Article
Immunology
Dandan Wang, Yewei Wang, Yan Chen, Lingfang Yu, Zenan Wu, Ruimei Liu, Juanjuan Ren, Xinyu Fang, Chen Zhang
Summary: This study aimed to compare the differences in cognitive functioning and inflammatory cytokine levels among different types of schizophrenia patients and healthy controls. The results showed that deficit schizophrenia patients had worse cognitive performance and higher levels of certain inflammatory cytokines compared to nondeficit schizophrenia patients and healthy controls. These findings suggest that deficit syndrome may be an independent endophenotype of schizophrenia with unique immune-inflammatory features.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jianhai Bi, Qiuchen Li, Zhigang Yang, Lei Cai, Tao Lv, Xun Yang, Li Yan, Xia Liu, Qian Wang, Xin Fu, Ran Xiao
Summary: Excessive consumption of high-fat diet (HFD) is a significant risk factor for many diseases, and induces low-grade systemic inflammation characterized by increased levels of pro-inflammatory cytokines, impairing the functions of mesenchymal stem cells (MSCs) like bone marrow MSCs. Specifically, continuous elevation of serum CXCL2 level in rats under HFD suppresses adipogenic potential, promotes migration and senescence of BMSCs via Rac1 activation, over-production of ELMO1 and ROS respectively.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Cory J. Evans, Ting Liu, Juliet R. Girard, Utpal Banerjee
Summary: This article focuses on the inflammatory response to sterile injury in Drosophila, specifically in embryos and adults. The study reveals that sterile injury activates Toll and Jun kinase (JNK) signaling, leading to the differentiation of a unique blood cell type called lamellocytes in larvae. Additionally, Toll and JAK/STAT signaling are required for the emergence of these injury-induced lamellocytes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Ingrydt de Alcantara Almeida, Betty Mancebo Dorvigny, Lethicia Souza Tavares, Lucas Nunes Santana, Jose Vitor Lima-Filho
Summary: Caffeine does not have direct antibacterial effects against L. monocytogenes in vitro, but it can enhance macrophage viability and reduce intracellular bacterial loads. In Swiss mice, caffeine treatment reduced leukocyte infiltration in the peritoneal cavity, as well as bacterial burden in the spleen and liver. Additionally, caffeine downregulated pro-inflammatory cytokines IL-1 beta, IL-6, and iNOS, while increasing anti-inflammatory cytokine IL-10 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Rheumatology
Cesar Diaz-Torne, M. Angels Ortiz, Andrea Garcia-Guillen, Sicylle Jeria-Navarro, Lluis Sainz, Susana Fernandez-Sanchez, Hector Corominas, Silvia Vidal
Summary: The study showed elevated levels of certain pro-inflammatory cytokines and metabolic proteins in intercritical gout patients. These levels were associated with estimated monosodium urate crystal deposition and cardiovascular risk factors.
Article
Biochemistry & Molecular Biology
Peter Smoak, Susan J. Burke, Thomas M. Martin, Heidi M. Batdorf, Z. Elizabeth Floyd, J. Jason Collier
Summary: Non-resolving pancreatic islet inflammation is a contributor to the decrease in beta-cell mass and function in both Type 1 and Type 2 diabetes. This study demonstrates the potential of 2',4'-dihydroxy-4-methoxydihydrochalcone (DMC2), a compound derived from Artemisia dracunculus L., as an anti-inflammatory agent that can preserve glucose-stimulated insulin secretion.
Review
Pharmacology & Pharmacy
Jialei Zhu, Jing Jin, Jing Tang
Summary: This review summarized the inflammatory pathological mechanisms associated with postpartum depression (PPD) and introduced potential therapeutic alternatives. Due to limited research, there are still many directions for further investigation into the inflammatory mechanisms of PPD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Mohamed Luban Sobah, Clifford Liongue, Alister C. Ward
Summary: Cytokine signaling is crucial for the immune system, with the SOCS family of proteins playing a key role in regulating these signals. By negatively regulating cytokine signaling, SOCS proteins influence immune cell development and function, impacting the development of inflammatory and malignant diseases.
FRONTIERS IN MEDICINE
(2021)
Review
Plant Sciences
Fabiolla Rocha Santos Passos, Heitor Gomes Araujo-Filho, Brenda Souza Monteiro, Saravanan Shanmugam, Adriano Antunes de Souza Araujo, Jackson Roberto Guedes da Silva Almeida, Parimelazhagan Thangaraj, Lucindo Jose Junior Quintans, Jullyana de Souza Siqueira Quintans
Summary: This review summarizes preclinical studies on the anti-inflammatory activity of steroidal saponins through the modulation of inflammatory cytokines. The results show that steroidal saponins and sapogenins have anti-inflammatory, antinociceptive, and antioxidant effects, and they mainly modulate inflammatory cytokines through the Nf-Kappa B, TLR4, and MAPKs pathways.
Article
Food Science & Technology
Chia-Chien Hsieh, Yen-Fang Wang, Pin-Yu Lin, Shih-Han Peng, Mei-Jia Chou
Summary: The study revealed that lunasin can reduce inflammation levels in obese mice, decrease macrophage infiltration in adipose tissue, and regulate spleen size and cell numbers. Additionally, lunasin promotes the production of interferon gamma and interleukin-2 in splenocytes, thus modulating immune responses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Plant Sciences
Isadora de Fatima Braga Magalhaes, Ana Leticia Marinho Figueiredo, Elizeu Mendes da Silva, Adryan Adam Batalha de Miranda, Claudia Quintino da Rocha, Katia da Silva Calabrese, Fernando Almeida-Souza, Ana Lucia Abreu-Silva
Summary: A study focuses on the anti-inflammatory potential of Passovia ovata extract, which contains high levels of flavonoids. The results demonstrate significant reduction in inflammatory markers both in cell experiments and animal models. This study indicates the potential of Passovia ovata extract as a new agent for suppressing inflammatory responses.
Review
Immunology
Syed Faizan Mehdi, Suma Pusapati, Raja Ram Khenhrani, Muhammad Saad Farooqi, Sobia Sarwar, Ahmad Alnasarat, Nimisha Mathur, Christine Noel Metz, Derek LeRoith, Kevin J. Tracey, Huan Yang, Michael J. Brownstein, Jesse Roth
Summary: Sepsis is a life-threatening inflammatory syndrome caused by dysregulated immune responses to infection. Human chorionic gonadotropin (hCG) and oxytocin, among other hormones, have anti-inflammatory properties and may play a role in limiting organ damage associated with sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'Dowd, Laura O'Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Summary: Clinical outcomes of SARS-CoV-2 infection show a wide range, from asymptomatic cases to severe pneumonia and death. This variability is influenced by differences in the immune response to the virus. A study measured inflammatory markers in patients with acute COVID-19 and found that most pro-inflammatory markers were significantly elevated, and specific markers were associated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Samuel Adler, Wyatt Olsen, Bryna Rackerby, Rachel Spencer, David C. Dallas
Summary: This study investigated the effects of whey protein isolate (WPI) supplementation on inflammatory markers in healthy older adults. The results showed that WPI supplementation did not significantly alter most inflammatory markers, but could alter the concentrations of some inflammatory markers.
Review
Immunology
Jingjin Song, Hua Peng, Min Lai, Huiyuan Kang, Xiaofang Chen, Ye Cheng, Xin Su
Summary: Aortic dissection is characterized by severe intramural hematoma formation and acute endometrial rupture, and its progression is significantly complicated due to the aberrant infiltration of pro-inflammatory cells and the aberrant expression of pro-inflammatory cytokines. These pro-inflammatory cytokines, such as TNF-α, IL-13, and IF, play an essential role in the pathological development of aortic dissection. Understanding the relationship between pro-inflammatory cytokines and aortic dissection can guide therapeutic strategies in clinical practice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Soraya Pourmollaei, Abolfazl Barzegari, Azizeh Farshbaf-Khalili, Mohammad Nouri, Amir Fattahi, Mahnaz Shahnazi, Ralf Dittrich
Review
Integrative & Complementary Medicine
Hanieh Salehi-Pourmehr, Alireza Ostadrahimi, Mehdi Ebrahimpour-Mirzarezaei, Azizeh Farshbaf-Khalili
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2020)
Article
Education, Scientific Disciplines
Roghaiyeh Nourizadeh, Samar Azami, Azizeh Farshbaf-Khalili, Esmat Mehrabi
JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
(2020)
Article
Orthopedics
Bina Eftekharsadat, Negar Fasaie, Dina Golalizadeh, Arash Babaei-Ghazani, Fatemeh Jahanjou, Yashar Eslampoor, Neda Dolatkhah
BMC MUSCULOSKELETAL DISORDERS
(2020)
Review
Genetics & Heredity
Fatemeh Diba-Bagtash, Azizeh Farshbaf-Khalili, Alyeh Ghasemzadeh, Laura Lotz, Amir Fattahi, Mahnaz Shahnazi, Ralf Dittrich
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Education, Scientific Disciplines
Masoumeh Hosseinpanahi, Mojgan Mirghafourvand, Azizeh Farshbaf-Khalili, Khalil Esmaeilpour, Masoumeh Rezaei, Jamileh Malakouti
JOURNAL OF EDUCATION AND HEALTH PROMOTION
(2020)
Article
Education, Scientific Disciplines
Jamileh Malakouti, Robab Golizadeh, Mojgan Mirghafourvand, Azizeh Farshbaf-Khalili
JOURNAL OF EDUCATION AND HEALTH PROMOTION
(2020)
Article
Medicine, General & Internal
Nava Ainehchi, Arash Khaki, Elaheh Ouladsahebmadarek, Mohamad Hammadeh, Laya Farzadi, Azizeh Farshbaf-Khalili, Solmaz Asnaashari, Hossein Jabbari Khamnei, Amir Afshin Khaki, Majid Shokoohi
ARCHIVES OF MEDICAL SCIENCE
(2020)
Article
Medicine, General & Internal
Bina Eftekharsadat, Fatemeh Jahanjoo, Vahideh Toopchizadeh, Fariba Heidari, Razieh Ahmadi, Arash Babaei-Ghazani
CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Shahla Barzgar-Molan, Azizeh Farshbaf-Khalili, Mohammad Asghari Jafarabadi, Jalil Babapour, Parisa Yavarikia
CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
(2020)
Article
Rehabilitation
Yashar Sarbaz, Kamran Naderi Beni, Azar Hosseininejad, Bina Eftekharsadat, Fatemeh Jahanjoo
INTERNATIONAL JOURNAL OF THERAPY AND REHABILITATION
(2020)
Article
Clinical Neurology
Mohammad Barzegar, Vahideh Toopchizadeh, Diena Golalizadeh, Ali Pirani, Fatemeh Jahanjoo
IRANIAN JOURNAL OF CHILD NEUROLOGY
(2020)
Article
Medicine, General & Internal
Vahideh Toopchizadeh, Shima Karimnia, Bina Eftekhar Sadat, Fatemeh Jahanjoo, Mohammad Zakaria Pezeshki
CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
(2020)