Article
Rehabilitation
Chae Hyeon Ryou, Se Young Shin, Nackhwan Kim, Ki Hoon Kim, Dong Hwee Kim, Hang Jae Lee
Summary: This study investigated a safe and accurate method for needle insertion in electromyography (EMG) of the flexor digitorum profundus (FDP) I and II muscles. Ultrasonography was used to identify the anatomical relationship between the palmaris longus (PL) tendon, FDP muscle, and neurovascular bundle. The study found that EMG of FDP I and II can be performed precisely and safely using the anterior approach with the PL tendon, without damaging blood vessels or nerves.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Orthopedics
Mohammad M. Haddara, Eric C. Mitchell, Louis M. Ferreira, Joshua Gillis
Summary: The purpose of this study was to investigate the impact of anatomical versus extra-anatomical repairs on tendon loads and work of flexion in zone II flexor digitorum profundus lacerations. The results showed that anatomical repairs had no effect on tendon loads or work of flexion, while extra-anatomical repairs increased tendon loads and work of flexion. It is recommended to restore the anatomical relationship of the flexor digitorum profundus and flexor digitorum superficialis during the repair of zone II flexor tendon lacerations.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung-Hwan Park, Bo Mi Chung, Sujin Kim
Summary: This study used MRI to demonstrate the interconnections between flexor hallucis longus (FHL) and flexor digitorum longus (FDL) around the Master knot of Henry (MKH). The majority of the interconnections observed were type 1 (81%), with type 5 being the second most common (10%), followed by types 2 and 4 (4% each). The FHL tendon slips contributed to the second toe, and in 51% of cases, also the second and third toes. The layering organization was predominantly two-layered (59%), followed by three-layered (35%) and single-layered (6%). The distance between branching site and bony landmarks was longer in FDL to FHL cases, and the cross-sectional area (CSA) of FHL to FDL tendon slips was larger than FDL to FHL.
EUROPEAN RADIOLOGY
(2023)
Article
Orthopedics
Farouk Dargai, Elodie Payet, Xavier Guillot, Guillaume Fricault, Taha Mouhib
Summary: This study treated 81 cases of complete flexor digitorum profundus tendon disruptions in Zones 2B and 2C using the modified Mantero technique. The patients were followed up for a median of 62 months after the operation. The results showed that pulley venting had a significant positive impact on the range of motion and quick DASH scores. The modified Mantero repair is recommended as an alternative in the repair of tendon disruptions in Zone 2B and 2C, with good outcomes and low complication rates.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Orthopedics
Jeremy W. Mortimer, Hamad Alsaykhan, Subashan Vadibeler, Philippa A. Rust, Jennifer Z. Paxton
Summary: This study investigated the anatomy and histomorphology of the flexor digitorum profundus (FDP) enthesis in human cadaveric fingers, revealing morphometric variations influenced by sex, finger, and distance along the enthesis. Macroscopically, a trapezoidal insertion shape was consistently observed, while microscopically, a fibrocartilaginous enthesis with regional variation in fibrocartilage and tendon fiber angle change before insertion was identified. The findings have implications for tissue engineers and hand surgeons in recreating optimal FDP enthesis and emphasize the importance of region-specific knowledge for assessing soft tissue insertions.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Christopher M. Belyea, Pooyan Abbasi, Kavya K. Sanghavi, Aviram M. Giladi, Kenneth R. Means Jr
Summary: This study compared two suturing techniques for reattaching the flexor digitorum profundus (FDP) using all-suture anchor. The H + K technique performed significantly better in cyclic and load-to-failure testing, with less gapping and higher load to failure. This suggests that the H + K technique provides better clinical outcomes by shifting the point of failure to the bone level.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2023)
Article
Orthopedics
Liqin Xu, Mei Wang, Anthony Trenga, Steven Grindel, Roger Daley
Summary: This study investigated the biomechanical effects of altering the attachment site of the flexor digitorum profundus (FDP) tendon on the distal phalanx on distal interphalangeal joint flexion forces and range of motion. The results showed that inserting the FDP tendon at the distal edge of its footprint generated significantly greater force compared to the proximal insertion site, closely resembling the intact FDP tendon.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2021)
Article
Orthopedics
Takuma Kuroda, Koji Moriya, Naoto Tsubokawa, Yutaka Maki, Katsunori Inagaki, Takae Yoshizu
Summary: This study compared the outcomes of bridge tendon grafts and end-to-side tendon transfers for treating closed ruptures of the flexor tendons in Zones 3 to 5 of the little finger. The choice of surgical procedure based on the passive distraction amplitude of the ruptured tendon showed no significant differences in outcomes. This finding suggests that determining the passive distraction amplitude of the ruptured tendon can be useful in clinical practice.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Anatomy & Morphology
Juan Fernando Velez-Garcia, Aura Cristina Arbelaez-Quinones, Karoll Dayanna Montealegre-Hurtado
Summary: The flexor digitorum profundus muscle in the northern tamandua is highly developed, with an innervation pattern indicating that the medial head of triceps brachii muscle is not fused with it. This evolutionary adaptation may have originated from a common ancestor of the northern tamandua and the tamandua.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2021)
Article
Orthopedics
Sebastien Durand, Thierry Christen, Natalia Papastergiou
Summary: The modified technique using FDP hemi-tendon transfer offers a feasible solution for SORL procedure, improving DIP joint extension and preventing PIP joint hyperextension.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2021)
Article
Orthopedics
Jun Wang, Lei Qian, Zhenfeng Liu, Xinhao Wang, Cecilia Li-Tsang, Jianan Li, Yongjun Rui
Summary: This study compared the effects of three different treatment protocols on the excursion distance and tension of flexor tendons during simulated active and passive motion. The active motion protocol required the strongest tension and had the longest excursion distance. The modified Duran protocol resulted in less excursion compared to the modified Kleinert protocol. The choice of treatment protocol should be based on the strength of surgical repair and any complications.
JOURNAL OF HAND THERAPY
(2022)
Article
Surgery
Soo Min Cha, Hyun Dae Shin, Seung Hoo Lee, Jae Woo Shin
Summary: This study retrospectively reports the outcomes of patients with multiple flexor injuries accompanied by injuries to the digital nerve or vessels around the distal interphalangeal crease. The results indicate that satisfactory outcomes can be achieved through appropriate repair methods, despite the presence of multiple injuries.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Orthopedics
Serdar Koluacik, Ozgur Yilmaz, Okan Aslanturk
Summary: Flexor tendon entrapment (FTE) is a rare complication of pediatric forearm fractures that may be overlooked. Surgical treatment of FTE in late cases can lead to excellent outcomes.
JOINT DISEASES AND RELATED SURGERY
(2021)
Article
Medicine, General & Internal
Clara Elsner, Andreas Steven Kunz, Nicole Wagner, Henner Huflage, Stefan Huebner, Karsten Sebastian Luetkens, Thorsten Alexander Bley, Rainer Schmitt, Sueleyman Erguen, Jan-Peter Grunz
Summary: Recent MRI-based morphologic analysis revealed the presence of the chiasma antebrachii, representing an intersection of the flexor digitorum superficialis tendons in the distal third of the forearm. The chiasma was found in 98.9% of patients with a median length of 28mm, and its distances from the distal radioulnar and elbow joint were 16mm and 215mm, respectively. Knowledge of the chiasma morphology is crucial for targeted therapeutic injections or reconstructive surgery.
Article
Orthopedics
Yukihiro Osanami, Mitsuhiro Aoki, Rikiya Shirato, Yuki Saito, Egi Hidaka, Hiroki Miyamoto, Eiichi Uchiyama
Summary: This study aimed to investigate the effect of different blocking techniques and angles on tendon forces after repair, with results showing a significant increase in tensile load during palmar blocking, but no significant increase during lateral blocking.
JOURNAL OF HAND THERAPY
(2021)
Article
Engineering, Biomedical
Andrew N. Rosenbaum, Alfredo L. Clavell, John M. Stulak, Atta Behfar
Summary: There is a lack of data on the invasive assessment of afterload and its impact on cardiac output in patients on LVAD therapy. Despite no direct association between mean aortic pressure (MAP) and cardiac index (CI), varying MAP levels led to different cardiac output responses to speed increments. Patients with elevated MAP were found to benefit from nitrate therapy, demonstrating improved biventricular filling pressures and increased cardiac index. High afterload in LVAD patients is common, but can be improved with nitrates, highlighting the importance of further research on the effects of high afterload and chronic vasodilator therapy in this patient population.
Article
Engineering, Biomedical
Andrew N. Rosenbaum, John M. Stulak, Alfredo L. Clavell, Atta Behfar
Summary: This study evaluated the prognostic significance of hemodynamic indices in LVAD patients and found that LVEDP is a central prognostic marker in this population.
Article
Engineering, Biomedical
Bradley Ternus, Atta Behfar, John Schirger, Gregory Barsness, Mackram Eleid, Parag Patel, John Stulak, Jacob Jentzer
Summary: This study aimed to evaluate the clinical outcomes of hemodynamic optimization using IABP in high-risk heart failure patients before LVAD implantation. The results showed that patients treated with IABP before LVAD implantation had better reductions in pulmonary artery pressures without an increase in postoperative complications.
Article
Cardiac & Cardiovascular Systems
Alexander J. Ryu, Vinayak Kumar, Barry A. Borlaug, Armando Manduca, Chaitanya K. Rao, Raymond J. Gibbons, Samuel J. Asirvatham, Bernard J. Gersh, Krishnaswamy Chandrasekaran, Philip A. Araoz, Jae K. Oh, Alexander C. Egbe, Atta Behfar, Nandan S. Anavekar
Summary: The study investigated the ratio of myocardial volume in systole to myocardial volume in diastole (MVs/MVd) to differentiate between normal hearts and various cardiomyopathies with normal ejection fractions.
Results showed significant differences in MVs/MVd ratio between pathological subgroups and normal subjects, suggesting its potential as a novel and easily-captured metric for assessing ventricular function.
The study concluded that MVs/MVd ratio can effectively distinguish normal ventricular function from different cardiomyopathies, indicating its clinical utility in assessing heart disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew N. Rosenbaum, Bradley W. Ternus, Siddharth Pahwa, John M. Stulak, Alfredo L. Clavell, Sarah D. Schettle, Atta Behfar, Jacob C. Jentzer
Summary: In patients undergoing left ventricular assist device implantation, right ventricular stroke work index, right heart catheterization, cardiopulmonary bypass time, and ultrafiltration are strongly associated with incident INT-LD and decreased 1-year survival. Optimization of these factors may reduce the risk of liver dysfunction but further validation is needed.
ANNALS OF THORACIC SURGERY
(2021)
Article
Orthopedics
Hongbin Lu, Shengcan Li, Tao Zhang, Zhanwen Wang, Can Chen, Huabin Chen, Han Xiao, Linfeng Wang, Yang Chen, Yifu Tang, Shanshan Xie, Bing Wu, Jianzhong Hu
Summary: Initiating treadmill running on postoperative day 7 had a more prominent effect on bone-tendon interface (BTI) healing, accelerating healing and repair compared to other treatment regimens in this study.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Orthopedics
Zhanwen Wang, Yang Chen, Han Xiao, Shengcan Li, Tao Zhang, Jianzhong Hu, Hongbin Lu, Hui Xie
Summary: The study showed that acetylcholine and pyridostigmine could enhance bone-tendon interface healing in a murine model of rotator cuff repair by increasing proteoglycan content, retaining M2 macrophages, and improving failure load and stiffness.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Shengcan Li, Zihan Xu, Zhanwen Wang, Jie Xiang, Tao Zhang, Hongbin Lu
Summary: The study found that LIPUS treatment can accelerate bone-tendon interface healing, which is associated with macrophages. Using a murine rotator cuff repair model, it was discovered that LIPUS treatment can promote the formation of fibrocartilage and improve bone quality.
Article
Oncology
Zhanwen Wang, Zeling Long, Hong Li, Hongbin Lu, Anne Gingery, Peter C. Amadio, Steven L. Moran, Chunfeng Zhao
Summary: The study found that there was no significant difference in repair strength and stiffness of the rotator cuff using mesh suture or FiberWire. However, the DRS technique resulted in significantly higher failure load when the same suture material was used. The repair technique has an impact on the biomechanical properties of rotator cuff repair.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
D. Kent Arrell, Ruben J. Crespo-Diaz, Satsuki Yamada, Ryounghoon Jeon, Armin Garmany, Sungjo Park, Jeffrey P. Adolf, Christopher Livia, Matthew L. Hillestad, Jozef Bartunek, Atta Behfar, Andre Terzic
Summary: Stem cell paracrine activity, specifically secreted proteins by cardiopoietic cells, play a key role in cardiac repair. Through systems analytics and RNA sequencing, miR-146 was identified as a regulator upstream of the decoded secretome. The therapeutic impact of cardiopoietic cell therapy on infarcted hearts is influenced by the inherent vasculogenic properties and smooth muscle differentiation of the secreted proteins.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Engineering, Biomedical
Can Chen, Qiang Shi, Muzhi Li, Yang Chen, Tao Zhang, Yan Xu, Yunjie Liao, Shulin Ding, Zhanwen Wang, Xing Li, Chunfeng Zhao, Lunquan Sun, Jianzhong Hu, Hongbin Lu
Summary: An optimized decellularization approach was developed to fabricate a book-shaped decellularized enthesis matrix (O-BDEM), which was then combined with recombinant growth factors (CBP-GFs) tethered to the collagen of O-BDEM to create a novel scaffold (CBP-GFs/O-BDEM) for rotator cuff repair. The low immunogenicity of CBP-GEs/O-BDEM was confirmed in a mouse model, and the high regenerative potential of the engineered graft was demonstrated in a canine model. These findings highlight the potential of CBP-GEs/O-BDEM as an excellent scaffold for large/massive rotator cuff tear repair and provide new insights into interfacing tissue fabrication.
BIOACTIVE MATERIALS
(2022)
Article
Cell & Tissue Engineering
Guidong Shi, Zeling Long, Rodolfo E. De la Vega, Atta Behfar, Steven L. Moran, Christopher Evans, Chunfeng Zhao
Summary: The study found that purified exosome product (PEP) can be internalized by cells at a fast rate and enhance cellular proliferation and migration while attenuating apoptosis. PEP can potentially increase the expression of PCNA and reduce the expression of CASP3/7/9 and BAX, suggesting an innovative strategy for chondrogenesis that could be applied to osteoarthritis repair in the future.
REGENERATIVE MEDICINE
(2023)
Article
Immunology
Lina Zhang, Zhanwen Wang, Feng Lyu, Chun Liu, Chunhui Li, Wei Liu, Xinhua Ma, Jieyu Zhou, Xinyu Qian, Zhaoxin Qian, Yong Lu
Summary: Understanding the inflammatory and immune responses to Omicron infection based on age is crucial in addressing this global health threat as it enables the development of tailored treatments for different age populations.
FRONTIERS IN IMMUNOLOGY
(2023)
