Review
Chemistry, Multidisciplinary
Nicolas Fantozzi, Jean-Noel Volle, Andrea Porcheddu, David Virieux, Felipe Garcia, Evelina Colacino
Summary: This article highlights the significance of green chemistry methods for promoting sustainable development, with a focus on batch and continuous mechanochemical methods in organic synthesis. The environmentally-friendly aspects of these methods are objectively assessed using green metrics and indicators, providing a comprehensive evaluation of their greenness. The article also provides an introduction to the topic, discusses variables influencing reaction outcomes, and offers an outlook for future research in this field.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Engineering, Environmental
Marina Godino-Ojer, Sergio Morales-Torres, Elena Perez-Mayoral, Francisco J. Maldonado-Hodar
Summary: A highly efficient method for selectively synthesizing nitrogen heterocycles using carbon-supported ZnO catalysts under green chemistry conditions is presented. The physicochemical properties of different carbon supports play a role in catalytic performance. The developed catalysts, prepared by simple impregnation and thermal treatment, show great performance in the selective synthesis of quinolines under mild conditions.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Applied
Abdelrahman S. Khder, Moataz Morad, Hatem M. Altass, Amr A. Ibrahim, Saleh A. Ahmed
Summary: A series of new 12-tungstophosphoric acid (HPW) encapsulated MOF 199 catalysts were synthesized by a simple one step method, with excellent performance in synthetic reactions attributed to the uniform HPW distribution inside MOF 199 cavities and the Lewis acidity property of MOF 199. The catalysts also demonstrated high reusability, showing no significant loss of catalytic performance in consecutive reactions.
JOURNAL OF POROUS MATERIALS
(2021)
Article
Chemistry, Applied
Sofiane Mekki, Yacine Laichi, Farouk Benourrad, Narimen Lagha, Redouane Chebout, Khaldoun Bachari, Salima Saidi-Besbes
Summary: A new heterogeneous catalyst based on copper complex of 1,2,3-triazole supported on Fe3O4@SiO2 nanoparticles was designed and characterized. The catalyst showed high catalytic activity in the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions. The advantages of this catalytic system include high yields, short reaction times, eco-friendliness, and easy workup and purification conditions.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Engineering, Environmental
Hai Truong Nguyen, Tan Van Le, Phuong Hoang Tran
Summary: A sulfonated amorphous carbon (AC-SO3H) prepared from rice husk was characterized and used to synthesize pyrano[2,3-c]pyrazoles with moderate to good yields in a deep eutectic solvent. The catalytic system, easily synthesized from low-cost, non-toxic, eco-friendly materials, has potential for large-scale applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Inorganic & Nuclear
Ehsan Roustaie, Mahmood Tajbakhsh, Rahman Hosseinzadeh
Summary: Zinc oxide was supported on the surface of ZSM-5 zeolite using the extract of Convolvulus persicus to create a stable nanocatalyst, ZnO/ZSM-5. The catalyst exhibited good catalytic behavior in the Biginelli reaction, producing high yields of products and allowing for easy recovery and reusability.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yangjie Li, Kai-Hung Huang, Nicolas M. Morato, R. Graham Cooks
Summary: Systematic screening of accelerated chemical reactions at solid/solution interfaces using desorption electrospray ionization mass spectrometry revealed that glass surfaces can accelerate various base-catalyzed reactions, acting as strong bases in protic solvents and as 'green' heterogeneous catalysts in aprotic solvents. Additionally, glass surfaces were found to act as degradation reagents for phospholipids, indicating potential issues with storing base/nucleophile-labile compounds in glass containers.
Article
Pharmacology & Pharmacy
Emilija Milovic, Nenad Jankovic, Jelena Petronijevic, Nenad Joksimovic, Marijana Kosanic, Tatjana Stanojkovic, Ivana Matic, Nada Grozdanic, Olivera Klisuric, Srdan Stefanovic
Summary: This paper describes the synthesis, characterization, and biological evaluation of novel tetrahydropyrimidines (THPMs). These compounds exhibit wide pharmacological activities, including antimicrobial, antifungal, and anticancer properties. The study shows that compounds 4a, 4b, and 4d have the highest antibacterial activity, while compounds 4e, 4f, and 4k exhibit the best antifungal activity. Compound 4g demonstrates the strongest alpha-glucosidase inhibitory activity. The cytotoxicity tests on tumor cell lines indicate that compounds 4b and 4k show promising anticancer activity against HeLa cell lines. The research also examines the cell cycle and mechanism of action of the most active compounds.
Article
Chemistry, Multidisciplinary
Ayushi Sethiya, Jay Soni, Anu Manhas, Prakash Chandra Jha, Shikha Agarwal
Summary: The study synthesized novel pyrimidine derivatives using VB1 as an organocatalyst, which eliminated metal contamination and proved to be a better catalyst under sustainable conditions. The designed protocol showed high product yields, good functional group tolerance, and easily recoverable and reusable catalyst. Compound 5e was found to be the most potent with good binding interactions against Staphylococcus aureus dihydropteroate synthase (saDHPS) and DNA gyrase proteins.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Chemistry, Applied
Mina Rajabi, Jaydee Cabral, Sarah Saunderson, M. Azam Ali
Summary: Chitooligosaccharide (COS), an emerging material carbohydrate polymer, was prepared using a microwave-assisted process. The COS was then used to synthesize COS-poly(ethylene glycol) diacrylate (PEGDA) derivatives through aza-Michael addition. The resulting COS-PEGDA hydrogels showed high biocompatibility and can be potentially used in biomedical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Hourieh-Sadat Oboudatian, Mohsen Moradian, Hossein Naeimi
Summary: This study presents a green and efficient procedure for synthesizing 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) using morpholinum sulphate salt immobilized onto magnetic nanoparticles as a catalyst under ultrasound irradiation in ethanol. The advantage of this method lies in the easy separation and recyclability of the nanocatalyst, as well as its non-toxicity, versatility, and high stability. The short reaction times and high yields make it a useful and attractive protocol for the synthesis of DHPMs.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Selvi Arumugam, Nangan Senthilkumar, Natesan Thirumalaivasan, Govindaraj Dharman, Saravanan Pandiaraj, Mostafizur Rahaman, Manikandan Palaniappan, Rubiga Muthusami, Tamiliniyaa Manogaran, Lavanya Mari, Kuppusamy Kanagaraj, Rajakumar Govindasamy, Rajavel Rangappan
Summary: A Copper(II) Schiff-base complex immobilized mesoporous silica-41 (Copper-Schiff base@MCM-41) was synthesized and characterized using various characterization techniques. The catalyst showed excellent catalytic activity in the Biginelli reaction, achieving high product yield at room temperature. It could be easily recovered and reused for multiple cycles without significant loss of catalytic activity. The study proposed a plausible reaction mechanism.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Polymer Science
Siyu Pan, Nan Zhang, Xianzhe He, Zhao Fang, Yuwei Wu, Yen Wei, Lei Tao
Summary: In this study, a method for efficiently preparing functional polymers and self-healing hydrogels was developed. The resulting hydrogel exhibited excellent antioxidant ability, self-healing property, and injectability, and showed low cytotoxicity in animal experiments. This study demonstrates the value of the Hantzsch reaction in designing antioxidant self-healing hydrogels for biomedical applications.
Article
Chemistry, Multidisciplinary
Hourieh Sadat Oboudatian, Hossein Naeimi, Mohsen Moradian
Summary: This study utilized a chemical co-precipitation method to prepare Fe3O4 nanoparticles, followed by coating a SiO2 shell using the Stober method, and finally coating CPTES and morpholine on the SiO2 shell to successfully synthesize Mag@Morph-AIL. The nanocatalyst showed easy separation, recyclability, non-toxicity, versatility, high stability, short reaction times, and excellent yields, making it a useful method for the preparation of 3,4-dihydropyrimidinones.
Article
Chemistry, Physical
Dnyaneshwar Sanap, Lata Avhad, Suresh Ghotekar, Nitin D. Gaikwad
Summary: For the first time, mixed-phase magnetic Fe2O3 nanorods were successfully synthesized by biosynthesis using a sol-gel auto-combustion method. The catalytic effect of these nanorods on the synthesis of 6-(chloromethyl)-1,2,3,4-tetrahydro-2-pyrimidinone derivatives was investigated. The phase formation, surface topography, and crystallinity of the nanorods were explored using various spectroscopy and microscopy techniques.
JOURNAL OF MOLECULAR STRUCTURE
(2023)