Comprehensive review on tumour active palladium compounds and structure-activity relationships

This article provides a comprehensive review of palladium compounds that have been evaluated for anticancer activity in vivo or in vitro from the era of discovery of cisplatin up to 2015. In total, 847 compounds have been discussed into three categories namely (1) potent palladium compounds, (2) palladium compounds with comparable activity and (3) palladium compounds with insignificant activity. Structure activity relationships are proposed that may aid in the design of new palladium compounds with greater antitumour activity. (C) 2016 Elsevier B.V. All rights reserved.