Christopher Gillberg, Eva Billstedt
Summary: This study aims to investigate the characteristics of autism spectrum disorder (ASD) in adult psychiatric outpatients and compare them with non-ASD patients. The results showed that the ASD group had a higher number of co-occurring psychiatric disorders and lower functional level compared to the non-ASD group. This study emphasizes the importance of comprehensive assessment of psychiatric disorders in ASD patients in adult psychiatric services.
Article
Plant Sciences
Boon Huat Cheah, Yu-Ling Chen, Jing-Chi Lo, I-Chien Tang, Kuo-Chen Yeh, Ya-Fen Lin
Summary: The study compared the physiological, transcriptional, and biochemical properties of rice subjected to zinc starvation or excess, revealing that both forms of zinc stress inhibited root and shoot growth, with different gene expressions showing unique responses to each form of zinc stress.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Ruksar Sande, Gaurav Doshi, Angel Godad
Summary: Metals and non-metals can affect the normal functions of the central nervous system (CNS), leading to neurological conditions such as epilepsy. Different metals and non-metals have various effects on CNS, such as manganese acting as a cofactor for antioxidant enzymes, iron and zinc leading to the formation of reactive species, and copper blocking neuronal transmission. Utilizing the potential of metals and non-metals in epilepsy treatment can help develop new adjuvant therapies.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Chemistry, Physical
Ling Li, Jiyao Zhou, Xinbin Pei
Summary: Manganese-based materials have shown promising electrochemical performance in aqueous zinc ion batteries. By doping the manganese site with metal, the synthesized MgCO3@2Mn0.99Co0.01CO3 material exhibits improved power capacity and two distinct morphologies, namely regular cubes with triangular pyramid and sheet structures.
Review
Cell Biology
Celine Deneubourg, Mauricio Ramm, Luke J. Smith, Olga Baron, Kritarth Singh, Susan C. Byrne, Michael R. Duchen, Mathias Gautel, Eeva-Liisa Eskelinen, Manolis Fanto, Heinz Jungbluth
Summary: Primary dysfunction of autophagy due to Mendelian defects affecting core components of the autophagy machinery or closely related proteins has been recognized as an important cause of genetic disease. These disorders can present throughout life, with severe early-onset neurodevelopmental disorders and more common adult-onset neurodegenerative disorders. The overlap between congenital autophagy disorders and other multisystem diseases reflects the complex roles of proteins and suggests a promising area for future research.
Article
Chemistry, Physical
Uladzislau Siamionau, Yauhen Aniskevich, Alexander Mazanik, Olga Kokits, Genady Ragoisha, Jae Hyeon Jo, Seung-Taek Myung, Eugene Streltsov
Summary: In this study, different MnO2 polymorphs were used as cathodes in zinc-ion batteries. The results showed that regardless of the polymorph, they exhibited similar electrochemical behavior and charge-discharge performance in weak acidic solutions, and underwent irreversible changes. These changes were caused by the dissolution and re-deposition of MnO2 and the formation of new manganese and zinc compounds. The newly formed MnO2 phase was amorphous and covered the surface of the initial crystalline particles, affecting the electrochemical behavior of the batteries. The electrochemical response of the MnO2 electrodes was strongly pH dependent.
JOURNAL OF POWER SOURCES
(2022)
Article
Chemistry, Multidisciplinary
Leipeng Li, Chongyang Cai, Xiaohuan Lv, Xingqiang Shi, Dengfeng Peng, Jianrong Qiu, Yanmin Yang
Summary: Due to the upcoming global energy crisis, the search for energy-saving materials has become more urgent. Mechanically induced luminescent materials have received considerable attention over the past two decades for their ability to convert waste into useful components, such as converting stress into light. This study introduces a strategy to improve mechanoluminescence (ML) of ZnO by embedding it in a ZnF2:Mn2+ matrix, which shows promising applications in various mechano-optics scenarios.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Daniel Perez-Antolin, Wolfgang Schuhmann, Jesus Palma, Edgar Ventosa
Summary: In this study, electrically-conducting and semi-flowable zinc semi-solid electrodes were proposed for mechanically-rechargeable alkaline zinc-air batteries. High energy densities were achieved thanks to the compromised flowability of the electrodes. Zinc semi-flowable electrodes serve as a green energy carrier, which can be generated using renewable sources and easily stored, transported, and used.
JOURNAL OF POWER SOURCES
(2022)
Review
Agriculture, Dairy & Animal Science
Santosh P. Lall, Sadasivam J. Kaushik
Summary: The article introduces fish mineral nutrition, discusses the complexity of mineral absorption and its relationship with dietary factors, highlights potential diseases caused by mineral deficiency, and emphasizes the importance of maintaining homeostasis in aquatic organisms.
Article
Biochemistry & Molecular Biology
Sergey A. Miroshnikov, Svetlana V. Notova, Margarita G. Skalnaya, Elena A. Sizova, Olga V. Marshinskaia, Tatiana V. Kazakova, Anatoly V. Skalny, Bernhard Michalke, Olga P. Ajsuvakova, Alexey A. Tinkov
Summary: The present study assessed the major copper and zinc species in dairy cow blood serum using a hybrid HPLC-ICP-MS technique. The study identified various species of copper and zinc and demonstrated their correlation. The findings can be used to assess the dietary status of trace elements in dairy cows.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Elena A. Sizova, Sergey A. Miroshnikov, Svetlana Notova, Olga Marshinskaya, Tatiana Kazakova, Alexey A. Tinkov, Anatoly Skalny
Summary: This study assessed hair and serum trace element and mineral levels in dairy cows in relation to daily milk yield. The results showed that serum trace element levels, in particular Se and Zn, were significantly associated with milk productivity in dairy cows. Serum minerals including Ca, Mg, and P were also found to be higher in highly productive cows, suggesting a potential tool for modulation of milk productivity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Environmental Sciences
Andre S. Olak, Willian S. Santos, Aline M. Susuki, Henrique Pott-Junior, Anatoly Skalny, Alexey A. Tinkov, Michael Aschner, Jose P. P. Pinese, Mariana R. Urbano, Monica M. B. Paoliello
Summary: Meteorological parameters play a significant role in modulating the transmission of the SARS-Cov-2 virus, with findings showing correlations between COVID-19 cases and various meteorological factors. Wind speed was identified as a key factor influencing the number of confirmed cases, encouraging the use of meteorological information in future risk assessment models.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2022)
Article
Biochemistry & Molecular Biology
Nidhi Girdhar, Heena Kansal, Kranti Garg, Siddharth Sharma, K. Sandeep Prabhu, Vishal Chopra, Alexey A. Tinkov, Anatoly Skalny, N. Tejo Prakash
Summary: This study investigated the correlation between serum selenium levels and the severity of asthma. The results showed that asthma patients had lower serum selenium levels compared to healthy individuals, with no significant differences based on gender and age. Patients with a family history of asthma and those using inhalers had slightly lower selenium concentrations.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yi Jing Ngu, Anatoly Skalny, Alexey A. Tinkov, Chien-Sung Tsai, Chun-Chao Chang, Yung-Kun Chuang, Vladimir N. Nikolenko, Dmitry A. Zotkin, Ching-Feng Chiu, Jung-Su Chang
Summary: The study found that exposure to essential metals may affect body composition and metabolic profiles, exacerbating the risk of metabolic syndrome.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Neurosciences
Beatriz Ferrer, Harshini Suresh, Alexey A. Tinkov, Abel Santamaria, Joao Batista Rocha, Anatoly Skalny, Aaron B. Bowman, Michael Aschner
Summary: Methylmercury is a global pollutant that damages the central nervous system, especially in vulnerable populations. Current therapeutic strategies for methylmercury poisoning are limited. Ghrelin has a protective effect against methylmercury-induced oxidative stress through upregulation of glutathione and induction of the NRF2/NQO1 pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Food Science & Technology
Anatoly Skalny, Michael Aschner, Marina Sekacheva, Abel Santamaria, Fernando Barbosa, Beatriz Ferrer, Jan Aaseth, Monica M. B. Paoliello, Joao B. T. Rocha, Alexey A. Tinkov
Summary: The present study reviewed epidemiological and experimental toxicology studies on the association between mercury (Hg) exposure and carcinogenesis over the past two decades. It was found that Hg exposure levels were linked to cancer risk and mortality in some studies, and the mechanisms involved interference with cellular signaling pathways and DNA repair mechanisms. Furthermore, Hg exposure may also impact epigenetic effects and contribute to carcinogenic activity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Anatoly V. Skalny, Eugeny P. Serebryansky, Tatiana V. Korobeinikova, Aristidis Tsatsakis, Constantine Vardavas, Monica M. B. Paoliello, Tatiana I. Sotnikova, Michael Aschner, Alexey A. Tinkov
Summary: The study found a significant association between smoking and levels of essential metals and metalloids in women, suggesting that smoking may alter the metabolism of these substances in the body.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Environmental Sciences
Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Alfred R. Bogdanov, Yousef Tizabi, Miriam B. Virgolini, Ji-Chang Zhou, Anatoly V. Skalny
Summary: The objective of this study was to review existing epidemiological and laboratory findings supporting the role of toxic metal exposure in non-alcoholic fatty liver disease (NAFLD). The existing studies demonstrate a link between exposure to cadmium, lead, arsenic, and mercury and an increased risk of NAFLD, as well as altered liver injury markers. Laboratory studies also show that metal exposure leads to hepatic lipid accumulation and affects metabolic pathways and inflammatory response.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
