Article
Chemistry, Physical
Jinbo Zhang, Manli Ma, Rong Zhou, Hongqiang Chu, Xue Wang, Shaojie Wang, Huhu Tian, Zhipeng Yan, Mingtao Li, Zhongyan Wu, Bin Li, Jiafeng Yan, Lan Anh Thi Nguyen, Rongxing Cao, Guoqing Wu, Xianghua Zeng, Hao-Li Zhang, Jaeyong Kim, Lin Wang, Yongjun Tian
Summary: In this study, it is demonstrated using multiple characterization techniques that the bowl-shaped clusters C18Te3Br4(Bu-O)(6) may undergo a Dehydro-Diels-Alder (DDA) reaction at high pressure, resulting in crystalline carbon materials with different transport properties.
Article
Chemistry, Organic
Yusuke Tomita, Naoto Haraguchi, Sayori Kiyota, Nobuyuki Komine, Masafumi Hirano
Summary: A traditional cobalt catalyst system has been found to exhibit previously undiscovered reactivity. Depending on the choice of tertiary phosphines and substrates, this catalytic system can catalyze diverse cycloadditions, yielding various cyclic compounds. The bite angles of the ligands used significantly contribute to the catalytic diversity.
Article
Chemistry, Multidisciplinary
Pablo Wessig, Dominik Badetko, Michael Koebe
Summary: This study reports the reaction results of two compounds containing methyl propiolate chromophores under triplet sensitization. Compared to non-sensitized irradiation, sensitized irradiation significantly increases the yield. Among several sensitizers, xanthone exhibits the best performance.
Article
Chemistry, Multidisciplinary
Steven Huss, Sikai Wu, Bo Chen, Tao Wang, Margaret C. Gerthoffer, Daniel J. Ryan, Stuart E. Smith, Vincent H. Crespi, John Badding, Elizabeth Elacqua
Summary: Carbon nanothreads, one-dimensional sp(3)-rich polymers, combine high tensile strength with flexibility due to their subnanometer widths and diamond-like cores. This study reports scalable synthesis of carbon nanothreads based on molecular furan, achievable at an onset reaction pressure of only 10 GPa due to reduced aromaticity. In-situ observations and various analyses support the formation of well-ordered crystalline material from liquid furan, providing evidence for the polymerization process and potential for large molecular weights.
Article
Chemistry, Multidisciplinary
David Fabian Leon Rayo, Young J. Hong, Dominic Campeau, Dean J. Tantillo, Fabien Gagosz
Summary: This article reports on the gold-catalyzed dehydro-Diels-Alder reactions of ynamide derivatives, which allow efficient access to various N-containing aromatic heterocycles. A dual gold catalysis mechanism was found, with the reaction proceeding in three stages: formation of a sigma,pi-digold complex, cyclization to produce a gem-diaurated aryl complex, and catalyst transfer to release the product and regenerate the sigma,pi-digold complex.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Zixi Zhu, Dale L. Boger
Summary: This article describes the second example of selective N1/N4 1,4-cycloaddition of 1,2,4,5-tetrazines with preformed or in situ generated enamines, promoted by the Lewis acid ZnCl2, with an expanded scope. The reaction involves a formal [4 + 2] cycloaddition across two nitrogen atoms (N1/N4 vs C3/C6) of a 1,2,4,5-tetrazine, followed by retro [4 + 2] cycloaddition, loss of a nitrile, and aromatization to provide 1,2,4-triazines. The optimization of reaction parameters, the simplification of the reaction through in situ enamine generation from ketones, the definition of the enamine reaction scope, and the exploration of the tetrazine scope are detailed, along with representative applications of the product 1,2,4-triazines. The work establishes and extends a powerful method for the efficient one-step regioselective synthesis of 1,2,4-triazines directly from easily accessible ketones, overcoming challenges in conventional approaches.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Rene Alberto Enriquez-Figueroa, Armando Pineda-Contreras, Octavio Barragan-Mares, Kayim Pineda-Urbina, Nancy Evelyn Magana-Vergara, Zeferino Gomez-Sandoval, Mikhail A. Tlenkopatchev
Summary: Benzyne derived from trichlorobenzene was employed in Diels-Alder cycloaddition reactions with dienes like furan and 2,5-dimethylfuran to synthesize novel dichloro-1,4-dihydro-1,4-epoxynaphtalene derivatives. The compounds were characterized using H-1 NMR spectra, with unambiguous proton chemical shift assignments based on 2D NMR data, and computational calculations were performed on the crystal structure of 5,6-dichloro-1,4-dihydro-1,4-epoxynaphtalene.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Organic
Nicole A. Carrillo Vallejo, Jonathan R. Scheerer
Summary: This study introduces a novel method for the synthesis of 1,4-oxazinone derivatives by Staudinger reductive cyclization and intermolecular cycloaddition/cycloreversion reactions. The synthesized compounds can be applied to the preparation of ErbB4 receptor inhibitors.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Engineering, Multidisciplinary
Qiong Wu, Qin-nan Hu, Ming-quan Li, Ze-wu Zhang, Wei-hua Zhu
Summary: In this study, NH2-substituted oxazoles and NO2/NF2/NHNO2-substituted ethylenes/acetylenes were designed to develop new bridge-ring insensitive high energy compounds through the Diels-Alder reaction. The designed compounds showed outstanding detonation performance and low impact sensitivity, suggesting potential applications in advanced insensitive high energy materials.
DEFENCE TECHNOLOGY
(2021)
Article
Chemistry, Organic
Fengjie Huang, Zhidao Huang, Guixia Liu, Zheng Huang
Summary: A trans-semihydrogenation of 1,3-enynes with ethanol was developed using a new (PCN)Ir complex and tBuNH2 as catalysts, providing an efficient synthesis of unsymmetrical (E,E)-1,4-diarylbutadienes.
Article
Chemistry, Organic
Bo-Wei Huang, Jeng-Liang Han
Summary: A vinylogous addition reaction of allyl aryl ketones can be catalyzed by squaramide catalysts to give good yields and excellent regioselectivity. Chiral tertiary alcohols and bicyclic pyrrolidones can be synthesized in good to excellent yields, enantioselectivities, and diaseteroselectivities. Experimental and DFT calculations suggest that the reaction favors 1,2-addition at lower temperatures and 1,4-addition/cyclization at higher temperatures. Compound 4 may form through either the 1,4-addition/cyclization pathway or retro-aldol reaction of compound 3, followed by subsequent 1,4-addition/cyclization.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Shigeki Isomura, Miyu Watanabe, Ayano Suzuki, Yoshinori Okuno, Misaki Okayasu, Isao Azumaya, Yasuo Sato
Summary: In this study, we synthesized an aminobutadiene derivative to investigate its role as an intermediate in the formation of 1,4-DHP and to study the reaction mechanism. The presence of excess ammonium salt increased the yield of the aminobutadiene derivative. Further experiments suggested that the predominant reaction pathway from the intermediate to 1,4-DHP involves the addition of a second amine molecule and the elimination of an amine.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Chemistry, Organic
Erandi Liyanage Perera, Daesung Lee
Summary: In this study, a sequential inter- and intramolecular addition reaction on electron-deficient 1,3-diynes conjugated with a ketone, ester, or imide functionality is described. This process is effectively directed by a propargylic -OH or -NH functionality. Alcohols, amines, and thiols show excellent reactivity for the initial addition. The addition of amines occurs at ambient temperature, whereas other nucleophiles require high temperatures and a base additive.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Jonathan R. Scheerer, Ella B. Leeth, Jennifer A. Sprow
Summary: A new method for preparing 1,4-oxazinone intermediates was developed via aza-conjugate addition of beta-amino alcohols to electron-deficient alkyne precursors. A tandem intramolecular cycloaddition and cycloreversion reaction sequence was evaluated and successfully applied in the synthesis of the guaipyridine alkaloid natural products rupestine M and L. The revised absolute configuration of natural rupestine L is suggested based on optical rotation, starting from (-)-citronellal and a known configuration of the C5 stereocenter.
SYNTHESIS-STUTTGART
(2023)
Article
Chemistry, Organic
Diksha Rajput, Dolma Tsering, Muthu Karuppasamy, Kamal K. Kapoor, Subbiah Nagarajan, C. Uma Maheswari, Nattamai Bhuvanesh, Vellaisamy Sridharan
Summary: An efficient synthetic method for oxazepino[5,4-b]quinazolin-9-ones, 6H-chromeno[4,3-b]quinolines, and dibenzo[b,h][1,6]naphthyridines was established using a substrate-based approach under microwave-assisted and conventional heating conditions, achieving high yields (up to 88%). The one-pot process involved CuBr2-catalyzed cascade annulation and delivered oxazepino[5,4-b]quinazolin-9-ones with two new heterocyclic rings and three new C-N bonds. Microwave assistance was found to be superior, providing clean and rapid reactions completed in 15 minutes, compared to longer reaction times and elevated temperatures required for conventional heating.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Computer Science, Artificial Intelligence
Lingbo Liu, Zewei Yang, Guanbin Li, Kuo Wang, Tianshui Chen, Liang Lin
Summary: This paper discusses an important task in land remote-sensing analysis, which is the automatic extraction of traffic roads from remote-sensing data. To address this problem, the authors introduce a novel neural network framework that utilizes the complementary information from different data sources to enhance the accuracy and robustness of road extraction.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Construction & Building Technology
Bing Cui, Huanling Wu, Canhui Zhao, Jiaping Liu, Zhiming Guo
Summary: Nanjing Jiangxinzhou Yangtze River Bridge is an innovative cable-stayed bridge in China with a unique steel-concrete composite structure. With the use of new materials, such as coarse aggregate reactive powder concrete, it has significantly improved the manufacturing speed and performance of the bridge, making significant contributions to the development of cable-stayed bridges.
STRUCTURAL ENGINEERING INTERNATIONAL
(2023)
Article
Materials Science, Paper & Wood
Jianjun Gu, Xiaofei Yan, Dongming Qi, Ruyi Xie, Xiaoming Yang, Yaobang Li, Jiawei Li
Summary: In this study, a durable multifunctional coating was successfully fabricated on cotton fabric, providing it with flame retardant, antibacterial, superhydrophobic and self-cleaning properties. The coated fabric exhibited excellent durability even after multiple washing cycles.
Article
Green & Sustainable Science & Technology
Gang Liu, Zhitao Han, Jiawei Li, Zhen Wang, Shaosi Cheng, Yubin Liu, Jing Yu, Xinxiang Pan
Summary: A novel method for removing pre-oxidized NOx using Na2SO3/THS composite solution is proposed in this study, aiming to achieve high NOx absorption efficiency and low nitrate concentration in scrubbed wastewater simultaneously.
ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY
(2023)
Article
Medical Informatics
Jiajun Liu, Shein-Chung Chow
Summary: In clinical trials, when the primary analysis fails to meet the study objective, the observed positive results in a specific sub-population analysis raise the question of whether they can be used to support regulatory submission. This article proposes several statistical evaluations for confirming the integrity and validity of the observed sub-population analysis results. The evaluations address selection bias, reproducibility, consistency, generalizability, and sensitivity index. A numerical example of a global clinical trial is presented, along with recommendations for incorporating statistical evaluations. Real-world data and evidence are suggested as possible solutions to address regulatory concerns and increase statistical power.
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2023)
Article
Oncology
Honghui Zhao, Dan Li, Jiayin Liu, Xinliang Zhou, Jing Han, Long Wang, Zhisong Fan, Li Feng, Jing Zuo, Yudong Wang
Summary: This study analyzed the characteristics of gut microbes in lung cancer patients and found that the differences in gut microbes are related to the effectiveness of anti-PD-1 therapy combined with chemotherapy. In particular, Bifidobacterium breve was identified as a potential biomarker for predicting efficacy.
Article
Computer Science, Interdisciplinary Applications
Maolin Yang, Pingyu Jiang, Jiajun Liu
Summary: Social product design (SPD) is a new pattern that utilizes socialized design resources to enhance design power with lower costs. However, the characteristics of socialized designers (SDs) result in problems such as low collaboration efficiency and trust. To address these problems, a Blockchain and modified Best-worst algorithm enhanced Blackboard model is established. The model improves collaboration efficiency and provides reliable recording and estimation of SDs' contributions during the SPD process, enhancing the operability of SPD application.
COMPUTERS & INDUSTRIAL ENGINEERING
(2023)
Article
Chemistry, Applied
Niuniu Cui, Jiawei Li, Ziwen Xie, Xiaofei Yan, Dongming Qi
Summary: The study introduces a novel pigment dyeing technology that uses charge attractions between cationic nanoscale pigment and cotton fabrics. This technology offers advantages such as no salt, recyclable dyebath, high uptake, and good wet fastness. The research explores the synthesis of cationic copolymer nanoparticle dispersants and the preparation of nanoscale pigment dispersion. The results demonstrate the excellent dispersion performance and colloid stability of the nanoscale pigment dispersion, as well as the higher coloring intensity and color fastness achieved in the dyeing of cotton fabrics. The recyclability of the dyebath significantly reduces dyeing effluent discharge, providing a promising and ecologically sustainable dyeing technology for cotton fabrics.
Article
Biochemistry & Molecular Biology
Xuhui Liu, Xiaoxiao Deng, Weilong Kong, Tong Sun, Yangsheng Li
Summary: Using genomics resources, we found that hybridization can significantly increase rice yield, especially by combining specific genotypes to increase grain number per panicle (GNPP).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Qian Wang, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Xun Wu, Tianqi Du, Yanliang Chen, Mingyu Tan, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Xiaohu Wang
Summary: The purpose of this study was to evaluate the biological effects of cancer stem cells (CSCs) irradiated by charged particle, including proliferation, invasion, migration, and changes in the molecular level. The results showed that CSCs have obvious radio-resistance compared with non-CSCs, and charged particle irradiation or in combination with drugs could overcome this resistance, specifically manifested in inhibiting CSCs' proliferation, invasion, migration, and causing more and harder to repair DNA double-stranded breaks (DSB) of CSCs.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Polymer Science
Yanning Zeng, Jiawei Li, Chaoying Hu, Bin Yang, Zhao Ning
Summary: Novel self-healing, weldable, and recyclable HTPB-based PU networks with dual reversible covalent bonds were fabricated using one-pot polycondensation. The networks exhibited good mechanical properties and the ability to be recycled.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Spectroscopy
Kang Wang, Gang Li, Mei Zhou, Huiquan Wang, Dan Wang, Ling Lin
Summary: This paper presents a novel method called spectral elimination for noninvasive quantitative analysis of human blood components. The method reduces the influence of non-target components on the detection of target components, resulting in high accuracy. Experimental results demonstrate the effectiveness of the method in predicting the content of multiple human blood components.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Nutrition & Dietetics
Bei Pan, Honghao Lai, Ning Ma, Dan Li, Xiyuan Deng, Xiaoman Wang, Qian Zhang, Qiuyu Yang, Qi Wang, Hongfei Zhu, Mengting Li, Xiao Cao, Jinhui Tian, Long Ge, Kehu Yang
Summary: Through a systematic review and meta-analysis of 37 cohort studies, it was found that an increased consumption of sugar-sweetened beverages (SSBs) per 250 mL/day was associated with a higher risk of breast, colorectal, biliary tract, and prostate cancer. Increased consumption of artificially sweetened beverages (ASBs) per 250 mL/day was associated with a higher risk of leukemia. Increased consumption of 100% fruit juice per 250 mL/day was associated with a higher risk of overall cancer, melanoma, squamous cell carcinoma, and thyroid cancer. There were linear dose-response associations between SSBs consumption and breast and kidney cancer, and between ASBs and fruit juices consumption and pancreatic cancer.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Biochemistry & Molecular Biology
Mingao Zhou, Yifei Jiang, Xuhui Liu, Weilong Kong, Chenhao Zhang, Jian Yang, Simin Ke, Yangsheng Li
Summary: The CYP76 subfamily, which belongs to the CYP superfamily, is crucial for phytohormone biosynthesis and response to environmental stresses in plants. Genome-wide analysis of the CYP76 subfamily in seven AA genome species revealed three groups, with Group 1 having the largest number of members. Analysis of cis-acting elements showed a high number of elements related to jasmonic acid and light response. Gene duplication analysis indicated expansion mainly through SD/WGD and tandem forms, with strong purifying selection during evolution. Expression pattern analysis showed that OsCYP76s exhibit restricted expression patterns in leaves and roots. qRT-PCR analysis of CYP76s under abiotic stresses revealed specific response patterns and functional divergence between japonica and indica rice. These findings provide valuable insights into the functional diversity and evolution of the CYP76 subfamily and have implications for improving stress tolerance and agronomic traits in rice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Xiang Shi, Yinpeng Liu, Jiawei Liu, Qikai Cheng, Wei Lu
Summary: Scientific papers are crucial for academic communication, but many of them lack in-depth research and present core content ambiguously, hindering the progression of science and technology. To address this challenge, the INTEGrity vERification (INTEGER) task is introduced to help researchers assess the integrity of their papers and verify the clarity of each knowledge unit. A multi-task learning model utilizing Tucker decomposition and span-level attention mechanism is proposed to accurately identify terms and their integrity. Experimental results show the effectiveness of the model.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)