期刊
JOURNAL OF NUCLEAR MEDICINE
卷 61, 期 12, 页码 -出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.120.255364
关键词
integrins; SARS-CoV-2; positron emission tomography; peptides; fibrosis
资金
- NIH [U01 CA217665]
The true impact and long-term damage to organs such as the lungs after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain to be determined. Noninvasive molecularly targeted imaging may play a critical role in aiding visualization and understanding of the systemic damage. We have identified alpha(v)beta(6) as a molecular target; an epithelium-specific cell surface receptor that is low or undetectable in healthy adult epithelium but upregulated in select injured tissues, including fibrotic lung. Herein we report the first human PET/CT images using the integrin alpha(v)beta(6)-binding peptide (F-18-alpha(v)beta(6)-BP) in a patient 2 mo after the acute phase of infection. Minimal uptake of F-18-alpha(v)beta(6)-BP was noted in normal lung parenchyma, with uptake being elevated in areas corresponding to opacities on CT. This case suggests that F-18-alpha(v)beta(6)-BP PET/CT is a promising noninvasive approach to identify the presence and potentially monitor the persistence and progression of lung damage.
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